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experimental anastomosis

Juan Manuel Suárez-Grau, Carlos Bernardos García, Carmen Cepeda Franco, Cristina Mendez García, Salud García Ruiz, Fernando Docobo Durantez, Salvador Morales-Conde, Javier Padillo Ruiz
AIM: To evaluate the effectiveness of human fibrinogen-thrombin collagen patch (TachoSil(®)) in the reinforcement of high-risk colon anastomoses. METHODS: A quasi-experimental study was conducted in Wistar rats (n = 56) that all underwent high-risk anastomoses (anastomosis with only two sutures) after colectomies. The rats were divided into two randomized groups: Control group (24 rats) and treatment group (24 rats). In the treatment group, high-risk anastomosis was reinforced with TachoSil(®) (a piece of TachoSil(®) was applied over this high-risk anastomosis, covering the gap)...
September 27, 2016: World Journal of Gastrointestinal Surgery
Gürhan Güngör, Gökhan Demiral, Metin Şenol, Barış Bayraktar, Yahya Çelik, Salih Bölük
INTRODUCTION: Major complications of colonic anastomosis include fistula, bleeding, and anastomotic stricture, and the most common one is anastomotic leakage. Many organic or inorganic tissue adhesives are being used such as fibrin glue or cyanoacrylate to strengthen or protect colonic anastomosis. Up to now, a great number of studies have been carried out to investigate the effects of these biomaterials. AIM: To determine the effect of cyanoacrylate application on anastomosis safety...
2016: Przegla̜d Gastroenterologiczny
Rahman Şenocak, Mustafa Tahir Özer, Şahin Kaymak, Zafer Kılbaş, Armağan Günal, Metin Uyanık, Orhan Kozak
PURPOSE: Anastomotic leaks following intestinal operations may cause devastating effects on patients. Ischemia may also occur at the intestinal walls in the presence of strangulations. In this study, we examined the effects of human recombinant (Hr)-epidermal growth factor (EGF) given at a single intramural dose into the intestinal walls and daily intraperitoneal cavity on ischemia and the healing process of anastomosis. MATERIALS AND METHODS: Sixteen male New Zeland white rabbits were randomly divided into four groups (n = 4 in each group)...
October 3, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Dagmara Hering, Carl Schultz, Markus P Schlaich
PURPOSE: Resistant hypertension (RH) is a major and growing public health problem. While noncompliance to antihypertensive medication is a major concern in RH patients, it is estimated that even with adequate multi-drug regimens, approximately 10% of patients diagnosed with hypertension fulfill the criteria of true RH. Patients with sustained blood pressure (BP) elevation display high risk for development of target organ damage and associated cardiovascular morbidity and mortality. While optimized pharmacologic therapy, including the use of mineralocorticoid receptor antagonists to guideline-based antihypertensive drug therapy, is effective for improving BP control in this patient cohort, a sizable proportion of RH patients' BP remains uncontrolled, and alternative therapeutic strategies are warranted...
September 23, 2016: Clinical Therapeutics
Sanaz Mosafer Khoorjestan, Gholamreza Rouhi, Karamollah Toolabi
How the distance of sutures from the edge of tissue and the horizontal distance between stitches affect the mechanical strength of anastomosis is investigated. In this study, 180 bovine intestines were used to investigate the optimum pattern in 18 groups by considering a 4, 6, and 8 mm horizontal distance between stitches, and a 3, 5, and 7 mm distance from the edge of tissue with 3-0 Silk and 3-0 PDS sutures to maximize the strength of anastomosis (10 specimens in each group). Also, 80 specimens were used to investigate the maximum effective distance of sutures from the edge of tissue in eight groups of: 3, 5, 7, and 10 mm distance from the edge, with the same type of sutures...
August 17, 2016: Biomedizinische Technik. Biomedical Engineering
Ömer Faik Ersoy, Namık Özkan, Zeki Özsoy, Hüseyin Ayhan Kayaoğlu, Erdinç Yenidoğan, Alper Çelik, Aziz Fikret Özuğurlu, Ebru Arabacı Çakır, Neşe Lortlar
BACKGROUND: The present objective was to identify effects of early melatonin application on healing of anastomotic wound and inflammation in an experimental sepsis model. METHODS: A total of 60 Wistar albino rats were divided into 2 groups. Cecal ligation puncture (CLP) and colonic resection anastomosis were performed on both the control group and the melatonin treatment group. Both groups were divided into 3 subgroups consisting of 10 rats each. One subgroup from each group underwent re-laparotomy at the 16th hour, the next on the 3rd day, and the final subgroup on the 7th day...
July 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
Andreas Kirschbaum, Stefanie Hemmerling, Thorsten Steinfeldt, Detlef K Bartsch, Nikolas Mirow
BACKGROUND: After resection of the carina with a length of more than 4 cm, anastomoses often need to be performed under tension despite maximum mobilization. If the patient cannot be extubated, the anastomosis remains under continued stress. Anastomoses of the carina can be constructed using various suture techniques, including single interrupted sutures, back wall running but front wall single interrupted sutures, and complete running suture. This experimental study was designed to determine the most tensile stress-resistant anastomotic suture technique...
