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https://www.readbyqxmd.com/read/28823079/mechanobiological-model-of-arterial-growth-and-remodeling
#1
Maziyar Keshavarzian, Clark A Meyer, Heather N Hayenga
A coupled agent-based model (ABM) and finite element analysis (FEA) computational framework is developed to study the interplay of bio-chemo-mechanical factors in blood vessels and their role in maintaining homeostasis. The agent-based model implements the power of REPAST Simphony libraries and adapts its environment for biological simulations. Coupling a continuum-level model (FEA) to a cellular-level model (ABM) has enabled this computational framework to capture the response of blood vessels to increased or decreased levels of growth factors, proteases and other signaling molecules (on the micro scale) as well as altered blood pressure...
August 19, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28823075/refractive-corneal-and-ocular-residual-astigmatism-distribution-in-a-german-population-and-age-dependency-the-gutenberg-health-study
#2
Alexander Karl-Georg Schuster, Norbert Pfeiffer, Andreas Schulz, René Hoehn, Katharina A Ponto, Philipp S Wild, Maria Blettner, Manfred E Beutel, Karl J Lackner, Thomas Münzel, Alireza Mirshahi
PURPOSE: Worldwide, the most frequent cause of visual impairment is uncorrected refractive error. This analysis focused on the distribution and associations of refractive, corneal and ocular residual astigmatism. METHODS: As part of the Gutenberg Health study, a population-based cross-sectional study was conducted in the general population of Germany. A comprehensive ophthalmological examination including refraction, tonometry, and Scheimpflug imaging of the anterior cornea (Pachycam) was performed...
August 19, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28823064/preoperative-hypoalbuminemia-is-an-independent-risk-factor-for-increased-high-grade-morbidity-after-elective-rectal-cancer-resection
#3
J Hardt, L Pilz, J Magdeburg, P Kienle, S Post, R Magdeburg
PURPOSE: This study investigated the association of preoperative hypoalbuminemia and postoperative complications after elective resection for rectal cancer. METHODS: From September 2009 to December 2014, all patients who underwent elective rectal resection for adenocarcinoma of the rectum were identified using a prospective colorectal cancer database. Hypoalbuminemia was defined as a serum albumin < 35 g/L. Characteristics and outcomes of hypoalbuminemic patients were compared to those of patients with normal albumin levels...
August 19, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28823050/a-scanning-electron-microscopy-study-of-early-development-in-vitro-of-contracaecum-multipapillatum-s-l-nematoda-anisakidae-from-a-brown-pelican-pelecanus-occidentalis-from-the-gulf-of-california-mexico
#4
Dolores Molina-Fernández, Isabel Valles-Vega, Sergio Hernández-Trujillo, Francisco Javier Adroher, Rocío Benítez
Eggs obtained from the uteri of female nematodes, genetically identified as Contracaecum multipapillatum s.l., found in a brown pelican (Pelecanus occidentalis) from Bahía de La Paz, Gulf of California, Mexico, were used to study the early developmental stages of this anisakid by scanning electron microscopy (SEM). Egg dimensions were approximately 54 × 45 μm measured by SEM. Observation of the eggs revealed an outer surface of fibrous appearance. The newly hatched larvae were ensheathed and highly motile...
August 19, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28823037/female-sex-is-associated-with-greater-rotatory-knee-laxity-in-collegiate-athletes
#5
Thomas R Pfeiffer, Ajay C Kanakamedala, Elmar Herbst, Kanto Nagai, Conor Murphy, Jeremy M Burnham, Adam Popchak, Richard E Debski, Volker Musahl
PURPOSE/HYPOTHESIS: The purpose of this observational study was to determine which factors, including sex, are associated with increased rotatory knee laxity in collegiate athletes with no history of knee injuries. It was hypothesized that increased rotatory knee laxity, measured by a quantitative pivot shift test, would correlate with female sex, increased anterior translation during the Lachman test, generalized ligamentous laxity, and knee hyperextension. METHODS: Ninety-eight collegiate athletes with a median age of 20 (range 18-25) years with no history of knee injuries were tested...
