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https://www.readbyqxmd.com/read/29220729/comparison-of-dynamic-cervical-implant-versus-anterior-cervical-discectomy-and-fusion-for-the-treatment-of-single-level-cervical-degenerative-disc-disease-a-five-year-follow-up
#1
Ce Zhu, Xi Yang, Lei Wang, Bo-Wen Hu, Li-Min Liu, Lin-Nan Wang, Hao Liu, Yue-Ming Song
OBJECTIVE: To compare clinical and radiographic outcomes of dynamic cervical implant(DCI) with anterior cervical discectomy and fusion(ACDF) in the treatment of single-level cervical degenerative disc disease (CDDD) 5 years after surgery. PATIENTS AND METHODS: Forty-three patients with DCI were matched one-to-one with patients with ACDF based on age, gender, and operative segment in this retrospective study. All patients had been followed up for more than 5 years...
December 5, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29220526/anti-pd-l1-treatment-induced-central-diabetes-insipidus
#2
Chen Zhao, Sri Harsha Tella, Jaydira Del Rivero, Anuhya Kommalapati, Ifechukwude Ebenuwa, James Gulley, Julius Strauss, Isaac Brownell
Context: Immune checkpoint inhibitors, including anti-PD-1, anti-PD-L1 and anti-CTLA4 monoclonal antibodies, have been widely used in cancer treatment. They are known to cause immune-related adverse events (irAEs), which resemble autoimmune diseases. Anterior pituitary hypophysitis with secondary hypopituitarism is a frequently reported irAE, especially in patients receiving anti-CTLA4 treatment. In contrast, posterior pituitary involvement, such as central diabetes insipidus (DI), is relatively rare and is unreported in patients undergoing PD-1/PD-L1 blockade...
December 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29220355/adults-with-patellofemoral-pain-do-not-exhibit-manifestations-of-peripheral-and-central-sensitization-when-compared-to-healthy-pain-free-age-and-sex-matched-controls-an-assessor-blinded-cross-sectional-study
#3
Michael Skovdal Rathleff, Camilla Rams Rathleff, Aoife Stephenson, Rebecca Mellor, Mark Matthews, Kay Crossley, Bill Vicenzino
Patellofemoral Pain (PFP) is highly prevalent among adults and adolescents. Localized mechanical hyperalgesia around the knee and tibialis anterior have been observed in people with PFP, but limited knowledge of potential manifestations of central sensitisation exists. The aims of this study were to study conditioned pain modulation (CPM) and wide-spread hyperalgesia in adults with PFP. This assessor-blinded cross-sectional study design compared CPM and mechanical pressure pain thresholds (PPT) between 33 adults (23 females) diagnosed with PFP and 32 age and sex matched pain-free controls...
2017: PloS One
https://www.readbyqxmd.com/read/29218672/effect-of-academic-status-on-outcomes-of-surgery-for-rectal-cancer
#4
Kristen Cagino, Maria S Altieri, Jie Yang, Lizhou Nie, Mark Talamini, Konstantinos Spaniolas, Paula Denoya, Aurora Pryor
BACKGROUND: The purpose of our study was to investigate surgical outcomes following advanced colorectal procedures at academic versus community institutions. METHODS: The SPARCS database was used to identify patients undergoing Abdominoperineal resection (APR) and Low Anterior Resection between 2009 and 2014. Linear mixed models and generalized linear mixed models were used to compare outcomes. Laparoscopic versus open procedures, surgery type, volume status, and stoma formation between academic and community facilities were compared...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29218670/systematic-review-of-robotic-low-anterior-resection-for-rectal-cancer
#5
Christoph Holmer, Martin E Kreis
BACKGROUND: Potential advantages of robotic surgery, such as 3-dimensional high-definition vision, wrist-like movements of instruments, stable camera holding, motion filter for tremor-free surgery, and improved ergonomics, may provide better clinical, oncological, and functional outcomes in rectal cancer surgery, as suggested in many comparative studies. However, there has not been a systematic review specific to LAR/TME for rectal cancer that includes both robotic versus laparoscopic and robotic versus open comparative studies...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29218607/-chemokines-in-ophthalmology
#6
REVIEW
T Bleul, G Schlunck, T Reinhard, T Lapp
Chemokines are chemotactically active cytokines, which coordinate the distribution of immune cells within the body and also regulate the migration of leukocytes in malignant and inflammatory processes. Chemokines are a heterogeneous group of short-chain proteins that are divided into different subgroups on the basis of their structure. In addition to the chemokines (ligands) various chemokine receptors also exist. The chemokine system is given its complexity by the high redundancy of ligand-receptor interactions: one single ligand can bind to different receptors and a single receptor can interact with different ligands...
December 7, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29218570/pure-correlates-of-exploration-and-exploitation-in-the-human-brain
#7
Tommy C Blanchard, Samuel J Gershman
Balancing exploration and exploitation is a fundamental problem in reinforcement learning. Previous neuroimaging studies of the exploration-exploitation dilemma could not completely disentangle these two processes, making it difficult to unambiguously identify their neural signatures. We overcome this problem using a task in which subjects can either observe (pure exploration) or bet (pure exploitation). Insula and dorsal anterior cingulate cortex showed significantly greater activity on observe trials compared to bet trials, suggesting that these regions play a role in driving exploration...
