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S Oksuzyan, C M Crespi, M Cockburn, G Mezei, L Kheifets
AIMS: We conducted a large registry-based study in California to investigate the association of perinatal factors and childhood CNS tumors, with analysis by tumor subtype. METHODS: We linked California cancer and birth registries to obtain information on 3308 cases and 3308 controls matched on age and sex. We examined the association of birth weight, gestational age, birth order, parental ages, maternal conditions during pregnancy, newborn abnormalities and the risk of childhood CNS tumors using conditional logistic regression, with adjustment for potential confounders...
August 2013: Cancer Epidemiology
P Gaviani, E Corsini, A Salmaggi, E Lamperti, A Botturi, A Erbetta, I Milanesi, F Legnani, B Pollo, A Silvani
Neoplastic meningitis (NM) is diagnosed in 1-2 % of patients with primary brain tumors. Standard treatment of NM includes single-agent or combination chemotherapy, with compounds such as methotrexate, thiotepa, and cytarabine (Ara-C) or its injectable, sustained-release formulation Depocyte(®). In this Report, we reported the data of efficacy and tolerability of an intrathecal Depocyte(®) regimen for patients presenting with NM from primary brain tumors. We described 12 patients with NM confirmed at magnetic resonance imaging (MRI) and with a positive cerebrospinal fluid (CSF) cytology...
December 2013: Neurological Sciences
Ervin Jancić, Hrvoje Cvitanović, Vesna Miholović, Diana Kralj, Biserka Hranilović
The aim of this study was to provide an overview of the central nervous system (CNS) tumours epidemiology in Karlovac region, over the 1995-2010 period. We analyzed data on 359 patients (194 men and 165 women), diagnosed with CNS tumours according to the World Health Organization's diagnostic criteria, in period 1995-2010. The data were obtained from the Neurology and Neurosurgery Department, including other medical records. The data were analysed with t-test and chi-square test. A total of 359 cases of tumours in CNS were recorded for the period of 1995-2010, with slight predominance of men (194;54...
September 2011: Collegium Antropologicum
Iliya Tsekov, Dilyan Ferdinandov, Ventzeslav Bussarsky, Svetlana Hristova, Zlatko Kalvatchev
A total of 111 fresh brain biopsies from patients with primary brain tumors were examined for JC polyomavirus sequences from the Large T antigen encoding region (LT) and the viral non-coding control region (NCCR). SYBR Green and TaqMan real-time polymerase chain reaction assays were used. In the glioblastoma group of 39 patients 48.7% were positive for LT sequences. Among the astrocytoma group (19 patients) and the oligodendroglioma group (12 patients) 31.6% and 33.3% were also positive. The prevalence of LT genomic sequences among the other groups was as follows: in 2 out of 3 oligoastrocytomas; in 3 out 5 gangliogliomas; in 2 out of 5 meduloblastomas; in 1 out 3 pineocytomas; and in none of the tested 5 ependimomas...
September 2011: Journal of Medical Virology
Georgios Bakaloudis, Francesco Lolli, Mario Di Silvestre, Tiziana Greggi, Stefano Astolfi, Konstantinos Martikos, Francesco Vommaro, Giovanni Barbanti-Brodano, Alfredo Cioni, Stefano Giacomini
The traditional surgical treatment of severe spinal deformities, both in adult and pediatric patients, consisted of a 360° approach. Posterior-based spinal osteotomy has recently been reported as a useful and safe technique in maximizing kyphosis and/or kyphoscoliosis correction. It obviates the deleterious effects of an anterior approach and can increase the magnitude of correction both in the coronal and sagittal plane. There are few reports in the literature focusing on the surgical treatment of severe spinal deformities in large pediatric-only series (age <16 years old) by means of a posterior-based spinal osteotomy, with no consistent results on the use of a single posterior-based thoracic pedicle subtraction osteotomy in the treatment of such challenging group of patients...
May 2011: European Spine Journal
J A Simal-Julián, R Sanchis-Martín, R Prat-Acín, P Miranda-Lloret, R Conde-Sardón, E Cárdenas-Ruiz-Valdepeñas, A Beltrán-Giner
INTRODUCTION: we report the clinical, radiological and pathological features of a spinal pleomorphic xanthoastrocytoma, an unusual neoplastic entity in a really rare location, establish an appropriated management of these lesions and review the short available english literature. CASE REPORT: a 60 years old woman consulted with doctor because she felt progressive clumsiness accompanied by occasional paresthesias on her left hand. Neurological examination showed up weakness and slight propioceptive disturbances...
