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https://www.readbyqxmd.com/read/27926647/central-fetal-monitoring-with-and-without-computer-analysis-a-randomized-controlled-trial
#1
Inês Nunes, Diogo Ayres-de-Campos, Austin Ugwumadu, Pina Amin, Philip Banfield, Antony Nicoll, Simon Cunningham, Paulo Sousa, Cristina Costa-Santos, João Bernardes
OBJECTIVE: To evaluate whether intrapartum fetal monitoring with computer analysis and real-time alerts decreases the rate of newborn metabolic acidosis or obstetric intervention when compared with visual analysis. METHODS: A randomized clinical trial carried out in five hospitals in the United Kingdom evaluated women with singleton, vertex fetuses of 36 weeks of gestation or greater during labor. Continuous central fetal monitoring by computer analysis and online alerts (experimental arm) was compared with visual analysis (control arm)...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27718221/auditory-toxicity-in-late-preterm-and-term-neonates-with-severe-jaundice
#2
Sanjiv B Amin, Satish Saluja, Arvind Saili, Nirupama Laroia, Mark Orlando, Hongyue Wang, Asha Agarwal
AIM: Jaundice may cause auditory toxicity (auditory neuropathy and hearing loss). However, total serum bilirubin (TSB) does not discriminate neonates at risk for auditory toxicity. We compared TSB, bilirubin:albumin molar ratio (BAMR), and unbound bilirubin for their association with auditory toxicity in neonates with severe jaundice (TSB ≥342μmol/L, or that met exchange transfusion). METHOD: Neonates greater or equal to 34 weeks gestational age with severe jaundice during the first 2 postnatal weeks were eligible for prospective cohort study, unless they had craniofacial malformations, chromosomal disorders, toxoplasmosis, other infections, rubella, cytomegalovirus, herpes simplex infections, surgery, or family history of congenital deafness...
October 8, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27689072/the-role-of-pancreatic-stone-protein-in-diagnosis-of-early-onset-neonatal-sepsis
#3
Anwar A Rass, Mohamed A Talat, Mohamed A Arafa, Hosam F El-Saadany, Ezzat K Amin, Mohamed Mohamed Abdelsalam, Mona A Mansour, Naglaa A Khalifa, Lamiaa Mahmoud Kamel
Introduction. Early diagnosis and treatment of neonatal sepsis may help decrease neonatal mortality. Aim of the Study. To evaluate the role of pancreatic stone protein as a marker for early onset neonatal sepsis. Methods. A hospital-based prospective study was conducted on 104 (52 uninfected and 52 infected neonates) admitted to the Neonatal Intensive Care Unit (NICU) of Zagazig University hospitals during the period from April 2014 to April 2015. All newborns were subjected to full history taking, careful neonatal assessment, blood, C-reactive protein (CRP), and serum pancreatic stone protein...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27575005/morphological-analysis-of-regenerated-bulbar-fibers-in-relation-to-neonatal-olfaction
#4
Masafumi Kuroiwa, Nanae Fukushima, Kumiko Yokouchi, Kyutaro Kawagishi, Tetsuji Moriizumi
It was revealed that regeneration of the lateral olfactory tract (LOT) occurred in developing rats and the regenerated olfactory system was functional 4 weeks after transection. The aim of this study was to determine the earliest onset of functional recovery in LOT-injured rats and to quantify regenerated nerve components with functional correlation. Neonatal rats on postnatal day (P) 2 were subjected to unilateral transection of the left LOT and underwent unilateral removal of the right olfactory bulb on P11...
August 26, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27546354/vaginal-progesterone-compared-to-intramuscular-17-alpha-hydroxyprogesterone-caproate-for-prevention-of-recurrent-spontaneous-preterm-birth-in-singleton-gestations-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#5
Gabriele Saccone, Adeeb Khalifeh, Andrew Elimian, Elham Bahrami, Kefayat Chaman-Ara, Mohammad Amin Bahrami, Vincenzo Berghella
OBJECTIVE: Randomized controlled trials (RCTs) have recently compared intramuscular 17-alpha-hydroxy-progesterone caproate (17-OHPC) to vaginal progesterone for reducing the risk of spontaneous preterm birth (SPTB) in singletons with prior SPTB. The aim of this systematic review with meta-analysis was to evaluate the efficacy of vaginal progesterone compared with 17-OHPC in prevention of SPTB in singleton gestations with prior SPTB. METHODS: Searches were performed in electronic databases...
