Md Al Amin Sikder, Ridwan B Rashid, Tufael Ahmed, Ismail Sebina, Daniel R Howard, Md Ashik Ullah, Muhammed Mahfuzur Rahman, Jason P Lynch, Bodie Curren, Rhiannon B Werder, Jennifer Simpson, Alec Bissell, Mark Morrison, Carina Walpole, Kristen J Radford, Vinod Kumar, Trent M Woodruff, Tan Hui Ying, Ayesha Ali, Gerard E Kaiko, John W Upham, Robert D Hoelzle, Páraic Ó Cuív, Patrick G Holt, Paul G Dennis, Simon Phipps
Poor maternal diet during pregnancy is a risk factor for severe lower respiratory infections (sLRIs) in the offspring, but the underlying mechanisms remain elusive. Here, we demonstrate that in mice a maternal low-fiber diet (LFD) led to enhanced LRI severity in infants because of delayed plasmacytoid dendritic cell (pDC) recruitment and perturbation of regulatory T cell expansion in the lungs. LFD altered the composition of the maternal milk microbiome and assembling infant gut microbiome. These microbial changes reduced the secretion of the DC growth factor Flt3L by neonatal intestinal epithelial cells and impaired downstream pDC hematopoiesis...
March 26, 2023: Immunity