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white matter changes multiple sclerosis migraine

Aya D Pusic, Heidi M Mitchell, Phillip E Kunkler, Neal Klauer, Richard P Kraig
Multiple sclerosis and migraine with aura are clinically correlated and both show imaging changes suggestive of myelin disruption. Furthermore, cortical myelin loss in the cuprizone animal model of multiple sclerosis enhances susceptibility to spreading depression, the likely underlying cause of migraine with aura. Since multiple sclerosis pathology involves inflammatory T cell lymphocyte production of interferon-gamma and a resulting increase in oxidative stress, we tested the hypothesis that spreading depression disrupts myelin through similar signaling pathways...
February 2015: Experimental Neurology
Guan-Yu Lin, Chih-Wei Wang, Tsung-Ta Chiang, Giia-Sheun Peng, Fu-Chi Yang
Multiple sclerosis (MS) is a chronic autoimmune disease that targets myelinated axons in the central nervous system. Headache has been reported as a subtle symptom of the onset of MS, with a variable frequency of 1.6-28.5%; however, it remains unclear whether headache is a true symptom of MS onset. Here, we report the case of a female patient who had a history of migraine without aura and experienced worsening of migraine-headache symptoms as the initial manifestation of MS. Three similar cases were reported previously; however, unlike this case, those cases had no history of migraine without aura...
2013: Journal of Headache and Pain
Christopher D Phillips, Steven J Zuckerman
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) can be confused with multiple sclerosis (MS). We report a man with a father diagnosed with MS via magnetic resonance imaging (MRI). The index patient was subsequently diagnosed with MS after MRI for evaluation of migraine headaches. Genetic testing confirmed the CADASIL diagnosis. CADASIL is characterized by a history of migraine headaches, mid-adult onset of progressive cerebrovascular disease, diffuse white matter changes, and dementia...
May 2010: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
F Moschiano, D D'Amico, M Di Stefano, N Rocca, G Bussone
Changes in cerebral white matter at CT or MRI have been reported in patients with migraine, especially in those with migraine with aura. Similar pictures may be present in asymptomatic subjects, and their nature is not completely understood, but their infarct-like nature is strongly suggested. Clinicians play an important role in the evaluation of those migraine patients in whom these nonspecific abnormalities are present. We suggest ruling out specific syndromes in which migraine attacks are associated with white matter changes (CADASIL, MELAS, multiple sclerosis and central nervous system vasculitis), as well as evaluating the presence of different vascular risk factors (genetic prothrombotic factors, patent foramen ovale, use of oral contraceptives, etc...
May 2007: Neurological Sciences
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