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Valerie Voon

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https://www.readbyqxmd.com/read/28606495/personality-traits-in-psychogenic-nonepileptic-seizures-pnes-and-psychogenic-movement-disorder-pmd-neuroticism-and-perfectionism
#1
Vindhya Ekanayake, Sarah Kranick, Kathrin LaFaver, Arshi Naz, Anne Frank Webb, W Curt LaFrance, Mark Hallett, Valerie Voon
OBJECTIVE: Psychogenic movement disorder (PMD) and psychogenic nonepileptic seizures (PNES) are two subtypes of conversion disorder (CD). In this case-control study, we asked whether these subtypes varied as a function of personality and history of childhood abuse. METHODS: Fifty-nine patients with PMD from the Human Motor Control Section Clinic at the National Institutes of Health, 43 patients with PNES from the Rhode Island Hospital Neuropsychiatry and Behavioral Neurology Division, and 26 healthy volunteers (HC) received a battery of neurological, psychiatric and psychological assessments, including the NEO Personality Inventory Revised (NEO PI-R), the Childhood Trauma Questionnaire (CTQ), and the Traumatic Life Events Questionnaire (TLEQ)...
June 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28599832/model-based-control-in-dimensional-psychiatry
#2
REVIEW
Valerie Voon, Andrea Reiter, Miriam Sebold, Stephanie Groman
We use parallel interacting goal-directed and habitual strategies to make our daily decisions. The arbitration between these strategies is relevant to inflexible repetitive behaviors in psychiatric disorders. Goal-directed control, also known as model-based control, is based on an affective outcome relying on a learned internal model to prospectively make decisions. In contrast, habit control, also known as model-free control, is based on an integration of previous reinforced learning autonomous of the current outcome value and is implicit and more efficient but at the cost of greater inflexibility...
April 23, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28458999/magnetization-transfer-imaging-identifies-basal-ganglia-abnormalities-in-adult-adhd-that-are-invisible-to-conventional-t1-weighted-voxel-based-morphometry
#3
Arjun Sethi, Edwin Evelyn-Rahr, Nicholas Dowell, Sanjay Jain, Valerie Voon, Hugo D Critchley, Neil A Harrison, Mara Cercignani
In childhood, Attention Deficit Hyperactivity Disorder (ADHD) is reliably associated with reduced volume of the striatum. In contrast, striatal abnormalities are infrequently detected in voxel-based morphometry (VBM) neuroimaging studies of adults with ADHD. This discrepancy has been suggested to reflect normalisation of striatal morphology with age and prolonged treatment of symptoms. If so, this would indicate that while striatal abnormalities are linked to symptom expression in childhood, they cannot explain the persistence of these symptoms in adulthood...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28419776/the-involuntary-nature-of-binge-drinking-goal-directedness-and-awareness-of-intention
#4
Nuria Doñamayor, Daniela Strelchuk, Kwangyeol Baek, Paula Banca, Valerie Voon
Binge drinking represents a public health issue and is a known risk factor in the development of alcohol use disorders. Previous studies have shown behavioural as well as neuroanatomical alterations associated with binge drinking. Here, we address the question of the automaticity or involuntary nature of the behaviour by assessing goal-directed behaviour and intentionality. In this study, we used a computational two-step task, designed to discern between model-based/goal-directed and model-free/habitual behaviours, and the classic Libet clock task, to study intention awareness, in a sample of 31 severe binge drinkers (BD) and 35 matched healthy volunteers...
April 16, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28363836/multi-echo-fmri-a-review-of-applications-in-fmri-denoising-and-analysis-of-bold-signals
#5
Prantik Kundu, Valerie Voon, Priti Balchandani, Michael V Lombardo, Benedikt A Poser, Peter A Bandettini
In recent years the field of fMRI research has enjoyed expanded technical abilities related to resolution, as well as use across many fields of brain research. At the same time, the field has also dealt with uncertainty related to many known and unknown effects of artifact in fMRI data. In this review we discuss an emerging fMRI technology, called multi-echo (ME)-fMRI, which focuses on improving the fidelity and interpretability of fMRI. Where the essential problem of standard single-echo fMRI is the indeterminacy of sources of signals, whether BOLD or artifact, this is not the case for ME-fMRI...
