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https://www.readbyqxmd.com/read/29352608/differences-in-lung-injury-after-imrt-or-proton-therapy-assessed-by-18fdg-pet-imaging
#1
Nadya Shusharina, Zhongxing Liao, Radhe Mohan, Amy Liu, Andrzej Niemierko, Noah Choi, Thomas Bortfeld
BACKGROUND AND PURPOSE: To compare lung injury among non-small cell lung cancer (NSCLC) patients treated with IMRT or proton therapy as revealed by 18F-FDG post-treatment uptake and to determine factors predictive for clinically symptomatic radiation pneumonitis. MATERIAL AND METHODS: For 83 patients treated with IMRT or proton therapy, planning CT and follow up 18F-FDG PET-CT were analyzed. Post-treatment PET-CT was aligned with planning CT to establish a voxel-to-voxel correspondence between PET and planning dose images...
January 15, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29345443/suv-calculation-in-breast-cancer-which-normalization-should-be-applied-when-using-18f-fdg-pet
#2
Olivier Humbert, Jean-Marc Riedinger, David Chardin, Isabelle Desmoulins, François Brunotte, Alexandre Cochet
BACKGROUND: When using 18F-FDG PET, glucose metabolism quantification is affected by various factors. We aimed to investigate the benefit of different SUV normalizations to improve the accuracy of 18F-FDG uptake to predict breast cancer aggressiveness and response to treatment. METHODS: Two hundred fifty-two women with locally advanced breast cancer treated with neoadjuvant chemotherapy (NAC) were included. Women underwent 18F-FDG PET before and after the first course of NAC...
January 17, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29344901/imaging-characteristics-and-first-experience-of-68ga-thp-psma-a-novel-probe-for-rapid-kit-based-ga-68-labeling-and-pet-imaging-comparative-analysis-with-68ga-psma-i-t
#3
Thorsten Derlin, Sebastian Schmuck, Cathleen Juhl, Steffi Teichert, Johanna Zörgiebel, Hans-Jürgen Wester, Sophie M Schneefeld, Almut C A Walte, James T Thackeray, Tobias L Ross, Frank M Bengel
PURPOSE: [68Ga]Trishydroxypyridinone (THP)-prostate-specific membrane antigen (PSMA) is a novel tracer that can be labeled in one step by cold reconstitution of a kit with unprocessed generator eluate, targeting PSMA via the lysine-urea-glutamate (KuE) motif. The aim of this study was to evaluate the human imaging characteristics of [68Ga]THP-PSMA. PROCEDURES: [68Ga]THP-PSMA positron emission tomography (PET)/x-ray computed tomography (CT) was performed in 25 patients with biochemical recurrence after radical prostatectomy for prostate cancer...
January 17, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29340798/diagnostic-implications-of-a-small-voxel-reconstruction-for-loco-regional-lymph-node-characterization-in-breast-cancer-patients-using-fdg-pet-ct
#4
Daniëlle Koopman, Jorn A van Dalen, Hester Arkies, Ad H J Oostdijk, Anne Brecht Francken, Jos Bart, Cornelis H Slump, Siert Knollema, Pieter L Jager
BACKGROUND: We evaluated the diagnostic implications of a small-voxel reconstruction for lymph node characterization in breast cancer patients, using state-of-the-art FDG-PET/CT. We included 69 FDG-PET/CT scans from breast cancer patients. PET data were reconstructed using standard 4 × 4 × 4 mm3 and small 2 × 2 × 2 mm3 voxels. Two hundred thirty loco-regional lymph nodes were included, of which 209 nodes were visualised on PET/CT. All nodes were visually scored as benign or malignant, and SUVmax and TBratio(=SUVmax/SUVbackground) were measured...
January 16, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29336922/segmentation-free-direct-tumor-volume-and-metabolic-activity-estimation-from-pet-scans
#5
Saeid Asgari Taghanaki, Noirin Duggan, Hillgan Ma, Xinchi Hou, Anna Celler, Francois Benard, Ghassan Hamarneh
Tumor volume and metabolic activity are two robust imaging biomarkers for predicting early therapy response in F-fluorodeoxyglucose (FDG) positron emission tomography (PET), which is a modality to image the distribution of radiotracers and thereby observe functional processes in the body. To date, estimation of these two biomarkers requires a lesion segmentation step. While the segmentation methods requiring extensive user interaction have obvious limitations in terms of time and reproducibility, automatically estimating activity from segmentation, which involves integrating intensity values over the volume is also suboptimal, since PET is an inherently noisy modality...
