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https://www.readbyqxmd.com/read/28733954/assessment-of-simplified-ratio-based-approaches-for-quantification-of-pet-11-c-pbr28-data
#1
Granville J Matheson, Pontus Plavén-Sigray, Anton Forsberg, Andrea Varrone, Lars Farde, Simon Cervenka
PURPOSE: Kinetic modelling with metabolite-corrected arterial plasma is considered the gold standard for quantification of [(11)C]PBR28 binding to the translocator protein (TSPO), since there is no brain region devoid of TSPO that can serve as reference. The high variability in binding observed using this method has motivated the use of simplified ratio-based approaches such as standardised uptake value ratios (SUVRs) and distribution volume (VT) ratios (DVRs); however, the reliability of these measures and their relationship to VT have not been sufficiently evaluated...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28733442/-89-zr-lumretuzumab-pet-imaging-before-and-during-her3-antibody-lumretuzumab-treatment-in-patients-with-solid-tumors
#2
Frederike Bensch, Laetitia E Lamberts, Michaël M Smeenk, Annelies Jorritsma-Smit, Marjolijn N Lub-de Hooge, Anton G T Terwisscha van Scheltinga, Johan R de Jong, Jourik A Gietema, Carolina P Schröder, Marlene Thomas, Wolfgang Jacob, Keelara Abiraj, Celine Adessi, Georgina Meneses-Lorente, Ian James, Martin Weisser, Adrienne H Brouwers, Elisabeth G de Vries
Purpose: We evaluated biodistribution and tumor targeting of (89)Zr-lumretuzumab before and during treatment with lumretuzumab, a human epidermal growth factor receptor 3 (HER3)-targeting monoclonal antibody. <p>Experimental design: 20 patients with histologically confirmed HER3-expressing tumors received (89)Zr-lumretuzumab and underwent Positron Emission Tomography (PET). In Part A, (89)Zr-lumretuzumab was given with additional, escalating doses of unlabeled lumretuzumab and scans were performed 2, 4 and 7 days postinjection to determine optimal imaging conditions...
July 21, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28733185/fdg-pet-parameters-as-predictors-of-pathologic-response-and-nodal-clearance-in-patients-with-stage-iii-non-small-cell-lung-cancer-receiving-neoadjuvant-chemoradiation-and-surgery
#3
Andrea L Arnett, Ann T Packard, Kristin Mara, Aaron S Mansfield, Dennis A Wigle, Michael G Haddock, Sean S Park, Kenneth R Olivier, Yolanda I Garces, Kenneth W Merrell
OBJECTIVE: Pathologic complete response (pCR) following neoadjuvant chemoradiation (CRT) is associated with improved outcomes in stage III non-small cell lung cancer. Conflicting results exist regarding the value of (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in predicting pCR. This study evaluated the association between post-CRT FDG-PET and pCR using novel FDG-PET parameters. METHODS AND MATERIALS: This retrospective study included patients treated with CRT and resection...
April 19, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28728462/increased-binding-potential-of-brain-adenosine-a-sub-1-sub-receptor-in-chronic-stages-of-patients-with-diffuse-axonal-injury-measured-with-1-methyl-sup-11-sup-c-8-dicyclopropylmethyl-1-methyl-3-propylxanthine-pet-imaging
#4
Shihori Hayashi, Motoki Inaji, Tadashi Nariai, Keiichi Oda, Muneyuki Sakata, Jun Toyohara, Kenji Ishii, Kiichi Ishiwata, Taketoshi Maehara
The positron emission tomography (PET) radioligand for adenosine A <sub>1</sub> receptor (A1R) [1-methyl- <sup>11</sup>C] 8-dicyclopropylmethyl-1-methyl-3-propylxanthine (MPDX) has recently been developed for human brain imaging. In the present study, we evaluated the alteration of the A1R in patients with diffuse axonal injury (DAI) in chronic stage <i>in vivo</i>. Ten patients with DAI (7 men and 3 women) were included in this study. Three PET examinations were sequentially performed to measure A1R binding with <sup>11</sup>C-MPDX, glucose metabolism with <sup>18</sup>F-fluorodeoxyglucose (FDG), and central benzodiazepine receptor binding with <sup>11</sup>C-flumazenil (FMZ), decreases of <sup>11</sup>C-FMZ uptake indicate neuronal loss...
