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Fat soluble vitamins

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https://www.readbyqxmd.com/read/29767694/shorter-time-to-pregnancy-with-increasing-preconception-carotene-concentrations-among-women-with-1-to-2-previous-pregnancy-losses
#1
Keewan Kim, Enrique F Schisterman, Robert M Silver, Brian D Wilcox, Anne M Lynch, Neil J Perkins, Richard W Browne, Laurie L Lesher, Joseph B Stanford, Aijun Ye, Jean Wactawski-Wende, Sunni L Mumford
Although maternal nutrition may impact fecundity, associations between preconception micronutrients and time to pregnancy (TTP) has not been examined. We assessed the relationship between preconception fat-soluble micronutrient concentrations and TTP among women with 1-2 prior pregnancy losses. This is a prospective cohort study of 1,228 women set in the EAGeR Trial (US, 2007-2011), which assessed the effect of preconception-initiated daily low dose aspirin on reproductive outcomes. We measured preconception zeaxanthin, cryptoxanthin, lycopene, α- and β-carotene, and α- and γ-tocopherol in serum...
May 14, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29766801/naringenin-and-its-nano-formulations-for-fatty-liver-cellular-modes-of-action-and-clinical-perspective
#2
Mahdi Zobeiri, Tarun Belwal, Fatemeh Parvizi, Rozita Naseri, Mohammad Hosein Farzaei, Seyed Fazel Nabavi, Antoni Sureda, Seyed Mohammad Nabavi
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease mainly caused by high fat diets and sudden feed changes, vitamin and energy deficiency, and inflammatory processes. Fatty liver leads to cirrhosis, hepatocellular carcinoma as well as liver failure. Lifestyle-modifying such as weight loss and healthy diet have an inverse correlation with the risk of fatty liver. The promising effect of a diet rich in vegetables and fruits against fatty liver has been evidenced by several empirical studies focused on flavonoids...
May 14, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29766340/the-cholic-acid-extension-study-in-zellweger-spectrum-disorders-results-and-implications-for-therapy
#3
Femke C C Klouwer, Bart G P Koot, Kevin Berendse, Elles M Kemper, Sacha Ferdinandusse, Kiran V K Koelfat, Martin Lenicek, Frédéric M Vaz, Marc Engelen, Peter L M Jansen, Ronald J A Wanders, Hans R Waterham, Frank G Schaap, Bwee Tien Poll-The
INTRODUCTION: Currently, no therapies are available for Zellweger spectrum disorders (ZSDs), a group of genetic metabolic disorders characterised by a deficiency of functional peroxisomes. In a previous study, we showed that oral cholic acid (CA) treatment can suppress bile acid synthesis in ZSD patients and, thereby, decrease plasma levels of toxic C27 -bile acid intermediates, one of the biochemical abnormalities in these patients. However, no effect on clinically relevant outcome measures could be observed after 9 months of CA treatment...
May 15, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29747473/supercritical-fluid-chromatography-with-photodiode-array-detection-in-the-determination-of-fat-soluble-vitamins-in-hemp-seed-oil-and-waste-fish-oil
#4
Katarzyna Tyśkiewicz, Roman Gieysztor, Izabela Maziarczyk, Paweł Hodurek, Edward Rój, Krystyna Skalicka-Woźniak
In the presented study for the first time a new, optimized, fast SFC (supercritical fluid chromatography) method was applied to separate in one run fat-soluble vitamins from waste fish oil, including cis -and tran s-retinyl palmitate, cis - and trans -retinyl acetate, retinol, α-tocopherol, β-tocopherol, γ‑tocopherol, δ-tocopherol, ergocalciferol (D₂), cholecalciferol (D₃), cis - and trans -phylloquinone (K₁) and menaquinone-4 (K₂-MK4). Vitamins were baseline separated on an Acquity UPC² (ultra performance convergence chromatography) HSS C18 SB (highly strength chemically modified silica) column within 13 min...