July 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/28247526/naltrexone-ameliorates-functional-network-abnormalities-in-alcohol-dependent-individuals
#6
Laurel S Morris, Kwangyeol Baek, Roger Tait, Rebecca Elliott, Karen D Ersche, Remy Flechais, John McGonigle, Anna Murphy, Liam J Nestor, Csaba Orban, Filippo Passetti, Louise M Paterson, Ilan Rabiner, Laurence Reed, Dana Smith, John Suckling, Eleanor M Taylor, Edward T Bullmore, Anne R Lingford-Hughes, Bill Deakin, David J Nutt, Barbara J Sahakian, Trevor W Robbins, Valerie Voon
Naltrexone, an opioid receptor antagonist, is commonly used as a relapse prevention medication in alcohol and opiate addiction, but its efficacy and the mechanisms underpinning its clinical usefulness are not well characterized. In the current study, we examined the effects of 50-mg naltrexone compared with placebo on neural network changes associated with substance dependence in 21 alcohol and 36 poly-drug-dependent individuals compared with 36 healthy volunteers. Graph theoretic and network-based statistical analysis of resting-state functional magnetic resonance imaging (MRI) data revealed that alcohol-dependent subjects had reduced functional connectivity of a dispersed network compared with both poly-drug-dependent and healthy subjects...
February 28, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28238272/psychiatric-presentations-of-c9orf72-mutation-what-are-the-diagnostic-implications-for-clinicians
#7
Simon Ducharme, Sepideh Bajestan, Bradford C Dickerson, Valerie Voon
The C9orf72 mutation was identified as the most frequent genetic cause of frontotemporal dementia (FTD). In light of multiple reports of predominant psychiatric presentations of FTD secondary to C9orf72 mutation, the American Neuropsychiatric Association Committee on Research reviewed all studies on psychiatric aspects of this mutation to identify clinically relevant features for diagnosis. The most common psychiatric presentation is psychosis (21%-56%), with delusions, and/or multimodal hallucinations. Other presentations include late-onset mania and depression with cognitive impairment or catatonia...
February 27, 2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28229895/impulse-control-disorders-and-levodopa-induced-dyskinesias-in-parkinson-s-disease-an-update
#8
REVIEW
Valerie Voon, T Celeste Napier, Michael J Frank, Veronique Sgambato-Faure, Anthony A Grace, Maria Rodriguez-Oroz, Jose Obeso, Erwan Bezard, Pierre-Olivier Fernagut
Dopaminergic medications used in the treatment of patients with Parkinson's disease are associated with motor and non-motor behavioural side-effects, such as dyskinesias and impulse control disorders also known as behavioural addictions. Levodopa-induced dyskinesias occur in up to 80% of patients with Parkinson's after a few years of chronic treatment. Impulse control disorders, including gambling disorder, binge eating disorder, compulsive sexual behaviour, and compulsive shopping occur in about 17% of patients with Parkinson's disease on dopamine agonists...
March 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28121259/neurobiology-of-the-premonitory-urge-in-tourette-s-syndrome-pathophysiology-and-treatment-implications
#9
Andrea E Cavanna, Kevin J Black, Mark Hallett, Valerie Voon
Motor and vocal tics are relatively common motor manifestations identified as the core features of Tourette's syndrome (TS). Although traditional descriptions have focused on objective phenomenological observations, such as anatomical location, number and frequency of tics, patients' first-person accounts have consistently reported characteristic subjective correlates. These sensory phenomena are often described as a feeling of mounting inner tension or urge to move ("premonitory urge"), which is transiently relieved by tic expression...
