keyword
MENU ▼
Read by QxMD icon Read
search

Suv

keyword
https://www.readbyqxmd.com/read/27904873/evaluation-of-the-effect-of-tumor-position-on-standardized-uptake-value-using-time-of-flight-reconstruction-and-point-spread-function
#1
Yasuharu Wakabayashi, Kenichi Kashikura, Yasuyuki Takahashi, Hitoshi Yabe, Akihiro Ichikawa, Souichi Yamamoto, Ayumi Ishii, Kunio Doi
OBJECTIVES: The present study was conducted to examine whether the standardized uptake value (SUV) may be affected by the spatial position of a lesion in the radial direction on positron emission tomography (PET) images, obtained via two methods based on time-of-flight (TOF) reconstruction and point spread function (PSF). METHODS: A cylinder phantom with the sphere (30 mm diameter), located in the center was used in this study. Fluorine-18 fluorodeoxyglucose ((18)F-FDG) concentrations of 5...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27904872/background-based-delineation-of-internal-tumor-volume-in-static-positron-emission-tomography-in-a-phantom-study
#2
Yangchun Chen, Xiangrong Chen, Ji-An Liu, Fanyong Li
OBJECTIVES: Considering the fact that the standardized uptake value (SUV) of a normal lung tissue is expressed as x±SD, x+3×SD could be considered as the threshold value to outline the internal tumor volume (ITV) of a lung neoplasm. METHODS: Three hollow models were filled with 55.0 kBq/mL fluorine-18 fluorodeoxyglucose ((18)F-FDG) to represent tumors. The models were fixed to a barrel filled with 5.9 kBq/mL (18)F-FDG to characterize normal lung tissues as a phantom...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27900518/the-reconstruction-algorithm-used-for-68-ga-psma-hbed-cc-pet-ct-reconstruction-significantly-influences-the-number-of-detected-lymph-node-metastases-and-coeliac-ganglia
#3
Thomas Krohn, Anita Birmes, Oliver H Winz, Natascha I Drude, Felix M Mottaghy, Florian F Behrendt, Frederik A Verburg
PURPOSE: To investigate whether the numbers of lymph node metastases and coeliac ganglia delineated on [(68)Ga]PSMA-HBED-CC PET/CT scans differ among datasets generated using different reconstruction algorithms. METHODS: Data were constructed using the BLOB-OS-TF, BLOB-OS and 3D-RAMLA algorithms. All reconstructions were assessed by two nuclear medicine physicians for the number of pelvic/paraaortal lymph node metastases as well the number of coeliac ganglia. Standardized uptake values (SUV) were also calculated in different regions...
November 29, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27898367/effectiveness-of-forward-collision-warning-and-autonomous-emergency-braking-systems-in-reducing-front-to-rear-crash-rates
#4
Jessica B Cicchino
The objective of this study was to evaluate the effectiveness of forward collision warning (FCW) alone, a low-speed autonomous emergency braking (AEB) system operational at speeds up to 19mph that does not warn the driver prior to braking, and FCW with AEB that operates at higher speeds in reducing front-to-rear crashes and injuries. Poisson regression was used to compare rates of police-reported crash involvements per insured vehicle year in 22 U.S. states during 2010-2014 between passenger vehicle models with FCW alone or with AEB and the same models where the optional systems were not purchased, controlling for other factors affecting crash risk...
November 26, 2016: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/27896627/n-11-c-methyl-amd3465-pet-as-a-tool-for-in-vivo-measurement-of-chemokine-receptor-4-cxcr4-occupancy-by-therapeutic-drugs
#5
S V Hartimath, M A Khayum, A van Waarde, R A J O Dierckx, E F J de Vries
PURPOSE: Chemokine receptor 4 (CXCR4) is overexpressed in many cancers and a potential drug target. We have recently developed the tracer N-[(11)C]methyl-AMD3465 for imaging of CXCR4 expression by positron emission tomography (PET). We investigated the pharmacokinetics of N-[(11)C]methyl-AMD3465 in rats bearing a C6 tumor and assessed whether the CXCR4 occupancy by the drug Plerixafor® can be measured with this PET tracer. PROCEDURE: A subcutaneous C6 tumor was grown in Wistar rats...
