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Leukemia cutis

Sergio Pina-Oviedo, Carlos A Torres-Cabala, Roberto N Miranda, Michael T Tetzlaff, Selina Singh, Ronald P Rapini, Victor G Prieto, Phyu P Aung
Leukemia cutis develops in <4% of all acute leukemias. Concurrent acute myeloid leukemia (AML) and Langerhans cell histiocytosis (LCH) is rare, with most cases involving lymph nodes or spleen, and no cutaneous involvement. We report the case of a 59-year-old man who presented with fever, malaise, and fatigue. The CBC showed leukocytosis (30.4 × 10/L, 9% blasts), anemia, and thrombocytopenia. Bone marrow biopsy was diagnosed with AML, not otherwise specified, with mutations of FLT3 and IDH2 (R140Q). The patient developed skin rash on the right flank with the clinical differential diagnosis of herpes simplex virus or varicella-zoster virus infection/reactivation versus leukemia cutis...
October 18, 2016: American Journal of Dermatopathology
V Santosh Kumar
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Matteo Coen, Jacques Serratrice
No abstract text is available yet for this article.
August 24, 2016: American Journal of Medicine
Catherine J Choi, Samir A Melki
No abstract text is available yet for this article.
September 2016: Ophthalmology
Tobias Gyárfás, Juergen Wintgens, Wolfgang Biskup, Ilske Oschlies, Wolfram Klapper, Reiner Siebert, Susanne Bens, Claudia Haferlach, Roland Meisel, Michaela Kuhlen, Arndt Borkhardt
BACKGROUND: Neonatal leukemia is a rare disease with an estimated prevalence of about one to five in a million neonates. The majority being acute myeloid leukemia (AML), neonatal leukemia can present with a variety of symptoms including hyperleucocytosis, cytopenia, hepatosplenomegaly, and skin infiltrates. Chromosomal rearrangements including mixed lineage leukemia (MLL) translocations are common in neonatal AML. CASE PRESENTATION: A female neonate born at 34 weeks gestation presented with cardiorespiratory failure, hepatosplenomegaly, pancytopenia, and coagulopathy...
December 2016: Molecular and Cellular Pediatrics
Sarah Y Siu, Qiujie Jiang, Onder Alpdogan, Ashley Gochoco, Jerald Gong, Jason B Lee, Joya Sahu
No abstract text is available yet for this article.
July 2016: JAAD Case Reports
Kshitij Joshi, Harsha Panchal, Sonia Parikh, Gaurang Modi, Avinash Talele, Asha Anand, Urmila Uparkar, Nitin Joshi, Itesh Khatawani
The author describes paediatric case of relapsed acute lymphoblastic leukaemia (ALL) presented as aleukemic leukaemia cutis (ALC). A 2 year old child was admitted in tertiary oncology centre. He suffered from pre B cell ALL with absent Philadelphia chromosome. This patient received multiagent induction chemotherapy as per Berlin-Frankfurt-Munster (BFM) protocol for ALL. He achieved remission after 28 days of treatment. Subsequently he presented with multiple skin lesions in the form of multiple small erythematous violaceous macules, papules, plaques and nodules on face, chest and back regions...
June 2016: Indian Journal of Hematology & Blood Transfusion
Taher Chharchhodawala, Smeeta Gajendra, Priya Tiwari, Ajay Gogia, Ritu Gupta
Acute myeloid leukemia (AML) with t(8;16)(p11;q13) is a distinct clinical and morphological entity with poor prognosis, which is characterized by a high frequency of extramedullary involvement, most commonly leukemia cutis; association with therapy related AML; frequent coagulopathy and morphologic features overlapping acute promyelocytic leukemia(APL). Herein, we present a case of 47 year-old post-menopausal woman developing secondary AML with t(8;16)(p11;q13) after 1 year of completion of therapy for breast carcinoma...
June 2016: Indian Journal of Hematology & Blood Transfusion
Gabriel H Lipshutz, Felix S Chew
We present the case of a 54-year-old woman who had calcinosis cutis related to sclerodermatous chronic graft versus host disease. Graft versus host disease had developed following stem cell transplantation for acute myelogenous leukemia 14 years earlier, but was shown by skin biopsy to have resolved by the time of presentation. Radiographs showed extensive cutaneous calcifications in the lower extremities.
2008: Radiology case reports
Jae Hur, Yong Seok Kim, Hee Joon Yu, Joung Soo Kim
Congenital leukemia is a rare condition diagnosed at birth to 6 weeks of life with an estimated incidence of 4.7 per million live births. In a review, about 25~30% of cases were well documented as leukemia cutis. We report a case of a 3-month-old infant presented with asymptomatic multiple erythematous to bluish patches and nodules, which had developed about two months ago. Biopsy of the cutaneous lesions revealed immature cells which are overall monotonous with large kidney shaped nucleus, prominent nucleoli and moderate cytoplasm...