May 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29736427/a-review-on-potential-roles-of-vitamins-in-incidence-progression-and-improvement-of-multiple-sclerosis
#5
REVIEW
Matin Khosravi-Largani, Parmida Pourvali-Talatappeh, Ali Mohammad Rousta, Maedeh Karimi-Kivi, Elahe Noroozi, Ali Mahjoob, Yasaman Asaadi, Alireza Shahmohammadi, Sarina Sadeghi, Shiva Shakeri, Kimiya Ghiyasvand, Masoumeh Tavakoli-Yaraki
Multiple Sclerosis (MS) is an inflammatory and neurodegenerative disease, with unknown etiology. Vitamins, as important micronutrients playing different roles in body, seem to be important in MS pathogenesis. In vitro , in vivo and human studies, supports the protective role of some vitamins in MS occurrence or progression. Current study reviews recent insights and reports about the importance of vitamins in MS incidence or progression. In accordance, the importance of all water and fat-soluble vitamins in MS pathogenesis based on observational studies in human population and their role in the function of immune system as well as possible therapeutic opportunities are discussed in depth throughout this review...
March 2018: ENeurologicalSci
https://www.readbyqxmd.com/read/29733984/long-chain-metabolites-of-vitamin-e-interference-with-lipotoxicity-via-lipid-droplet-associated-protein-plin2
#6
Lisa Schmölz, Martin Schubert, Jasmin Kirschner, Stefan Kluge, Francesco Galli, Marc Birringer, Maria Wallert, Stefan Lorkowski
The long-chain metabolites of vitamin E (LCM) emerge as a new class of regulatory metabolites and have been considered as the active compounds formed during vitamin E metabolism. The bioactivity of the LCM is comparable to the already established role of other fat-soluble vitamins. The biological modes of action of the LCM are far from being unraveled, but first insights pointed to distinct effects and suggested a specific receptor, which in turn lead to the aforementioned hypothesis. Here, a new facet on the interaction of LCM with foam cell formation of THP-1 macrophages is presented...
May 4, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29729124/analysis-of-retinol-%C3%AE-tocopherol-25-hydroxyvitamin-d2-and-25-hydroxyvitamin-d3-in-plasma-of-patients-with-cardiovascular-disease-by-hplc-ms-ms-method
#7
Marta Karaźniewicz-Łada, Anna Główka, Anna Komosa, Łukasz Kruszyna, Agnieszka Graczyk-Szuster, Maciej Lesiak, Dagmara Sowińska, Juliusz Przysławski
Fat-soluble vitamins play a pivotal role in the progression of atherosclerosis and development of cardiovascular disease. Therefore, plasma monitoring of their concentrations may be useful in the diagnosis of these disorders as well as in the process of treatment. The study aimed to develop and validate an HPLC-MS/MS method for determination of retinol, α-tocopherol, 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 in plasma of patients with cardiovascular disease. The analytes were separated on HPLC Kinetex F5 column via gradient elution with water and methanol, both containing 0...
May 5, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29713611/chylomicron-retention-disease-a-description-of-a-new-mutation-in-a-very-rare-disease
#8
Helena Ferreira, Raquel Nuñez Ramos, Cinthia Flores Quan, Susana Redecillas Ferreiro, Vanessa Cabello Ruiz, Javi Juampérez Goñi, Jesus Quintero Bernabeu, Oscar Segarra Cantón, Marina Álvarez Beltran
Chylomicron retention disease, also known as Anderson's disease, is a rare hereditary hypocholesterolemic disorder, recessive inherited, characterized by nonspecific symptoms as abdominal distension, steatorrhea, and vomiting associated with failure to thrive. We describe a patient with failure to thrive, chronic diarrhea and steatorrhea who the diagnosis of chylomicron retention disease was established after several months of disease progression. The genetic study confirmed a homozygosity mutation in SAR1B gene, identifying a mutation never previous described [c...
April 2018: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/29701137/impact-of-food-pantry-donations-on-diet-of-a-low-income-population
#9
Tamara Y Mousa, Jean H Freeland-Graves
OBJECTIVE: This cross-sectional study assessed the effect of food donations on total nutrient intake of clients of a food pantry in Central Texas. METHODS: Nutrient intakes of total, base and food donation diets were estimated for 112 food pantry recipients using specific questionnaires; and then compared to the dietary reference intakes (DRI) and 2015-2020 US Dietary Guidelines. RESULTS: Food donations accounted for more than half of the client's daily intake of energy, carbohydrates, vitamin B6 , phosphorus, copper and selenium...
April 27, 2018: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29693762/growth-body-composition-and-bone-density-following-pediatric-liver-transplantation
#10
Amin Sheikh, Tim Cundy, Helen Maria Evans
Patients transplanted for cholestatic liver disease are often significantly fat-soluble vitamin deficient and malnourished pretransplant, with significant corticosteroid exposure post-transplant, with increasing evidence of obesity and metabolic syndrome post-LT. Our study aimed to assess growth, body composition, and BMD in patients post-pediatric LT. Body composition and bone densitometry scans were performed on 21 patients. Pre- and post-transplant anthropometric data were analyzed. Bone health was assessed using serum ALP, calcium, phosphate, and procollagen-1-N-peptide levels...
