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https://www.readbyqxmd.com/read/28079829/breath-hold-and-free-breathing-f-18-fdg-pet-ct-in-malignant-melanoma-detection-of-additional-tumoral-foci-and-effects-on-quantitative-parameters
#1
Robert Bärwolf, Mariana Zirnsak, Martin Freesmeyer
During PET/CT acquisition, respiratory motion generates artifacts in the form of breath-related blurring, which may impair lesion detectability and diagnostic accuracy. This observational study was undertaken to verify whether breath-hold F-18-FDG-PET/CT (bhPET) detects additional foci compared to free-breathing PET/CT (fbPET) in cases of malignant melanoma, and to assess the impact of breath-holding on standard uptake values (SUV) and metabolic isocontoured volume (mVic40).Thirty-four patients with melanoma were examined...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28075185/cerebellar-heterogeneity-and-its-impact-on-pet-data-quantification-of-5-ht-receptor-radioligands
#2
Melanie Ganz, Ling Feng, Hanne Demant Hansen, Vincent Beliveau, Claus Svarer, Gitte M Knudsen, Douglas N Greve
In the quantification of positron emission tomography (PET) radiotracer binding, a commonly used method is reference tissue modeling (RTM). RTM necessitates a proper reference and a ubiquitous choice for G-protein coupled receptors is the cerebellum. We investigated regional differences in uptake within the grey matter of the cerebellar hemispheres (CH), the cerebellar white matter (CW), and the cerebellar vermis (CV) for five PET radioligands targeting the serotonin system. Furthermore, we evaluated the impact of choosing different reference regions when quantifying neocortical binding...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28073639/association-between-volume-and-glucose-metabolism-of-abdominal-adipose-tissue-in-healthy-population
#3
Hyun Woo Kwon, Sang Mi Lee, Jeong Won Lee, Jung-Eun Oh, Se-Whan Lee, Shin Young Kim
OBJECTIVE: We investigated the association of adipose tissue volume and metabolic activity with cardiometabolic risk factors. METHODS: 232 healthy subjects (43.23±4.09y) having (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) results were included. Clinical information, anthropometry and laboratory results were obtained. Volume and metabolic activity of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) was obtained from FDG PET/CT...
January 7, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28072621/risk-stratification-of-pediatric-patients-with-neuroblastoma-using-volumetric-parameters-of-18f-fdg-and-18f-dopa-pet-ct
#4
Chia-Ju Liu, Meng-Yao Lu, Yen-Lin Liu, Chi-Lun Ko, Kuan-Yin Ko, Kai-Yuan Tzen, Hsiu-Hao Chang, Yung-Li Yang, Shiann-Tarng Jou, Wen-Ming Hsu, Ruoh-Fang Yen
PURPOSE: This study determined the prognostic value of volumetric parameters derived from pretreatment F-FDG and F-DOPA PET/CT of neuroblastoma and their correlation with clinical and histopathologic features. PATIENTS AND METHODS: A total of 25 children with neuroblastoma underwent pretreatment F-FDG and F-DOPA PET/CT within 4 weeks. The SUVmax of primary tumors on F-FDG and F-DOPA PET were recorded as SUVFDG and SUVDOPA, respectively. For volumetric parameters of primary tumors, 40% of SUVmax was used to generate volume of interest...
January 9, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28070735/assessment-of-atherosclerotic-plaque-calcification-using-f18-naf-pet-ct
#5
Maria João Vidigal Ferreira, Manuel Oliveira-Santos, Rodolfo Silva, Andreia Gomes, Nuno Ferreira, Antero Abrunhosa, João Lima, Mariano Pego, Lino Gonçalves, Miguel Castelo-Branco
BACKGROUND: The aim of the present study was to evaluate the uptake of F18-NaF by the arterial wall in patients with high cardiovascular (CV) risk profile. The tracer uptake was assessed in relation to gender and the number of CV risk factors. METHODS AND RESULTS: 25 patients without known CV disease were included and evaluated by PET-CT with F18-NaF: 14 (56%) men and 11 (44%) women. The mean target-to-background ratio (TBR: max SUV/mean blood-pool SUV) but not the corrected uptake per lesion (CUL: max SUV - mean blood-pool SUV) was higher in men than women (TBR: 1...