November 28, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27872957/utility-of-18-f-fluoroestradiol-18-f-fes-pet-ct-imaging-as-a-pharmacodynamic-marker-in-patients-with-refractory-estrogen-receptor-positive-solid-tumors-receiving-z-endoxifen-therapy
#6
Frank I Lin, E M Gonzalez, S Kummar, K Do, J Shih, S Adler, K A Kurdziel, A Ton, B Turkbey, P M Jacobs, S Bhattacharyya, A P Chen, J M Collins, J H Doroshow, P L Choyke, M L Lindenberg
BACKGROUND: Z-endoxifen is the most potent of the metabolites of tamoxifen, and has the potential to be more effective than tamoxifen because it bypasses potential drug resistance mechanisms attributable to patient variability in the expression of the hepatic microsomal enzyme CYP2D6. (18)F-FES is a positron emission tomography (PET) imaging agent which selectively binds to estrogen receptor alpha (ER-α) and has been used for non-invasive in vivo assessment of ER activity in tumors. This study utilizes (18)F-FES PET imaging as a pharmacodynamic biomarker in patients with ER+ tumors treated with Z-endoxifen...
November 21, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27869259/the-effect-of-top-layer-chemistry-on-the-formation-of-supported-lipid-bilayers-on-polyelectrolyte-multilayers-primary-versus-quaternary-amines
#7
E Diamanti, P Andreozzi, R Anguiano, L Yate, D Gregurec, N Politakos, R F Ziolo, E Donath, S E Moya
The influence of the surface chemistry of polyelectrolyte multilayers (PEMs) on the formation of lipid bilayers is studied here for PEMs with either polyallylamine hydrochloride (PAH) or polydiallyldimethylammonium chloride (PDADMAC) as a polycation as a top layer, and polystyrene sulfonate (PSS) as a polyanion. Small unilamellar vesicles (SUVs) composed of phosphatidyl choline and phosphatidyl serine at a 50 : 50 molar ratio are deposited on top of the PEM films. The assembly of the SUVs into bilayers is studied via a quartz crystal microbalance with dissipation (QCM-D) and fluorescence recovery after photobleaching (FRAP)...
November 30, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27856631/11c-er176-a-radioligand-for-18-kda-translocator-protein-tspo-has-adequate-sensitivity-to-robustly-image-all-three-affinity-genotypes-in-human-brain
#8
Masamichi Ikawa, Talakad G Lohith, Stal Shrestha, Sanjay Telu, Sami S Zoghbi, Sabrina Castellano, Sabrina Taliani, Federico Da Settimo, Masahiro Fujita, Victor W Pike, Robert B Innis
: For positron emission tomography (PET) imaging of 18-kDa translocator protein (TSPO), a biomarker of neuroinflammation, most second-generation radioligands are sensitive to the single nucleotide polymorphism rs6971; however this is probably not the case for the prototypical agent (11)C-PK 11195, which has a relatively lower signal-to-noise ratio. We recently found that (11)C-ER176, a new analog of (11)C-(R)-PK 11195, showed little sensitivity to rs6971 when tested in vitro and had high specific binding in monkey brain...
November 17, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27849386/18f-fdg-pet-suv-as-a-prognostic-marker-of-increasing-size-in-thyroid-cancer-tumors
#9
Ishita Singh, Athanasios Bikas, Carlos A Garcia, Sameer Desale, Leonard Wartofsky, Kenneth D Burman
Background 18F-FDG- PET/CT scans are used in high-risk thyroid cancer patients to determine the presence of metastasis. The prognostic significance of increases in SUVs (Standard Unit Values) has not been clearly defined. This pilot study investigated the correlation between increases in SUV with subsequent changes in size of individual lesions. Methods A retrospective chart review of patients with histologically confirmed thyroid cancer, monitored with serial 18F-FDG- PET/CT scans from 2008 to 2013, was performed...
November 16, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27835825/a-useful-pet-probe-11-c-bu99008-with-ultra-high-specific-radioactivity-for-small-animal-pet-imaging-of-i2-imidazoline-receptors-in-the-hypothalamus
#10
Kazunori Kawamura, Yoko Shimoda, Joji Yui, Yiding Zhang, Tomoteru Yamasaki, Hidekatsu Wakizaka, Akiko Hatori, Lin Xie, Katsushi Kumata, Masayuki Fujinaga, Masanao Ogawa, Yusuke Kurihara, Nobuki Nengaki, Ming-Rong Zhang
INTRODUCTION: A positron emission tomography (PET) probe with ultra-high specific radioactivity (SA) enables measuring high receptor specific binding in brain regions by avoiding mass effect of the PET probe itself. It has been reported that PET probe with ultra-high SA can detect small change caused by endogenous or exogenous ligand. Recently, Kealey et al. developed [(11)C]BU99008, a more potent PET probe for I2-imidazoline receptors (I2Rs) imaging, with a conventional SA (mean 76GBq/μmol) showed higher specific binding in the brain...
