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https://www.readbyqxmd.com/read/28371911/molecular-epidemiology-of-a-malassezia-pachydermatis-neonatal-unit-outbreak
#1
Amin Ilahi, Inès Hadrich, Sabrina Goudjil, Guy Kongolo, Christèle Chazal, André Léké, Ali Ayadi, Taieb Chouaki, Stéphane Ranque
The non-lipid-dependent yeast Malassezia pachydermatis is predominantly zoophilic but occasionally colonizes the human skin. This yeast caused an outbreak in a neonatal iIntensive care unit (NICU). This study aimed to describe the molecular epidemiology of this M. pachydermatis outbreak. All the M. pachydermatis isolates collected at a French University Hospital from January 2012 to April 2013 were included in the study. M. pachydermatis isolates, sampled from various biological samples sites in 25 patients, were identified via MALDI-TOF mass spectrometry and typed using intergenic-spacer 1 (IGS1) nucleotide sequence polymorphisms analysis...
March 24, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28284951/hippocampal-bdnf-overexpression-or-micror124a-silencing-reduces-anxiety-and-autism-like-behaviors-in-rats
#2
Amine Bahi
MicroRNA124a (miR124a) has emerged recently as a key player for multiple neuropsychiatric disorders including depression, anxiety, alcoholism, and cocaine addiction. Although we have previously reported that miR124a and its target the brain-derived neutrophic factor (BDNF) play an important role in autism-like behaviors, the molecular and behavioral dysfunctions remain unknown. The aim of this study was to understand the effects of sustained decreases in miR124a and increases of BDNF in the dentate gyrus (DG) on neonatal isolation-induced anxiety-and autism like behaviors in rats...
March 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28260766/perinatal-complications-in-diabetes-mellitus-with-pregnancy-comparison-between-gestational-diabetes-mellitus-gdm-and-diabetes-mellitus-prior-to-pregnancy
#3
F B Rashid, H Khatoon, M A Hasnat, R Amin, A K Azad
Diabetes is alarmingly high among Bangladeshi people. But there have been very few studies assessing the effect of diabetes on perinatal outcomes, particularly comparing diabetes prior to pregnancy and gestational diabetes (GDM). This cross sectional observational study was conducted in the Department of Obstetrics & Gynaecology, BIRDEM Hospital, Dhaka, Bangladesh from September 2010 to February 2011. Pregnant women admitted in BIRDEM Hospital for delivery after 28 weeks of gestation were selected to assess perinatal complications of GDM and diabetes prior to pregnancy and to compare them after taking permission from institutional review board...
January 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28203335/is-the-bayley-scales-of-infant-and-toddler-developmental-screening-test-valid-and-reliable-for-persian-speaking-children
#4
Farin Soleimani, Nadia Azari, Roshanak Vameghi, Firoozeh Sajedi, Soheila Shahshahani, Hossein Karimi, Adis Kraskian, Amin Shahrokhi, Robab Teymouri, Masoud Gharib
BACKGROUND: Advances in perinatal and neonatal care have substantially improved the survival of at-risk infants over the past two decades. OBJECTIVES: The purpose of this study was to assess the reliability and validity of the Bayley Scales of infant and toddler developmental Screening test in Persian-speaking children. METHODS: This was a cross-sectional prospective study of 403 children aged 1 - 42-months. The Bayley scales screening instrument, which consists of five domains (cognitive, receptive, and expressive communication and fine and gross motor items), was used to measure infants' and toddlers' development...
October 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/28201627/editor-s-highlight-in-utero-exposure-to-gadolinium-and-adverse-neonatal-outcomes-in-premature-infants
#5
Radhika Amin, Thomas Darrah, Hongyue Wang, Sanjiv Amin
Gadolinium is a toxic rare earth element that is used as a contrast enhancement agent for diagnostic medical imaging. However, because of safety concerns to the developing fetus derived from preclinical studies, gadolinium can only be used during pregnancy if the potential benefits justify the potential risks to a fetus. Because there are no previous well designed safety studies on the developing fetus, we aimed to evaluate the potential adverse effects of in utero gadolinium exposure in high-risk premature infants...
