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https://www.readbyqxmd.com/read/28328855/head-to-head-comparison-of-11c-pib-and-18f-fc119s-for-a%C3%AE-imaging-in-healthy-subjects-mild-cognitive-impairment-patients-and-alzheimer-s-disease-patients
#1
Byung Hyun Byun, Byung Il Kim, Su Yeon Park, In Ok Ko, Kyo Chul Lee, Kyeong Min Kim, Yu Kyeong Kim, Jun-Young Lee, Seon Hee Bu, Jung Hwa Kim, Dae Yoon Chi, Jeong Ho Ha, Sang Moo Lim
As a new beta amyloid (Aβ) positron emission tomography (PET) tracer, F-FC119S has shown higher cortical uptake in patients with Alzheimer's disease (AD) than that in healthy control subjects without adverse effects in a previous preliminary study. The aim of this study was to compare F-FC119S PET and C-PiB PET in healthy control (HC) subjects, mild cognitive impairment (MCI) patients, and AD patients.A total of 48 subjects, including 28 HC subjects, 10 MCI patients, and 10 AD patients, underwent static F-FC119S PET (30 minutes after intravenous [i...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28326465/pet-ct-evaluation-of-amyloid-systemic-involvement-with-18-f-florbetaben-in-patient-with-proved-cardiac-amyloidosis-a-case-report
#2
Dario Genovesi, Giuseppe Vergaro, Michele Emdin, Assuero Giorgetti, Paolo Marzullo
BACKGROUND: One of the most frequent disorders which lead to cardiac amyloidosis is transthyretin-related amyloidosis (ATTR). Some PET radio-pharmaceuticals for the detection of beta-amyloid deposits within the brain have shown to be able to detect also cardiac amyloid deposits. We present a case of a man with ATTR studied with [(18)F]-florbetaben PET-CT. RESULTS: Total-body scan showed a moderate uptake in the bone marrow, especially in correspondence of the vertebral column, while no significant myocardial uptake was present...
March 21, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28326436/reference-region-selection-and-the-association-between-the-rate-of-amyloid-accumulation-over-time-and-the-baseline-amyloid-burden
#3
Janusch Blautzik, Matthias Brendel, Julia Sauerbeck, Sebastian Kotz, Franziska Scheiwein, Peter Bartenstein, John Seibyl, Axel Rominger
Relative quantitative analysis of amyloid plaque burden in Alzheimer's disease (AD) patients can be reported as standardized uptake value ratio (SUVR) from positron emission tomography (PET). Here, the SUVR is the ratio of the mean amyloid radioligand retention in a composite (COMP) neocortical volume of interest (VOI) to that in a reference VOI, such as the cerebellum, brainstem (BST)/pons, or white matter (WM). Some longitudinal PET investigations show that the rate of amyloid accumulation to follow-up has an inverted U relationship with baseline amyloid SUVR relative to cerebellar or brainstem/pons reference VOIs...
March 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28324966/random-forests-to-predict-tumor-recurrence-following-cervical-cancer-therapy-using-pre-and-per-treatment-18-f-fdg-pet-parameters
#4
Geoffrey Roman-Jimenez, Oscar Acosta, Julie Leseur, Anne Devillers, Henri Der Sarkissian, Lina Guzman, Eloi'se Grossiord, Juan-David Ospina, Renaud De Crevoisier
The ability to predict tumor recurrence after chemoradiotherapy of locally advanced cervical cancer is a crucial clinical issue to intensify the treatment of the most high-risk patients. The objective of this study was to investigate tumor metabolism characteristics extracted from pre- and per-treatment (18)F-FDG PET images to predict 3-year overall recurrence (OR). A total of 53 locally advanced cervical cancer patients underwent pre- and per-treatment (18)F-FDG PET (respectively PET1 and PET2). Tumor metabolism was characterized through several delineations using different thresholds, based on a percentage of the maximum uptake, and applied by region-growing...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324340/quantitative-18-f-fluorocholine-positron-emission-tomography-for-prostate-cancer-correlation-between-kinetic-parameters-and-gleason-scoring
#5
Joshua J D Schaefferkoetter, Ziting Wang, Mary C Stephenson, Sharmili Roy, Maurizio Conti, Lars Eriksson, David W Townsend, Thomas Thamboo, Edmund Chiong
BACKGROUND: The use of radiolabeled choline as a positron emission tomography (PET) agent for imaging primary tumors in the prostate has been evaluated extensively over the past two decades. There are, however, conflicting reports of its sensitivity and the relationship between choline PET imaging and disease staging is not fully understood. Moreover, relatively few studies have investigated the correlation between tracer uptake and histological tumor grade. This work quantified (18)F-fluorocholine in tumor and healthy prostate tissue using pharmacokinetic modeling and stratified uptake parameters by histology grade...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28315906/nineteen-cases-with-synchronous-multiple-primary-cancers-studied-by-18-f-fdg-pet-ct
#6
Lifang Pang, Guobing Liu, Hongcheng Shi, Pengcheng Hu, Beilei Li, Dengfeng Cheng
OBJECTIVE: To evaluate the value of fluorine -18-fuoro-2-deoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) in evaluating synchronous multiple primary cancers (SMPC). METHODS: Nineteen patients with pathologically-confirmed SMPC were collected. Clinical and (18)F-FDG PET/CT characteristics of these patients were reviewed and analyzed. Maximum standardized uptake value, (SUVmax) of all lesions was measured and difference (Δ)SUVmax between the SUV of two primary tumors in each patient was calculated as: [(the larger SUVmax - the smaller SUVmax)/ the larger SUVmax]×100%...