June 2008: Annals of Dermatology
Joseph Caravaglio, Rachel Wheatley, Molly Orban, Jeffrey Greenwald
No abstract text is available yet for this article.
March 2016: JAAD Case Reports
L Martínez-Leboráns, A M Victoria-Martínez, J L Torregrosa-Calatayud, V Alegre de Miquel
Dermatologic manifestations of leukemia can be both specific and nonspecific (e.g., opportunistic infections, purpura and ecchymosis, Sweet syndrome). Leukemia cutis refers to the infiltration of the skin with neoplastic leukocytes and its early diagnosis has important prognostic implications. We report on 17 cases of leukemia cutis seen in our department between 1994 and 2014 and describe the characteristics of the patients (age, sex, medical history), the morphology of the lesions, and associations with systemic disease...
May 19, 2016: Actas Dermo-sifiliográficas
Luciana de Sales Caldato, Juliana de Sousa Britto, Ligia Niero-Melo, Hélio Amante Miot
Bullous leukemia cutis is an uncommon clinical manifestation of cutaneous infiltration by leukemic cells, from B-cell chronic lymphocytic leukemia. We present the case of a 67-year-old, female, chronic lymphocytic leukemia patient. She was taking chlorambucil and developed facial edema with erythema and warmth, misjudged as facial cellulitis. Two days later, she developed bullous lesions in the arms, legs, neck and face. The histopathology of facial and bullous lesions confirmed leukemia cutis. All lesions disappeared following the administration of rituximab combined with cycles of fludarabine and cyclophosphamide...
April 2016: Anais Brasileiros de Dermatologia
Andrés Eduardo Campuzano-García, Bertha Torres-Álvarez, Juan Pablo Castanedo-Cázares
No abstract text is available yet for this article.
November 2015: JAAD Case Reports
Mariana Cruz Manzano, Lilliana Ramírez García, Julio E Sánchez Pont, Ana I Velázquez Mañana, Jorge L Sánchez
Leukemia cutis describes the infiltration and dissemination of neoplastic leukemic cells into the epidermis, dermis, or subcutis, resulting in clinically identifiable cutaneous lesions. Depending on the type of leukemia, a wide range of clinical and histopathological findings may be encountered. This report describes a patient with a rosacea-like eruption as a unique clinical presentation of T-cell prolymphocytic leukemia.
August 2016: American Journal of Dermatopathology
Eui Han Chung, Young Hwan Kim
No abstract text is available yet for this article.
March 2016: Archives of Plastic Surgery
Bin Xu, Daisy Naughton, Klaus Busam, Melissa Pulitzer
Leukemia cutis (LC) and reactive myeloid infiltrates in the skin may be difficult to distinguish pathologically, sometimes even after an extensive immunohistochemical work-up. This poses a serious clinical dilemma, as the prognosis and treatment of either condition are markedly different. Although most reactive myeloid infiltrates require a simple course of corticosteroids before the symptoms regress, the development of LC may require chemotherapeutic or transplant-variant interventions. Erythroblast transformation specific regulated gene-1 (ERG) is a member of the erythroblast transformation specific family of transcription factors, which are downstream effectors of mitogenic signaling transduction pathways...
September 2016: American Journal of Dermatopathology
Alexandros Iliadis, Triantafyllia Koletsa, Elisavet Georgiou, Aikaterini Patsatsi, Dimitrios Sotiriadis, Ioannis Kostopoulos
Leukemic infiltrates may be seen in the skin in the absence of detectable bone marrow involvement. Leukemia cutis may exceptionally occupy the eyelids. An unusual case of a 58-year-old man presenting bilateral erythematous eyelid lesions, proven to be aleukemic leukemia cutis, is reported. Biopsy was conducted and hematoxylin/eosin stained sections were histologically evaluated. Immunohistochemistry was also performed.Light microscopy revealed cutaneous infiltration by a neoplastic population consisting of medium-sized cells...
April 2016: American Journal of Dermatopathology
Kyle Stang, Fiori Alite, Jennifer Steber, Bahman Emami, Murat Surucu
Malignancies with a superficial involvement of the scalp present a unique technical challenge for radiation treatment planning. As an example of this, leukemic infiltration of the superficial skin as the only presentation of the disease is a rare entity. For such cases, radiation oncologists have typically treated with 3D conformal radiotherapy with matched electron fields, a technique that can lead to significant dose inhomogeneity. In this report, we describe the case of a patient with leukemia cutis with a superficial involvement of the scalp, face, and shoulders that was treated with volumetric modulated arc radiotherapy, with an impressive clinical response...
December 23, 2015: Curēus
Hongbin Zhu, Xuechun Lu, Lei Zhang
No abstract text is available yet for this article.
January 2016: American Journal of the Medical Sciences
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