August 22, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27493242/tlr2-mediated-leukocyte-trafficking-to-the-developing-brain
#6
Amin Mottahedin, Peter Lawrence Phillip Smith, Henrik Hagberg, C Joakim Ek, Carina Mallard
Inflammation is a significant risk factor for brain injury in the perinatal period. In this study, we tested the hypothesis that activation of peripheral TLR induces inflammation in the brain, including leukocyte trafficking. Postnatal day 8 mice were injected intraperitoneally with a TLR1/2 (Pam3CSK4, P3C), TLR2/6 (FSL-1) or TLR4 (LPS) agonist, and the peripheral and central cytokine and chemokine response was determined. Infiltration of immune cells to the CSF and brain was examined by flow cytometry, and brain permeability was investigated by radioactively labeled sucrose...
August 4, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27432157/an-fc-small-molecule-conjugate-for-targeted-inhibition-of-the-adenosine-2a-receptor
#7
Po-Yuan Hsiao, Jay Kalin, Im-Hong Sun, Mohammed Amin, Ying-Chun Lo, Meng-Jung Chiang, John Giddens, Polina Sysa-Shah, Kathleen Gabrielson, Lai-Xi Wang, Jonathan Powell, Philip A Cole
The adenosine A2A receptor (A2AR) is expressed in immune cells as well as heart and lung tissue and has been intensively studied as a therapeutic target for multiple disease indications.Inhibitors of the A2AR have the potential for stimulating immune response which could be valuable for cancer immune surveillance and mounting a response against pathogens. One well-established potent and selective small-molecule A2AR antagonist, ZM-241385 (ZM), has a short pharmacokinetic half-life and has the potential for systemic toxicity due to A2AR effects in the brain and the heart...
July 19, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27257052/histamine-is-correlated-with-liver-fibrosis-in-biliary-atresia
#8
Kejun Zhou, Guoxiang Xie, Jie Wen, Jun Wang, Weihua Pan, Ying Zhou, Yongtao Xiao, Yang Wang, Wei Jia, Wei Cai
BACKGROUND AND AIMS: Biliary atresia (BA) is a severe neonatal cholestasis disease that is caused by obstruction of extra bile ducts. Liver fibrosis progresses dramatically in BA, and the underlying molecular mechanism is largely unknown. METHODS: Amino acids and biogenic amines were quantified by targeted metabolomic methods in livers of 52 infants with BA and 16 infants with neonatal hepatitis syndrome (NHS). Normal adjacent nontumor liver tissues from 5 hepatoblastoma infants were used as controls...
August 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27235205/bilirubin-binding-capacity-in-the-preterm-neonate
#9
REVIEW
Sanjiv B Amin
Total serum/plasma bilirubin (TB), the biochemical measure currently used to evaluate and manage hyperbilirubinemia, is not a useful predictor of bilirubin-induced neurotoxicity in premature infants. Altered bilirubin-albumin binding in premature infants limits the usefulness of TB in premature infants. In this article, bilirubin-albumin binding, a modifying factor for bilirubin-induced neurotoxicity, in premature infants is reviewed.
June 2016: Clinics in Perinatology
https://www.readbyqxmd.com/read/27211062/sustained-lentiviral-mediated-overexpression-of-microrna124a-in-the-dentate-gyrus-exacerbates-anxiety-and-autism-like-behaviors-associated-with-neonatal-isolation-in-rats
#10
Amine Bahi
Autism spectrum disorders (ASD) are highly disabling psychiatric disorders. Despite a strong genetic etiology, there are no efficient therapeutic interventions that target the core symptoms of ASD. Emerging evidence suggests that dysfunction of microRNA (miR) machinery may contribute to the underlying molecular mechanisms involved in ASD. Here, we report a stress model demonstrating that neonatal isolation-induced long-lasting hippocampal elevation of miR124a was associated with reduced expression of its target BDNF mRNA...
