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https://www.readbyqxmd.com/read/29679921/electromyographic-and-biomechanical-analysis-of-step-negotiation-in-charcot-marie-tooth-subjects-whose-level-walk-is-not-impaired
#1
Tiziana Lencioni, Giuseppe Piscosquito, Marco Rabuffetti, Enrica Di Sipio, Manuela Diverio, Isabella Moroni, Luca Padua, Emanuela Pagliano, Angelo Schenone, Davide Pareyson, Maurizio Ferrarin
BACKGROUND: Charcot-Marie-Tooth (CMT) is a slowly progressive disease characterized by muscular weakness and wasting with a length-dependent pattern. Mildly affected CMT subjects showed slight alteration of walking compared to healthy subjects (HS). RESEARCH QUESTION: To investigate the biomechanics of step negotiation, a task that requires greater muscle strength and balance control compared to level walking, in CMT subjects without primary locomotor deficits (foot drop and push off deficit) during walking...
April 13, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29679559/foxd1-is-required-for-terminal-differentiation-of-anterior-hypothalamic-neuronal-subtypes
#2
Elizabeth A Newman, Dong Won Kim, Jun Wan, Jie Wang, Jiang Qian, Seth Blackshaw
Although the hypothalamus functions as a master homeostat for many behaviors, little is known about the transcriptional networks that control its development. To investigate this question, we analyzed mice deficient for the Forkhead domain transcription factor Foxd1. Foxd1 is selectively expressed in neuroepithelial cells of the prethalamus and hypothalamus prior to the onset of neurogenesis, and is later restricted to neural progenitors of the prethalamus and anterior hypothalamus. During early stages of neurogenesis, we observed that Foxd1-deficient mice showed reduced expression of Six3 and Vax1 in anterior hypothalamus, but overall patterning of the prethalamus and hypothalamus is unaffected...
April 18, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29679514/dutch-validation-of-the-low-anterior-resection-syndrome-score
#3
Britt Jp Hupkens, Stéphanie O Breukink, Carlijn Olde Reuver Of Briel, Pieter J Tanis, Mirre E de Noo, Peter van Duijvendijk, Henderik L van Westreenen, Jan Willem T Dekker, Tina Yt Chen, Therese Juul
AIM: The aim of this study was to validate the Dutch translation of the Low Anterior Resection Syndrome (LARS) score in a population of Dutch rectal cancer patients. METHOD: Patients who underwent surgery for rectal cancer received the LARS score questionnaire, a single quality of life category question and the EORTC QLQ-C30 questionnaire. A subgroup of patients received the LARS score twice to assess the test-retest reliability. RESULTS: A total of 165 patients were included in the analysis, identified in six Dutch centres...
April 21, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29679498/7t-ultra-high-field-body-mr-imaging-with-an-8-channel-transmit-32-channel-receive-radiofrequency-coil-array
#4
Stefan H G Rietsch, Stephan Orzada, Stefan Maderwald, Sascha Brunheim, Bart W J Philips, Tom W J Scheenen, Mark E Ladd, Harald H Quick
PURPOSE: In this work a combined body coil array with 8 transmit/receive (Tx/Rx) meander elements and with 24 receive-only (Rx) loops (8Tx/32Rx) was developed and evaluated in comparison to an 8-channel transmit/receive body array (8Tx/Rx) based on meander elements serving as the reference standard. METHODS: Systematic evaluation of the RF array was performed on a body-sized phantom. Body imaging at 7T was performed in 6 volunteers in the body regions pelvis, abdomen, and heart...
April 21, 2018: Medical Physics
https://www.readbyqxmd.com/read/29679375/muscle-ultrasound-evaluation-in-healthy-paediatric-subjects-age-related-normative-data
#5
Silvia Lori, Francesco Lolli, Elisabetta Molesti, Maria Bastianelli, Simonetta Gabbanini, Valentina Saia, Sara Trapani, Marinella Marinoni
INTRODUCTION: The Muscle Ultrasound examination (MUS) is a non-invasive and inexpensive technique for evaluating neuromyopathies. Standardized MUS normative data are incomplete in paediatric subjects. METHODS: We performed a MUS study with 120 healthy children (59 males; mean age 10.44; age range 2-16 years). We measured the width and the echogenicity bilaterally in the following muscles: biceps brachii and brachialis, brachioradialis, forearm-flexors, rectus femori sand vastus intermedius, tibialis anterior, extensor hallucis longus, lateral and medial gastrocnemius ...
