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https://www.readbyqxmd.com/read/27863029/endoluminal-vacuum-therapy-for-ivor-lewis-anastomotic-leaks-a-pilot-study-in-a-swine-model
#1
R B Scott, L A Ritter, A L Shada, S H Feldman, D E Kleiner
Anastomotic leaks are a serious complication associated with Ivor Lewis esophagectomies. Endoluminal negative pressure vacuum devices create a possible treatment alternative to conventional surgical intervention. Ten pigs had an intrathoracic esophageal anastomosis with a 1-cm defect. The experimental group had the device placed intraoperatively across the defect, whereas the control group did not. Once treatment was completed, a contrast fluoroscopic study and necropsy was performed. All control pigs had contrast extravasation on fluoroscopy and contamination on necropsy...
November 11, 2016: Clinical and Translational Science
https://www.readbyqxmd.com/read/27859294/tgf-%C3%AE-antagonist-attenuates-fibrosis-but-not-luminal-narrowing-in-experimental-tracheal-stenosis
#2
Juan L Antón-Pacheco, Alicia Usategui, Iván Martínez, Carmen M García-Herrero, Antonio P Gamez, Montserrat Grau, Ana M Martínez, José L Rodríguez-Peralto, José L Pablos
OBJECTIVE: Acquired tracheal stenosis (ATS) is an unusual disease often secondary to prolonged mechanical trauma. Acquired tracheal stenosis pathogenesis involves inflammation and subsequent fibrosis with narrowing of the tracheal lumen. Transforming growth factor-β1 (TGF-β) represents a pivotal factor in most fibrotic processes, and therefore a potential target in this context. The aim of this study is to analyze the role of TGF-β as a target for anti-fibrotic interventions in tracheal stenosis...
November 16, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27853330/effect-of-human-amniotic-membrane-on-prevention-of-colorectal-anastomosis-leakage-in-cases-with-neoadjuvant-radiotherapy-an-experimental-animal-study
#3
Sam Moslemi, Sajjad Ahmadi Joraghi, Reza Roshanravan, Leila Ghahramani, Mohammad Mohammadianpanah, Masood Hosseinzadeh, Abbas Rezaianzadeh, Ahmed Mohammed Ali Hussein, Neda Najibpour, Seyed Vahid Hosseini
BACKGROUND: Radiotherapy is one of the most important factors which results in negative effects on wound healing and increases anastomosis leakage. Diverting loop ileostomy has been usually performed after colorectal anastomosis in cases of colorectal cancer with a history of neoadjuvant radiotherapy to decrease the chance of leakage. Considering the side effects of diverting loop ileostomy, the objective of the present study is to investigate the effect of human amniotic membrane (HAM) on colorectal anastomosis leakage after neo-adjuvant radiotherapy...
November 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27849374/impact-of-motorized-articulating-laparoscopic-devices-with-three-dimension-visualizing-system-a-pilot-study
#4
Serdar Aykan, Yigit Akin, Sabri Pelit, Hakan Gulmez, Murat Tuken, Aykut Colakerol, Atilla Semercioz, Ahmet Yaser Muslumanoglu
OBJECTIVE: To compare the efficacy between motorized articulating (AI) and rigid conventional laparoscopic instruments (CI) in chancing visualizing systems, respectively 2-dimension (2D) and 3-dimension (3D). METHODS: Sixty physicians were divided into 3 groups according to their previous experience as medical students (Group 1), residents (Group 2), and expert surgeons (Group 3). Four experimental sets were created, respectively CI-2D visualizing system (CI-2D), CI-3D visualizing system (CI-3D), AI-2D visualizing system (AI-2D), and AI-3D visualizing system (AI-3D) platforms...
November 16, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27805444/feasibility-repeatability-and-safety-of-ultrasound-guided-stimulation-of-the-first-cervical-nerve-at-the-alar-foramen-in-horses
#5
Céline Mespoulhès-Rivière, Olivier Brandenberger, Fabrice Rossignol, Céline Robert, Justin D Perkins, Jean-Paul Marie, Norm Ducharme
OBJECTIVE To develop and assess the feasibility, repeatability, and safety of an ultrasound-guided technique to stimulate the first cervical nerve (FCN) at the level of the alar foramen of the atlas of horses. ANIMALS 4 equine cadavers and 6 clinically normal Standardbreds. PROCEDURES In each cadaver, the FCN pathway was determined by dissection, and any anastomosis between the first and second cervical nerves was identified. Subsequently, each of 6 live horses underwent a bilateral ultrasound-guided stimulation of the FCN at the alar foramen 3 times at 3-week intervals...