December 27, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/29333463/characteristics-of-smoothing-filters-to-achieve-the-guideline-recommended-positron-emission-tomography-image-without-harmonization
#6
Yuji Tsutsui, Shinichi Awamoto, Kazuhiko Himuro, Yoshiyuki Umezu, Shingo Baba, Masayuki Sasaki
Objectives: The aim of this study is to examine the effect of different smoothing filters on the image quality and SUVmax to achieve the guideline recommended positron emission tomography (PET) image without harmonization. Methods: We used a Biograph mCT PET scanner. A National Electrical Manufacturers Association (NEMA) the International Electrotechnical Commission (IEC) body phantom was filled with 18F solution with a background activity of 2.65 kBq/mL and a sphere-to-background ratio of 4...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29327944/diagnostic-accuracy-of-f-18-fdg-pet-or-pet-ct-for-the-characterization-of-adrenal-masses-a-systematic-review-and-meta-analysis
#7
Seong-Jang Kim, Sang Woo Lee, Kyoungjune Pak, In-Ju Kim, Keunyoug Kim
OBJECTIVE: We aimed to explore the role of the diagnostic accuracy of F-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET) or positron emission tomography/computed tomography (PET/CT) for characterization of adrenal lesions through a systematic review and meta-analysis. METHODS: The MEDLINE, EMBASE, and Cochrane Library database, from the earliest available date of indexing through April 30, 2017, were searched for studies evaluating the diagnostic performance of F-18 FDG PET or PET/CT for characterization of adrenal lesions...
January 12, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29327129/quantification-of-osteoblastic-activity-in-epiphyseal-growth-plates-by-quantitative-bone-spect-ct
#8
Tomohiko Yamane, Ichiei Kuji, Akira Seto, Ichiro Matsunari
OBJECTIVE: Quantifying the function of the epiphyseal plate is worthwhile for the management of children with growth disorders. The aim of this retrospective study was to quantify the osteoblastic activity at the epiphyseal plate using the quantitative bone SPECT/CT. MATERIALS AND METHODS: We enrolled patients under the age of 20 years who received Tc-99m hydroxymethylene diphosphonate bone scintigraphy acquired by a quantitative SPECT/CT scanner. The images were reconstructed by ordered subset conjugate-gradient minimizer, and the uptake on the distal margin of the femur was quantified by peak standardized uptake value (SUVpeak)...
January 11, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29326354/accuracy-of-dose-calibrators-for-gallium-68-pet-imaging-unexpected-findings-in-a-multi-centre-clinical-pre-trial-assessment
#9
Dale L Bailey, Michael S Hofman, Nicholas J Forwood, Graeme J O'Keefe, Andrew M Scott, Winifred M van Wyngaardt, Bonnie Howe, Olga Kovacev, Roslyn J Francis
AIMS: We report the discovery of a systematic miscalibration during the work-up process for site validation of a multi-centre clinical PET imaging trial using 68Ga, which manifested as a consistent and reproducible underestimation in the quantitative accuracy (assessed by SUV) of a range of PET cameras from different manufacturers at a number of different facilities around Australia. METHODS: Sites were asked to follow a strict preparation protocol to create a radioactive phantom with 68Ga to be imaged using a standard clinical protocol prior to commencing imaging in the trial...