July 20, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28712692/volumetric-parameters-of-2-deoxy-2-18f-fluoro-d-glucose-positron-emission-tomography-computed-tomography-can-predict-histopathologic-treatment-response-after-neoadjuvant-chemoradiotherapy-in-pancreatic-adenocarcinoma
#5
Makoto Sakane, Mitsuaki Tatsumi, Masatoshi Hori, Hiromitsu Onishi, Takahiro Tsuboyama, Atsushi Nakamoto, Takashi Ota, Hidetoshi Eguchi, Kenichi Wakasa, Jun Hatazawa, Noriyuki Tomiyama
PURPOSE: The purpose of this study was to investigate the clinical potential of 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography (FDG PET/CT) to evaluate histopathologic effects of preoperative chemoradiotherapy (CRT) in pancreatic adenocarcinoma, with particular focus on volumetric PET/CT parameters. MATERIAL AND METHODS: This study included 25 patients with pancreatic adenocarcinoma who underwent radical surgery after gemcitabine- and S-1-based preoperative-CRT...
June 23, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28709149/uptake-of-psma-ligands-in-normal-tissues-is-dependent-on-tumor-load-in-patients-with-prostate-cancer
#6
Florian C Gaertner, Khalil Halabi, Hojjat Ahmadzadehfar, Stefan Kürpig, Elisabeth Eppard, Charalambos Kotsikopoulos, Nikolaos Liakos, Ralph A Bundschuh, Holger Strunk, Markus Essler
Radioligand therapy (RLT) with Lu-177-labeled PSMA-ligands is a new therapy option for prostate cancer. Biodistribution in normal tissues is of interest for therapy planning. We evaluated if the biodistribution of Ga-68-PSMA-11 is influenced by tumor load. RESULTS: In patients with high tumor load, SUVmean was reduced to 61.5% in the lacrimal glands, to 56.6% in the parotid glands, to 63.7% in the submandibular glands, to 61.3% in the sublingual glands and to 55.4% in the kidneys (p < 0...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28705918/in-vivo-quantification-of-er-%C3%AE-expression-by-pharmacokinetic-modeling-studies-with-18-f-fhnp-pet
#7
Inês F Antunes, Antoon T M Willemsen, Jurgen W A Sijbesma, Ate S Boerema, Aren van Waarde, Andor W J M Glaudemans, Rudi A Dierckx, Elisabeth G E de Vries, Geke A P Hospers, Erik F de Vries
The estrogen receptor (ER) is a target for endocrine therapy in breast cancer patients. Individual quantification of ERα and ERβ expression, rather than total ER levels, might enable better prediction of the response to treatment. We recently developed the tracer 2-(18)F-fluoro-6-(6-hydroxynaphthalen-2-yl)pyridin-3-ol ((18)F-FHNP) for assessment of ERβ levels with positron emission tomography (PET). Here we investigated several pharmacokinetic analysis methods to quantify changes in ERβ availability with (18)F-FHNP-PET...
July 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28697195/fluorine-18-fdg-pet-ct-in-a-patient-with-angiomyolipoma-response-to-mammalian-target-of-rapamycin-inhibitor-therapy
#8
Hoda Anwar, Christos Sachpekidis, Matthias Schwarzbach, Antonia Dimitrakopoulou-Strauss
We report on a 27 years old female patient who was referred to our department for whole-body as well as dynamic positron emission tomography/computed tomography (dPET/CT) scan of the upper and middle abdomen with fluorine-18-fluorodeoxy glucose ((18)F-FDG), for further evaluation of a mass in the left adrenal gland region. Positron emission tomography showed a suspicious, enlarged, hypermetabolic mass with an average standardized uptake value (SUV) of 4.5 and a maximum SUV of 5.9. The patient was referred for biopsy, which revealed an angiomyolipoma, a perivascular epithelioid cell tumor (PEComa) of the adrenal gland...
July 12, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28689281/optimal-fdg-pet-ct-volumetric-parameters-for-risk-stratification-in-patients-with-locally-advanced-non-small-cell-lung-cancer-results-from-the-acrin-6668-rtog-0235-trial
#9
Ali Salavati, Fenghai Duan, Bradley S Snyder, Bo Wei, Sina Houshmand, Benjapa Khiewvan, Adam Opanowski, Charles B Simone, Barry A Siegel, Mitchell Machtay, Abass Alavi
PURPOSE: In recent years, multiple studies have demonstrated the value of volumetric FDG-PET/CT parameters as independent prognostic factors in patients with non-small cell lung cancer (NSCLC). We aimed to determine the optimal cut-off points of pretreatment volumetric FDG-PET/CT parameters in predicting overall survival (OS) in patients with locally advanced NSCLC and to recommend imaging biomarkers appropriate for routine clinical applications. METHODS: Patients with inoperable stage IIB/III NSCLC enrolled in ACRIN 6668/RTOG 0235 were included...