April 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28196600/genome-editing-in-hpscs-reveals-gata6-haploinsufficiency-and-a-genetic-interaction-with-gata4-in-human-pancreatic-development
#6
Zhong-Dong Shi, Kihyun Lee, Dapeng Yang, Sadaf Amin, Nipun Verma, Qing V Li, Zengrong Zhu, Chew-Li Soh, Ritu Kumar, Todd Evans, Shuibing Chen, Danwei Huangfu
Human disease phenotypes associated with haploinsufficient gene requirements are often not recapitulated well in animal models. Here, we have investigated the association between human GATA6 haploinsufficiency and a wide range of clinical phenotypes that include neonatal and adult-onset diabetes using CRISPR (clustered regularly interspaced short palindromic repeat)/Cas9-mediated genome editing coupled with human pluripotent stem cell (hPSC) directed differentiation. We found that loss of one GATA6 allele specifically affects the differentiation of human pancreatic progenitors from the early PDX1+ stage to the more mature PDX1+NKX6...
May 4, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28164936/the-effects-of-acoustic-white-noise-on-the-rat-central-auditory-system-during-the-fetal-and-critical-neonatal-periods-a-stereological-study
#7
Mohammad Saied Salehi, Mohammad Reza Namavar, Amin Tamadon, Raziyeh Bahmani, Mohammad Reza Jafarzadeh Shirazi, Homayoun Khazali, Leila Dargahi, Sareh Pandamooz, Farzad Mohammad-Rezazadeh, Fatemeh Sadat Rashidi
AIM: To evaluate the effects of long-term, moderate level noise exposure during crucial periods of rat infants on stereological parameters of medial geniculate body (MGB) and auditory cortex. MATERIALS AND METHODS: Twenty-four male offspring of 12 pregnant rats were divided into four groups: fetal-to-critical period group, which were exposed to noise from the last 10 days of fetal life till postnatal day (PND) 29; fetal period group that exposed to noise during the last 10 days of fetal life; critical period group, exposed to noise from PND 15 till PND 29, and control group...
January 2017: Noise & Health
https://www.readbyqxmd.com/read/28139935/systemic-activation-of-toll-like-receptor-2-suppresses-mitochondrial-respiration-and-exacerbates-hypoxic-ischemic-injury-in-the-developing-brain
#8
Amin Mottahedin, Pernilla Svedin, Syam Nair, Carl-Johan Mohn, Xiaoyang Wang, Henrik Hagberg, Joakim Ek, Carina Mallard
Infection and inflammation are known risk factors for neonatal brain injury. Mycoplasma and Gram-positive bacteria, for which Toll-like receptor 2 (TLR2) plays a key role in recognition and inflammatory response, are among the most common pathogens in the perinatal period. Here, we report that systemic activation of TLR2 by Pam3CSK4 (P3C) increases neural tissue loss and demyelination induced by subsequent hypoxia-ischemia (HI) in neonatal mice. High-resolution respirometry of brain isolated mitochondria revealed that P3C suppresses ADP-induced oxidative phosphorylation, the main pathway of cellular energy production...
April 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27998162/antibiotic-sensitivity-pattern-of-bacterial-isolates-of-neonatal-septicemia-in-peshawar-pakistan
#9
Obaid Ullah, Aftab Khan, Arif Ambreen, Israr Ahmad, Tasleem Akhtar, Amin Jan Gandapor, Arif Mehmood Khan
BACKGROUND: Septicemia plays an important role in neonatal morbidity and mortality, especially in developing countries. OBJECTIVE: To investigate the bacterial pathogens causing neonatal sepsis and their antibiotic susceptibility profile. METHODOLOGY: A total of 2,685 neonates aged 0-28 days were included in the study. Blood from each neonate was cultured and isolates were identified using standard biochemical tests. Antibiotic sensitivity pattern was analyzed using modified Kirby-Bauer disc diffusion method...
December 2016: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/27938357/erratum-to-neonatal-hyperbilirubinemia-in-infants-with-g6pd-c-563c%C3%A2-%C3%A2-t-variant
#10
Bushra Moiz, Amna Nasir, Sarosh Ahmed Khan, Saleema Amin Kherani, Maqbool Qadir
No abstract text is available yet for this article.