March 20, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28315904/prognostic-value-of-bone-marrow-18-f-fdg-uptake-on-pet-ct-in-lymphoma-patients-with-negative-bone-marrow-involvement
#7
Jeong Won Lee, Sang Cheol Lee, Han Jo Kim, Sang Mi Lee
OBJECTIVE: The study evaluated the significance of 18F fluorodeoxyglucose ((18)F-FDG) uptake of bone marrow (BM) for predicting progression-free survival (PFS) in lymphoma patients without BM involvement. SUBJECTS AND METHODS: Ninety-five patients with histopathologically proven lymphoma, 7 Hodgkin's lymphoma and 88 non-Hodgkin's lymphoma, who underwent (18)F-FDG positron emission tomography/computed tomography (PET/CT) and BM biopsy for staging work-up and 40 normal subjects were retrospectively enrolled...
March 20, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28314183/identification-of-metabolic-biomarkers-using-serial-18-f-fdg-pet-ct-for-prediction-of-recurrence-in-advanced-epithelial-ovarian-cancer
#8
Tae Hun Kim, Junhwan Kim, Yeon-Koo Kang, Maria Lee, Hee Seung Kim, Gi Jeong Cheon, Hyun Hoon Chung
PURPOSE: To evaluate the prognostic value of metabolic parameters derived from serial (18)F fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with advanced epithelial ovarian cancer (EOC). METHODS: Thirteen patients with advanced EOC who received surgical staging and adjuvant platinum-based combination chemotherapy were prospectively enrolled. (18)F-FDG PET/CT was performed before and after the surgical staging, and after third cycle of chemotherapy...
March 14, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28306620/diagnostic-performance-of-a-novel-dedicated-breast-pet-scanner-with-c-shaped-ring-detectors
#9
Ryusuke Nakamoto, Yuji Nakamoto, Takayoshi Ishimori, Kayo Nishimatsu, Kanae K Miyake, Shotaro Kanao, Mami Iima, Masakazu Toi, Kaori Togashi
BACKGROUND: A dedicated breast PET scanner with C-shaped detectors (C scanner) has been newly developed. The purpose of this study was to re-evaluate the diagnostic performance of high-resolution PET images with the new reconstruction conditions, obtained using this C scanner in breast cancer patients, and to compare the standardized uptake values (SUVs) of lesions obtained from the C scanner with those from whole-body PET/computed tomography (CT) (WB PET/CT). PATIENTS AND METHODS: A total of 159 female patients with known or suspected breast carcinomas (total 188 lesions: 172 invasive carcinomas; eight noninvasive ductal carcinomas in situ; eight benign lesions) were analysed...
March 16, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28302761/performance-characteristics-of-the-whole-body-discovery-iq-pet-ct-system
#10
Gabriel Reynes-Llompart, Cristina Gámez-Cenzano, Inma Romero-Zayas, Laura Rodriguez-Bel, José Luís Vercher-Conejero, Josep M Martí-Climent
Purpose: The aim of this study was to assess the physical performance of a new PET/CT system Discovery IQ 5 Rings (General Electric, Milwaukee, WI). Methods: Performance measurements were obtained using the NEMA NU2-2012 methodology. Image quality was extended by accounting for different acquisition parameters (lesion-to-background ratios of 8:1, 4:1 and 2:1 and acquisition times) as well as different reconstruction algorithms (VPHD, VPHD-S and Q.Clear). Tomographic reconstruction was also assessed using a Jaszczak phantom...