July 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28682793/impact-of-pet-and-mri-threshold-based-tumor-volume-segmentation-on-patient-specific-targeted-radionuclide-therapy-dosimetry-using-clr1404
#10
Abigail E Besemer, Benjamin Titz, Joseph J Grudzinski, Jamey P Weichert, John S Kuo, H Ian Robins, Lance T Hall, Bryan P Bednarz
Variations in tumor volume segmentation methods in targeted radionuclide therapy (TRT) may lead to dosimetric uncertainties. This work investigates the impact of PET and MRI threshold-based tumor segmentation on TRT dosimetry in patients with primary and metastatic brain tumors. In this study, PET/CT images of five brain cancer patients were acquired at 6, 24, and 48 h post-injection of (124)I-CLR1404. The tumor volume was segmented using two standardized uptake value (SUV) threshold levels, two tumor-to-background ratio (TBR) threshold levels, and a T1 Gadolinium-enhanced MRI threshold...
July 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28678576/reliability-of-18-f-fdg-pet-metabolic-parameters-derived-using-simultaneous-pet-mri-and-correlation-with-prognostic-factors-of-invasive-ductal-carcinoma-a-feasibility-study
#11
Amarnath Jena, Sangeeta Taneja, Aru Singh, Pradeep Negi, Ramesh Sarin, Pratap K Das, Manish Singhal
OBJECTIVE: The objective of our study was to correlate semiquantitative PET parameters-standardized uptake value (SUV) and total lesion glycolysis (TLG)-derived in simultaneous PET/MRI using MRI-based attenuation correction with clinical and histopathologic prognostic factors in patients with breast cancer. MATERIALS AND METHODS: Eighty-two invasive ductal carcinomas in 69 women were included in the study. All the subjects underwent whole-body (WB) PET/MRI (supine WB mode) and dedicated PET/MRI of the breast (prone breast imaging mode) for staging on a simultaneous PET/MRI system...
July 5, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28677098/integration-of-solid-state-nanopores-into-a-functional-device-designed-for-electrical-and-optical-cross-monitoring
#12
Raphaël Marchand, Christophe Thibault, Franck Carcenac, Christophe Vieu, Emmanuelle Trévisiol
We present a new strategy for fabricating a silicon nanopore device allowing straightforward fluidic integration and electrical as well as optical monitoring. The device presents nanopores of diameters 10 nm to 160 nm, and could therefore be used to obtain solvent-free free-standing lipid bilayers from small unilamellar vesicles (SUV) or large unilamellar vesicles (LUV). The silicon chip fabrication process only requires front side processing of a silicon-on-insulator (SOI) substrate. A polydimethylsiloxane (PDMS) microfluidic interface is assembled on the silicon chip for fluidic handling and electrical addressing...
September 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28677069/high-fdg-uptake-on-pet-is-associated-with-negative-cell-to-cell-adhesion-molecule-e-cadherin-expression-in-lung-adenocarcinoma
#13
Kotaro Higashi, Yoshimichi Ueda, Miyako Shimasaki, Yasuhito Ishigaki, Yuka Nakamura, Manabu Oguchi, Tsutomu Takegami, Naoto Watanabe
OBJECTIVES: E-cadherin is a main cell-to-cell adhesion molecule. A negative expression of E-cadherin correlates with distant metastasis in lung cancer. Recently, it was reported that there is an association between FDG uptake on PET and epithelial-mesenchymal transition (EMT) in non-small cell lung cancer. Downregulation of E-cadherin is one of the best markers of EMT. The purpose of this study was to compare E-cadherin expression with FDG uptake on PET, cell differentiation, aggressiveness and post-operative recurrence in patients with lung adenocarcinoma, and to investigate whether FDG uptake on PET is associated with E-cadherin expression...
July 4, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28676945/verification-of-the-tumor-volume-delineation-method-using-a-fixed-threshold-of-peak-standardized-uptake-value
#14
Kazuya Koyama, Takuya Mitsumoto, Takahiro Shiraishi, Keisuke Tsuda, Atsushi Nishiyama, Kazumasa Inoue, Kyosan Yoshikawa, Kazuo Hatano, Kazuo Kubota, Masahiro Fukushi
We aimed to determine the difference in tumor volume associated with the reconstruction model in positron-emission tomography (PET). To reduce the influence of the reconstruction model, we suggested a method to measure the tumor volume using the relative threshold method with a fixed threshold based on peak standardized uptake value (SUVpeak). The efficacy of our method was verified using (18)F-2-fluoro-2-deoxy-D-glucose PET/computed tomography images of 20 patients with lung cancer. The tumor volume was determined using the relative threshold method with a fixed threshold based on the SUVpeak...