October 2010: Neurocirugía
M Gelabert-González, A Arcos-Algaba, R Serramito-García, D Castro-Bouzas, J M Santín-Amo, E Aran-Echabe, A Prieto-González, F J Bandin-Diéguez, A García-Allut
OBJECTIVE: to analyze the clinical, radiological and surgical outcome of a series of filum terminale ependymomas. Patients and methods. This retrospective study involved 20 patients with 21 ependymomas of the filum terminale encountered during a 21 year period (1988- 2008). All patients were diagnosed using MRI and surgically treated. RESULTS: the male: female ratio was 1:1.5, and the mean age at diagnosis was 44.8 years (range 15-64). First symptom included radicular pain (12 cases) and lumbar pain in the other 8 cases, with average symptom duration of 8...
October 2010: Neurocirugía
V V Dmytrenko, T V Bukreieva, K O Shostak, N Ia Vitak, Iu A Pekars'kyĭ, T A Malysheva, M I Shamaiev, V D Rozumenko, V V Kondratiuk, Iu P Zozulia, V M Kavsan
A comparison of gene expression profiles in different types of human brain tumours and normal brain by Serial Analysis of Gene Expression (SAGE) revealed exceptionally high content of CTTGGGTTTT tag in meningioma and ependimoma SAGE-libraries. A search of the most relevant gene for this tag on the website "SAGE Anatomic Viewer" showed that it belonged to the nucleotide sequence of insulin-like growth factor II (IGF-II) gene as well as to the open reading frame 43 on a chromosome 11 (C11orf43). This nucleotide sequence encodes putative insulin-like growth factor II associated protein (IGF-IIA)...
March 2007: Ukraïnsʹkyĭ Biokhimichnyĭ Z︠h︡urnal
M Gelabert-González
INTRODUCTION: Primary intraspinal tumours comprise between 10 and 15% of all central nervous system tumours. Classically are classified into three groups, based on its location; namely: extradural, intradural extramedullary, and intramedurally spinal tumours. PATIENTS AND METHODS: We review retrospectively 173 intradural spinal tumours (in 168 patients) operated between 1980-2004. Age, sex, duration and type of symptoms, topographical locations, radiological and surgical results, histological features and outcome are analyzed...
March 1, 2007: Revista de Neurologia
S Bulnes-Sesma, N Ullibarri-Ortiz de Zárate, J V Lafuente-Sánchez
INTRODUCTION: Experimental central nervous system (CNS) tumours have been proposed as a useful model for the study of oncogenesis, epiphenomena related to cancer and for the design of new therapeutic strategies. DEVELOPMENT: The administration of chemical substances is one of the most commonly-used methods to induce CNS neoplasms. N-ethyl-N-nitrosourea (ENU) belongs to the nitrosourea family, a wide group of alkylating agents that are able to induce brain tumours in litters after transplacentary administration at the 15th day of pregnancy...
December 16, 2006: Revista de Neurologia
Antonio Balsamo, Alessandra Antelli, Lilia Baldazzi, Federico Baronio, Dina Lazareva, Alessandra Cassio, Alessandro Cicognani
We report on a DAX1 gene investigation in a patient with X-linked adrenal hypoplasia congenita (AHC) and hypogonadotropic hypogonadism (HH) in order to identify mutations causing this disorder and to confirm the clinical diagnosis. The description of the clinical course of the condition with a detailed documentation of longitudinal data is also reported. A male newborn was referred at 45 days of life because of vomiting, dehydration, and weight loss. The diagnosis was primary adrenal insufficiency. The appropriateness of glucocorticoid therapy during the prepubertal period was difficult to judge because of elevated ACTH levels on one hand and progressive retardation of bone age on the other hand...