September 15, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27186550/efficacy-and-safety-of-vitamin-d-supplementation-during-pregnancy-a-randomized-trial-of-two-different-levels-of-dosing-on-maternal-and-neonatal-vitamin-d-outcome
#11
Shahnaz Ahmad Mir, Shariq Rashid Masoodi, Shafia Shafi, Iqra Hameed, Maqsood Ahmad Dar, Mir Iftikhar Bashir, Arshad Iqbal Wani, Zaffar Amin Shah, Shameema Parveen, Abdul Hamid Zargar, Parviz Ahmad Shah
INTRODUCTION: Pregnant women represent a typical group susceptible to dietary and mineral deficiencies. This study was sought to assess the efficacy and safety of various doses of 25-hydroxyvitamin D (25[OH]D) supplementation during pregnancy and ratify the inadequacy of the recommended daily allowance for Vitamin D in vulnerable groups. MATERIALS AND METHODS: A total of 100 pregnant women were included in this open-label, parallel group, prospective, randomized, and controlled trial...
May 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27111097/the-presence-of-physician-champions-improved-kangaroo-mother-care-in-rural-western-india
#12
Apurv Soni, Amee Amin, Dipen V Patel, Nisha Fahey, Nikhil Shah, Ajay G Phatak, Jeroan Allison, Somashekhar M Nimbalkar
AIM: This study determined the effect of physician champions on the two main components of Kangaroo Mother Care (KMC): skin-to-skin care and breastfeeding. METHODS: KMC practices among a retrospective cohort of 648 infants admitted to a rural Indian neonatal intensive care unit (NICU) between January 5, 2011 and October 7, 2014 were studied. KMC champions were identified based on their performance evaluation. We examined the effect of withdrawing physician champions on overall use, time to initiation and intensity of skin-to-skin care and breastfeeding, using separate models...
September 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27081237/atypical-mr-lenticular-signal-change-in-infantile-isovaleric-acidemia
#13
Nisar A Wani, Umer Amin Qureshi, Majid Jehangir, Kaiser Ahmad, Zahid Hussain
Isovaleric acidemia (IVA) is an inborn error of branched chain amino acid metabolism that may manifest as acute neonatal metabolic acidosis or as chronic intermittent form with developmental delay or recurrent episodes of acute metabolic acidosis. Early diagnosis is the key to prevent morbidity and mortality. Brain imaging abnormalities are rarely described in IVA. We report a case of chronic intermittent IVA with acute presentation in a 4-month-old infant who presented with acute metabolic acidosis. Brain magnetic resonance imaging (MRI) revealed symmetric signal intensity changes in bilateral lentiform nuclei with an unreported T1-weighted (T1W) symmetric hyperintense ring-like appearance in bilateral putamen...
January 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/26952116/unbound-bilirubin-and-auditory-neuropathy-spectrum-disorder-in-late-preterm-and-term-infants-with-severe-jaundice
#14
Sanjiv B Amin, Hongyue Wang, Nirupama Laroia, Mark Orlando
OBJECTIVE: This study evaluates whether unbound bilirubin is a better predictor of auditory neuropathy spectrum disorder (ANSD) than total serum bilirubin (TSB) or the bilirubin:albumin molar ratio (BAMR) in late preterm and term neonates with severe jaundice (TSB ≥20 mg/dL or TSB that met exchange transfusion criteria). STUDY DESIGN: Infants ≥34 weeks' gestation with severe jaundice during the first 2 weeks of life were eligible for the prospective observational study...
June 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/26944323/phosphodiesterase-inhibitor-kmup-3-displays-cardioprotection-via-protein-kinase-g-and-increases-cardiac-output-via-g-protein-coupled-receptor-agonist-activity-and-ca-2-sensitization
#15
Chung-Pin Liu, Jwu-Lai Yeh, Shu-Fen Liou, Bin-Nan Wu, Ing-Jun Chen
KMUP-3 (7-{2-[4-(4-nitrobenzene) piperazinyl]ethyl}-1, 3-dimethylxanthine) displays cardioprotection and increases cardiac output, and is suggested to increase cardiac performance and improve myocardial infarction. To determine whether KMUP-3 improves outcomes in hypoperfused myocardium by inducing Ca(2+) sensitization to oppose protein kinase (PK)G-mediated Ca(2+) blockade, we measured left ventricular systolic blood pressure, maximal rates of pressure development, mean arterial pressure and heart rate in rats, and measured contractility and expression of PKs/RhoA/Rho kinase (ROCK)II in beating guinea pig left atria...