December 9, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27926647/central-fetal-monitoring-with-and-without-computer-analysis-a-randomized-controlled-trial
#11
Inês Nunes, Diogo Ayres-de-Campos, Austin Ugwumadu, Pina Amin, Philip Banfield, Antony Nicoll, Simon Cunningham, Paulo Sousa, Cristina Costa-Santos, João Bernardes
OBJECTIVE: To evaluate whether intrapartum fetal monitoring with computer analysis and real-time alerts decreases the rate of newborn metabolic acidosis or obstetric intervention when compared with visual analysis. METHODS: A randomized clinical trial carried out in five hospitals in the United Kingdom evaluated women with singleton, vertex fetuses of 36 weeks of gestation or greater during labor. Continuous central fetal monitoring by computer analysis and online alerts (experimental arm) was compared with visual analysis (control arm)...
January 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27718221/auditory-toxicity-in-late-preterm-and-term-neonates-with-severe-jaundice
#12
Sanjiv B Amin, Satish Saluja, Arvind Saili, Nirupama Laroia, Mark Orlando, Hongyue Wang, Asha Agarwal
AIM: Jaundice may cause auditory toxicity (auditory neuropathy and hearing loss). However, total serum bilirubin (TSB) does not discriminate neonates at risk for auditory toxicity. We compared TSB, bilirubin:albumin molar ratio (BAMR), and unbound bilirubin for their association with auditory toxicity in neonates with severe jaundice (TSB ≥342μmol/L, or that met exchange transfusion). METHOD: Neonates greater or equal to 34 weeks gestational age with severe jaundice during the first 2 postnatal weeks were eligible for prospective cohort study, unless they had craniofacial malformations, chromosomal disorders, toxoplasmosis, other infections, rubella, cytomegalovirus, herpes simplex infections, surgery, or family history of congenital deafness...
March 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27689072/the-role-of-pancreatic-stone-protein-in-diagnosis-of-early-onset-neonatal-sepsis
#13
Anwar A Rass, Mohamed A Talat, Mohamed A Arafa, Hosam F El-Saadany, Ezzat K Amin, Mohamed Mohamed Abdelsalam, Mona A Mansour, Naglaa A Khalifa, Lamiaa Mahmoud Kamel
Introduction. Early diagnosis and treatment of neonatal sepsis may help decrease neonatal mortality. Aim of the Study. To evaluate the role of pancreatic stone protein as a marker for early onset neonatal sepsis. Methods. A hospital-based prospective study was conducted on 104 (52 uninfected and 52 infected neonates) admitted to the Neonatal Intensive Care Unit (NICU) of Zagazig University hospitals during the period from April 2014 to April 2015. All newborns were subjected to full history taking, careful neonatal assessment, blood, C-reactive protein (CRP), and serum pancreatic stone protein...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27575005/morphological-analysis-of-regenerated-bulbar-fibers-in-relation-to-neonatal-olfaction
#14
Masafumi Kuroiwa, Nanae Fukushima, Kumiko Yokouchi, Kyutaro Kawagishi, Tetsuji Moriizumi
It was revealed that regeneration of the lateral olfactory tract (LOT) occurred in developing rats and the regenerated olfactory system was functional 4 weeks after transection. The aim of this study was to determine the earliest onset of functional recovery in LOT-injured rats and to quantify regenerated nerve components with functional correlation. Neonatal rats on postnatal day (P) 2 were subjected to unilateral transection of the left LOT and underwent unilateral removal of the right olfactory bulb on P11...
August 26, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27546354/vaginal-progesterone-vs-intramuscular-17%C3%AE-hydroxyprogesterone-caproate-for-prevention-of-recurrent-spontaneous-preterm-birth-in-singleton-gestations-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#15
REVIEW
G Saccone, A Khalifeh, A Elimian, E Bahrami, K Chaman-Ara, M A Bahrami, V Berghella
OBJECTIVE: Randomized controlled trials (RCTs) have recently compared intramuscular 17α-hydroxyprogesterone caproate (17-OHPC) with vaginal progesterone for reducing the risk of spontaneous preterm birth (SPTB) in singleton gestations with prior SPTB. The aim of this systematic review and meta-analysis was to evaluate the efficacy of vaginal progesterone compared with 17-OHPC in prevention of SPTB in singleton gestations with prior SPTB. METHODS: Searches of electronic databases were performed to identify all RCTs of asymptomatic singleton gestations with prior SPTB that were randomized to prophylactic treatment with either vaginal progesterone (intervention group) or intramuscular 17-OHPC (comparison group)...
