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Leukemia cutis

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https://www.readbyqxmd.com/read/29723350/clinical-and-pathological-features-of-myeloid-leukemia-cutis
#1
Li Li, Yanan Wang, Christine Guo Lian, Nina Hu, Hongzhong Jin, Yuehua Liu
BACKGROUND: Myeloid leukemia cutis is the terminology used for cutaneous manifestations of myeloid leukemia. OBJECTIVE: The purpose of this study was to study the clinical, histopathological and immunohistochemical features of myeloid leukemia cutis. METHODS: This was a retrospective study of clinical and pathological features of 10 patients with myeloid leukemia cutis. RESULTS: One patient developed skin lesions before the onset of leukemia, seven patients developed skin infiltration within 4-72 months after the onset of leukemia, and two patients developed skin lesions and systemic leukemia simultaneously...
March 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29660158/cutaneous-presentation-preceding-acute-myeloid-leukemic-with-cd4-cd56-expression-misdiagnosed-as-a-blastic-plasmocytoid-dendritic-cell-neoplasm-a-case-report
#2
Vanessa Szablewski, Valérie Costes, Caroline Bret, Olivier Dereure, Hicheri Yosr, Melissa Alame, Valère Cacheux
Acute myeloid leukemia (AML) may initially present as cutaneous lesions corresponding to blasts involving the skin as the first clinical manifestation prior to blood and bone marrow (BM) infiltration. Such presentation is known as myeloid leukemia cutis (LC). Blastic plasmocytoid dendritic cell neoplasm (BPDCN) is an aggressive tumour derived from the precursors of plasmocytoid dendritic cells with cutaneous and bone marrow (BM) involvement and leukemic dissemination. Myeloid LC and BPDCN may be difficult to distinguish as they share similar clinical and histopathological features, in particular AML with monocytic differentiation...
April 16, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29607809/leukemia-cutis
#3
Joachim Dissemond, Elvir Cesko
No abstract text is available yet for this article.
March 16, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29443697/t-lymphoblastic-leukemia-lymphoma-with-annular-skin-rash-and-epidermotropism
#4
Parisa Mansoori, Arash Taheri, Stacey S OʼNeill, Omar P Sangueza
Leukemia cutis is uncommon in patients with acute lymphoblastic leukemia. It typically presents with dermal papules or subcutaneous nodules, with no epidermal or upper papillary dermal involvement on histopathology. We present an unusual clinical presentation of leukemia cutis, with annular plaques and epidermotropism.
February 7, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29286213/risk-factors-for-invasive-fungal-infection-among-thai-oncologic-patients-with-febrile-neutropenia-and-cutaneous-presentation-a-5-year-retrospective-study-in-southern-thailand
#5
Kumpol Aiempanakit, Surarit Naorungroj, Kanokphorn Chiratikarnwong, Sauvarat Auepemkiate, Benjawan Apinantriyo
Background: Febrile neutropenia (FNP) is a condition defined by fever and neutropenia. There are current only limited data on related cutaneous manifestations. This study aimed to assess cutaneous lesions and their etiologies in a Thai group of FNP patients. Methods: A retrospective analysis was conducted on 43 non-transplant febrile neutropenic patients with concurrent cutaneous lesions, as determined by dermatopathologic studies at Songklanagarind Hospital in Thailand over a five-year period. Results: The mean age was 39 years (SD: 18...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29033820/pachyderma-in-primary-cutaneous-nk-and-t-cell-lymphoma-and-leukemia-cutis
#6
Eve Lebas, Cesar Chian, Nazli Nikkels-Tassoudji, Jorge E Arrese, Arjen F Nikkels
BACKGROUND: Pachyderma is defined as severely thickened skin with deep folds and is occasionally observed with primary cutaneous NK and T-cell lymphoma (pCNKTCL), primary cutaneous B-cell lymphoma (pCBCL), and leukemia cutis (LC). AIM: To describe the clinical, histological, and therapeutic particularities of a series of pCNKTCL, pCBCL, and LC patients with pachyderma. RESULTS: In a series of pCNKTCL ( n = 70), pCBCL ( n = 12), and LC ( n = 2) patients followed up during 9 years, 6 cases of pachyderma were observed...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28981149/an-interesting-case-of-pyoderma-gangrenosum-with-immature-hystiocytoid-neutrophils
#7
Catherine Besner Morin, Benoit Côté, Annie Belisle
We present a unique case of a 36-year-old male who developed more than 20 pyoderma gangrenosum (PG) ulcers showing on histopathology a dense inflammatory infiltrate composed of histiocytoid mononuclear immature cells with a strong positivity for myeloperoxidase and Leder stain, suggesting a myeloid lineage in the absence of a concomitant myeloproliferative disorder. Histiocytoid Sweet syndrome (SS) is now recognized as a histological subtype of SS. Although PG and SS belong to the spectrum of neutrophilic diseases, to the best of our knowledge, this is the first case of a "Histiocytoid pyoderma gangrenosum" encompassing immature granulocytes in the absence of leukemia cutis...