April 24, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29686863/fat-soluble-vitamins-a-and-e-and-health-disparities-in-a-cohort-of-pregnant-women-at-delivery
#11
Corrine Hanson, Marina Verdi Schumacher, Elizabeth Lyden, Dejun Su, Jeremy Furtado, Rex Cammack, Bradley Bereitschaft, Matthew Van Ormer, Howard Needelman, Elizabeth McGinn, Katherine Rilett, Caleb Cave, Rebecca Johnson, Kara Weishaar, Ann Anderson-Berry
The objective of the present study was to evaluate intakes and serum levels of vitamin A, vitamin E, and related compounds in a cohort of maternal-infant pairs in the Midwestern USA in relation to measures of health disparities. Concentrations of carotenoids and tocopherols in maternal serum were measured using HPLC and measures of socio-economic status, including food security and food desert residence, were obtained in 180 mothers upon admission to a Midwestern Academic Medical Center labour and delivery unit...
2018: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29665470/application-of-supercritical-fluid-chromatography-coupled-to-mass-spectrometry-to-the-determination-of-fat-soluble-vitamins-in-selected-food-products
#12
Jean-Marie Oberson, Esther Campos-Giménez, Johann Rivière, Frédéric Martin
In the present manuscript, we describe a fully optimized and validated method suitable to analyse nine compounds (retinyl acetate, retinyl palmitate, retinol, α-tocopherol, α-tocopheryl acetate, cholecalciferol, ergocalciferol, phylloquinone, menaquinone-4) representing the major contributors to the fat-soluble vitamin activity of selected food products (infant formulas, adult nutritionals, infant cereals and mixed meals). Sample preparation involves direct solvent extraction using enzyme-assisted matrix disintegration and methanolic protein precipitation...
April 10, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29659879/orlistat-therapy-for-children-with-type-1-hyperlipoproteinemia-a-randomized-clinical-trial
#13
Nivedita Patni, Claudia Quittner, Abhimanyu Garg
Context: Patients with Type I Hyperlipoproteinemia (T1HLP), a rare genetic disorder, present with significant chylomicronemia and recurrent episodes of acute pancreatitis. Currently, the only therapeutic option is to consume an extremely low fat diet, as the triglyceride lowering medications are not efficacious. Objective: To determine the efficacy of Orlistat, a gastric and pancreatic lipase inhibitor, Orlistat, in reducing serum triglyceride levels in patients with T1HLP...
April 5, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29658451/-clinical-and-genetic-analysis-of-a-pediatric-patient-with-sodium-taurocholate-cotransporting-polypeptide-deficiency
#14
Hua Li, Jian-Wu Qiu, Gui-Zhi Lin, Mei Deng, Wei-Xia Lin, Ying Cheng, Yuan-Zong Song
Sodium taurocholate cotransporting polypeptide (NTCP) deficiency is an inborn error of bile acid metabolism caused by mutations of SLC10A1 gene. This paper reports the clinical and genetic features of a patient with this disease. A 3.3-month-old male infant was referred to the hospital with the complaint of jaundiced skin and sclera over 3 months. Physical examination revealed moderate jaundice of the skin and sclera. The liver was palpable 3.5 cm below the right subcostal margin with a medium texture. Serum biochemistry analysis revealed markedly elevated bilirubin (predominantly direct bilirubin) and total bile acids (TBA), as well as decreased 25-OH-VitD level...
April 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29653100/vitamin-d-nanoemulsion-enhances-hapatoprotective-effect-of-conventional-vitamin-d-in-rats-fed-with-a-high-fat-diet
#15
Mohamed El-Sherbiny, Mohamed Eldosoky, Mohamed El-Shafey, Gamal Othman, Hany A Elkattawy, Tamer Bedir, Nehal Mohsen Elsherbiny
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is associated with hyperlipidemia, obesity and type II diabetes. Due to increasing prevalence of these diseases globally, NAFLD is considered as a common form of chronic liver diseases. Vitamin D is a fat soluble vitamin with reported anti-inflammatory, anti-oxidant and immune modulating activity. Hypovitaminosis D often coexists with NAFLD and various studies reported beneficial role of vitamin D in modulating NAFLD. However, variable oral bioavailability, poor water solubility, and chemical degradation hinder the clinical application of vitamin D...