March 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27493242/tlr2-mediated-leukocyte-trafficking-to-the-developing-brain
#16
Amin Mottahedin, Peter Lawrence Phillip Smith, Henrik Hagberg, C Joakim Ek, Carina Mallard
Inflammation is a significant risk factor for brain injury in the perinatal period. In this study, we tested the hypothesis that activation of peripheral TLR induces inflammation in the brain, including leukocyte trafficking. Postnatal day 8 mice were injected intraperitoneally with a TLR1/2 (Pam3CSK4, P3C), TLR2/6 (FSL-1) or TLR4 (LPS) agonist, and the peripheral and central cytokine and chemokine response was determined. Infiltration of immune cells to the CSF and brain was examined by flow cytometry, and brain permeability was investigated by radioactively labeled sucrose...
January 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27432157/an-fc-small-molecule-conjugate-for-targeted-inhibition-of-the-adenosine%C3%A2-2a-receptor
#17
Po-Yuan Hsiao, Jay H Kalin, Im-Hong Sun, Mohammed N Amin, Ying-Chun Lo, Meng-Jung Chiang, John Giddens, Polina Sysa-Shah, Kathleen Gabrielson, Lai-Xi Wang, Jonathan D Powell, Philip A Cole
The adenosine A2A receptor (A2A R) is expressed in immune cells, as well as brain and heart tissue, and has been intensively studied as a therapeutic target for multiple disease indications. Inhibitors of the A2A R have the potential for stimulating immune response, which could be valuable for cancer immune surveillance and mounting a response against pathogens. One well-established potent and selective small molecule A2A R antagonist, ZM-241385 (ZM), has a short pharmacokinetic half-life and the potential for systemic toxicity due to A2A R effects in the brain and the heart...
October 17, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27257052/histamine-is-correlated-with-liver-fibrosis-in-biliary-atresia
#18
Kejun Zhou, Guoxiang Xie, Jie Wen, Jun Wang, Weihua Pan, Ying Zhou, Yongtao Xiao, Yang Wang, Wei Jia, Wei Cai
BACKGROUND AND AIMS: Biliary atresia (BA) is a severe neonatal cholestasis disease that is caused by obstruction of extra bile ducts. Liver fibrosis progresses dramatically in BA, and the underlying molecular mechanism is largely unknown. METHODS: Amino acids and biogenic amines were quantified by targeted metabolomic methods in livers of 52 infants with BA and 16 infants with neonatal hepatitis syndrome (NHS). Normal adjacent nontumor liver tissues from 5 hepatoblastoma infants were used as controls...
August 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27235205/bilirubin-binding-capacity-in-the-preterm-neonate
#19
REVIEW
Sanjiv B Amin
Total serum/plasma bilirubin (TB), the biochemical measure currently used to evaluate and manage hyperbilirubinemia, is not a useful predictor of bilirubin-induced neurotoxicity in premature infants. Altered bilirubin-albumin binding in premature infants limits the usefulness of TB in premature infants. In this article, bilirubin-albumin binding, a modifying factor for bilirubin-induced neurotoxicity, in premature infants is reviewed.
June 2016: Clinics in Perinatology
https://www.readbyqxmd.com/read/27211062/sustained-lentiviral-mediated-overexpression-of-microrna124a-in-the-dentate-gyrus-exacerbates-anxiety-and-autism-like-behaviors-associated-with-neonatal-isolation-in-rats
#20
Amine Bahi
Autism spectrum disorders (ASD) are highly disabling psychiatric disorders. Despite a strong genetic etiology, there are no efficient therapeutic interventions that target the core symptoms of ASD. Emerging evidence suggests that dysfunction of microRNA (miR) machinery may contribute to the underlying molecular mechanisms involved in ASD. Here, we report a stress model demonstrating that neonatal isolation-induced long-lasting hippocampal elevation of miR124a was associated with reduced expression of its target BDNF mRNA...
September 15, 2016: Behavioural Brain Research
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