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experimental anastomosis

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https://www.readbyqxmd.com/read/28076621/experimental-model-for-sutureless-proximal-anastomosis-by-the-viabahn-open-revascularization-technique-vortec
#1
Lucas Marcelo Dias Freire, Giuliana Biasi Gobbi, Inácio Maria Dal Fabbro, Fábio Hüsemann Menezes
Introduction: In the treatment of complex aneurysms, debranching is an extra-anatomical revascularization of visceral arteries followed by endograft coverage of the thoracoabdominal aorta. It eliminates the need for a thoracotomy and aortic clamping, but requires the performance of several technically demanding visceral anastomosis. In 2008, Lachat described visceral revascularization with the use of a sutureless distal anastomosis, performed by the telescoping of an endograft in the visceral branch, named VORTEC (Viabahn Open Revascularization TEChnique)...
November 2016: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28052453/comparison-of-calculated-and-experimentally-determined-sid-of-cp-and-aa-in-complex-diets-differing-in-aa-contents-for-grower-finisher-pigs
#2
K Büsing, A Berk, S Müller, S Kieckhäven, K Krüger, A Zeyner
In practice, the content of standardized ileal digestible AA in complex feeds for pigs is calculated on the basis of tabulated values for individual feedstuffs. It comes into question, however, whether this truly reflects an accurate content based upon the estimate made for the individual feedstuffs. The objective of this study was to compare standardized ileal digestibility (SID) of crude protein (CP) and selected AA in complex feeds for grower and finisher pigs either calculated or experimentally determined...
January 4, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28040750/a-minimally-invasive-approach-for-open-surgical-thoracoabdominal-aortic-replacement-experimental-concept-for-a-novel-surgical-procedure
#3
Terézia B Andrási, Violetta Kékesi, Béla Merkely, Marius Grossmann, Bernhard C Danner, Friedrich A Schöndube
OBJECTIVES: We aimed to develop a simple, reliable, and timesaving technique for the therapy of thoracoabdominal aortic (TAA) aneurysms that are not suitable for endovascular repair. METHODS: In this pilot study, we sought to combine the advantages of classic open vascular procedure with the use of endoscopic surgical tools and small skin incisions to develop a minimally invasive approach for TAA replacement. The following procedures were used: endoscopic exposure and closure of the lower intercostal arteries; small posterolateral thoracotomy and left retroperitoneal incisions to expose the anastomotic regions of the aorta; partial anticoagulation; passive bypass and sequential aortic clamping; tunnelling of the graft through the native aortic lumen (endoaneurysmorrhaphy) and open performance of vascular anastomosis...
December 31, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28033272/intraoperative-dexmedetomidine-and-postoperative-cerebral-hyperperfusion-syndrome-in-patients-who-underwent-superficial-temporal-artery-middle-cerebral-artery-anastomosis-for-moyamoya-disease-a-retrospective-observational-study
#4
Hyungseok Seo, Ho-Geol Ryu, Je Do Son, Jeong-Soo Kim, Eun Jin Ha, Jeong-Eun Kim, Hee-Pyoung Park
Dexmedetomidine, a selective α2-agonist, reduces cerebral blood flow and has neuroprotective effects against cerebral ischemia/reperfusion injury in experimental animals. We examined whether intraoperative dexmedetomidine would reduce the incidence of postoperative cerebral hyperperfusion syndrome (CHS) after superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis in patients with moyamoya disease.The electronic medical records of 117 moyamoya patients who underwent STA-MCA anastomosis were reviewed retrospectively...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28009756/regeneration-and-cell-recruitment-in-an-improved-heterotopic-auxiliary-partial-liver-transplantation-model-in-the-rat
#5
Yoshihiro Ono, Angelica Pérez-Gutiérrez, Mladen I Yovchev, Kentaro Matsubara, Shinichiro Yokota, Jorge Guzman-Lepe, Kan Handa, Alexandra Collin de l'Hortet, Angus W Thomson, David A Geller, Hiroshi Yagi, Michael Oertel, Alejandro Soto-Gutierrez
BACKGROUND: Auxiliary partial liver transplantation (APLT) in humans is a therapeutic modality used especially to treat liver failure in children or congenital metabolic disease. Animal models of APLT have helped to explore therapeutic options. Though many groups have suggested improvements, standardizing the surgical procedure has been challenging. Additionally, the question of whether graft livers are reconstituted by recipient-derived cells after transplantation has been controversial...
