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Walter Stummer, Floriano Rodrigues, Philippe Schucht, Matthias Preuss, Dorothee Wiewrodt, Ulf Nestler, Marco Stein, José Manuel Cabezudo Artero, Nunzio Platania, Jane Skjøth-Rasmussen, Alessandro Della Puppa, John Caird, Søren Cortnum, Sam Eljamel, Christian Ewald, Laura González-García, Andrew J Martin, Ante Melada, Aurelia Peraud, Angela Brentrup, Thomas Santarius, Hans Herbert Steiner
BACKGROUND: Five-aminolevulinic acid (Gliolan, medac, Wedel, Germany, 5-ALA) is approved for fluorescence-guided resections of adult malignant gliomas. Case reports indicate that 5-ALA can be used for children, yet no prospective study has been conducted as of yet. As a basis for a study, we conducted a survey among certified European Gliolan users to collect data on their experiences with children. METHODS: Information on patient characteristics, MRI characteristics of tumors, histology, fluorescence qualities, and outcomes were requested...
December 2014: Acta Neurochirurgica
Eike Wilbers, Gunnar Hargus, Johannes Wölfer, Walter Stummer
No abstract text is available yet for this article.
October 2014: Acta Neurochirurgica
J Slof, R Díez Valle, J Galván
OBJECTIVE: This study evaluates the cost-effectiveness of 5-aminolevulinic acid (5-ALA, Gliolan®) in patients undergoing surgery for malignant glioma, in standard clinical practice conditions in Spain. MATERIAL AND METHODS: Cost-effectiveness ratios were determined in terms of incremental cost per complete resection (CR) and incremental cost per additional quality-adjusted life year (QALY), based on data collected in the VISIONA observational study. RESULTS: Incremental cost with 5-ALA versus conventional surgery using white light only amounts to € 4550 per additional CR achieved and € 9021 per QALY gained...
April 2015: Neurología: Publicación Oficial de la Sociedad Española de Neurología
R Díez Valle, J Slof, J Galván, C Arza, C Romariz, C Vidal
OBJECTIVE: To assess effectiveness of 5-aminolevulinic acid (5-ALA, Gliolan(®)) in patients treated for malignant glioma under typical daily practice conditions in Spain, using complete resection rate (CR) and progression free survival at 6 months (PFS6). MATERIAL AND METHODS: Retrospective review of data from 18 neurosurgery departments that were categorised as either using or not using 5-ALA. The study included adult patients with suspected malignant gliomas for whom the intended treatment plan included complete resection followed by radiotherapy and chemotherapy with temozolomide...
April 2014: Neurología: Publicación Oficial de la Sociedad Española de Neurología
Søren Cortnum, René Johannes Laursen
INTRODUCTION: Malignant gliomas remain associated with a poor prognosis despite both surgical treatment and radiochemotherapy.Previous studies have shown that complete resection of contrast-enhancing tumours is achieved in less than 20-30% of patients. 5-aminolevulinic acid (5-ALA) is a pro-drug that leads to accumulation of fluorescent protoporphyrins in malignant gliomas. The fluorescence can be visualized intraoperatively by use of a modified microscope. The Department of Neurosurgery at Aalborg Hospital has recently adopted this new technique as the first centre in Denmark...
August 2012: Danish Medical Journal
Barbara Krammer, Kristjan Plaetzer
ALA-induced protoporphyrin IX (PpIX) is used for fluorescence diagnosis (ALA-FD) and for fluorescence-guided resection of both (pre)malignant and non-malignant diseases. ALA is also applied in photodynamic therapy (ALA-PDT) of superficial (pre)malignant lesions in dermatology, urology, neurosurgery, otorhinolaryngology, gynecology and gastroenterology. Today, ALA is approved as Levulan for actinic keratoses, the ALA-methyl ester Metvix for actinic keratoses and basal cell carcinoma, the ALA-hexyl ester Hexvix for the diagnosis of bladder cancer and Gliolan for malignant glioma...
March 2008: Photochemical & Photobiological Sciences
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