October 26, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27834658/single-channel-sparse-nonnegative-blind-source-separation-method-for-automatic-3d-delineation-of-lung-tumor-in-pet-images
#11
Ivica Kopriva, Wei Ju, Bin Zhang, Fei Shi, Dehui Xiang, Kai Yu, Ximing Wang, Ulas Bagci, Xinjian Chen
In this paper, we propose a novel method for single-channel blind separation of non-overlapped sources and, to the best of our knowledge, apply it for the first time to automatic segmentation of lung tumors in Positron Emission Tomography (PET) images. Our approach first converts 3D PET image into a pseudo multichannel image. Afterwards, regularization free sparseness constrained nonnegative matrix factorization is used to separate tumor from other tissues. By using complexity based criterion, we select tumor component as the one with minimal complexity...
November 3, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27834284/brain-energy-metabolism-and-neuroinflammation-in-ageing-app-ps1-21-mice-using-longitudinal-18f-fdg-and-18f-dpa-714-pet-imaging
#12
Jatta S Takkinen, Francisco R López-Picón, Rana Al Majidi, Olli Eskola, Anna Krzyczmonik, Thomas Keller, Eliisa Löyttyniemi, Olof Solin, Juha O Rinne, Merja Haaparanta-Solin
Preclinical animal model studies of brain energy metabolism and neuroinflammation in Alzheimer's disease have produced conflicting results, hampering both the elucidation of the underlying disease mechanism and the development of effective Alzheimer's disease therapies. Here, we aimed to quantify the relationship between brain energy metabolism and neuroinflammation in the APP/PS1-21 transgenic mouse model of Alzheimer's disease using longitudinal in vivo (18)F-FDG and (18)F-DPA-714) PET imaging and ex vivo brain autoradiography...
November 8, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27831761/prognostic-importance-of-the-presence-of-early-metabolic-response-and-absence-of-extrahepatic-metastasis-after-selective-internal-radiation-therapy-in-colorectal-cancer-liver-metastasis
#13
Cigdem Soydal, Nuriye Ozlem Kucuk, Deniz Balci, Ethem Gecim, Sadik Bilgic, Atilla Halil Elhan
AIMS: In this study, the authors aimed to identify prognostic factors after selective internal radiation therapy (SIRT) for colorectal cancer (CRC) liver metastasis. METHODS: Forty-nine (28 male, 21 female; mean age: 64.6 ± 10.8) patients who received SIRT for CRC liver metastasis were studied. Effects of number (<5 vs. ≥5), maximum dimension, and standardized uptake value (SUV) of liver metastases, liver tumor load (<25% vs. 26%-50% vs. 51%-75%), presence of extrahepatic disease, and metabolic early response on overall survival were analyzed...
November 2016: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27826556/living-donor-liver-transplantation-for-hepatocellular-carcinoma-achieves-better-outcomes
#14
REVIEW
Chih-Che Lin, Chao-Long Chen
Liver transplantation (LT) for hepatocellular carcinoma (HCC) at Kaohsiung Chang Gung Memorial Hospital mainly relies on live donor LT (LDLT). Owing to taking the risk of LD, we are obligated to adopt strict selection criteria for HCC patients and optimize the pre-transplant conditions to ensure a high disease-free survival similar to those without HCC, even better than deceased donor LT (DDLT). Better outcomes are attributed to excellent surgical results and optimal patient selection. The hospital mortality of primary and salvage LDLT are lower than 2% in our center...
October 2016: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/27824931/glucose-metabolism-and-its-complicated-relationship-with-tumor-growth-and-perfusion-in-head-and-neck-squamous-cell-carcinoma
#15
Noriyuki Fujima, Tomohiro Sakashita, Akihiro Homma, Kenji Hirata, Tohru Shiga, Kohsuke Kudo, Hiroki Shirato
OBJECTIVE: To determine the relationship between tumor glucose metabolism and tumor blood flow (TBF) in head and neck squamous cell carcinoma (HNSCC). METHODS: We retrospectively analyzed 57 HNSCC patients. Tumor glucose metabolism was assessed by maximum and mean standardized uptake values (SUVmax and SUVmean) obtained by 18F-fluorodeoxyglucose positron-emission tomography. TBF values were obtained by arterial spin labeling with 3-tesla MRI. The correlations between both SUVs and TBF were assessed in the total series and among patients divided by T-stage (T1-T3 and T4 groups) and tumor location (pharynx/oral cavity and sinonasal cavity groups)...