June 15, 2005: American Journal of Medical Genetics. Part A
I Vega, A León, P Zolezzi, H Ibarra, C Faúndez, J Montecinos
BACKGROUND: Little information is available in Chile about hepatitis C virus (HCV) in hematological and oncohematological patients. AIM: To evaluate the prevalence of hepatitis C virus markers in a group of hematological and oncohematological pediatric patients seen at Valdivia Regional Hospital. PATIENTS AND METHODS: Antibodies against virus C, determined by ELISA and viral RNA, determined using RT-polymerase chain reaction, were measured in 54 blood samples from children with hematological diseases (34 with Acute Lymphoblastic Leukaemia, 4 with Hodgkin Diseases, 4 with Haemolytic Anemia, 5 with Sarcomas, 2 with Non-Hodgkin Lymphoma, 2 with Thrombocytopenic Purpura, 1 with an Ependimoma, one with a Wilms Tumor and 1 with a Von Willebrand Disease)...
January 2001: Revista Médica de Chile
Sörensen, Savitcheva, Engler, Langstrom
Purpose: The aim of the study was to examine the utility of PET with 11C-Methionine in diagnosis and evaluation of the treatment efficacy in childhood brain tumors.Methods: 16 PET-studies were performed in 11 children, 4-17years old, 3 boys and 8 girls, with brain tumors or tumor suspicion. Reasons for PET-study were an unclear diagnosis of tumor (7 cases), treatment efficacy definition (5 cases) and identification of tumor recurrence (3 cases). Studies were performed after i.v. injection of 11C-Methionine (6-9 MBq/kg)...
July 2000: Clinical Positron Imaging: Official Journal of the Institute for Clinical P.E.T
E Cattaneo, L Magrassi, C De-Fraja, L Conti, I Di Gennaro, G Butti, S Govoni
BACKGROUND: Recent demonstrations that the JAK/STAT and ShcA signalling proteins are abundant in the developing CNS at the stage of maximal cell proliferation prompted us to determine whether these proteins were expressed in various human brain tumors. MATERIALS AND METHODS: Using Western blot assay, we analyzed specimens from control peritumoral brain tissue, medulloblastomas, ependimomas, astrocytomas, anaplastic astrocytomas and glioblastomas. RESULTS: Our analyses revealed that Jak1 and Stat3 were consistently more elevated in low grade gliomas (LG) (tumors characterized by a more pronounced glial phenotype) as compared to high grade gliomas (HG) (less differentiated glial tumors)...
July 1998: Anticancer Research
V Tugnoli, M R Tosi, G Barbarella, R Ricci, M Leonardi, F Calbucci, A Bertoluzza
In this study we report an in vitro 1H magnetic resonance spectroscopy (MRS) characterization of water soluble metabolites obtained from 17 low grade extra and intracerebral human tumors (8 meningiomas, 5 oligodendrogliomas, 2 subependimomas and 2 ependimomas). In addition, the in vivo localized 1H MRS results for 4 of the meningiomas are reported. The main metabolic features characterizing low grade tumors were investigated. Meningiomas are characterized by high Cho/Cr and Ala/Cr ratios; in many cases both in the in vitro and the in vivo spectra these ratios cannot be evaluated, due to the absence of the Cr metabolite...
September 1998: Oncology Reports
F Pacini, A Vivaldi, M Santoro, M Fedele, A Fusco, C Romei, F Basolo, A Pinchera
Sequences of the SV40 virus, a virus of Asian macaques, have been found in human tumors, such as pleural mesotheliomas, ependimomas and choroid plexus tumors. Transgenic mice carrying the SV40 large T gene under the transcriptional control of the thyroglobulin gene promoter, develop thyroid dedifferentiation and follicular thyroid cell proliferation, leading to thyroid hyperplasia and adenocarcinomas. On these bases we investigated the presence of SV40 DNA sequences in 69 samples of papillary thyroid carcinomas (PTC) and in other thyroid and non-thyroid carcinomas, as well as in benign thyroid diseases...
February 5, 1998: Oncogene
Z Zaprianov, I Khubavenska, A Berberova, Zh Peshev
8136 deceased at the clinics of the Higher Medical Institute "I. P. Pavlov" for the period of 1975-1984 are studied. 265 of the deceased (3.28%) have tumours of the central nervous system (cns), among which astroglial tumours predominate (73.21%), while nonastroglial tumours represent 26.79%. The largest is the number of astrocytomas II degree--99 cases, followed by astrocytomas III degree--47 cases, multiform glioblastomas--28 cases and astrocytomas I degree--20 cases in accordance with differentiation of astroglial tumours...
1989: Eksperimentalna Meditsina i Morfologiia
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