August 31, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
Farzad Borumandi, James P Higgins, Heinz Buerger, Anna Vasilyeva, Memmet Emre Benlidayi, Leman Sencar, Alexander Gaggl
In arterialized venous flaps (AVFs) the venous network is used to revascularize the flap. While the feasibility of AVFs in soft tissues has been reported there is no study on osseous AVFs. In this study we aim to assess the flap survival of osseous AVFs in a pig model. Medial femoral condyle flaps were elevated in 18 pigs. Three groups were created: AVF (n = 6), conventional arterial flap (cAF, n = 6) and bone graft (BG, n = 6). The AVFs were created by anastomosis of genicular artery with one vena comitans while leaving one efferent vein for drainage...
2016: Scientific Reports
Juramt Bold, Hiromi Sakata-Haga, Yoshihiro Fukui
To examine in detail spinal nerve defects induced by prenatal exposure to valproic acid in mice, pregnant ICR mice were subcutaneously injected with a single dose of 400 mg/kg valproic acid on gestational day 6, 7, 8, or 9, and their embryos were observed on gestational day 10. The whole-mount immunostaining using an anti-neurofilament antibody allowed us to identify spinal nerve defects, such as a loss of bundle, anastomosis among bundles arising from adjacent segment, and a disrupted segmental pattern of the dorsal root ganglia, in valproic acid-exposed embryos...
August 22, 2016: Anatomical Science International
Osman Bilgin Gulcicek, Ali Solmaz, Hakan Yiğitbaş, Candas Ercetin, Erkan Yavuz, Kamil Ozdogan, Sinan Arici, Asli Kahraman Akkalp, Tulin Sarac, Fatih Çelebi, Atilla Celik
Introduction. Short bowel syndrome can crop up if more than 50% of small intestine is resected or when less than 100 cm of small bowel is left. Glutamine is the main food source of enterocytes. Curcumin has protective effects on intestinal ischemia-reperfusion damage. Nesfatin-1 is a satiety molecule. It has protective effects on gastric mucosa. The primary purpose of this study is to compare effects of glutamine, curcumin, and nesfatin-1 on the gastric serosal surface neomucosa formation on rats. Materials and Methods...
2016: Gastroenterology Research and Practice
Flavio H F Galvão, Daniel R Waisberg, Victor E Seid, Anderson C L Costa, Eleazar Chaib, Rachel Rossini Baptista, Vera Luiza Capelozzi, Cinthia Lanchotte, Ruy J Cruz, Jun Araki, Luiz Carneiro D'Albuquerque
Fecal incontinence is a challenging condition with numerous available treatment modalities. Success rates vary across these modalities, and permanent colostomy is often indicated when they fail. For these cases, a novel potential therapeutic strategy is anorectal transplantation (ATx). We performed four isogeneic (Lewis-to-Lewis) and seven allogeneic (Wistar-to-Lewis) ATx procedures. The anorectum was retrieved with a vascular pedicle containing the aorta in continuity with the inferior mesenteric artery and portal vein in continuity with the inferior mesenteric vein...
2016: Scientific Reports
Murat Arikan, Guray Togral, Askin Esen Hasturk, Bahriye Horasanli, Fatma Helvacioglu, Atilla Dagdeviren, Mustafa Agah Tekindal, Murat Parpucu
AIM: We analyzed the therapeutic effects of long-term alpha lipoic acid and vitamin B12 use via histomorphometric methods and electron microscopy in the transected sciatic nerves of rats. MATERIAL AND METHODS: Forty rats were randomized into five groups (n=8/group). In group 1, 1 cm segment of sciatic nerve was resected without any other intervention. In group 2 (sham), primary epineural anastomosis was performed and in group 3 (saline), after nerve transection intraperitoneal physiologic saline was applied...
February 20, 2015: Turkish Neurosurgery
Shu-Ling Hung, Yu-Hua Lin, Hsing-Yu Yang, Chia-Chan Kao, Hong-Yu Tung, Li-Hsiang Wei
AIMS AND OBJECTIVES: To assess the efficacy of pelvic floor muscle exercise for enhancing fecal incontinence quality of life after coloanal anastomosis in colorectal cancer patients. BACKGROUND: Methods of improving incontinence have been evaluated in many countries, but never in a Taiwan population. DESIGN: A longitudinal experimental study. METHODS: Fifty-two colorectal cancer patients who had received colostomy closure and coloanal anastomosis surgery were recruited from a general hospital in southern Taiwan and randomly assigned to an experimental group (n = 26) or a control group (n = 26)...
