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dopaminergic amblyopia

Junfeng Mao, Shuangzhen Liu, Chunyan Fu
The retinal dopaminergic system is involved in the myopic shift following form deprivation. Citicoline has been demonstrated to stimulate the dopaminergic system in the brain and retina. Furthermore, citicoline has been used in many neurogenic diseases, such as senile cognitive impairment, stroke and Parkinson's disease as well as in amblyopia and glaucoma. Our aim was to investigate the effect of citicoline on the refractive state and retinal dopamine level in form deprivation myopia of guinea pigs. Guinea pigs, at an age of four weeks, were randomly divided into normal control, deprivation, deprived + citicoline and deprived + vehicle groups...
June 2016: Experimental Biology and Medicine
M Reza Razeghinejad, M Hossein Nowroozzadeh, M Hossein Eghbal
The visual impairment in traumatic and ischemic optic neuropathy and amblyopia may be permanent. Hence, lots of efforts have been focused on neuroprotection. Dopamine is one of the suggested neuroprotective agents. Besides its important role in the brain, dopamine is found in various cell types of the retina, and is claimed to play a neuromodulator and neurotransmitter role there. The dopamine D1 receptor is the most highly expressed subtype of dopamine receptors, and its activation has been shown to be potentially neuroprotective against oxidative-stress damage in retinal neurons...
January 2016: Clinical Neuropharmacology
Julien Spatazza, Elizabeth Di Lullo, Alain Joliot, Edmond Dupont, Kenneth L Moya, Alain Prochiantz
Homeoproteins constitute a major class of transcription factors active throughout development and in adulthood. Their membrane transduction properties were discovered over 20 years ago, opening an original field of research in the domain of vector peptides and signal transduction. In early development, homeoprotein transfer participates in tissue patterning, cell/axon guidance, and migration. In the axon guidance model, homeoproteins exert their non-cell autonomous activity through the regulation of translation, in particular, that of nuclear-transcribed mitochondrial mRNAs...
January 2013: Pharmacological Reviews
Emilio C Campos, Michela Fresina
A brief review is provided on the role of experimental modulation of the visual system during its plastic period. The importance of several substances has been demonstrated. Potential clinical applications of available studies on the treatment of amblyopia are summarized. The role of the dopaminergic system and particularly of dopamine in amblyopia are also discussed. The results of the use of cytidine-5'-diphosphocholine (citicoline) in amblyopia are evaluated in detail. The advantages of and indications for an association of citicoline with part-time occlusion are also discussed...
June 2006: Strabismus
Robert Rejdak, Jerzy Toczołowski, Janusz Solski, Dariusz Duma, Paweł Grieb
Citicoline (exogenous cytidine-5'-diphosphocholine) was reported to enhance dopaminergic neurotransmission in the brain. A few clinical studies showed beneficial effects of this drug on the function of the visual pathway in patients with glaucoma or amblyopia. The present study was aimed at determining whether citicoline could influence retinal catecholamine levels in adult male Albino rabbits. The animals received the drug (50 mg/kg i.p., twice daily) or vehicle for 7 days, and retinal catecholamine concentrations were determined by HPLC...
May 2002: Ophthalmic Research
R A Apak, M Topçu
Paroxysmal tonic upgaze of childhood is a rare, distinctive, childhood syndrome that may be associated with ataxia and sometimes strabismus or amblyopia. Neurological examination as well as metabolic studies, electroencephalogram and neuroradiological investigations are normal in these patients. Although it has been considered as an age-related, dopa-sensitive dystonia, the exact pathogenetic mechanism is still unknown. Aggravation of attacks by fatigue, intercurrent infection or vaccination, and possible corticomesencephalic dysmaturation may underlie this abnormality...
1999: European Journal of Paediatric Neurology: EJPN
C Williams, D Papakostopoulos
BACKGROUND: Electrodiagnostic tests have been used to investigate retinal function in amblyopia but previous results have been conflicting. METHODS: It was decided to investigate whether the electro-oculogram (EOG) showed any abnormalities in 12 adult amblyopes and 12 age and sex matched controls with normal vision. The mean amplitudes of the EOG recordings from each eye during 12 minutes of darkness and 18 minutes of light were compared. RESULTS: The mean values from the amblyopic eyes were lower than those from the fellow non-amblyopic eyes...
March 1995: British Journal of Ophthalmology
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