January 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28885352/successful-5-azacytidine-treatment-of-myeloid-sarcoma-and-leukemia-cutis-associated-with-myelodysplastic-syndrome-a-case-report-and-literature-review
#8
REVIEW
Takayuki Katagiri, Takashi Ushiki, Masayoshi Masuko, Tomoyuki Tanaka, Shukuko Miyakoshi, Kyoko Fuse, Yasuhiko Shibasaki, Jun Takizawa, Sadao Aoki, Hirohito Sone
RATIONALE: Myeloid sarcoma (MS) and leukemia cutis (LC) are extramedullary tumors comprising myeloid blasts. They can occur de novo or concurrently with hematological disorders, usually acute myeloid leukemia (AML). AML chemotherapy is generally the initial therapy for MS and LC, and hematopoietic stem cell transplantation (HSCT) can be considered as additional therapy. However, treatment for older patients who are unable to continue intensive chemotherapy is not currently standardized...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28802501/myeloid-neoplasms
#9
REVIEW
Antonio Subtil
The classification of myeloid neoplasms has undergone major changes and currently relies heavily on genetic abnormalities. Cutaneous manifestations of myeloid neoplasms may be the presenting sign of underlying bone marrow disease. Dermal infiltration by neoplastic cells may occur in otherwise normal skin or in sites of cutaneous inflammation. Leukemia cutis occasionally precedes evidence of blood and/or bone marrow involvement (aleukemic leukemia cutis).
September 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28731674/-leukemia-cutis
#10
Noelia M Gómez, Cristina Battagliotti, Silvina Sartori, Gabriela Gea Sánchez
No abstract text is available yet for this article.
August 1, 2016: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28670077/mixed-phenotypic-acute-leukemia-with-leukemia-cutis-and-neuroleukemiosis
#11
Rona Joseph Poikayil, Geetha Narayanan, Harish Sugathan, Lali V Soman
Leukemia cutis and neuroleukemiosis are two rare extramedullary manifestations of acute leukemia. We report a 32-year-old woman with multiple skin lesions and painful peripheral neuropathy. Bone marrow biopsy and skin biopsy confirmed the diagnosis of mixed phenotypic acute leukemia. After induction chemotherapy, she attained marrow remission, her skin lesion resolved completely, and her neurologic symptoms significantly improved.
July 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28620566/leukemia-cutis-associated-with-secondary-plasma-cell-leukemia
#12
Nicole C DeMartinis, Megan M Brown, Brian R Hinds, Philip R Cohen
Plasma cell leukemia is an uncommon, aggressive variant of leukemia that may occur de novo or in association with multiple myeloma. Leukemia cutis is the cutaneous manifestation of leukemia, and indicates an infiltration of the skin by malignant leukocytes or their precursors. Plasma cell leukemia cutis is a rare clinical presentation of leukemia. We present a man who developed plasma cell leukemia cutis in association with multiple myeloma. Cutaneous nodules developed on his arms and legs 50 days following an autologous stem cell transplant...
May 9, 2017: Curēus
https://www.readbyqxmd.com/read/28556258/extramedullary-disease-at-diagnosis-of-aml-does-not-influence-outcome-of-patients-undergoing-allogeneic-hematopoietic-cell-transplant-in-cr1
#13
Christianne Bourlon, Jeffrey H Lipton, Uday Deotare, Vikas Gupta, Dennis D Kim, John Kuruvilla, Auro Viswabandya, Santhosh Thyagu, Hans A Messner, Fotios V Michelis
OBJECTIVE: Extramedullary disease (EMD) at diagnosis of acute myeloid leukemia (AML) has been associated with increased risk of relapse and worse outcomes post-chemotherapy. This study sought to investigate the association of EMD with outcomes following allogeneic hematopoietic cell transplantation (allo-HCT). METHODS: This single-center retrospective study investigated the impact of EMD at diagnosis on the outcome of patients transplanted for AML in first complete remission (CR1)...
September 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28376531/aleukemic-myeloid-leukemia-cutis-with-a-kikuchi-disease-like-inflammatory-pattern-in-myelodysplastic-syndrome
#14
Michelle Khieu, Alexis Beauvais, Rebecca Matz, Adrian Bersabe, Patrick Brown, Alexander Brown, Eric Fillman, Jordan Hall
Myeloid leukemia cutis (MLC) is a rare disease characterized by the infiltration of neoplastic myeloid, myelomonocytic, or monocytic precursors into the skin, producing clinically nonspecific-appearing papules, nodules, plaques, or purpura that necessitate biopsy for definitive diagnosis. In general, it is considered an extramedullary manifestation of acute myeloid leukemia (AML) similar to myeloid sarcoma, also known as a chloroma. MLC often develops in patients with an established diagnosis of AML and is only rarely seen before the onset of systemic disease...