December 7, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/29218482/a-novel-muscle-sparing-high-thoracotomy-for-upper-thoracic-spine-resection-and-reconstruction
#8
Derek T Bernstein, Wu Zhuge, Shanda H Blackmon, Rex A W Marco
PURPOSE: High thoracotomy allows access to the anterior cervicothoracic and upper thoracic vertebrae; however, traditional techniques transect shoulder girdle muscles, leading to postoperative shoulder dysfunction. Muscle-sparing techniques diminish this concern, but often sacrifice the quality of exposure. We describe a novel muscle-sparing, high thoracotomy approach for the treatment of ventral cervicothoracic and upper thoracic spine lesions. METHODS: A novel muscle-sparing, high thoracotomy approach is described, utilizing a midline posterior incision with lateral extension from the lateral decubitus position...
December 7, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29218423/early-intraocular-pressure-change-after-peripheral-iridotomy-with-ultralow-fluence-pattern-scanning-laser-and-nd-yag-laser-in-primary-angle-closure-suspect-kowloon-east%C3%A2-pattern-scanning-laser-study-report-no-3
#9
Jeffrey Chi Wang Chan, Bonnie Nga Kwan Choy, Orlando Chia Chieh Chan, Kenneth Kai Wang Li
PURPOSE: Our purpose was to assess the early intraocular pressure (IOP) changes of ultralow fluence laser iridotomy using pattern scanning laser followed by neodymium:yttrium-aluminum-gamet (Nd:YAG) laser. METHODS: This is a prospective interventional study. Thirty-three eyes of 33 adult Chinese primary angle-closure suspect subjects were recruited for prophylactic laser peripheral iridotomy. Sequential laser peripheral iridotomy was performed using pattern scanning laser followed by Nd:YAG laser...
December 7, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29218385/bilateral-carotid-anterior-cerebral-artery-anastomoses-associated-with-bilateral-ophthalmic-arteries-arising-from-the-anastomotic-arteries-diagnosed-by-magnetic-resonance-angiography-a-case-report
#10
Akira Uchino, Naoko Saito, Norio Tanahashi
Rarely, the anterior cerebral artery (ACA) arises from the ophthalmic segment of the internal carotid artery, a condition described as carotid-ACA anastomosis or infraoptic course of the ACA that generally demonstrates right-sided predominance. We diagnosed a case of bilateral anastomoses of the carotid and ACA vessels in which bilateral ophthalmic arteries arose from the origins of the anastomotic vessels using magnetic resonance (MR) angiography. Identification of rare arterial variations on MR angiography requires careful scrutiny of source images, and creation of partial volume-rendering images can aid visualization of detailed anatomic structures...
December 7, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29218288/giant-anterior-neck-lipoma-with-bleeding-pressure-ulcer-in-an-elderly-man-a-rare-entity
#11
Gaurav Jain, Ila Tyagi, Leela Pant, Namrata Nargotra
Giant lipomas are benign soft tissue tumors found rarely in the neck and are still rarer in the anterior part of the neck. A 70-year-old male patient was presented with a huge swelling measuring 35 cm in maximum dimension, in the front of the neck, reaching up till the umbilicus. The swelling was painless, slow growing and acquired the huge size in approximately 20 years. Ultrasound and CT scan findings were suggestive of a soft tissue lesion. Fine needle aspiration cytology yielded mature adipose tissue fragments...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29218276/role-of-square-flap-in-post-burn-axillary-contractures
#12
Durga Karki, Ravi Prakash Narayan
BACKGROUND: Post-burn contractures are a commonly encountered problem and many techniques have been described in their treatment. Z-plasties are the commonest local flap procedure done for linear bands with adjacent healthy tissue. Our aim was to assess the use of square flap technique in axillary contractures. METHODS: Ten patients with type I and II axillary contractures underwent release by the square flap technique. All cases were followed up for at least one year and analysed for range of motion and aesthetic outcome...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29218260/a-case-of-streptococcus-anginosus-brain-abscess-caused-by-contiguous-spread-from-sinusitis-in-an-immunocompetent-patient
#13
Nathan Esplin, John W Stelzer, Sean All, Sundeep Kumar, Ejaz Ghaffar, Sayed Ali
Brain abscesses are infections of the brain parenchyma that can arise from either contiguous spread from local infection or by hematogenous spread from a distant site. Streptococcus anginosus of the Streptococcus anginosus group (SAG) is a commensal microbe of the mucosae of the oral cavity, gastrointestinal tract, and urogenital tract. We present a case of mono-microbial brain abscess caused by contiguous spread from relatively asymptomatic sinusitis that initially presented as a subdural hemorrhage on computed tomography...