January 11, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29324917/sequential-18f-fdg-pet-ct-imaging-parameters-for-differentiating-benign-from-malignant-lymph-nodes-in-head-and-neck-carcinoma
#10
Agata Pietrzak, J Kazmierska, Witold Cholewinski
OBJECTIVE: The aim of this study was to differentiate between benign and malignant head and neck lymph nodes by sequential imaging. SUBJECTS AND METHODS: The total of 56 retrospectively analysed patients with suspected or histopathologically confirmed head and neck malignancy (nasopharyngeal cancers mainly; 28 patients), before any treatment, underwent sequential fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) examinations for staging purposes...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29322068/measuring-temporal-stability-of-positron-emission-tomography-standardized-uptake-value-bias-using-long-lived-sources-in-a-multicenter-network
#11
Darrin Byrd, Rebecca Christopfel, Grae Arabasz, Ciprian Catana, Joel Karp, Martin A Lodge, Charles Laymon, Eduardo G Moros, Mikalai Budzevich, Sadek Nehmeh, Joshua Scheuermann, John Sunderland, Jun Zhang, Paul Kinahan
Positron emission tomography (PET) is a quantitative imaging modality, but the computation of standardized uptake values (SUVs) requires several instruments to be correctly calibrated. Variability in the calibration process may lead to unreliable quantitation. Sealed source kits containing traceable amounts of [Formula: see text] were used to measure signal stability for 19 PET scanners at nine hospitals in the National Cancer Institute's Quantitative Imaging Network. Repeated measurements of the sources were performed on PET scanners and in dose calibrators...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29313814/biomarker-integrated-neoadjuvant-dasatinib-trial-in-resectable-malignant-pleural-mesothelioma
#12
Anne S Tsao, Heather Lin, Brett W Carter, J Jack Lee, David Rice, Ara Vaporcyan, Steven Swisher, Reza Mehran, John Heymach, Monique Nilsson, Youhong Fan, Maria Nunez, Lixia Diao, Jing Wang, Junya Fujimoto, Ignacio I Wistuba, Waun Ki Hong
Window-of-opportunity trials in malignant pleural mesothelioma (MPM) are challenging but can yield important translational information about a novel agent. We treated MPM patients (n=24) with 4 weeks of oral dasatinib followed by surgery with or without radiotherapy and then an optional 2 years of maintenance dasatinib. The primary endpoint was biomarker modulation of p-SrcTyr419. For all patients, the median PFS was 7.5 months and OS 19.1 months. No significant responses were seen after 4 weeks of dasatinib therapy, however, modulation of p-SrcTyr419 immunohistochemistry (IHC) scores (median (interquartile range) = 70 (37...
December 4, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29301932/a-post-reconstruction-harmonization-method-for-multicenter-radiomic-studies-in-pet
#13
Fanny Orlhac, Sarah Boughdad, Cathy Philippe, Hugo Stalla-Bourdillon, Christophe Nioche, Laurence Champion, Michaël Soussan, Frédérique Frouin, Vincent Frouin, Irène Buvat
Introduction: Several reports have shown that radiomic feature values are affected by the acquisition and reconstruction parameters, thus hampering multicenter studies. We propose a method to standardize features measured from Positron Emission Tomography (PET) images obtained using different imaging protocols to remove the center effect while preserving patient-specific effects. Methods: Pre-treatment 18F-FDG-PET images of patients with breast cancer were included. In Department A, 63 patients were scanned using a Gemini Time-Of-Flight-PET/Computed-Tomography scanner including 16 triple-negative lesions (TN)...
January 4, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29301931/translocator-protein-as-an-imaging-marker-of-macrophage-and-stromal-activation-in-ra-pannus
#14
Nehal Narayan, David Owen, Harpreet Mandhair, Erica Smyth, Francesco Carlucci, Azeem Saleem, Roger Gunn, Eugenii Ilan A Rabiner, Lisa Wells, Stephanie Dakin, Afsie Sabokbar, Peter Taylor
Positron Emission Tomography (PET) radioligands targeted to Translocator protein (TSPO), offer a highly sensitive and specific means of imaging joint inflammation in rheumatoid arthritis (RA). Through high expression of TSPO on activated macrophages, TSPO PET has been widely reported in several studies of RA as a means of imaging synovial macrophages in vivo. However, this premise does not take into account the ubiquitous expression of TSPO. This study aimed to investigate TSPO expression in major cellular constituents of RA pannus; monocytes, macrophages, fibroblast-like synoviocytes (FLS) and CD4+ T lymphocytes, to more accurately interpret TSPO PET signal from RA synovium...
January 4, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29299706/18f-fdg-pet-ct-an-accurate-method-to-assess-the-activity-of-takayasu-s-arteritis
#15
Xiaojie Zhang, Jun Zhou, Ying Sun, Hongcheng Shi, Zongfei Ji, Lindi Jiang
The objective of the study is to investigate the value of 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) for assessment of the activity of Takayasu's arteritis (TA) and the correlation between acute-phase reactive proteins (ARPs) and standard uptake value (SUV). Analyses of the clinical characteristics and 42 18F-FDG-PET/CT scans in 39 TA patients were undertaken. The degree of FDG uptake in the blood vessel walls was assessed quantitatively by SUV. TA activity was analyzed by physician global assessment (PGA)...