January 2017: Transplantation
https://www.readbyqxmd.com/read/27975009/effect-of-previous-irradiation-on-vascular-thrombosis-of-microsurgical-anastomosis-a-preclinical-study-in-rats
#6
Sergi Barrera-Ochoa, Irene Gallardo-Calero, Alba López-Fernández, Cleofe Romagosa, Ramona Vergés, Marius Aguirre-Canyadell, Francisco Soldado, Roberto Velez
BACKGROUND: The objective of the present investigation was to compare the effect of neoadjuvant irradiation on the microvascular anastomosis in cervical bundle using an experimental model in rats. METHODS: One hundred forty male Sprague-Dawley rats were allocated into 4 groups: group I, control, arterial microanastomosis; group II, control, venous microanastomosis; group III, arterial microanastomosis with previous irradiation (20 Gy); and group IV, venous microanastomosis with previous irradiation (20 Gy)...
November 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27917665/the-potential-effect-of-biological-sealants-on-colorectal-anastomosis-healing-in-experimental-research-involving-severe-diabetes
#7
K Stergios, K Kontzoglou, V Pergialiotis, L M Korou, M Frountzas, O Lalude, N Nikiteas, D N Perrea
Colorectal anastomoses continuous to pose a significant challenge in current surgical practice. Anastomotic leakage remains one of the most frequent and dramatic complications of colorectal surgery, even in centres of high specialisation. Diabetes is a well-established independent factor which results in higher anastomotic leakage rates. Fibrin sealants have been applied in experimental and clinical studies for the prevention of anastomotic dehiscence. However, little is known regarding their impact on diabetic patients...
December 5, 2016: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27863029/endoluminal-vacuum-therapy-for-ivor-lewis-anastomotic-leaks-a-pilot-study-in-a-swine-model
#8
R B Scott, L A Ritter, A L Shada, S H Feldman, D E Kleiner
Anastomotic leaks are a serious complication associated with Ivor Lewis esophagectomies. Endoluminal negative pressure vacuum devices create a possible treatment alternative to conventional surgical intervention. Ten pigs had an intrathoracic esophageal anastomosis with a 1-cm defect. The experimental group had the device placed intraoperatively across the defect, whereas the control group did not. Once treatment was completed, a contrast fluoroscopic study and necropsy was performed. All control pigs had contrast extravasation on fluoroscopy and contamination on necropsy...
November 11, 2016: Clinical and Translational Science
https://www.readbyqxmd.com/read/27859294/tgf-%C3%AE-antagonist-attenuates-fibrosis-but-not-luminal-narrowing-in-experimental-tracheal-stenosis
#9
Juan L Antón-Pacheco, Alicia Usategui, Iván Martínez, Carmen M García-Herrero, Antonio P Gamez, Montserrat Grau, Ana M Martínez, José L Rodríguez-Peralto, José L Pablos
OBJECTIVE: Acquired tracheal stenosis (ATS) is an unusual disease often secondary to prolonged mechanical trauma. Acquired tracheal stenosis pathogenesis involves inflammation and subsequent fibrosis with narrowing of the tracheal lumen. Transforming growth factor-β1 (TGF-β) represents a pivotal factor in most fibrotic processes, and therefore a potential target in this context. The aim of this study is to analyze the role of TGF-β as a target for anti-fibrotic interventions in tracheal stenosis...
November 16, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27853330/effect-of-human-amniotic-membrane-on-prevention-of-colorectal-anastomosis-leakage-in-cases-with-neoadjuvant-radiotherapy-an-experimental-animal-study
#10
Sam Moslemi, Sajjad Ahmadi Joraghi, Reza Roshanravan, Leila Ghahramani, Mohammad Mohammadianpanah, Masood Hosseinzadeh, Abbas Rezaianzadeh, Ahmed Mohammed Ali Hussein, Neda Najibpour, Seyed Vahid Hosseini
BACKGROUND: Radiotherapy is one of the most important factors which results in negative effects on wound healing and increases anastomosis leakage. Diverting loop ileostomy has been usually performed after colorectal anastomosis in cases of colorectal cancer with a history of neoadjuvant radiotherapy to decrease the chance of leakage. Considering the side effects of diverting loop ileostomy, the objective of the present study is to investigate the effect of human amniotic membrane (HAM) on colorectal anastomosis leakage after neo-adjuvant radiotherapy...