August 19, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28823023/posttraumatic-stress-disorder-symptoms-and-white-matter-abnormalities-among-combat-exposed-veterans
#6
Kirstin Aschbacher, Synthia H Mellon, Owen M Wolkowitz, Clare Henn-Haase, Rachel Yehuda, Janine D Flory, Linda M Bierer, Duna Abu-Amara, Charles R Marmar, Susanne G Mueller
Posttraumatic stress disorder (PTSD) is associated with abnormalities in functional connectivity of a specific cortico-limbic network; however, less is known about white matter abnormalities providing structural connections for this network. This study investigated whether the diagnosis and symptoms of PTSD are associated with alterations in fractional anisotropy (FA), an index reflecting white matter organization, across six, a priori-defined tracts. White matter FA was quantified by diffusion tensor imaging using 3 T-MRI among 57 male, combat-exposed veterans with no history of moderate to severe head injuries or current alcohol dependence: 31 met criteria for PTSD and 26 were demographically comparable, combat-exposed controls without PTSD...
August 19, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28822999/preservation-of-remnant-with-poor-synovial-coverage-has-no-beneficial-effect-over-remnant-sacrifice-in-anterior-cruciate-ligament-reconstruction
#7
Bo Hyun Kim, Joong Il Kim, Osung Lee, Ki Woung Lee, Myung Chul Lee, Hyuk Soo Han
PURPOSE: The purpose of the study was to evaluate the influence of synovial coverage of the remnant on clinical outcomes and graft healing in anterior cruciate ligament (ACL) reconstruction. METHODS: Seventy-five patients who underwent second-look arthroscopy after a single-bundle ACL reconstruction using autologous quadriceps tendon graft were included. The patients were divided into two groups according to whether the remnant was preserved (group P, n = 42) or sacrificed (group S, n = 33)...
August 19, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28822956/a-novel-web-support-intervention-to-promote-recovery-following-anterior-cruciate-ligament-reconstruction-a-pilot-randomised-controlled-trial
#8
Pazit Levinger, Karen Hallam, Darren Fraser, Rebecca Pile, Clare Ardern, Brett Moreira, Simon Talbot
BACKGROUND: Self-efficacy is positively associated with adherence behaviours and rehabilitation outcomes following Anterior Cruciate Ligament (ACL) reconstruction. An internet resource can be an effective way to provide information, goal setting, patient monitoring and hence support overall self-management. PURPOSE: This study examined the feasibility of a three month 'internet-based intervention' (mobile-oriented site) to enhance recovery for patients following ACL reconstruction...
June 8, 2017: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28822908/pseudophyllomitus-vesiculosus-larsen-and-patterson-1990-lee-2002-a-poorly-studied-phagotrophic-biflagellate-is-the-first-characterized-member-of-stramenopile-environmental-clade-mast-6
#9
Takashi Shiratori, Rabindra Thakur, Ken-Ichiro Ishida
There are many eukaryotic lineages that are exclusively composed of environmental sequences and lack information about which species are included. Regarding stramenopiles, at least 18 environmental lineages, known as marine stramenopiles (MAST), have been recognized. Since each MAST lineage forms deep branches in the stramenopiles, the characterization of MAST members is key to understanding the diversity and evolution of stramenopiles. In this study, we established a culture of Pseudophyllomitus vesiculosus, which is a poorly studied phagotrophic flagellate of uncertain taxonomic position...
July 6, 2017: Protist
https://www.readbyqxmd.com/read/28822871/altered-language-network-in-benign-childhood-epilepsy-patients-with-spikes-from-non-dominant-side-a-resting-state-fmri-study
#10
Jiajia Fang, Sihan Chen, Cheng Luo, Qiyong Gong, Dongmei An, Dong Zhou
Benign childhood epilepsy with centrotemporal spikes (BECTS) is one of the most common childhood epilepsy syndromes, and language deficits associated with BECTS have become a hot topic. This study investigated alterations of the language network in BECTS children with spikes from the non-dominant side in comparison with healthy controls. Twenty-three children with BECTS and 20 age-matched healthy controls were enrolled. Region of interest -based whole brain functional connectivity analysis was used to identify the potential differences in the functional connectivity of the Broca's area between the two groups...