November 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27788509/experimental-electrophysiological-and-pressure-responses-of-urinary-bladder-detrusor-to-lumbar-to-sacral-nerve-rerouting-an-animal-study-with-negative-results
#6
Pavel Zerhau, Zdeněk Mackerle, Matej Husár, Daniela Sochůrková, Eva Brichtová, Eduard Gopfert, Martin Faldyna, Martin Kubát, Ladislav Plánka
: Background/Aims/Objectives: To verify the transfer of evoked potentials through anastomosis of an experimentally created micturition reflex arc and to detect said potentials directly on the detrusor and sphincter of rabbit urinary bladder. METHODS: During 2013-2015, 17 rabbits were operated upon and measurement followed during reoperation 3-16 months later. Suitable ventral spinal roots were electrophysiologically detected following laminectomy, and a somatic-central nervous system-autonomic micturition reflex arc was created...
2016: Urologia Internationalis
https://www.readbyqxmd.com/read/27721926/fibrinogen-thrombin-collagen-patch-reinforcement-of-high-risk-colonic-anastomoses-in-rats
#7
Juan Manuel Suárez-Grau, Carlos Bernardos García, Carmen Cepeda Franco, Cristina Mendez García, Salud García Ruiz, Fernando Docobo Durantez, Salvador Morales-Conde, Javier Padillo Ruiz
AIM: To evaluate the effectiveness of human fibrinogen-thrombin collagen patch (TachoSil(®)) in the reinforcement of high-risk colon anastomoses. METHODS: A quasi-experimental study was conducted in Wistar rats (n = 56) that all underwent high-risk anastomoses (anastomosis with only two sutures) after colectomies. The rats were divided into two randomized groups: Control group (24 rats) and treatment group (24 rats). In the treatment group, high-risk anastomosis was reinforced with TachoSil(®) (a piece of TachoSil(®) was applied over this high-risk anastomosis, covering the gap)...
September 27, 2016: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27713784/cyanoacrylate-application-on-colonic-anastomosis-is-it-safe-or-not
#8
Gürhan Güngör, Gökhan Demiral, Metin Şenol, Barış Bayraktar, Yahya Çelik, Salih Bölük
INTRODUCTION: Major complications of colonic anastomosis include fistula, bleeding, and anastomotic stricture, and the most common one is anastomotic leakage. Many organic or inorganic tissue adhesives are being used such as fibrin glue or cyanoacrylate to strengthen or protect colonic anastomosis. Up to now, a great number of studies have been carried out to investigate the effects of these biomaterials. AIM: To determine the effect of cyanoacrylate application on anastomosis safety...
2016: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/27690726/can-human-recombinant-epidermal-growth-factor-improve-ischemia-and-induce-healing-of-anastomosis-in-an-experimental-study-in-a-rabbit-model
#9
Rahman Şenocak, Mustafa Tahir Özer, Şahin Kaymak, Zafer Kılbaş, Armağan Günal, Metin Uyanık, Orhan Kozak
PURPOSE: Anastomotic leaks following intestinal operations may cause devastating effects on patients. Ischemia may also occur at the intestinal walls in the presence of strangulations. In this study, we examined the effects of human recombinant (Hr)-epidermal growth factor (EGF) given at a single intramural dose into the intestinal walls and daily intraperitoneal cavity on ischemia and the healing process of anastomosis. MATERIALS AND METHODS: Sixteen male New Zeland white rabbits were randomly divided into four groups (n = 4 in each group)...
October 3, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27671866/device-therapies-for-resistant-hypertension
#10
Dagmara Hering, Carl Schultz, Markus P Schlaich
PURPOSE: Resistant hypertension (RH) is a major and growing public health problem. While noncompliance to antihypertensive medication is a major concern in RH patients, it is estimated that even with adequate multi-drug regimens, approximately 10% of patients diagnosed with hypertension fulfill the criteria of true RH. Patients with sustained blood pressure (BP) elevation display high risk for development of target organ damage and associated cardiovascular morbidity and mortality. While optimized pharmacologic therapy, including the use of mineralocorticoid receptor antagonists to guideline-based antihypertensive drug therapy, is effective for improving BP control in this patient cohort, a sizable proportion of RH patients' BP remains uncontrolled, and alternative therapeutic strategies are warranted...