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28299432/higher-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-fdg-pet-uptake-in-tuberculous-compared-to-bacterial-spondylodiscitis
#11
Matteo Bassetti, Maria Merelli, Fernando Di Gregorio, Paola Della Siega, Maria Screm, Claudio Scarparo, Elda Righi
BACKGROUND: Tuberculous spondylodiscitis can be difficult to diagnose because of its nonspecific symptoms and the similarities with non-tubercular forms of spinal infection. Fluorine-18-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG PET-CT) is increasingly used for the diagnosis and monitoring of tubercular diseases. METHODS: Retrospective, case-control study comparing tuberculous spondylodiscitis with biopsy-confirmed pyogenic spondylodiscitis in the period 2010-2012...
March 15, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28296431/does-unbelted-safety-requirement-affect-protection-for-belted-occupants
#12
Jingwen Hu, Kathleen D Klinich, Miriam A Manary, Carol A C Flannagan, Prabha Narayanaswamy, Matthew P Reed, Margaret Andreen, Mark Neal, Chin-Hsu Lin
OBJECTIVE: Federal regulations in the United States require vehicles to meet occupant performance requirements with unbelted test dummies. Removing the test requirements with unbelted occupants might encourage the deployment of seatbelt interlocks and allow restraint optimization to focus on belted occupants. The objective of this study is to compare the performance of restraint systems optimized for belted only occupants with those optimized for both belted and unbelted occupants using computer simulations and field crash data analyses...
March 15, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28291005/the-correlation-between-pre-treatment-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-parameters-and-clinical-prognostic-factors-in-pediatric-hodgkin-lymphoma
#13
Ebru Tatcı, İnci Uslu Biner, Suna Emir, Hikmet Gülşah Tanyıldız, Özlem Özmen, Engin Alagöz, Atila Gökçek, Gürses Şahin
OBJECTIVE: To compare standardized uptake values (SUV) derived from pre-treatment (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging and clinical prognostic factors in pediatric patients with Hodgkin lymphoma (HL). METHODS: Pre-treatment FDG PET/CT findings of 28 children with HL were evaluated in this retrospective study. Metabolic tumor volume (MTV), SUVmax normalized by weight (SUVweight), lean body mass (SUVlbm), body surface area (SUVbsa) and plasma glucose levels of tumors (SUVglucose) were calculated using pre-treatment FDG PET/CT scan images...
February 5, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28289967/a-pilot-trial-evaluating-zoledronic-acid-induced-changes-in-18-f-fmau-positron-emission-tomography-imaging-of-bone-metastases-in-prostate-cancer
#14
Ulka N Vaishampayan, Omid S Tehrani, Jawana M Lawhorn-Crews, Lance K Heilbrun, Kimberlee Dobson, Daryn Smith, Brenda Dickow, Anthony F Shields
PURPOSE: We conducted a pilot trial utilizing [(18)F]FMAU [1-(2'-deoxy-2'-[(18)F]fluoro-β-D-arabinofuranosyl thymine] as a tumor tracer in positron emission tomography (PET) and evaluated its reproducibility, and changes in maximum and peak standardized uptake value (SUVmax and SUVpeak) with zoledronic acid treatment in castrate resistant prostate cancer (CRPC) patients with bone metastases (BM). PROCEDURES: Eligible patients had CRPC with radiographic evidence of BM and creatinine clearance >30 ml/min...
March 13, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28288726/prevalence-of-drink-driving-and-speeding-in-china-a-time-series-analysis-from-two-cities
#15
Q Li, H He, L Duan, Y Wang, D M Bishai, A A Hyder
OBJECTIVES: To confront the public health challenge imposed by road traffic injuries in China. STUDY DESIGN: A consortium of international partners designed and implemented targeted interventions, such as social media campaigns, advocacy for legislative change and law enforcement training, to reduce the percentage of drink driving and speeding in two Chinese cities, Dalian and Suzhou, from 2010 to 2014. METHODS: Time series models were developed to detect changes in the prevalence of drink driving and speeding using data collected through four years of observational studies...