August 1, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28822849/cyclic-3-5-adenosine-monophosphate-camp-signaling-in-the-anterior-pituitary-gland-in-health-and-disease
#11
REVIEW
Laura C Hernández-Ramírez, Giampaolo Trivellin, Constantine A Stratakis
The cyclic 3',5'-adenosine monophosphate (cAMP) was the first among the so-called "second messengers" to be described. It is conserved in most organisms and functions as a signal transducer by mediating the intracellular effects of multiple hormones and neurotransmitters. In this review, we first delineate how different members of the cAMP pathway ensure its correct compartmentalization and activity, mediate the terminal intracellular effects, and allow the crosstalk with other signaling pathways. We then focus on the pituitary gland, where cAMP exerts a crucial function by controlling the responsiveness of the cells to hypothalamic hormones, neurotransmitters and peripheral factors...
August 16, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28822825/comparison-of-transforaminal-lumbar-interbody-fusion-outcomes-in-patients-receiving-rhbmp-2-versus-autograft
#12
Taleef R Khan, Kalin R Pearce, Steven J McAnany, Colleen M Peters, Munish C Gupta, Lukas P Zebala
BACKGROUND CONTEXT: Recombinant human bone morphogenetic protein 2 (rhBMP-2) plays a pivotal role in complex spine surgery. Despite its limited approval, the off-label use of rhBMP-2 is prevalent, particularly in transforaminal lumbar interbody fusions (TLIF) PURPOSE: To determine the effectiveness and safety of rhBMP-2 use in TLIF procedures versus autograft. STUDY DESIGN: Retrospective Cohort Study PATIENT SAMPLE: Patients older than 18 years undergoing spine surgery for lumbar degenerative spine disease at a single academic institution...
August 16, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28822760/anterior-chamber-perfusion-versus-posterior-chamber-perfusion-does-not-influence-measurement-of-aqueous-outflow-facility-in-living-mice-by-constant-flow-infusion
#13
Navita N Lopez, Gaurang C Patel, Urmimala Raychaudhuri, Subhash Aryal, Tien N Phan, Abbot F Clark, J Cameron Millar
Mice are now routinely utilized in studies of aqueous humor outflow dynamics. In particular, conventional aqueous outflow facility (C) is routinely measured via perfusion of the aqueous chamber by a number of laboratories. However, in mouse eyes perfused ex-vivo, values for C are variable depending upon whether the perfusate is introduced into the posterior chamber (PC) versus the anterior chamber (AC). Perfusion via the AC leads to posterior bowing of the iris, and traction on the iris root/scleral spur, which may increase C...
August 16, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28822721/postural-assessment-in-class-iii-patients-before-orthognathic-surgery
#14
Fernando Zugno Kulczynski, Fernando de Oliveira Andriola, Pedro Henrique Deon, Denizar Alberto da Silva Melo, Rogério Miranda Pagnoncelli
PURPOSE: To determine the postural characteristics of patients with Class III dentofacial deformities before orthognathic surgery by photogrammetry using SAPO postural assessment software. MATERIALS AND METHODS: This was a cross-sectional study. Eligible participants were adult patients who had an indication for orthognathic surgery to correct skeletal Class III dentofacial deformities and were undergoing orthodontic preparation for surgery. Patients were recruited at the outpatient clinic for dentofacial deformities of the authors' institution from March to November 2015...
July 25, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28822704/corneal-confocal-microscopy-and-dry-eye-findings-in-contact-lens-discomfort-patients
#15
Aysun Sanal Dogan, Canan Gurdal, Nese Arslan
OBJECTIVES: To evaluate the corneal confocal microscopy and dry eye findings in patients with contact lens discomfort. METHODS: The study included 3 groups of participants: Contact lens wearers using silicone hydrogel soft contact lenses who are symptomatic (CLD, n=15) or asymptomatic (ACL, n=11) and non-wearers as controls (n=14). Duration of contact lens wear, Ocular Surface Disease Index (OSDI) questionnaire responses, fluorescein tear break-uptime (FBUT), and corneal confocal microscopy findings were recorded...