September 23, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27639265/an-investigation-of-the-effects-of-suture-patterns-on-mechanical-strength-of-intestinal-anastomosis-an-experimental-study
#11
Sanaz Mosafer Khoorjestan, Gholamreza Rouhi, Karamollah Toolabi
How the distance of sutures from the edge of tissue and the horizontal distance between stitches affect the mechanical strength of anastomosis is investigated. In this study, 180 bovine intestines were used to investigate the optimum pattern in 18 groups by considering a 4, 6, and 8 mm horizontal distance between stitches, and a 3, 5, and 7 mm distance from the edge of tissue with 3-0 Silk and 3-0 PDS sutures to maximize the strength of anastomosis (10 specimens in each group). Also, 80 specimens were used to investigate the maximum effective distance of sutures from the edge of tissue in eight groups of: 3, 5, 7, and 10 mm distance from the edge, with the same type of sutures...
August 17, 2016: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/27598601/effects-of-melatonin-on-cytokine-release-and-healing-of-colonic-anastomoses-in-an-experimental-sepsis-model
#12
Ömer Faik Ersoy, Namık Özkan, Zeki Özsoy, Hüseyin Ayhan Kayaoğlu, Erdinç Yenidoğan, Alper Çelik, Aziz Fikret Özuğurlu, Ebru Arabacı Çakır, Neşe Lortlar
BACKGROUND: The present objective was to identify effects of early melatonin application on healing of anastomotic wound and inflammation in an experimental sepsis model. METHODS: A total of 60 Wistar albino rats were divided into 2 groups. Cecal ligation puncture (CLP) and colonic resection anastomosis were performed on both the control group and the melatonin treatment group. Both groups were divided into 3 subgroups consisting of 10 rats each. One subgroup from each group underwent re-laparotomy at the 16th hour, the next on the 3rd day, and the final subgroup on the 7th day...
July 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/27577554/initial-resistance-of-carina-anastomoses-with-increasing-tensile-stress-an-ex-vivo-model-comparing-different-suture-techniques
#13
Andreas Kirschbaum, Stefanie Hemmerling, Thorsten Steinfeldt, Detlef K Bartsch, Nikolas Mirow
BACKGROUND: After resection of the carina with a length of more than 4 cm, anastomoses often need to be performed under tension despite maximum mobilization. If the patient cannot be extubated, the anastomosis remains under continued stress. Anastomoses of the carina can be constructed using various suture techniques, including single interrupted sutures, back wall running but front wall single interrupted sutures, and complete running suture. This experimental study was designed to determine the most tensile stress-resistant anastomotic suture technique...
August 31, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27558705/arterialized-venous-bone-flaps-an-experimental-investigation
#14
Farzad Borumandi, James P Higgins, Heinz Buerger, Anna Vasilyeva, Memmet Emre Benlidayi, Leman Sencar, Alexander Gaggl
In arterialized venous flaps (AVFs) the venous network is used to revascularize the flap. While the feasibility of AVFs in soft tissues has been reported there is no study on osseous AVFs. In this study we aim to assess the flap survival of osseous AVFs in a pig model. Medial femoral condyle flaps were elevated in 18 pigs. Three groups were created: AVF (n = 6), conventional arterial flap (cAF, n = 6) and bone graft (BG, n = 6). The AVFs were created by anastomosis of genicular artery with one vena comitans while leaving one efferent vein for drainage...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27550043/spinal-nerve-defects-in-mouse-embryos-prenatally-exposed-to-valproic-acid
#15
Juramt Bold, Hiromi Sakata-Haga, Yoshihiro Fukui
To examine in detail spinal nerve defects induced by prenatal exposure to valproic acid in mice, pregnant ICR mice were subcutaneously injected with a single dose of 400 mg/kg valproic acid on gestational day 6, 7, 8, or 9, and their embryos were observed on gestational day 10. The whole-mount immunostaining using an anti-neurofilament antibody allowed us to identify spinal nerve defects, such as a loss of bundle, anastomosis among bundles arising from adjacent segment, and a disrupted segmental pattern of the dorsal root ganglia, in valproic acid-exposed embryos...
