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https://www.readbyqxmd.com/read/28436173/relationship-between-endobronchial-ultrasound-guided-ebus-transbronchial-needle-aspiration-utility-and-computed-tomography-staging-node-size-at-ebus-and-positron-emission-tomography-scan-node-standard-uptake-values-a-retrospective-analysis
#1
Clare Marchand, Andrew R L Medford
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) diagnoses and stages mediastinal lymph node pathology. This retrospective study determined the relationship between EBUS-TBNA utility and non-small cell lung cancer (NSCLC) stage, lymph node size, and positron emission tomography (PET) standard uptake values (SUV), and the utility of neck ultrasound in bulky mediastinal disease. METHODS: Data of 284 consecutive patients who had undergone EBUS-TBNA was collected...
April 24, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28428718/clinical-implication-of-fdg-uptake-of-bone-marrow-on-pet-ct-in-gastric-cancer-patients-with-surgical-resection
#2
Jeong Won Lee, Moon-Soo Lee, Il Kwon Chung, Myoung Won Son, Young Sin Cho, Sang Mi Lee
AIM: To determine the relationship between F-18 fluorodeoxyglucose (FDG) uptake of bone marrow (BM) on positron emission tomography/computed tomography (PET/CT) and clinical factors and to assess the prognostic value of FDG uptake of BM in gastric carcinoma. METHODS: We retrospectively enrolled 309 gastric cancer patients who underwent staging FDG PET/CT and curative surgical resection. FDG uptake of primary tumor was visually classified as positive or negative FDG uptake...
April 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28423698/parameters-of-simultaneous-18f-fdg-pet-mri-predict-tumor-stage-and-several-histopathological-features-in-uterine-cervical-cancer
#3
Alexey Surov, Hans Jonas Meyer, Stefan Schob, Anne-Kathrin Höhn, Kristina Bremicker, Marc Exner, Patrick Stumpp, Sandra Purz
The purpose of this study was to analyze associations between apparent diffusion coefficient (ADC) and standardized uptake values (SUV) values and different histopathological parameters in uterine cervical cancer. 21 patients with primary uterine cervical cancer were involved into the study. All patients underwent a whole body simultaneous18F-FDG PET/MRI. Mean and maximum SUV were noted (SUVmean and SUVmax). In all tumors minimal, mean, and maximal ADC values (ADCmin, ADCmean, and ADCmax) were estimated. Combined parameters were calculated: SUVmax/SUVmean, ADCmin/ ADCmean, SUVmax/ADCmin and SUVmax/ADCmean...
March 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422979/correlation-of-egfr-or-kras-mutation-status-with-18f-fdg-uptake-on-pet-ct-scan-in-lung-adenocarcinoma
#4
Kazuya Takamochi, Kaoru Mogushi, Hideya Kawaji, Kota Imashimizu, Mariko Fukui, Shiaki Oh, Masayoshi Itoh, Yoshihide Hayashizaki, Weijey Ko, Masao Akeboshi, Kenji Suzuki
BACKGROUND: 18F-fluoro-2-deoxy-glucose (18F-FDG) positron emission tomography (PET) is a functional imaging modality based on glucose metabolism. The correlation between EGFR or KRAS mutation status and the standardized uptake value (SUV) of 18F-FDG PET scanning has not been fully elucidated. METHODS: Correlations between EGFR or KRAS mutation status and clinicopathological factors including SUVmax were statistically analyzed in 734 surgically resected lung adenocarcinoma patients...
2017: PloS One
https://www.readbyqxmd.com/read/28422299/incorporation-of-pre-therapy-18-f-fdg-uptake-data-with-ct-texture-features-into-a-radiomics-model-for-radiation-pneumonitis-diagnosis
#5
Gregory J Anthony, Alexandra Cunliffe, Richard Castillo, Ngoc Pham, Thomas Guerrero, Samuel G Armato, Hania Al-Hallaq
PURPOSE: To determine whether the addition of standardized uptake value (SUV) from PET scans to CT lung texture features could improve a radiomics-based model of radiation pneumonitis (RP) diagnosis in patients undergoing radiotherapy. METHODS AND MATERIALS: Anonymized data from 96 esophageal cancer patients (18 RP-positive cases of Grade ≥ 2) were collected including pre-therapy PET/CT scans, pre-/post-therapy diagnostic CT scans and RP status. Twenty texture features (first-order, fractal, Laws' filter and gray-level co-occurrence matrix) were calculated from diagnostic CT scans and compared in anatomically matched regions of the lung...