2016: PloS One
https://www.readbyqxmd.com/read/27824238/breath-hold-68ga-dota-toc-pet-ct-in-neuroendocrine-tumors-detection-of-additional-lesions-and-effects-on-quantitative-parameters
#16
Mariana Zirnsak, Robert Bärwolf, Martin Freesmeyer
BACKGROUND: Respiratory motion during PET/CT acquisition generates artifacts in the form of breath-related blurring, which influences the lesion detectability and diagnostic accuracy. The goal of this study was to verify whether breath-hold [68Ga]DOTA-TOC PET/CT (bhPET) allows detection of additional foci compared to free-breathing PET/CT (fbPET), and to assess the impact of breath-holding on standard uptake values (SUV) and isocontoured volume (Vic40) in patients with neuroendocrine tumors (NET)...
November 8, 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27823640/impact-of-pet-ct-on-radiation-treatment-in-patients-with-esophageal-cancer-a-systematic-review
#17
REVIEW
Jing Lu, Xiang-Dong Sun, Xi Yang, Xin-Yu Tang, Qin Qin, Hong-Cheng Zhu, Hong-Yan Cheng, Xin-Chen Sun
PURPOSE: With the advances in radiotracers, positron emission tomography/computed tomography (PET/CT) is recognized as a useful adjunct to anatomic imaging with CT, MRI and endoscopic ultrasonography (EUS). The objective of this review was to comprehensively analyze the roles of PET/CT for the radiotherapy of esophageal cancer. METHODS: In this review, we focused on issues concerning the application of PET/CT in TNM staging, target volume delineation and response to therapy, both for the primary tumor and regional lymph nodes...
November 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27822900/reproducibility-of-18-f-fluoromisonidazole-intratumour-distribution-in-non-small-cell-lung-cancer
#18
Milan Grkovski, Jazmin Schwartz, Andreas Rimner, Heiko Schöder, Sean D Carlin, Pat B Zanzonico, John L Humm, Sadek A Nehmeh
BACKGROUND: Hypoxic tumours exhibit increased resistance to radiation, chemical, and immune therapies. (18)F-fluoromisonidazole (FMISO) positron emission tomography (PET) is a non-invasive, quantitative imaging technique used to evaluate the presence and spatial distribution of tumour hypoxia. To facilitate the use of FMISO PET for identification of individuals likely to benefit from hypoxia-targeted treatments, we investigated the reproducibility of FMISO PET spatiotemporal intratumour distribution in patients with non-small cell lung cancer (NSCLC)...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27822700/-68-ga-psma-hbed-cc-pet-imaging-in-breast-carcinoma-patients
#19
Mike Sathekge, Thabo Lengana, Moshe Modiselle, Mariza Vorster, JanRijn Zeevaart, Alex Maes, Thomas Ebenhan, Christophe Van de Wiele
BACKGROUND: To report on imaging findings using (68)Ga-PSMA-HBED-CC PET in a series of 19 breast carcinoma patients. METHODS: (68)Ga-PSMA-HBED-CC PET imaging results obtained were compared to routinely performed staging examinations and analyzed as to lesion location and progesterone receptor status. RESULTS: Out of 81 tumor lesions identified, 84% were identified on (68)Ga-PSMA-HBED-CC PET. (68)Ga-PSMA-HBED-CC SUVmean values of distant metastases proved significantly higher (mean, 6...
November 8, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27819858/18f-fdg-pet-ct-metabolic-tumor-volume-and-intratumoral-heterogeneity-in-pancreatic-adenocarcinomas-impact-of-dual-time-point-and-segmentation-methods
#20
Esther Mena, Sara Sheikhbahaei, Mehdi Taghipour, Abhinav K Jha, Esther Vicente, Jennifer Xiao, Rathan M Subramaniam
OBJECTIVES: We aimed to determine the consistency of quantitative PET measurements of metabolic tumor volume (MTV) and intratumoral heterogeneity index for primary untreated pancreatic adenocarcinomas, when using dual-time point F-FDG PET/CT imaging. METHODS: This is an institutional review board-approved, retrospective study including 71 patients with pancreatic adenocarcinoma, who underwent dual-time point F-FDG PET/CT imaging, at approximately 1 hour (early) and 2 hours (delayed), after injection...
November 4, 2016: Clinical Nuclear Medicine
keyword
keyword
117938
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"