August 22, 2016: Anatomical Science International
https://www.readbyqxmd.com/read/27525002/comparison-of-the-effects-of-glutamine-curcumin-and-nesfatin-1-on-the-gastric-serosal-surface-neomucosa-formation-an-experimental-rodent-model
#16
Osman Bilgin Gulcicek, Ali Solmaz, Hakan Yiğitbaş, Candas Ercetin, Erkan Yavuz, Kamil Ozdogan, Sinan Arici, Asli Kahraman Akkalp, Tulin Sarac, Fatih Çelebi, Atilla Celik
Introduction. Short bowel syndrome can crop up if more than 50% of small intestine is resected or when less than 100 cm of small bowel is left. Glutamine is the main food source of enterocytes. Curcumin has protective effects on intestinal ischemia-reperfusion damage. Nesfatin-1 is a satiety molecule. It has protective effects on gastric mucosa. The primary purpose of this study is to compare effects of glutamine, curcumin, and nesfatin-1 on the gastric serosal surface neomucosa formation on rats. Materials and Methods...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27488366/allogeneic-anorectal-transplantation-in-rats-technical-considerations-and-preliminary-results
#17
Flavio H F Galvão, Daniel R Waisberg, Victor E Seid, Anderson C L Costa, Eleazar Chaib, Rachel Rossini Baptista, Vera Luiza Capelozzi, Cinthia Lanchotte, Ruy J Cruz, Jun Araki, Luiz Carneiro D'Albuquerque
Fecal incontinence is a challenging condition with numerous available treatment modalities. Success rates vary across these modalities, and permanent colostomy is often indicated when they fail. For these cases, a novel potential therapeutic strategy is anorectal transplantation (ATx). We performed four isogeneic (Lewis-to-Lewis) and seven allogeneic (Wistar-to-Lewis) ATx procedures. The anorectum was retrieved with a vascular pedicle containing the aorta in continuity with the inferior mesenteric artery and portal vein in continuity with the inferior mesenteric vein...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27476916/histomorphometric-and-ultrastructural-evaluation-of-long-term-alpha-lipoic-acid-and-vitamin-b12-use-after-experimental-sciatic-nerve-injury-in-rats
#18
Murat Arikan, Guray Togral, Askin Esen Hasturk, Bahriye Horasanli, Fatma Helvacioglu, Atilla Dagdeviren, Mustafa Agah Tekindal, Murat Parpucu
AIM: We analyzed the therapeutic effects of long-term alpha lipoic acid and vitamin B12 use via histomorphometric methods and electron microscopy in the transected sciatic nerves of rats. MATERIAL AND METHODS: Forty rats were randomized into five groups (n=8/group). In group 1, 1 cm segment of sciatic nerve was resected without any other intervention. In group 2 (sham), primary epineural anastomosis was performed and in group 3 (saline), after nerve transection intraperitoneal physiologic saline was applied...
February 20, 2015: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27461451/pelvic-floor-muscle-exercise-for-fecal-incontinence-quality-of-life-after-coloanal-anastomosis
#19
Shu-Ling Hung, Yu-Hua Lin, Hsing-Yu Yang, Chia-Chan Kao, Hong-Yu Tung, Li-Hsiang Wei
AIMS AND OBJECTIVES: To assess the efficacy of pelvic floor muscle exercise for enhancing fecal incontinence quality of life after coloanal anastomosis in colorectal cancer patients. BACKGROUND: Methods of improving incontinence have been evaluated in many countries, but never in a Taiwan population. DESIGN: A longitudinal experimental study. METHODS: Fifty-two colorectal cancer patients who had received colostomy closure and coloanal anastomosis surgery were recruited from a general hospital in southern Taiwan and randomly assigned to an experimental group (n = 26) or a control group (n = 26)...
September 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27403676/the-effects-of-limited-adventitiectomy-on-vascular-anastomosis-an-experimental-study-in-rats
#20
Alper Mete Ugurlu, Salih Onur Basat, Fatih Ceran, Burhan Ozalp, Omer Berkoz
OBJECTIVE: Blockages in anastomotic vessels cause complete loss of free tissue transfer and replanted limb. Many studies have been conducted in the last 30 years to solve this problem. There are insufficient studies dealing with the effects of the limited adventitiectomy done before surgery for sympathetic overactivity leading situations. The aim of this experimental study is to reveal the effects of limited adventitiectomy. METHODS: In this study, limited adventitiectomy was performed in a wide area before surgery, and the effect of this practice on the vessel diameter and anastomosis was investigated...
July 12, 2016: Journal of Plastic Surgery and Hand Surgery
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