April 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28419166/comparison-of-standardized-uptake-value-of-18f-fdg-pet-ct-with-21-gene-recurrence-score-in-estrogen-receptor-positive-her2-negative-breast-cancer
#6
Sung Gwe Ahn, Jae-Hoon Lee, Hak Woo Lee, Tae Joo Jeon, Young Hoon Ryu, Kun Min Kim, Joohyuk Sohn, Mijin Yun, Seung Ah Lee, Joon Jeong, Seung Il Kim
BACKGROUND: We investigated the relationship between 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG-PET-CT) standardized uptake value (SUV) and 21-gene recurrence score (RS) in estrogen receptor (ER)-positive/HER2-negative breast cancer. MATERIALS AND METHODS: One hundred sixty-seven patients were identified among those who underwent preoperative 18F-FDG-PET-CT and had RS. Maximum SUV was obtained from 18F-FDG-PET-CT; the cut-off point was 4...
2017: PloS One
https://www.readbyqxmd.com/read/28415990/prognostic-value-of-pretreatment-standardized-uptake-value-of-f-18-fluorodeoxyglucose-pet-in-patients-with-gastric-cancer-a-meta-analysis
#7
Zhonghua Wu, Junhua Zhao, Peng Gao, Yongxi Song, Jingxu Sun, Xiaowan Chen, Bin Ma, Zhenning Wang
BACKGROUND: F-18- fluorodeoxyglucose Positron emission tomography ((18)FDG-PET) has been widely used in clinical practice. However, the prognostic value of the pretreatment standardized uptake value (SUV) for patients with gastric cancer remains controversial. METHODS: Major databases were systematically searched. The quality of the included studies was assessed using the Newcastle-Ottawa scale; the PET protocols were also evaluated. The pooled hazard ratio (HR) for overall survival (OS) and recurrence-free survival (RFS) were used to estimate the effect size...
April 17, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28413794/comparative-evaluation-of-iodine-131-metaiodobenzylguanidine-and-18-fluorodeoxyglucose-positron-emission-tomography-in-assessing-neural-crest-tumors-will-they-play-a-complementary-role
#8
Soumyakanti Kundu, Purushottam Kand, Sandip Basu
BACKGROUND: 18-Fluorodeoxyglucose positron emission tomography (FDG-PET) has established a role in the evaluation of several malignancies. However, its precise clinical role in the neural crest cell tumors continues to evolve. PURPOSE: The purpose of this study was to compare iodine-131 metaiodobenzylguanidine ((131)I-MIBG) and FDG-PET of head to head in patients with neural crest tumors both qualitatively and semiquantitatively and to determine their clinical utility in disease status evaluation and further management...
January 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28412923/fdg-pet-ct-predicts-outcome-in-oropharingeal-carcinoma-patients-undergoing-intensity-modulated-radiation-therapy-with-dose-escalation-to-fdg-avid-tumour-volumes
#9
Paola Mapelli, Sara Broggi, Elena Incerti, Pierpaolo Alongi, Margarita Kirienko, Claudio Fiorino, Italo Dell Oca, Federico Fallanca, Emilia Giovanna Vanoli, Nadia Gisella Di Muzio, Luigi Gianolli, Maria Picchio
PURPOSE: To evaluate the predictive value of FDG-PET/CT parameters on outcome of oropharyngeal squamocellular cancer (OSCC) patients undergoing helical tomotherapy (HTT), with dose escalation to FDG-PET/CT positive tumour volumes using the simultaneous integrated boost (SIB) technique. MATERIALS AND METHODS: We analysed 41 patients studied by FDG-PET/CT and treated with radical intent between 2005 and 2014 for OSCC. HTT-SIB was delivered in 30 fractions concomitantly: 69 Gy, as SIB, to the PET-positive volume (biological target volume - BTV-PET), both to the primary tumour (T) and lymph nodes (N), 66 Gy to the T and positive N, 54 Gy to the laterocervical nodes at risk...
April 13, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28410141/fdg-pet-ct-as-theranostic-imaging-in-diagnosis-of-non-small-cell-lung-cancer
#10
Margarita Kirienko, Francesca Gallivanone, Martina Sollini, Giulia Veronesi, Emanuele Voulaz, Lidjia Antunovic, Lorenzo Leonardi, Giorgio Testanera, Isabella Castiglioni, Arturo Chiti
Objective of this work was to evaluate the role of 18F-fluorodeoxyglucose (FDG) positron-emission tomography features as theranostic imaging biomarkers in non-small cell lung cancer. In a retrospective protocol, 31 stage I-III NSCLC patients were enrolled. Patients underwent FDG PET/CT for staging purposes before surgery and were followed for two years after surgery. PET images were quantitatively analyzed. For the primary lesion, metabolic tumour volume, maximum standardized uptake value (SUV), SUV corrected for partial volume effect, total lesion glycolysis, 14 histogram and four shape-and-size features were extracted as PET imaging features...