July 4, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/28669720/ultra-low-friction-between-boundary-layers-of-hyaluronan-phosphatidylcholine-complexes
#15
Linyi Zhu, Jasmine Seror, Anthony J Day, Nir Kampf, Jacob Klein
The boundary layers coating articular cartilage in synovial joints constitute unique biomaterials, providing lubricity at levels unmatched by any human-made materials. The underlying molecular mechanism of this lubricity, essential to joint function, is not well understood. Here we study the interactions between surfaces bearing attached hyaluronan (hyaluronic acid, or HA) to which different phosphatidylcholine (PC) lipids had been added, in the form of small unilamellar vesicles (SUVs or liposomes), using a surface force balance, to shed light on possible cartilage boundary lubrication by such complexes...
June 29, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28668434/clinical-evaluation-of-whole-body-oncologic-pet-with-time-of-flight-and-point-spread-function-for-the-hybrid-pet-mr-system
#16
Kun Shang, Bixiao Cui, Jie Ma, Dongmei Shuai, Zhigang Liang, Floris Jansen, Yun Zhou, Jie Lu, Guoguang Zhao
PURPOSE: Hybrid positron emission tomography/magnetic resonance (PET/MR) imaging is a new multimodality imaging technology that can provide structural and functional information simultaneously. The aim of this study was to investigate the effects of the time-of-flight (TOF) and point-spread function (PSF) on small lesions observed in PET/MR images from clinical patient image sets. MATERIALS AND METHODS: This study evaluated 54 small lesions in 14 patients who had undergone (18)F-fluorodeoxyglucose (FDG) PET/MR...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28666386/effect-of-cholesterol-on-the-stability-and-lubrication-efficiency-of-phosphatidylcholine-surface-layers
#17
Raya Sorkin, Nir Kampf, Jacob Klein
The lubrication properties of saturated PC lipid vesicles containing high cholesterol content under high loads were examined by detailed surface force balance measurements of normal and shear forces between two surface-attached lipid layers. Forces between two opposing mica surfaces bearing distearoylphosphatidylcholine (PC) (DSPC) small unilamellar vesicles (SUVs, or liposomes), or bilayers, with varying cholesterol content were measured across water, whereas dimyristoyl PC (DMPC), dipalmitoyl PC (DPPC), and DSPC SUVs containing 40% cholesterol were measured across liposome dispersions of SUVs of the same lipid composition as in the adsorbed layers...
July 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28664283/-positron-emission-tomography-computed-tomography-in-rheumatology
#18
T Derlin
Combined positron emission tomography/computed tomography (PET/CT) is a whole-body imaging procedure, which enables sensitive detection of inflammatory changes. It may be used to simultaneously obtain both precise anatomical and molecular information in order to comprehensively characterize diseases. The glucose analogue (18)F-fluorodeoxyglucose (FDG) represents a universally applicable radiotracer for imaging of inflammatory processes. Its accumulation in tissues can be semiquantitatively characterized by use of standardized uptake values (SUV)...
June 29, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28660218/diagnosis-of-brain-tumors-using-amino-acid-transport-pet-imaging-with-18-f-fluciclovine-a-comparative-study-with-l-methyl-11-c-methionine-pet-imaging
#19
Naohiro Tsuyuguchi, Yuzo Terakawa, Takehiro Uda, Kosuke Nakajo, Yonehiro Kanemura
OBJECTIVES: (18)F-fluciclovine (trans-1-amino-3-[(18)F] fluorocyclobutanecarboxylic acid, [FACBC]) is an artificial amino acid radiotracer used for positron emission tomography (PET) studies, which is metabolically stable in vivo and has a long half-life. It has already been shown that FACBC-PET is useful for glioma imaging. However, there have been no reports evaluating the efficiency of FACBC-PET in the diagnosis of brain tumors in comparison with other PET tracers in clinical studies...
2017: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/28655782/ada-07-suppresses-solar-ultraviolet-induced-skin-carcinogenesis-by-directly-inhibiting-topk
#20
Ge Gao, Tianshun Zhang, Qiushi Wang, Kanamata Reddy, Hanyong Chen, Ke Yao, Keke Wang, Eunmiri Roh, Tatyana Zykova, Weiya Ma, Joohyun Ryu, Clara Curiel-Lewandrowski, David Alberts, Sally E Dickinson, Ann M Bode, Ying Xing, Zigang Dong
Cumulative exposure to solar ultraviolet (SUV) irradiation is regarded as the major etiologic factor in the development of skin cancer. The activation of the mitogen-activated protein kinase (MAPK) cascades occurs rapidly and is vital in the regulation of SUV-induced cellular responses. The T-LAK cell-originated protein kinase (TOPK), an upstream activator of MAPKs, is heavily involved in inflammation, DNA damage, and tumor development. However, the chemopreventive and therapeutic effects of specific TOPK inhibitors in SUV-induced skin cancer have not yet been elucidated...
June 27, 2017: Molecular Cancer Therapeutics
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