April 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28329516/precursor-b-cell-all-leukemia-cutis-resembling-lipomas-an-atypical-presentation-of-a-rare-entity-and-a-review-of-the-literature
#15
REVIEW
Yuan Yu Michael Huang, Melinda Liu, Jennifer S Ruth, Silvia Potenziani, Sylvia Hsu
Leukemia cutis (LC) is an extramedullary manifestationof leukemia owing to cutaneous infiltration ofneoplastic cells resulting in characteristic firm,erythematous nodules. Most cases of LC occur inpatients with acute myelogenous leukemia andchronic myelogenous leukemia. However in rarecases, LC has presented in patients with acutelymphoblastic leukemia (ALL). In these rare ALLassociatedcases, only 10 cases of precursor-B-ALL(pre-B-ALL) have been described in the literature.We report a case of a 22-year-old man with relapsingpre-B-ALL who presented with a 4-day history ofmultiple asymptomatic, soft, dome-shaped, lipomalikemounds on his scalp and chin, which exhibitedcutaneous involvement by leukemic cells...
March 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28296991/clinicopathologic-immunohistochemical-and-molecular-features-of-histiocytoid-sweet-syndrome
#16
Victoria Alegría-Landa, Socorro María Rodríguez-Pinilla, Angel Santos-Briz, José Luis Rodríguez-Peralto, Victor Alegre, Lorenzo Cerroni, Heinz Kutzner, Luis Requena
Importance: Histiocytoid Sweet syndrome is a rare histopathologic variant of Sweet syndrome. The nature of the histiocytoid infiltrate has generated considerable controversy in the literature. Objective: The main goal of this study was to conduct a comprehensive overview of the immunohistochemical phenotype of the infiltrate in histiocytoid Sweet syndrome. We also analyze whether this variant of Sweet syndrome is more frequently associated with hematologic malignancies than classic Sweet syndrome...
July 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28272239/cutaneous-presentation-preceding-acute-monocytic-leukemia-a-care-compliant-article
#17
Xianhua Jin, Fuqiu Li, Xue Li, Wenjing Zhu, Yan Mou, Yang Huang, Huanyu Zhao, Wei Gao, Jianxin Xia
RATIONALE: Cutaneous presentation preceding acute myeloid leukemia (AML) is rare, and the prognosis is poor. PATIENT CONCERNS: We report 4 cases of AML cutis, where skin infiltration precedes any blood or bone marrow evidence of leukemia. We also reviewed 13 cases reported in English and Chinese literature. The 4 cases all presented typical cutaneous lesions without any systemic evidence of leukemia. Histopathological examination found that dense monomorphous cell infiltration involved the dermis...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28183685/a-case-of-leukemia-cutis-with-acute-myeloid-leukemia-on-azacitidine-therapy
#18
Asude Kara, Aslı Akın Belli, Volkan Karakuş, Yelda Dere, Erdal Kurtoğlu
No abstract text is available yet for this article.
June 5, 2017: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/28097792/fish-identifies-a-kat6a-crebbp-fusion-caused-by-a-cryptic-insertional-t-8-16-in-a-case-of-spontaneously-remitting-congenital-acute-myeloid-leukemia-with-a-normal-karyotype
#19
Rachel Barrett, Barbara Morash, David Roback, Chantale Pambrun, Lesley Marfleet, Rhett P Ketterling, Karen Harrison, Jason N Berman
Cytogenetics can inform risk stratification in pediatric acute myeloid leukemia (AML). We describe the first case of a newborn with leukemia cutis found to have AML harboring a cryptic insertional t(8;16)(p11.2;p13.3) with associated KAT6A/CREBBP fusion identified exclusively by fluorescence in situ hybridization (FISH). Expectant management resulted in spontaneous leukemia resolution. The identification of t(8;16)(p11.2;p13.3) may serve as a biomarker for spontaneous remission in congenital AML. FISH for this translocation is warranted in congenital AML with a normal karyotype, and patients with KAT6A/CREBBP fusion should be conservatively managed...
August 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28093639/the-effectiveness-of-radiotherapy-for-leukemia-cutis
#20
Khaled Elsayad, Michael Oertel, Uwe Haverkamp, Hans Theodor Eich
BACKGROUND: Leukemia cutis (LC) is a rare clinical presentation of leukemia that is associated with poor prognosisabs. To date, the value of radiotherapy (RT) for the treatment of LC remains controversial. Therefore, the aim of this study was to analyse the effectiveness of various RT doses for LC. METHODS AND MATERIALS: Between January 2000 and January 2016, 13 patients underwent RT at our institution after exhibiting progressive disease following other treatment modalities...
May 2017: Journal of Cancer Research and Clinical Oncology
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