June 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28409880/osajin-inhibits-solar-uv-induced-cyclooxygenase-2-expression-through-direct-inhibition-of-rsk2
#11
Jong-Eun Kim, Yong-Seok Heo, Ki Won Lee
Solar ultraviolet light (sUV) has been shown to promote the development of skin disorders including inflammation, photoaging, and skin carcinogenesis. Osajin is the major bioactive isoflavone present in the fruit of Maclura pomifera, commonly referred to as the Osage orange. In this study, we observed that osajin inhibited sUV-induced cyclooxygenase (COX)-2 protein expression in both HaCaT and JB6 cells. COX-2 is a major mediator of skin inflammation. sUV activated the transcription factors nuclear factor- κB and activator protein-1 which, in turn, induces COX-2 expression...
April 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28405726/inter-heterogeneity-and-intra-heterogeneity-of-%C3%AE-v%C3%AE-3-in-non-small-cell-lung-cancer-and-small-cell-lung-cancer-patients-as-revealed-by-68-ga-rgd2-pet-imaging
#12
Fei Kang, Zhe Wang, Guoquan Li, Shengjun Wang, Daliang Liu, Mingru Zhang, Mingxuan Zhao, Weidong Yang, Jing Wang
PURPOSE: Integrin αvβ3 is the therapeutic target of the anti-angiogenic drug cilengitide. The objective of this study was to compare αvβ3 levels in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) patients, by using the positron emission tomography (PET) tracer (68)Ga-labeled dimerized-RGD ((68)Ga-RGD2). METHODS: Thirty-one patients with pathologically confirmed lung cancer were enrolled (21 were NSCLC and 10 were SCLC). PET/CT images were acquired using (68)Ga-RGD2...
April 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28404919/paeonol-suppresses-solar-ultraviolet-induced-skin-inflammation-by-targeting-t-lak-cell-originated-protein-kinase
#13
Peipei Xue, Yong Wang, Fanfan Zeng, Ruijuan Xiu, Jingwen Chen, Jinguang Guo, Ping Yuan, Lin Liu, Juanjuan Xiao, Hui Lu, Dan Wu, Huaxiong Pan, Mingmin Lu, Feng Zhu, Fei Shi, Qiuhong Duan
Excessive exposure to solar UV (SUV) is related with numerous human skin disorders, such as skin inflammation, photoaging and carcinogenesis. T-LAK cell- originated protein kinase (TOPK), an upstream of p38 mitogen-activated protein kinase (p38) and c-Jun N-terminal kinases (JNKs), plays an important role in SUV -induced skin inflammation, and targeting TOPK has already been a strategy to prevent skin inflammation. In this study, we found that the expression of TOPK, phosphorylation of p38 or JNKs was increased in human solar dermatitis tissues...
February 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28403341/anatomo-radiological-correlation-using-18-fdg-pet-in-abdominal-sepsis-model-in-rats-a-preliminary-study
#14
Ítalo Medeiros Azevedo, Marília Daniela Ferreira Carvalho, Rafael Pereira Nascimento, Robson Macedo, Mônica Raquel de Souza Aquino, Aldo Cunha Medeiros
Purpose: To examine a correlation of micro-PET images with photographic images of the digestive organs in abdominal sepsis model. Methods: Male Wistar rats weighing 265±18g were used. Abdominal sepsis was induced by ligature and cecal puncture. Micro-PET Images from abdominal cavity septic foci were obtained using 18-Fluoro-deoxyglucose, looking for a correlation with photographic images of abdominal cavity organs. Pearson's correlation test was used. Results: The mean standard uptake values (SUV) and lesion areas were 2...
March 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28397608/clinical-usefulness-of-fdg-pet-ct-for-the-evaluation-of-various-types-of-adult-t-cell-leukemia
#15
Sawako Nakachi, Masahiro Okada, Satoko Morishima, Yurika Agarie, Sakiko Kitamura, Sachie Uchibori, Shouhei Tomori, Taeko Hanashiro, Natsuki Shimabukuro, Keita Tamaki, Iori Tedokon, Kazuho Morichika, Yukiko Nishi, Takeaki Tomoyose, Kennosuke Karube, Takuya Fukushima, Sadayuki Murayama, Hiroaki Masuzaki
PURPOSE: The aim was to explore undefined useful indices for clinically grading adult T-cell leukemia (ATL) using [(18)F] 2-fluoro-2-deoxyglucose (FDG) - positron emission tomography/computed tomography (PET/CT). METHODS: A total of 28 patients with ATL (indolent, 9; aggressive, 19) were enrolled; all patients with aggressive ATL underwent FDG-PET/CT before chemotherapy. Patients with indolent ATL underwent FDG-PET/CT at the time of suspected disease progression and/or transformation; some received lymph node biopsy...