2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28105707/binge-drinking-differentially-affects-cortical-and-subcortical-microstructure
#10
Laurel S Morris, Nicholas G Dowell, Mara Cercignani, Neil A Harrison, Valerie Voon
Young adult binge drinkers represent a model for endophenotypic risk factors for alcohol misuse and early exposure to repeated binge cycles. Chronic or harmful alcohol use leads to neurochemical, structural and morphological neuroplastic changes, particularly in regions associated with reward processing and motivation. We investigated neural microstructure in 28 binge drinkers compared with 38 matched healthy controls. We used a recently developed diffusion magnetic resonance imaging acquisition and analysis, which uses three-compartment modelling (of intracellular, extracellular and cerebrospinal fluid) to determine brain tissue microstructure features including neurite density and orientation dispersion index (ODI)...
January 20, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28103527/distinct-cortico-striatal-connections-with-subthalamic-nucleus-underlie-facets-of-compulsivity
#11
Laurel S Morris, Kwangyeol Baek, Valerie Voon
The capacity to flexibly respond to contextual changes is crucial to adapting to a dynamic environment. Compulsivity, or behavioural inflexibility, consists of heterogeneous subtypes with overlapping yet discrete neural substrates. The subthalamic nucleus (STN) mediates the switch from automatic to controlled processing to slow, break or stop behaviour when necessary. Rodent STN lesions or inactivation are linked with perseveration or repetitive, compulsive responding. However, there are few studies examining the role of latent STN-centric neural networks and compulsive behaviour in healthy individuals...
March 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28040671/decisional-impulsivity-and-the-associative-limbic-subthalamic-nucleus-in-obsessive-compulsive-disorder-stimulation-and-connectivity
#12
RANDOMIZED CONTROLLED TRIAL
Valerie Voon, Fabien Droux, Laurel Morris, Stephan Chabardes, Thierry Bougerol, Olivier David, Paul Krack, Mircea Polosan
Why do we make hasty decisions for short-term gain? Rapid decision-making with limited accumulation of evidence and delay discounting are forms of decisional impulsivity. The subthalamic nucleus is implicated in inhibitory function but its role in decisional impulsivity is less well-understood. Here we assess decisional impulsivity in subjects with obsessive compulsive disorder who have undergone deep brain stimulation of the limbic and associative subthalamic nucleus. We show that stimulation of the subthalamic nucleus is causally implicated in increasing decisional impulsivity with less accumulation of evidence during probabilistic uncertainty and in enhancing delay discounting...
February 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27882998/dopamine-and-opioid-neurotransmission-in-behavioral-addictions-a-comparative-pet-study-in-pathological-gambling-and-binge-eating
#13
Joonas Majuri, Juho Joutsa, Jarkko Johansson, Valerie Voon, Kati Alakurtti, Riitta Parkkola, Tuuli Lahti, Hannu Alho, Jussi Hirvonen, Eveliina Arponen, Sarita Forsback, Valtteri Kaasinen
Although behavioral addictions share many clinical features with drug addictions, they show strikingly large variation in their behavioral phenotypes (such as in uncontrollable gambling or eating). Neurotransmitter function in behavioral addictions is poorly understood, but has important implications in understanding its relationship with substance use disorders and underlying mechanisms of therapeutic efficacy. Here, we compare opioid and dopamine function between two behavioral addiction phenotypes: pathological gambling (PG) and binge eating disorder (BED)...
April 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27787929/compulsive-sexual-behavior-prefrontal-and-limbic-volume-and-interactions
#14
Casper Schmidt, Laurel S Morris, Timo L Kvamme, Paula Hall, Thaddeus Birchard, Valerie Voon
BACKGROUND: Compulsive sexual behaviors (CSB) are relatively common and associated with significant personal and social dysfunction. The underlying neurobiology is still poorly understood. The present study examines brain volumes and resting state functional connectivity in CSB compared with matched healthy volunteers (HV). METHODS: Structural MRI (MPRAGE) data were collected in 92 subjects (23 CSB males and 69 age-matched male HV) and analyzed using voxel-based morphometry...