February 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/26899816/the-effect-of-prenatal-and-intrapartum-care-on-the-stillbirth-rate-among-women-in-rural-ethiopia
#16
Karen Ballard, Zelalem Belete, Hirut Kinfu, Mebkyou Tadesse, Mohammed Amin, Habtamu Atnafu
OBJECTIVE: To determine whether community-based prenatal and intrapartum care in Ethiopia results in a lower stillbirth rate. METHODS: Between May and December 2014, a randomly selected sample of women in northern and eastern Ethiopia who had delivered a neonate in the preceding 12months completed a face-to-face survey about their experiences of maternal services and the fetal outcome for each delivery. The stillbirth rates among women delivering at home and at health facilities were compared...
May 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/26871809/classic-case-report-of-donohue-syndrome-leprechaunism-omim-246200-the-impact-of-consanguineous-mating
#17
Yousif Nijim, Youssef Awni, Amin Adawi, Abdalla Bowirrat
Donohue syndrome ([DS]; leprechaunism) describes a genetic autosomal recessive disorder that results from the presence of homozygous or compound heterozygous mutations in the insulin receptor gene (INSR; 19p13.3-p13.2).Donohue syndrome is associated with a fatal congenital form of dwarfism with features of intrauterine and postnatal growth retardation, exaggerated hyperglycemia with hyperinsulinism and dysmorphic abnormalities.We present a case of DS owing to the rarity of this syndrome (1 case in every million births)...
February 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26817868/first-case-report-of-smith-magenis-syndrome-sms-among-the-arab-community-in-nazareth-view-and-overview
#18
Yousif Nijim, Amin Adawi, Bishara Bisharat, Abdalla Bowirrat
Smith-Magenis syndrome (SMS0) is a complex and rare genetic multisystem disorder characterized by a variable pattern of cognitive deficits accompanied by a1 distinctive behavioral phenotype. SMS is characterized by subtle facial dysmorphology, short stature, sleep disturbances, and neurobehavioral abnormalities. Little is known about the manifestation of his unique case among Arab population and its strategic treatment.This study comes to present a case of SMS in an Arab newborn male who was born in spontaneous delivery on June 29, 2015, with tachypnea, tracheomalacia, and mild hypotonia...
January 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26815511/-biliary-atresia-and-polysplenia-syndrome
#19
Yosra Kerkeni, Amine Ksia, Hayet Zitouni, Mohsen Belghith, Sahnoun Lassad, Imed Krichene, Mongi Mekki, Abdellatif Nouri
Polysplenia syndrome is a rare malformation characterized by the association of multiple rates and other congenital anomalies dominated by cardiac, vascular, intestinal and bile malformations. We report the observation of a patient operated in the neonatal period (3 days) for an upper intestinal obstruction with situs inversus. Surgical exploration noted the presence of multiple rates, a preduodenal vein, a biliary atresia and a duodenal atresia. The surgical procedures performed were a latero-lateral duodeno-duodenostomy and hepatoportoenterostomy of KASAI with simple immediate and delayed outcomes...
August 2015: La Tunisie Médicale
https://www.readbyqxmd.com/read/26733859/spike-detection-for-large-neural-populations-using-high-density-multielectrode-arrays
#20
Jens-Oliver Muthmann, Hayder Amin, Evelyne Sernagor, Alessandro Maccione, Dagmara Panas, Luca Berdondini, Upinder S Bhalla, Matthias H Hennig
An emerging generation of high-density microelectrode arrays (MEAs) is now capable of recording spiking activity simultaneously from thousands of neurons with closely spaced electrodes. Reliable spike detection and analysis in such recordings is challenging due to the large amount of raw data and the dense sampling of spikes with closely spaced electrodes. Here, we present a highly efficient, online capable spike detection algorithm, and an offline method with improved detection rates, which enables estimation of spatial event locations at a resolution higher than that provided by the array by combining information from multiple electrodes...
2015: Frontiers in Neuroinformatics
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