November 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27849374/impact-of-motorized-articulating-laparoscopic-devices-with-three-dimension-visualizing-system-a-pilot-study
#11
Serdar Aykan, Yigit Akin, Eyyup Sabri Pelit, Hakan Gulmez, Murat Tuken, Aykut Colakerol, Atilla Semercioz, Ahmet Yaser Muslumanoglu
OBJECTIVE: To compare the efficacy between motorized articulating instruments (AI) and rigid conventional laparoscopic instruments (CI) in chancing visualizing systems, respectively two-dimension (2D) and three-dimension (3D). METHODS: Sixty physicians were divided into three groups according to their previous experience as medical students (Group 1), residents (Group 2), and expert surgeons (Group 3). Four experimental sets were created, respectively CI-2D visualizing system (CI-2D), CI-3D visualizing system (CI-3D), AI-2D visualizing system (AI-2D), and AI-3D visualizing system (AI-3D) platforms...
December 16, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27805444/feasibility-repeatability-and-safety-of-ultrasound-guided-stimulation-of-the-first-cervical-nerve-at-the-alar-foramen-in-horses
#12
Céline Mespoulhès-Rivière, Olivier Brandenberger, Fabrice Rossignol, Céline Robert, Justin D Perkins, Jean-Paul Marie, Norm Ducharme
OBJECTIVE To develop and assess the feasibility, repeatability, and safety of an ultrasound-guided technique to stimulate the first cervical nerve (FCN) at the level of the alar foramen of the atlas of horses. ANIMALS 4 equine cadavers and 6 clinically normal Standardbreds. PROCEDURES In each cadaver, the FCN pathway was determined by dissection, and any anastomosis between the first and second cervical nerves was identified. Subsequently, each of 6 live horses underwent a bilateral ultrasound-guided stimulation of the FCN at the alar foramen 3 times at 3-week intervals...
November 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27788509/experimental-electrophysiological-and-pressure-responses-of-urinary-bladder-detrusor-to-lumbar-to-sacral-nerve-rerouting-an-animal-study-with-negative-results
#13
Pavel Zerhau, Zdeněk Mackerle, Matej Husár, Daniela Sochůrková, Eva Brichtová, Eduard Gopfert, Martin Faldyna, Martin Kubát, Ladislav Plánka
: Background/Aims/Objectives: To verify the transfer of evoked potentials through anastomosis of an experimentally created micturition reflex arc and to detect said potentials directly on the detrusor and sphincter of rabbit urinary bladder. METHODS: During 2013-2015, 17 rabbits were operated upon and measurement followed during reoperation 3-16 months later. Suitable ventral spinal roots were electrophysiologically detected following laminectomy, and a somatic-central nervous system-autonomic micturition reflex arc was created...
2016: Urologia Internationalis
https://www.readbyqxmd.com/read/27721926/fibrinogen-thrombin-collagen-patch-reinforcement-of-high-risk-colonic-anastomoses-in-rats
#14
Juan Manuel Suárez-Grau, Carlos Bernardos García, Carmen Cepeda Franco, Cristina Mendez García, Salud García Ruiz, Fernando Docobo Durantez, Salvador Morales-Conde, Javier Padillo Ruiz
AIM: To evaluate the effectiveness of human fibrinogen-thrombin collagen patch (TachoSil(®)) in the reinforcement of high-risk colon anastomoses. METHODS: A quasi-experimental study was conducted in Wistar rats (n = 56) that all underwent high-risk anastomoses (anastomosis with only two sutures) after colectomies. The rats were divided into two randomized groups: Control group (24 rats) and treatment group (24 rats). In the treatment group, high-risk anastomosis was reinforced with TachoSil(®) (a piece of TachoSil(®) was applied over this high-risk anastomosis, covering the gap)...
September 27, 2016: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27713784/cyanoacrylate-application-on-colonic-anastomosis-is-it-safe-or-not
#15
Gürhan Güngör, Gökhan Demiral, Metin Şenol, Barış Bayraktar, Yahya Çelik, Salih Bölük
INTRODUCTION: Major complications of colonic anastomosis include fistula, bleeding, and anastomotic stricture, and the most common one is anastomotic leakage. Many organic or inorganic tissue adhesives are being used such as fibrin glue or cyanoacrylate to strengthen or protect colonic anastomosis. Up to now, a great number of studies have been carried out to investigate the effects of these biomaterials. AIM: To determine the effect of cyanoacrylate application on anastomosis safety...