March 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/27769568/specific-frontostriatal-circuits-for-impaired-cognitive-flexibility-and-goal-directed-planning-in-obsessive-compulsive-disorder-evidence-from-resting-state-functional-connectivity
#15
Matilde M Vaghi, Petra E Vértes, Manfred G Kitzbichler, Annemieke M Apergis-Schoute, Febe E van der Flier, Naomi A Fineberg, Akeem Sule, Rashid Zaman, Valerie Voon, Prantik Kundu, Edward T Bullmore, Trevor W Robbins
BACKGROUND: A recent hypothesis has suggested that core deficits in goal-directed behavior in obsessive-compulsive disorder (OCD) are caused by impaired frontostriatal function. We tested this hypothesis in OCD patients and control subjects by relating measures of goal-directed planning and cognitive flexibility to underlying resting-state functional connectivity. METHODS: Multiecho resting-state acquisition, combined with micromovement correction by blood oxygen level-dependent sensitive independent component analysis, was used to obtain in vivo measures of functional connectivity in 44 OCD patients and 43 healthy comparison subjects...
April 15, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/27536223/compulsivity-across-the-pathological-misuse-of-drug-and-non-drug-rewards
#16
Paula Banca, Neil A Harrison, Valerie Voon
Behavioral adaptation is required for the successful navigation of a constantly changing environment. Impairments in behavioral flexibility are commonly observed in psychiatric disorders including those of addiction. This study investigates two distinct facets of compulsivity, namely reversal learning and attentional set shifting, implicating orbitofrontal and lateral prefrontal regions respectively, across disorders of primary and secondary rewards. Obese subjects with and without binge eating disorder (BED), individuals with compulsive sexual behaviors (CSB), alcohol dependence (AD) and pathological video-gaming (VG) were tested with two computerized tasks: the probabilistic reversal task (trials to criterion and win-stay/lose-shift errors) and the intra/extra-dimensional set shift task (IED)...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27470127/searching-for-clarity-in-muddy-water-future-considerations-for-classifying-compulsive-sexual-behavior-as-an-addiction
#17
Shane W Kraus, Valerie Voon, Ariel Kor, Marc N Potenza
No abstract text is available yet for this article.
July 28, 2016: Addiction
https://www.readbyqxmd.com/read/27427940/the-role-of-social-novelty-in-risk-seeking-and-exploratory-behavior-implications-for-addictions
#18
Simon Mitchell, Jennifer Gao, Mark Hallett, Valerie Voon
Novelty preference or sensation seeking is associated with disorders of addiction and predicts rodent compulsive drug use and adolescent binge drinking in humans. Novelty has also been shown to influence choice in the context of uncertainty and reward processing. Here we introduce a novel or familiar neutral face stimuli and investigate its influence on risk-taking choices in healthy volunteers. We focus on behavioural outcomes and imaging correlates to the prime that might predict risk seeking. We hypothesized that subjects would be more risk seeking following a novel relative to familiar stimulus...
2016: PloS One
https://www.readbyqxmd.com/read/27418067/translatable-and-back-translatable-measurement-of-impulsivity-and-compulsivity-convergent-and-divergent-processes
#19
REVIEW
Valerie Voon, Jeffrey W Dalley
Impulsivity and compulsivity have emerged as important dimensional constructs that challenge traditional psychiatric classification systems. Both are present in normal healthy populations where the need to act quickly and repeatedly without hesitation can be highly advantageous. However, when excessively expressed, impulsive and compulsive behavior can lead to adverse consequences and spectrum disorders exemplified by attention-deficit/hyperactivity disorder (ADHD), obsessive compulsive disorder (OCD), autism, and drug addiction...
2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27207916/dissociated-accumbens-and-hippocampal-structural-abnormalities-across-obesity-and-alcohol-dependence
#20
Tom B Mole, Elijah Mak, Yee Chien, Valerie Voon
BACKGROUND: Processing of food and drug rewards involves specific neurocircuitry, and emerging evidence implicates subcortical abnormalities, particularly the nucleus accumbens and hippocampus. We specifically hypothesized that these 2 established regions in addiction neurocircuitry are associated with distinctive in vivo structural abnormalities in obesity and alcohol dependence. METHODS: To specifically investigate anatomically discrete volumetric changes associated with overconsumption of different rewards, we acquired T1 MRI data from 118 subjects in 3 groups comprising obesity (n=42), alcohol dependence (n=32), and healthy volunteer controls (n=44)...
September 2016: International Journal of Neuropsychopharmacology
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