August 16, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28822654/polarity-independent-effects-of-tdcs-on-paired-associative-stimulation-induced-plasticity
#16
Hanna Faber, Alexander Opitz, Florian Müller-Dahlhaus, Ulf Ziemann
BACKGROUND: Transcranial direct current stimulation (tDCS) can polarize the cortex of the human brain. OBJECTIVE/HYPOTHESIS: We sought to verify the hypothesis that posterior-anterior (PA) but not anterior-posterior (AP) tDCS of primary motor cortex (M1) produces cooperative effects with corticospinal plasticity induced by paired associative stimulation of the supplementary motor area (SMA) to M1 projection (PASSMA→M1) in a highly controlled experimental design...
July 27, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28822639/level-of-the-subscapularis-split-during-arthroscopic-latarjet
#17
Alexandre Lädermann, Patrick J Denard, Paolo Arrigoni, Pablo Narbona, Stephen S Burkhart, Johannes Barth
PURPOSE: To determine the location of the subscapularis split during arthroscopic Latarjet created by an inside-out technique passing a switching stick from the posterior portal across the glenohumeral joint. METHODS: An inside-out technique was used to arthroscopically create a subscapularis split in 20 fresh-frozen human cadaveric shoulders. The distance between the exit point of the switching stick and the upper border of the subscapularis and the anterior circumflex vessels was measured arthroscopically and after open dissection...
August 16, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28822638/modified-anterolateral-portals-in-elbow-arthroscopy-a-cadaveric-study-on-safety
#18
Stephen Thon, Peter Gold, Lane Rush, Michael J O'Brien, Felix H Savoie
PURPOSE: To evaluate the proximity to the radial nerve on cadaveric specimens of 2 modified anterolateral portals used for elbow arthroscopy. METHODS: Ten fresh cadaveric elbow specimens were prepared. Four-millimeter Steinman pins were inserted into 3 anterolateral portal sites in relation to the lateral epicondyle: (1) the standard distal anterolateral portal, (2) a modified direct anterolateral portal, and (3) a modified proximal anterolateral portal. These were defined as follows: direct portals 2 cm directly anterior to the lateral epicondyle, and proximal portals 2 cm proximal and 2 cm directly anterior to the lateral epicondyle...
August 16, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28822635/radiographic-tibial-tunnel-assessment-after-anterior-cruciate-ligament-reconstruction-using-hamstring-tendon-autografts-and-biocomposite-screws-a-prospective-study-with-5-year-follow-up
#19
Ioannis Karikis, Lars Ejerhed, Ninni Sernert, Lars Rostgård-Christensen, Jüri Kartus
PURPOSE: To radiographically assess the tibial tunnel up to 5 years after anterior cruciate ligament (ACL) reconstruction using hamstring tendon autografts and biocomposite interference screws. METHODS: Fifty-one patients underwent anatomic single-bundle ACL reconstruction with metal interference screws in the femur and biocomposite interference screws in the tibia. Standardized digital radiographs with weight-bearing anteroposterior and lateral views of the index knee were taken in the early postoperative period and at 2 and 5 years postoperatively...
August 16, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28822633/arthroscopic-latarjet-procedure-with-anterior-capsular-reconstruction-clinical-outcome-and-radiologic-evaluation-with-a-minimum-2-year-follow-up
#20
Yi-Ming Zhu, Chunyan Jiang, Guanyang Song, Yi Lu, Fenglong Li
PURPOSE: To investigate the clinical and radiographic outcomes of the modified arthroscopic Latarjet procedure at a minimum of 2 years after surgery. METHODS: Patients who had traumatic unidirectional anterior shoulder instability and treated with a modified arthroscopic Latarjet procedure were included. During surgery, the anterior capsule was preserved and repaired back to the glenoid after the coracoid transfer. The clinical results (range of motion, American Shoulder and Elbow Surgeons [ASES] score, Constant-Murley score, and Rowe score) and computed tomographic results were followed...
August 16, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
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