October 4, 2017: Curēus
https://www.readbyqxmd.com/read/29218139/herbivory-by-leaf-cutter-ants-changes-the-glandular-trichomes-density-and-the-volatile-components-in-an-aromatic-plant-model
#14
Luiz Ricardo Dos Santos Tozin, Marcia Ortiz Mayo Marques, Tatiane Maria Rodrigues
Herbivory can induce several structural and functional alterations in the plant secretory system. Glandular trichomes are the main sites of production of volatile organic compounds (VOCs) with several chemical properties in Lamiaceae species. Ocimum species usually have three morphotypes of glandular trichomes (morphotype I is peltate and has a wide four-celled head; morphotype II is capitate and has a unicellular head; and morphotype III is capitate with a bicellular head) which produce a great amount of terpenes, although other chemical categories of substances are also produced...
November 2017: AoB Plants
https://www.readbyqxmd.com/read/29218098/overexpression-of-microrna-145-protects-against-rat-myocardial-infarction-through-targeting-pdcd4
#15
Hao Xu, Heng Cao, Guoqing Zhu, Shaowen Liu, Hongli Li
Myocardial infarction (MI) is a common cardiovascular disease with high mortality. The aim of the present study was to determine the biological role of miR-145 in MI rats and hypoxia-injured cardiomyocytes and to elucidate the potential mechanism. MI rats were induced by left anterior descending artery (LAD) ligation. qRT-PCR and western blot analysis were performed to determine the mRNA and protein levels, respectively. Compared with sham group, miR-145 levels in MI group were significantly decreased. We observed that lentivirus-mediated overexpression of miR-145 significantly improves cardiac function, reduces infarcted tissue size and prevents post-infarction induced apoptosis in rats after MI...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29217962/spectrophotometric-evaluation-of-crown-fragment-a-year-after-reattachment-using-fiber-reinforced-post-a-case-report
#16
Fundaoğlu Funda Küçükekencı, Ahmet Serkan Küçükekencı
Background: Crown fracture is the most common type of fracture and frequently affects the anterior teeth. Crown fractures have been treated in several ways depending on the location and kind of fracture. This case emphasizes reattachment of fractured fragments using fiber-reinforced post. Also this case report underlines the related aesthetic concerns of reattaching of the fractured fragment. Case Report: Intraorally, examination revealed a complicated crown-root fracture of the left maxillary central (#21) and lateral incisor (#22)...
September 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217945/a-3-year-review-of-the-outcome-of-pars-plana-vitrectomy-for-dropped-lens-fragments-after-cataract-surgery-in-a-tertiary-eye-hospital-in-dhaka-bangladesh
#17
Lateefat Olokoba, Tajul Islam, Nazmun Nahar, Abdulraheem Mahmoud, Abdulfatai Olokoba
Background: Dropped lens fragments into the vitreous are uncommon, but potentially sight threatening complications of cataract surgery. The recommended approach for removal of dropped lens matter is pars plana vitrectomy with or without ultrasonic emulsification with the fragmatome. This study aimed to determine the visual outcome following pars plana vitrectomy for dropped lens fragments complicating cataract surgery at 6 weeks, 3 months and 6 months. Methods: This study is a retrospective review of patients who had PPV as treatment for dropped lens fragments complicating cataract surgery at Ispahani Islamia Eye hospital and Institute...
July 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217747/mr-perfusion-to-determine-the-status-of-collaterals-in-patients-with-acute-ischemic-stroke-a-look-beyond-time-maps
#18
K Nael, A Doshi, R De Leacy, J Puig, M Castellanos, J Bederson, T P Naidich, J Mocco, M Wintermark
BACKGROUND AND PURPOSE: Patients with acute stroke with robust collateral flow have better clinical outcomes and may benefit from endovascular treatment throughout an extended time window. Using a multiparametric approach, we aimed to identify MR perfusion parameters that can represent the extent of collaterals, approximating DSA. MATERIALS AND METHODS: Patients with anterior circulation proximal arterial occlusion who had baseline MR perfusion and DSA were evaluated...
December 7, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29217627/the-gastric-caecum-of-larval-aedes-aegypti-stimulation-of-epithelial-ion-transport-by-5-hydroxytryptamine-and-camp
#19
Natalie M D'Silva, Michael J O'Donnell
We report measurements of ion transport across the gastric caecum of larvae of Aedes aegypti, a vector of yellow fever that inhabits a variety of aquatic habitats ranging from freshwater to brackish water. We provide the first measurements of the effect of 5-hydroxytryptamine (5-HT) on transepithelial potential (TEP), luminal ion concentrations and electrochemical potentials, as well as basolateral membrane potential and H+, Na+ and K+ fluxes. TEP, basolateral membrane potential, and H+, K+, and Na+ fluxes across the gastric caeca declined within 3-6 mins after isolation of the entire midgut from the larva...
December 7, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29217351/endophthalmitis-then-and-now
#20
Nidhi Relhan, Richard K Forster, Harry W Flynn
PURPOSE: To report historically evolving strategies (then and now) in prevention and management of endophthalmitis. DESIGN: A perspective on relevant topics in the prophylaxis and management of endophthalmitis. METHODOLOGY: This is an author selected review of studies leading to changes in strategies for endophthalmitis management over the last 100 years. RESULTS: The current perspective discusses the trends and strategies over the past century...
December 4, 2017: American Journal of Ophthalmology
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