September 2016: Journal of Clinical Nursing
Alper Mete Ugurlu, Salih Onur Basat, Fatih Ceran, Burhan Ozalp, Omer Berkoz
OBJECTIVE: Blockages in anastomotic vessels cause complete loss of free tissue transfer and replanted limb. Many studies have been conducted in the last 30 years to solve this problem. There are insufficient studies dealing with the effects of the limited adventitiectomy done before surgery for sympathetic overactivity leading situations. The aim of this experimental study is to reveal the effects of limited adventitiectomy. METHODS: In this study, limited adventitiectomy was performed in a wide area before surgery, and the effect of this practice on the vessel diameter and anastomosis was investigated...
July 12, 2016: Journal of Plastic Surgery and Hand Surgery
Remzi Kızıltan, Özkan Yılmaz, Sebahattin Çelik, Serkan Yıldırm, Hamit Hakan Alp, Abbas Aras, Çetin Kotan
AIM: To evaluate the effect of thymoquinone on the healing of experimental left colon anastomosis in rats. METHODS: Forty Wistar albino rats weighing 250-300 g were randomly divided into four groups (10 rats/group). Group 1 (control group) rats were not administered Thymoquinone (TQ) for 3 days after the operation. Group 2 was administered daily TQ for 3 days starting from the first day after the operation. Group 3 was not administered TQ for 7 days after the operation...
2016: SpringerPlus
Idoia Díaz-Güemes Martín-Portugués, Ana Maria Matos-Azevedo, Silvia Enciso Sanz, Francisco Miguel Sánchez-Margallo
OBJECTIVE: To evaluate the feasibility of laparoscopic cholecystoduodenostomy in canine cadavers using barbed self-locking sutures. STUDY DESIGN: In vivo experimental study. ANIMALS: Fresh male Beagle cadavers (n=5). METHODS: Surgery was performed by a single veterinary surgeon. Dogs were placed in dorsal recumbency and 15° reverse Trendelenburg position. The surgical procedure was performed with four 5 mm entry ports and a 5 mm 30° telescope...
July 6, 2016: Veterinary Surgery: VS
Qiang Xiao, Xuepu Zhang, Yuexin Wu
This study is intended to explore the role of human umbilical-cord-derived mesenchymal stem cells (HUC-MSCs) in nerve end-to-side anastomosis, as well as in the induction and promotion of growth of nerve lateral bud. The chitosan nerve conduit was prepared based on the biological characteristics of chitosan, and the nerve conduit was filled with HUC-MSCs, and was used to bridge the nerve end-to-side anastomotic stoma. The experimental animals were randomly assigned into three groups (10 in each group), and the nerve end-to-side anastomosis was conducted: (1) group A (control group): traditional tibial nerve-common peroneal nerve end-to-side anastomosis; (2) group B (experimental group 1): tibial nerve-common peroneal nerve end-to-side anastomotic stoma bridged with chitosan nerve conduit; (3) group C (experimental group 2): tibial nerve-common peroneal nerve end-to-side anastomotic stoma bridged by chitosan nerve conduit filled with HUC-MSCs...
November 2015: Cell Biochemistry and Biophysics
Jihoon Park, Sangjun Yim, Seok-Chan Eun
Face allotransplantation represents a novel frontier in complex human facial defect reconstruction. To develop more refined surgical techniques and yield fine results, it is first imperative to make a suitable animal model. The development of a composite facial allograft model in swine is more appealing: the facial anatomy, including facial nerve and vascular anatomy, is similar to that of humans. Two operative teams performed simultaneously, one assigned to harvest the donor and the other to prepare the recipient in efforts to shorten operative time...
June 2016: Journal of Craniofacial Surgery
Marcus Krüger, Norman Zinne, Christian Biancosino, Klaus Höffler, Taufiek K Rajab, Karl-Heinz Waldmann, Danny Jonigk, Murat Avsar, Axel Haverich, Doris Hoeltig
OBJECTIVES: Lung auto-transplantation is the surgical key step in experiments involving ex vivo therapy of severe or end-stage lung diseases. Ex vivo therapy has become a clinical reality because of systems such as the Organ Care System (OCS) Lung, which is the only commercially available portable lung perfusion system. However, survival experiments involving porcine lung auto-transplantation pose special surgical and anaesthesiological challenges. This current study was designed to describe the development of surgical techniques and aneasthesiological management strategies that facilitate lung auto-transplantation survival surgery including a follow-up period of 4 days...
September 2016: Interactive Cardiovascular and Thoracic Surgery
Dániel Kollár, Tamás Huszár, Zsolt Pohárnok, Éva Cselovszky, Attila Oláh
The prevalence of pancreatic diseases needing surgical intervention is continuously rising. Distal pancreatectomy is performed in the case of pathologies affecting the left side of the pancreas. More and more sophisticated surgical techniques have appeared and an increasing number of published articles discuss the possibilities for closure of the pancreatic remnant. However, the optimum solution is still under debate, as none of the examined techniques have been proven superior in reducing the incidence of the most common surgical complication, the formation of a postoperative pancreatic fistula (PF)...
2016: Digestive Surgery
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