January 9, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28068944/the-acceleration-of-glucose-accumulation-in-renal-cell-carcinoma-assessed-by-fdg-pet-ct-demonstrated-acquisition-of-resistance-to-tyrosine-kinase-inhibitor-therapy
#6
Noboru Nakaigawa, Keiichi Kondo, Daiki Ueno, Kazuhiro Namura, Kazuhide Makiyama, Kazuki Kobayashi, Koichi Shioi, Ichiro Ikeda, Takeshi Kishida, Tomohiro Kaneta, Ryogo Minamimoto, Ukihide Tateishi, Tomio Inoue, Masahiro Yao
BACKGROUND: Tyrosine-kinase inhibitor (TKI) targeting angiogenesis improves the prognosis of patients with metastatic renal cell carcinoma (RCC), but its effect is temporary. In order to understand the mechanism by which RCC acquires resistance to TKI, we investigated the change of glucose accumulation in RCC by FDG PET/CT when they demonstrated progression disease (PD) against TKI. METHODS: We monitored the FDG accumulation in RCC of 38 patients treated with TKI by 162 PET/CT sequentially until they were judged to demonstrate PD...
January 9, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28062595/the-clinical-impact-of-additional-late-pet-ct-imaging-with-68ga-psma-11-hbed-cc-in-the-diagnosis-of-prostate-cancer
#7
Ali Afshar-Oromieh, Lars Peter Sattler, Walter Mier, Boris Hadaschik, Jürgen Debus, Tim Holland-Letz, Klaus Kopka, Uwe Haberkorn
PURPOSE: While Positron Emission Tomography/Computed Tomography (PET/CT) with (68)Ga-PSMA-11 in the diagnosis of prostate cancer (PCa) is routinely performed at 1h post injection (p.i.), later scans may be beneficial since most lesions present with higher uptake and contrast. This evaluation aimed to investigate the clinical impact of additional late (68)Ga-PSMA-11-PET/CT. METHODS: Between 2011 and 2016, 112 patients with PCa who received early (at 1h p.i.) and late (at 3h p...
January 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28057031/-18-fdg-pet-ct-for-predicting-the-outcome-in-er-her2-breast-cancer-patients-comparison-of-clinicopathological-parameters-and-pet-image-derived-indices-including-tumor-texture-analysis
#8
David Groheux, Antoine Martineau, Luis Teixeira, Marc Espié, Patricia de Cremoux, Philippe Bertheau, Pascal Merlet, Charles Lemarignier
BACKGROUND: This study investigated the value of some clinicopathological parameters and 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography ((18)FDG-PET/CT) indices, including textural features, to predict event-free survival (EFS) in estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+/HER2-) locally advanced breast cancer (BC) patients. METHODS: FDG-PET/CT indices and clinicopathological parameters were assessed before neoadjuvant chemotherapy (NAC)...