April 20, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29679342/fundoplication-with-180-degree-wrap-during-esophagogastrostomy-after-robotic-proximal-gastrectomy-for-early-gastric-cancer
#6
Toshiyasu Ojima, Mikihito Nakamori, Masaki Nakamura, Keiji Hayata, Shimpei Maruoka, Hiroki Yamaue
BACKGROUND: Compared with total gastrectomy, proximal gastrectomy (PG) has potential advantages from a nutritional perspective, such as anemia and postoperative loss of body weight. However, PG is associated with some postoperative functional disorders, such as reflux esophagus (13-31%) and anastomotic stenosis (3-29%).1 We therefore developed a new procedure for fundoplication during esophago-gastrostomy after robotic PG (RPG). METHODS: We performed RPG for early gastric cancer localized in the upper third of the stomach using the da Vinci Surgical System (Intuitive, Sunnyvale, CA)...
April 20, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29679215/diagnostic-role-of-serum-tryptase-in-anaphylactic-deaths-in-forensic-medicine-a-systematic-review-and-meta-analysis
#7
REVIEW
Kai-Jian Sun, Jie-Tao He, Hong-Yan Huang, Ye Xue, Xiao-Li Xie, Qi Wang
Postmortem diagnosis of sudden death due to anaphylaxis can be very difficult due to the non-specific pathological findings in forensic practice. Postmortem serum tryptase has been used as an indicator of possible ante-mortem anaphylaxis. Though many previous studies have been conducted to explore the diagnostic significance of serum tryptase for lethal anaphylaxis, inconsistent results were documented. In this study, we made a retrospective study and presented a systematic review and meta-analysis that aims to summarize the diagnostic significance of postmortem serum tryptase in the deceased with and without anaphylactic shock and to calculate a cutoff value for future reference in the identification of deaths due to anaphylactic shock...
April 21, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29679196/role-of-mr-spectroscopy-in-diagnosis-of-intracranial-neuroenteric-cyst
#8
R V Phadke, Suprava Naik, Alok Udiya, Gurucharan S Shetty, Vivek Singh, Sanjeev Kumar Bhoi
INTRODUCTION: Neuroenteric cysts are rare benign endodermal lesions of the central nervous system that result from incomplete resorption of neuroenteric canal and mostly found in cervical and upper thoracic spinal canal. Intracranial neuroenteric cysts are extra axial and commonly located anteriorly in the posterior cranial fossa. MRI demonstrates variable intensity within the lesion on T1, T2W, and DWI sequences. METHODS: Three cases of posterior fossa non-enhancing cystic lesions of variable signal intensity underwent MRI with MR spectroscopy, where MR spectroscopy demonstrated dominant peak at 2 ppm, mimicking normal Nacetyl aspartate (NAA)...
April 20, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29679171/pedicled-gastric-seromuscular-patch-for-one-stage-closure-of-a-bronchopleural-fistula-a-case-report
#9
Jun Suzuki, Hiroyuki Oizumi, Hirohisa Kato, Akira Hamada, Hikaru Watarai, Kenta Nakahashi, Takayuki Sasage, Mitsuaki Sadahiro
BACKGROUND: One-stage closure and fenestration are the available surgical options for bronchopleural fistula (BPF). One-stage closure may be applicable in cases with favorable infection control. Closing the bronchopleural stump is difficult due to thick adhesion caused by inflammation and a high risk of pulmonary artery injury. We report the successful closure of a BPF using a gastric seromuscular patch with an omental pedicle flap. CASE PRESENTATION: A 73-year-old man underwent right lower lobectomy with ND2a-2 lymph node dissection for lung adenocarcinoma...