April 11, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28389044/fdg-pet-predicts-treatment-efficacy-and-surgical-outcome-of-pre-operative-chemoradiation-therapy-for-resectable-and-borderline-resectable-pancreatic-cancer
#16
H Akita, H Takahashi, H Ohigashi, A Tomokuni, S Kobayashi, K Sugimura, N Miyoshi, J-H Moon, M Yasui, T Omori, H Miyata, M Ohue, Y Fujiwara, M Yano, O Ishikawa, M Sakon
BACKGROUND: The efficacy of neoadjuvant chemoradiotherapy (NACRT) for resectable and borderline resectable pancreatic cancer is important for predicting outcomes after radical surgery, but few clinical indicators predict outcome before resection. This study examined the utility of FDG-PET in predicting the efficacy of NACRT and outcome after radical surgery. METHODS: Eighty-three pancreatic cancer patients who underwent FDG-PET before and after NACRT and had positive standard uptake values (SUVs) before NACRT were enrolled in this study...
March 31, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28386697/postoperative-changes-after-surgical-mesh-hernia-repair-a-pitfall-in-interpretation-of-18f-fdg-pet-ct
#17
T Davidson, E Klang, E Goshen, J Goldstein, M Khaikin, B Chikman, S Ben-Haim
OBJECTIVE: A number of case reports have demonstrated FDG uptake around mesh prostheses after hernia repair surgery. This study characterizes FDG PET-CT findings after hernia repair with synthetic mesh in a series of cancer patients. MATERIALS AND METHODS: FDG PET-CT studies were reviewed for increased FDG uptake consistent with CT appearances of post-surgical hernia repair in cancer patients. The findings were correlated with clinical data and follow-up studies...
April 6, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28381292/reproducibility-and-repeatability-of-same-day-two-sequential-fdg-pet-mr-and-pet-ct
#18
David Groshar, Hanna Bernstine, Natalia Goldberg, Meital Nidam, Dan Stein, Ifat Abadi-Korek, Liran Domachevsky
BACKGROUND: To determine PET/CT and PET/MR reproducibility and PET/MR repeatability of fluorine 18 fluorodeoxyglucose (FDG) uptake measurements in tumors in cancer patients. METHODS: This IRB approved prospective study was performed between October 2015 and February 2016 in consecutive patients who performed same day PET/CT and two sequential PET/MR. Thirty three patients with visible tumors (N = 63) were included. SUV for body weight (SUV) and lean body mass (SUL) were obtained...
April 5, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28376406/availability-of-dopamine-transporters-in-heroin-dependent-subjects-a-18-f-fecnt-pet-imaging-study
#19
Shasha Xu, Ying Liu, Yu Li, Yangping Deng, Jie Yuan, Rongbin Lv, Yuankai Wang, Guangming Zhang, Zhirui Guo, Daxu Fu, Hui Zeng, Mei Han, Xingdang Liu
This study was to reconfirm the reduced dopamine transporter (DAT) availability in heroin-dependent subjects and validate the use of 2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl)-nortropane ((18)F-FECNT) as a PET radiotracer to assess the changes of striatal DAT in drug addicted subjects. Herein, we assessed DAT standardized uptake values (SUV) of (18)F-FECNT in the striatum and cerebellum of 20 heroin-dependent subjects and 10 healthy controls and analyzed the correlation between DAT availability and heroin withdrawal symptom scores and anxiety/depression rating scales in heroin-dependent subjects, as well as the relationship between the withdrawal symptoms scores and age...
March 25, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28371832/timed-sequential-therapy-of-the-selective-t-type-calcium-channel-blocker-mibefradil-and-temozolomide-in-patients-with-recurrent-high-grade-gliomas
#20
Matthias Holdhoff, Xiaobu Ye, Jeffrey G Supko, Louis B Nabors, Arati S Desai, Tobias Walbert, Glenn J Lesser, William L Read, Frank S Lieberman, Martin A Lodge, Jeffrey Leal, Joy D Fisher, Serena Desideri, Stuart A Grossman, Richard L Wahl, David Schiff
Background.: Mibefradil (MIB), previously approved for treatment of hypertension, is a selective T-type calcium channel blocker with preclinical activity in high-grade gliomas (HGGs). To exploit its presumed mechanism of impacting cell cycle activity (G1 arrest), we designed a phase I study to determine safety and the maximum tolerated dose (MTD) of MIB when given sequentially with temozolomide (TMZ) in recurrent (r)HGG. Methods.: Adult patients with rHGG ≥3 months from TMZ for initial therapy received MIB in 4 daily doses (q...
March 22, 2017: Neuro-oncology
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