April 10, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29610168/vitamin-a-deficiency-due-to-selective-eating-as-a-cause-of-blindness-in-a-high-income-setting
#16
Silvia Martini, Angela Rizzello, Ilaria Corsini, Benedetta Romanin, Michelangelo Fiorentino, Sara Grandi, Rosalba Bergamaschi
Vitamin A is a fat-soluble micronutrient involved in the regulation of several physiologic functions, such as visual acuity, epithelial tissue integrity, immune response, and gene expression, thus playing a crucial role in childhood growth and development. Although vitamin A deficiency (VAD) in resource-limited settings is still an actual issue and represents the leading cause of preventable childhood blindness, its occurrence in high-income countries is rare, although possibly underdiagnosed because of its nonspecific early manifestations...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29567059/conversion-of-standard-roux-en-y-gastric-bypass-to-distal-bypass-for-weight-loss-failure-and-metabolic-syndrome-3-year-follow-up-and-evolution-of-technique-to-reduce-nutritional-complications
#17
Saber Ghiassi, Kelvin Higa, Steven Chang, Pearl Ma, Aaron Lloyd, Keith Boone, Eric J DeMaria
BACKGROUND: Standard proximal Roux-en-Y gastric bypass (RYGB) fails to achieve long-term weight maintenance and/or control of metabolic syndrome in up to 35% of patients. OBJECTIVES: To improve the performance of the standard proximal gastric bypass by increasing the biliopancreatic limb length at the expense of the common channel. SETTINGS: Academic-affiliated private practice. METHODS: A retrospective review of all patients who underwent conversion to distal RYGB from 2010 to 2016 was performed...
January 31, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29565157/-influence-of-liver-transplantation-in-the-nutritional-profile-of-severe-cirrhotic-patients
#18
Caroline Pinho R Andrade, Mileda L T Portugal, Ellén De Sousa Paz, Paula A Freitas, Ana Filomena C S Daltro, Kaluce G S Almondes, Carla Soraya C Maia, Ariclecio Cunha de Oliveira
OBJECTIVE: The aim of this study was to analyze the influence of liver transplantation in food intake and nutritional status of severe cirrhotic patients. METHODS: The sample consisted of 23 patients who underwent liver transplantation. Three 24-hour dietary recall were applied and anthropometric measurements were collected before and three months after transplantation. The consumption of macronutrients and fat soluble vitamins were also evaluated. The anthropometric data evaluated were body mass index, abdominal circumference, percentage of adequacy of arm circumference, triceps skinfold thickness and arm muscle circumference...
January 16, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29560688/prevalence-of-fat-soluble-vitamin-a-d-and-e-and-zinc-deficiency-in-patients-with-cirrhosis-being-assessed-for-liver-transplantation
#19
A Teriaky, M Mosli, N Chandok, B Al-Judaibi, P Marotta, K Qumosani
PURPOSE: To evaluate the prevalence of fat-soluble vitamin (A, D, and E) and zinc deficiency in patients with cirrhosis being assessed for liver transplantation and the correlations between vitamin deficiencies, nutritional markers, and severity of liver disease. METHODS: This is a single centre retrospective study. Serum vitamin A, D, E, and zinc levels were collected in adult patients being assessed for liver transplantation between January and July 2012. Patient and liver disease demographics, nutritional markers, Child-Pugh score, and MELD-Na score were collected...
April 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29543697/nutritional-status-the-first-two-years-of-life-in-cystic-fibrosis-diagnosed-by-newborn-screening
#20
Anne Munck, Rym Boulkedid, Laurence Weiss, Pierre Foucaud, Nathalie Wizla-Derambure, Philippe Reix, François Bremont, Jocelyne Derelle, Julien Schroedt, Corinne Alberti
OBJECTIVE: To evaluate nutritional status and associated factors in a cystic fibrosis (CF) cohort diagnosed by newborn screening and followed up to month 24. METHODS: A prospective longitudinal multicenter study assessing nutritional status according to pancreatic status, feeding modalities, prescriptions, pulmonary outcome and biological nutritional parameters. RESULTS: One-hundred-and-five infants were recruited and 99 completed the study...
March 14, 2018: Journal of Pediatric Gastroenterology and Nutrition
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