April 20, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29679143/early-foraging-life-spatial-and-temporal-aspects-of-landmark-learning-in-the-ant-cataglyphis-noda
#10
Pauline Nikola Fleischmann, Wolfgang Rössler, Rüdiger Wehner
Within the powerful navigational toolkit implemented in desert ants, path integration and landmark guidance are the key routines. Here, we use cue-conflict experiments to investigate the interplay between these two routines in ants, Cataglyphis noda, which start their foraging careers (novices) with learning walks and are then tested at different stages of experience. During their learning walks, the novices take nest-centered views from various directions around the nest. In the present experiments, these learning walks are spatially restricted by arranging differently sized water moats around the nest entrance and thus, limiting the space available around the nest and the nest-feeder route...
April 20, 2018: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/29679136/the-pedicle-instrumentation-and-percutaneous-elevation-pi-pe-a-new-cementless-surgical-technique-in-type-a-post-traumatic-vertebral-fractures
#11
Andrea Piazzolla, Giuseppe Solarino, Davide Bizzoca, Claudia Parato, Gaetano Monteleone, Franca Dicuonzo, Biagio Moretti
PURPOSE: To investigate if bone substitutes are strictly necessary to restore the vertebral body height and improve the clinical outcome, in patients with thoracolumbar or lumbar AO type A post-traumatic vertebral fractures, managed with balloon kyphoplasty combined with posterior screw and rod system. METHODS: 105 patients with post-traumatic thoracolumbar spine fracture were recruited. At baseline, the patients underwent a CT and an MRI of the spine. Clinical evaluation was performed, using the Visual Analog Scale (VAS) and the Oswestry Disability Index (ODI), at baseline, 48 h after surgery, at 3-month follow-up (FU), 6-month FU, 48 h after the instrumentation removal and at 24-month FU...
April 20, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29679117/the-infrapatellar-fat-pad-is-a-dynamic-and-mobile-structure-which-deforms-during-knee-motion-and-has-proximal-extensions-which-wrap-around-the-patella
#12
Joanna M Stephen, Ran Sopher, Sebastian Tullie, Andrew A Amis, Simon Ball, Andy Williams
PURPOSE: The infrapatellar fat pad (IFP) is a common cause of knee pain and loss of knee flexion and extension. However, its anatomy and behavior are not consistently defined. METHODS: Thirty-six unpaired fresh frozen knees (median age 34 years, range 21-68) were dissected, and IFP attachments and volume measured. The rectus femoris was elevated, suprapatellar pouch opened and videos recorded looking inferiorly along the femoral shaft at the IFP as the knee was flexed...
April 20, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29679100/g-spotplasty-a-new-surgical-plastic-intervention-the-preliminary-study
#13
Adam Ostrzenski
BACKGROUND: Ostrzenski's G-pot anatomical structure discovery has been verified by the anatomy, histology, MRI in vivo, and electrovaginography in vivo studies. The objectives of this scientific-clinical investigation were to develop a new surgical reconstructive intervention (G-spotplasty); to determine the ability of G-spotplasty surgical implementation; to observe for potential complications; and to gather initial information on whether G-spotplasty improves female sexual activity, sexual behaviors, and sexual concerns...
April 20, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29679087/optical-and-tectonic-corneal-transplant-outcomes-in-a-tertiary-hospital-in-singapore-within-the-singapore-corneal-transplant-registry
#14
Dawn Ho, Charmaine Chai, Hazel Lin, Hla Myint Htoon, Anna Marie Tan, Ray Manotosh, Donald Tan
INTRODUCTION: This study aimed to describe and compare corneal graft survival and optical outcomes following deep anterior lamellar keratoplasty (DALK) and Descemet's stripping automated endothelial keratoplasty (DSAEK) with penetrating keratoplasty (PK), and to document tectonic success of patch grafts. MATERIALS AND METHODS: This was a retrospective, non-randomised, comparative and descriptive cohort study. A total of 139 eyes that underwent primary keratoplasty between 2000 and 2016 were included, and the following data was extracted: demographics, clinical diagnosis and primary indication, pre- and intraoperative risk factors, postkeratoplasty outcomes, and complications...
March 2018: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29678820/trigeminal-trophic-syndrome-following-anterior-inferior-cerebellar-artery-infarction
#15
Ummer Karadan, Robin George Manappallil, Anisha Janardhanan, Ramesh Naga Supreeth
No abstract text is available yet for this article.