January 5, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28048815/su-f-j-59-assessment-of-dose-response-distribution-in-individual-human-tumor
#9
D Yan, S Chen, D Krauss, P Chen, G Wilson
PURPOSE: To fulfill precision radiotherapy via adaptive dose painting by number, voxel-by-voxel dose response or radio-sensitivity in individual human tumor needs to be determined in early treatment to guide treatment adaptation. In this study, multiple FDG PET images obtained pre- and weekly during the treatment course were utilized to determine the distribution/spectrum of dose response parameters in individual human tumors. METHODS: FDG PET/CT images of 18 HN cancer patients were used in the study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048762/su-f-t-130-18f-fdg-uptake-dose-response-in-lung-correlates-linearly-with-proton-therapy-dose
#10
D Kim, U Titt, D Mirkovic
PURPOSE: Analysis of clinical outcomes in lung cancer patients treated with protons using 18F-FDG uptake in lung as a measure of dose response. METHODS: A test case lung cancer patient was selected in an unbiased way. The test patient's treatment planning and post treatment positron emission tomography (PET) were collected from picture archiving and communication system at the UT M.D. Anderson Cancer Center. Average computerized tomography scan was registered with post PET/CT through both rigid and deformable registrations for selected region of interest (ROI) via VelocityAI imaging informatics software...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048737/mo-de-207b-01-jack-fowler-junior-investigator-competition-winner-between-somatic-mutations-and-pet-based-radiomic-features-in-non-small-cell-lung-cancer
#11
S Yip, J Kim, T Coroller, E Rios Velazquez, C Parmar, R Mak, H Aerts
PURPOSE: Although PET-based radiomic features have been proposed to quantify tumor heterogeneity and shown promise in outcome prediction, little is known about their relationship with tumor genetics. This study assessed the association of [(18) F]fluorodeoxyglucose (FDG)-PET-based radiomic features with non-small cell lung cancer (NSCLC) mutations. METHODS: 348 NSCLC patients underwent FDG-PET/CT scans before treatment and were tested for genetic mutations. 13% (44/348) and 28% (96/348) patients were found to harbor EGFR (EGFR+) and KRAS (KRAS+) mutations, respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048721/su-f-j-222-using-pet-imaging-to-evaluate-proliferation-and-blood-flow-in-irradiated-and-non-irradiated-bone-marrow-1-year-after-chemoradiation-therapy
#12
S McGuire, L Ponto, Y Menda
PURPOSE: To compare proliferation and blood flow in pelvic and thoracic bone marrow 1 year after pelvic chemoradiation. METHODS: Sixteen pelvic cancer patients were enrolled in an IRB-approved protocol to acquire FLT PET images during radiation therapy simulation (baseline) and 1 year after chemoradiation therapy. Three subjects also had optional O-15 water PET images acquired 1 year after chemoradiation therapy. Baseline FLT PET images were used to create IMRT plans to spare pelvic bone marrow identified as regions with FLT SUV ≥ 2 without compromising PTV coverage or OAR sparing...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048576/we-h-207a-04-impact-of-lesion-location-on-the-repeatability-of-18f-naf-pet-ct
#13
C Lin, T Perk, S Harmon, S Perlman, G Liu, R Jeraj
PURPOSE: Quantifying the repeatability of imaging biomarkers is critical for assessing therapeutic response. While (18) F-NaF PET/CT has shown to be a repeatable imaging method, research has not shown which factors may influence its repeatability. The purpose of this study was to evaluate whether the location of the lesion impacts the repeatability of quantitative (18) F-NaF PET-derived SUV metrics. METHODS: Metastatic castrate-resistant prostate cancer patients with multiple bone lesions received whole-body test-retest NaF PET/CT scans...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048445/su-c-207a-07-cumulative-18f-fdg-uptake-histogram-relative-to-radiation-dose-volume-histogram-of-lung-after-imrt-or-pspt-and-their-association-with-radiation-pneumonitis
#14
N Shusharina, Z Liao, R Mohan, N Choi, T Bortfeld
PURPOSE: To determine whether the difference in cumulative 18F-FDG uptake histogram of lung treated with either IMRT or PSPT is associated with radiation pneumonitis (RP) in patients with inoperable stage II and III NSCLC. METHODS: We analyzed 24 patients from a prospective randomized trial to compare IMRT (n=12) with vs. PSPT (n=12) for inoperable NSCLC. All patients underwent PET-CT imaging between 35 and 88 days post-therapy. Post-treatment PET-CT was aligned with planning 4D CT to establish a voxel-to-voxel correspondence between post-treatment PET and planning dose images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048444/th-cd-202-10-tumor-metabolic-control-probability-dose-response-mapping-for-adaptive-dose-painting-by-number