January 3, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29285044/metabolic-activity-of-normal-glandular-tissue-on-18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-correlation-with-menstrual-cycles-and-parenchymal-enhancements
#16
Young-Sil An, Yongsik Jung, Ji Young Kim, Sehwan Han, Doo Kyoung Kang, Seon Young Park, Tae Hee Kim
Purpose: The aims of our study were to correlate the degree of metabolic activity in normal glandular tissue measured on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) with qualitative background parenchymal enhancement (BPE) grades on magnetic resonance imaging (MRI), and to investigate the change in standardized uptake value (SUV) according to the patients' menstrual cycles. Methods: From January 2013 to December 2015, 298 consecutive premenopausal patients with breast cancer who underwent both breast MRI and 18F-FDG PET/CT were identified...
December 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29280066/diagnostic-accuracy-of-11c-methionine-pet-in-detecting-neuropathologically-confirmed-recurrent-brain-tumor-after-radiation-therapy
#17
Annika Kits, Heather Martin, Alejandro Sanchez-Crespo, Anna F Delgado
OBJECTIVE: This study aims to determine the diagnostic test accuracy (DTA) of 11C-methionine (MET) PET in the discrimination between recurrent tumor and radiation-induced injury in neuropathologically confirmed cases. METHODS: A retrospective cohort of 30 patients with previously irradiated intracranial tumors (23 gliomas, 6 metastases, and 1 meningioma) was included. All patients underwent a preoperative MET PET and postoperative neuropathological analysis. Maximum and mean standardized uptake values (SUV) were obtained in the lesion, in the contralateral mirror region, and in the contralateral frontal cortex...
December 26, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29260365/prognostic-importance-of-peritoneal-lesion-to-primary-tumour-standardized-uptake-value-ratio-in-advanced-serous-epithelial-ovarian-cancer
#18
Hyun Hoon Chung, Jae-Weon Kim, Noh-Hyun Park, Yong Sang Song, Gi Jeong Cheon
OBJECTIVES: Using preoperative PET/CT, we evaluated the prognostic value of preoperative [18F]FDG uptake ratio between various metastatic lesions and primary tumour in patients with advanced serous epithelial ovarian cancer (EOC). METHODS: We retrospectively reviewed patients with International Federation of Gynecology and Obstetrics (FIGO) stage III, IV serous EOC who underwent preoperative [18F]FDG PET/CT scans. Clinico-pathological variables and PET/CT parameters such as maximum standardized uptake value of the ovarian cancer (SUVovary), pelvic or para-aortic LN (SUVLN), peritoneal (SUVperit) and distant extra-peritoneal (SUVdist) metastatic lesions, and the metastatic lesion-to-ovarian cancer standardized uptake value ratio were assessed...
December 19, 2017: European Radiology
https://www.readbyqxmd.com/read/29251647/pretreatment-18f-fluorodeoxyglucose-positron-emission-tomography-standardized-uptake-values-and-tumor-size-in-medically-inoperable-nonsmall-cell-lung-cancer-is-prognostic-of-overall-2-year-survival-after-stereotactic-body-radiation-therapy
#19
Madison R Kocher, Anand Sharma, Elizabeth Garrett-Mayer, James G Ravenel
OBJECTIVE: The aim of this study was to determine prognostic value of tumor size and metabolic activity on survival for patients with early stage nonsmall cell lung cancer receiving stereotactic body radiation therapy. METHODS: We retrospectively evaluated the patients who underwent positron emission tomography-computed tomography scan before stereotactic body radiation therapy treatment. Tumor diameter, tumor volume, maximum standardized uptake value (SUVmax), standardized uptake value (SUV) average, and SUV volume were obtained...
December 14, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29251083/effects-of-constraint-induced-movement-therapy-on-brain-glucose-metabolism-in-a-rat-model-of-cerebral-ischemia-a-micro-pet-ct-study
#20
Ying-Ying Li, Bei Zhang, Ke-Wei Yu, Ce Li, Hong-Yu Xie, Wei-Qi Bao, Yan-Yan Kong, Fang-Yang Jiao, Yi-Hui Guan, Yu-Long Bai
PURPOSE: Constraint-induced movement therapy (CIMT) can improve motor functions in stroke patients and ischemic rats. This study examined the effect of CIMT in ischemic rats using positron emission tomography (PET). METHODS: We used middle cerebral artery occlusion (MCAO) procedure to induce cerebral ischemia in rats. Male rats were divided into a negative control group (Normal, n = 4), a sham-operated group (Sham, n = 6), an ischemic group (Control, n = 6), and an ischemic CIMT-treated group (CIMT, n = 6)...
December 18, 2017: International Journal of Neuroscience
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