April 20, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29678764/relation-of-nnos-isoforms-to-mitochondrial-density-and-pgc-1alpha-expression-in-striated-muscles-of-mice
#16
Oliver Baum, Dea Aaldijk, Anna Lena Engeli, Matthias Spree, Serge Summermatter, Christoph Handschin, Andreas Zakrzewicz
The expression of neuronal NO synthase (nNOS) alpha- and beta-isoforms in skeletal muscle is well documented but only little information is available about their regulation/functions. Using different mouse models, we now assessed whether the expression of nNOS-isoforms in muscle fibers is related to mitochondria content/activity and regulated by peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha). Catalytic histochemistry revealed highest nNOS-concentrations to be present in type-2 oxidative muscle fibers...
April 17, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29678714/transmuscle-ultrasonography-in-the-placement-of-thoracolumbar-pedicle-screws-a-cadaveric-study
#17
Cheng-Long Xie, Qi-Shan Huang, Long Wu, Lei Xu, Hai-Cheng Dou, Xiang-Yang Wang, Zhong-Ke Lin
BACKGROUND: Transpedicular screws fixation has a biomechanical advantage of improving fusion rates. In the posterior thoracolumbar immobilization, a large number of screws cause perforation to pedicle or vertebra body. Techniques as radiograph and CT were used to minimize this complication. However, ultrasound in detecting the pedicle breach during the placement of the screw in unknown. Our goal is to evaluate the sensitivity of ultrasound for detecting the breaches. METHODS: A B-type transducer was used for scanning 216 Titanium pins inserted into the cadaveric pedicle...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678707/long-term-clinical-and-radiological-postoperative-outcomes-after-c1-c2-pedicle-screw-techniques-for-pediatric-atlantoaxial-rotatory-dislocation
#18
Xinjie Wu, Yafeng Li, Mingsheng Tan, Ping Yi, Feng Yang, Xiangsheng Tang, Qingying Hao
BACKGROUND: Although C1-C2 pedicle screw techniques have been extensively reported in paediatric series, reports on their use have examined only small series with short follow-up periods. Here, we present a study on paediatric patients with atlantoaxial rotatory dislocation (AARD) treated with these techniques with a minimum 5-year follow-up period. METHODS: A total of 27 paediatric patients with AARD who underwent C1-C2 pedicle screw fixation between 2004 and 2012 were retrospectively evaluated...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678703/anterior-controllable-antedisplacement-fusion-acaf-for-severe-cervical-ossification-of-the-posterior-longitudinal-ligament-comparison-with-anterior-cervical-corpectomy-with-fusion-accf
#19
Haisong Yang, Jingchuan Sun, Jiangang Shi, Guodong Shi, Yongfei Guo, Yong Yang
OBJECTIVE: Anterior cervical corpectomy and fusion (ACCF), in which a ventral constriction is resected, can decompress myelopathy and is considered the optimal treatment for ossification of the posterior longitudinal ligament (OPLL) up to now. However, its disadvantages are incomplete decompression, high surgery- and implant-related complication rates, and extremely surgical technique demanding. Our object was to introduce anterior controllable antedisplacement fusion (ACAF), a new surgical technique to treat OPLL, and compare it with ACCF...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678681/genome-wide-meta-analysis-identifies-novel-gender-specific-loci-associated-with-thyroid-antibodies-level-in-croatians
#20
Antonela Matana, Marijana Popović, Thibaud Boutin, Vesela Torlak, Dubravka Brdar, Ivana Gunjača, Ivana Kolčić, Vesna Boraska Perica, Ante Punda, Ozren Polašek, Caroline Hayward, Maja Barbalić, Tatijana Zemunik
Autoimmune thyroid diseases (AITD) are multifactorial endocrine diseases most frequently accompanied by Tg and TPO autoantibodies. Both antibodies have a higher prevalence in females and act under a strong genetic influence. To identify novel variants underlying thyroid antibody levels, we performed GWAS meta-analysis on the plasma levels of TgAb and TPOAb in three Croatian cohorts, as well as gender specific GWAS and a bivariate analysis. No significant association was detected with the level of TgAb and TPOAb in the meta-analysis of GWAS or bivariate results for all individuals...
April 17, 2018: Genomics
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