2016: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/27690726/can-human-recombinant-epidermal-growth-factor-improve-ischemia-and-induce-healing-of-anastomosis-in-an-experimental-study-in-a-rabbit-model
#16
Rahman Şenocak, Mustafa Tahir Özer, Şahin Kaymak, Zafer Kılbaş, Armağan Günal, Metin Uyanık, Orhan Kozak
PURPOSE: Anastomotic leaks following intestinal operations may cause devastating effects on patients. Ischemia may also occur at the intestinal walls in the presence of strangulations. In this study, we examined the effects of human recombinant (Hr)-epidermal growth factor (EGF) given at a single intramural dose into the intestinal walls and daily intraperitoneal cavity on ischemia and the healing process of anastomosis. MATERIALS AND METHODS: Sixteen male New Zeland white rabbits were randomly divided into four groups (n = 4 in each group)...
October 3, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27671866/device-therapies-for-resistant-hypertension
#17
REVIEW
Dagmara Hering, Carl Schultz, Markus P Schlaich
PURPOSE: Resistant hypertension (RH) is a major and growing public health problem. While noncompliance to antihypertensive medication is a major concern in RH patients, it is estimated that even with adequate multi-drug regimens, approximately 10% of patients diagnosed with hypertension fulfill the criteria of true RH. Patients with sustained blood pressure (BP) elevation display high risk for development of target organ damage and associated cardiovascular morbidity and mortality. While optimized pharmacologic therapy, including the use of mineralocorticoid receptor antagonists to guideline-based antihypertensive drug therapy, is effective for improving BP control in this patient cohort, a sizable proportion of RH patients' BP remains uncontrolled, and alternative therapeutic strategies are warranted...
October 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27639265/an-investigation-of-the-effects-of-suture-patterns-on-mechanical-strength-of-intestinal-anastomosis-an-experimental-study
#18
Sanaz Mosafer Khoorjestan, Gholamreza Rouhi, Karamollah Toolabi
How the distance of sutures from the edge of tissue and the horizontal distance between stitches affect the mechanical strength of anastomosis is investigated. In this study, 180 bovine intestines were used to investigate the optimum pattern in 18 groups by considering a 4, 6, and 8 mm horizontal distance between stitches, and a 3, 5, and 7 mm distance from the edge of tissue with 3-0 Silk and 3-0 PDS sutures to maximize the strength of anastomosis (10 specimens in each group). Also, 80 specimens were used to investigate the maximum effective distance of sutures from the edge of tissue in eight groups of: 3, 5, 7, and 10 mm distance from the edge, with the same type of sutures...
August 17, 2016: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/27598601/effects-of-melatonin-on-cytokine-release-and-healing-of-colonic-anastomoses-in-an-experimental-sepsis-model
#19
Ömer Faik Ersoy, Namık Özkan, Zeki Özsoy, Hüseyin Ayhan Kayaoğlu, Erdinç Yenidoğan, Alper Çelik, Aziz Fikret Özuğurlu, Ebru Arabacı Çakır, Neşe Lortlar
BACKGROUND: The present objective was to identify effects of early melatonin application on healing of anastomotic wound and inflammation in an experimental sepsis model. METHODS: A total of 60 Wistar albino rats were divided into 2 groups. Cecal ligation puncture (CLP) and colonic resection anastomosis were performed on both the control group and the melatonin treatment group. Both groups were divided into 3 subgroups consisting of 10 rats each. One subgroup from each group underwent re-laparotomy at the 16th hour, the next on the 3rd day, and the final subgroup on the 7th day...
July 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/27577554/initial-resistance-of-carina-anastomoses-with-increasing-tensile-stress-an-ex-vivo-model-comparing-different-suture-techniques
#20
Andreas Kirschbaum, Stefanie Hemmerling, Thorsten Steinfeldt, Detlef K Bartsch, Nikolas Mirow
BACKGROUND: After resection of the carina with a length of more than 4 cm, anastomoses often need to be performed under tension despite maximum mobilization. If the patient cannot be extubated, the anastomosis remains under continued stress. Anastomoses of the carina can be constructed using various suture techniques, including single interrupted sutures, back wall running but front wall single interrupted sutures, and complete running suture. This experimental study was designed to determine the most tensile stress-resistant anastomotic suture technique...
August 31, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
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