#15
S Chen, D Yan, G Wilson, D Krauss, P Chen
PURPOSE: Adaptive dose-painting-by-number (DPbN) requires a dose-response-mapping (DRM) obtained early in the treatment course. To obtain DRM, voxel-by-voxel tumor dose response needs to be quantified. Our recent study has demonstrated that voxel-by-voxel radio-sensitivity of patient tumor can be determined using tumor-metabolic-ratio measured early during the treatment using FDG-PET images. In this study, the measurements were utilized to construct tumor metabolic control probability (TMCP) and DRM for DPbN...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048288/su-d-202-01-functional-lung-avoidance-and-response-adaptive-escalation-flare-rt-feasibility-of-a-precision-radiation-oncology-strategy
#16
S Bowen, E Lee, R Miyaoka, J Saini, P Kinahan, G Sandison, T Wong, H Vesselle, R Rengan, J Zeng
PURPOSE: NSCLC patient RT is planned without consideration of spatial heterogeneity in lung function or tumor response, which may have contributed to failed uniform dose escalation in a randomized trial. The feasibility of functional lung avoidance and response-adaptive escalation (FLARE) RT to reduce dose to [(9 9m) Tc]MAA-SPECT/CT perfused lung while redistributing 74Gy within [(1 8) F]FDG-PET/CT biological target volumes was assessed. METHODS: Eight Stage IIB-IIIB NSCLC patients underwent FDG-PET/CT and MAA-SPECT/CT treatment planning scans...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048184/su-f-j-95-impact-of-shape-complexity-on-the-accuracy-of-gradient-based-pet-volume-delineation
#17
M Dance, G Wu, Y Gao, S Pirozzi, A Nelson, S Das, J Lian
PURPOSE: Explore correlation of tumor complexity shape with PET target volume accuracy when delineated with gradient-based segmentation tool. METHODS: A total of 24 clinically realistic digital PET Monte Carlo (MC) phantoms of NSCLC were used in the study. The phantom simulated 29 thoracic lesions (lung primary and mediastinal lymph nodes) of varying size, shape, location, and (18) F-FDG activity. A program was developed to calculate a curvature vector along the outline and the standard deviation of this vector was used as a metric to quantify a shape's "complexity score"...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048137/su-f-i-55-performance-evaluation-of-digital-pet-ct-medical-physics-basis-for-the-clinical-applications
#18
J Zhang, M Miller, M V Knopp
PURPOSE: Replacement of conventional PMT-based detector with next generation digital photon counting (DPC) detector is a technology leap for PET imaging. This study evaluated the performance and characteristics of the DPC system and its stability within a 1 year time window following its installation focusing on the medical physics basis for clinical applications. METHODS: A digital PET/CT scanner using 1:1 coupling of 23,040 crystal: detector elements was introduced and became operational at OSU...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047766/su-c-202-04-adapting-biologically-optimized-dose-escalation-based-on-mid-treatment-pet-ct-for-non-small-cell-lung-cancer
#19
P Zhang, L Kuo, E Yorke, Y Hu, N Lockney, G Mageras, J Deasy, A Rimner
PURPOSE: To develop a biological modeling strategy which incorporates the response observed on the mid-treatment PET/CT into a dose escalation design for adaptive radiotherapy of non-small-cell lung cancer. METHOD: FDG-PET/CT was acquired midway through standard fractionated treatment and registered to pre-treatment planning PET/CT to evaluate radiation response of lung cancer. Each mid-treatment PET voxel was assigned the median SUV inside a concentric 1cm-diameter sphere to account for registration and imaging uncertainties...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047654/mo-ab-bra-05-18f-naf-pet-ct-imaging-biomarkers-in-metastatic-prostate-cancer
#20
S Harmon, T Perk, C Lin, J Eickhoff, P Choyke, W Dahut, A Apolo, J Humm, S Larson, M J Morris, S Perlman, G Liu, R Jeraj
PURPOSE: Clinical use of (18) F-Sodium Fluoride (NaF) PET/CT in metastatic settings often lacks technology to quantitatively measure full disease dynamics due to high tumor burden. This study assesses radiomics-based extraction of NaF PET/CT measures, including global metrics of overall burden and local metrics of disease heterogeneity, in metastatic prostate cancer for correlation to clinical outcomes. METHODS: Fifty-six metastatic Castrate-Resistant Prostate Cancer (mCRPC) patients had NaF PET/CT scans performed at baseline and three cycles into chemotherapy (N=16) or androgen-receptor (AR) inhibitors (N=39)...
June 2016: Medical Physics
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