March 2017: Public Health
https://www.readbyqxmd.com/read/28288043/prognostic-value-of-pretreatment-metabolic-tumor-volume-and-total-lesion-glycolysis-using-18f-fdg-pet-ct-in-patients-with-metastatic-renal-cell-carcinoma-treated-with-anti-vascular-endothelial-growth-factor-targeted-agents
#16
Sang Hyun Hwang, Arthur Cho, Mijin Yun, Young Deuk Choi, Sun Young Rha, Won Jun Kang
PURPOSE: The aim of this study was to evaluate the prognostic value of pretreatment metabolic tumor volume (MTV) and total lesion glycolysis (TLG) using F-FDG PET/CT in patients with metastatic renal cell carcinoma (RCC) after treatment with anti-vascular endothelial growth factor-targeted agents. METHODS: Fifty-six patients with metastatic RCC who underwent F-FDG PET/CT for staging and recurrence evaluation were retrospectively enrolled. SUVmax, MTV, and TLG were measured using F-FDG PET/CT in all patients...
March 10, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28288042/metabolic-tumor-volume-and-total-lesion-glycolysis-in-oropharyngeal-cancer-treated-with-definitive-radiotherapy-which-threshold-is-the-best-predictor-of-local-control
#17
Joël Castelli, Adrien Depeursinge, Berardino de Bari, Anne Devillers, Renaud de Crevoisier, Jean Bourhis, John O Prior
PURPOSE: In the context of oropharyngeal cancer treated with definitive radiotherapy, the aim of this retrospective study was to identify the best threshold value to compute metabolic tumor volume (MTV) and/or total lesion glycolysis to predict local-regional control (LRC) and disease-free survival. METHODS: One hundred twenty patients with a locally advanced oropharyngeal cancer from 2 different institutions treated with definitive radiotherapy underwent FDG PET/CT before treatment...
March 10, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28288041/lymph-node-activation-by-pet-ct-following-vaccination-with-licensed-vaccines-for-human-papillomaviruses
#18
Emily E Coates, Pamela J Costner, Martha C Nason, Douglas M Herrin, Shielah Conant, Peter Herscovitch, Uzma N Sarwar, Lasonji Holman, Jillian Mitchell, Galina Yamshchikov, Richard A Koup, Barney S Graham, Corina M Millo, Julie E Ledgerwood
BACKGROUND: While PET using F-FDG is most commonly used for imaging malignant tumors, vaccination is known to cause transient inflammation of lymph nodes inducing positive findings on F-FDG PET scans. The pattern, magnitude, and duration of lymph node activation following vaccination have not been clearly defined. Furthermore, the addition of adjuvants to vaccines can further enhance the immune response. The presented study was designed to define lymph node activation following administration of the Food and Drug Administration-licensed human papillomavirus vaccines, Cervarix and Gardasil, which contain similar antigens with different adjuvants...
March 10, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28275483/variations-in-positron-emission-tomography-computed-tomography-findings-for-patients-receiving-neoadjuvant-and-non-neoadjuvant-therapy-for-non-small-cell-lung-cancer
#19
Jae Kil Park, Jae Jun Kim, Seok Whan Moon
BACKGROUND: The aims of this study were to predict locoregional lymph node (LN) metastases using positron emission tomography-computed tomography (PET-CT) and investigate variations in PET-CT findings for patients receiving neoadjuvant (NT) and non-neoadjuvant (non-NT) for non-small cell lung cancer (NSCLC). METHODS: Data from 578 consecutive patients from January 2010 to December 2015 who met this study inclusion criteria were retrospectively reviewed. All patients underwent curative and complete resections for NSCLC in a Korean hospital...
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28267531/-18-f-fdg-pet-ct-and-contrast-enhanced-ct-findings-of-pulmonary-cryptococcosis
#20
Si-Yun Wang, Gang Chen, Dong-Lan Luo, Dan Shao, En-Tao Liu, Taotao Sun, Shu-Xia Wang
PURPOSE: Pulmonary cryptococcosis is an uncommon cause of pulmonary nodules in non-AIDS patients. This study reports the (18)F-fluorodeoxyglucose-positron emission tomography ((18)F-FDG PET/CT) and contrast-enhanced CT (CE-CT) findings of 42 patients with pulmonary cryptococcosis. MATERIALS AND METHODS: A retrospective review of the (18)F-FDG PET/CT and CE-CT findings of 42 patients with histologically proven pulmonary cryptococcosis was conducted. All patients underwent PET/CT and CE-CT in the same session...
April 2017: European Journal of Radiology
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