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Mostafa Herajy, Fei Liu, Christian Rohr, Monika Heiner
BACKGROUND: Hybrid simulation of (computational) biochemical reaction networks, which combines stochastic and deterministic dynamics, is an important direction to tackle future challenges due to complex and multi-scale models. Inherently hybrid computational models of biochemical networks entail two time scales: fast and slow. Therefore, it is intricate to efficiently and accurately analyse them using only either deterministic or stochastic simulation. However, there are only a few software tools that support such an approach...
July 28, 2017: BMC Systems Biology
Heidi Ledford
No abstract text is available yet for this article.
June 16, 2016: Nature
Anna Borovikova, Alexey Tamarov, Alexei Borovikov
No abstract text is available yet for this article.
March 2016: Plastic and Reconstructive Surgery. Global Open
Kerry A Miller, Tiong Y Tan, Megan F Welfare, Susan M White, Zornitza Stark, Ravi Savarirayan, Trent Burgess, Andrew A Heggie, Georgina Caruana, John F Bertram, John F Bateman, Peter G Farlie
The 22q11.2 deletion syndrome (22q11DS) is thought to be a contiguous gene syndrome caused by haploinsufficiency for a variable number of genes with overlapping function during the development of the craniofacial, pharyngeal and cardiac structures. The complexity of genetic and developmental anomalies resulting in 22q11DS has made attributing causation to specific genes difficult. The CRKL gene resides within the common 3-Mb region, most frequently affected in 22q11DS, and has been shown to play an essential role in the development of tissues affected in 22q11DS...
December 2014: Molecular Syndromology
Hannah Greenwood, Jaimin Patel, Rahul Mahida, Qian Wang, Dhruv Parekh, Rachel C A Dancer, Heena Khiroya, Elizabeth Sapey, David R Thickett
BACKGROUND: Community-acquired pneumonia (CAP) is considered the leading cause of death from infectious disease in developed countries, while complications of CAP - sepsis being the most common and challenging - increase the risk of mortality. During the progression of sepsis, a state of neutrophil 'paralysis' develops resulting in the impairment of neutrophil anti-microbial functions including: chemotaxis, production of reactive oxygen species, and formation of neutrophil extracellular traps (NETs)...
August 22, 2014: Trials
Maki Yoshihama, Akihiro Nakao, Naoya Kenmochi
BACKGROUND: Small nucleolar RNAs (snoRNAs) are a class of non-coding RNAs that guide the modification of specific nucleotides in ribosomal RNAs (rRNAs) and small nuclear RNAs (snRNAs). Although most non-coding RNAs undergo post-transcriptional modifications prior to maturation, the functional significance of these modifications remains unknown. Here, we introduce the snoRNA orthological gene database (snOPY) as a tool for studying RNA modifications. FINDINGS: snOPY provides comprehensive information about snoRNAs, snoRNA gene loci, and target RNAs...
2013: BMC Research Notes
Nikolaos Panagiotopoulos, James Barnard, Francis Wells
No abstract text is available yet for this article.
March 2014: European Journal of Cardio-thoracic Surgery
Wolfgang Marwan, Christian Rohr, Monika Heiner
Using the example of phosphate regulation in enteric bacteria, we demonstrate the particular suitability of stochastic Petri nets to model biochemical phenomena and their simulative exploration by various features of the software tool Snoopy.
2012: Methods in Molecular Biology
T H Szymanski, H S Hinton
A reconfigurable intelligent optical backplane architecture for parallel computing and communications is described. The backplane consists of a large number of reconfigurable optical channels organized in a ring with relatively simple point-to-point optical interconnections between neighboring smart-pixel arrays. The intelligent backplane can implement (l) dynamically reconfigurable connections between any printed circuit boards, (2) dynamic embeddings of classical interconnection networks such as buses, rings, multidimensional meshes, hypercubes, shuffles, and crossbars, (3) multipoint switching, (4) sorting, (5) parallel-prefix operations, (6) pattern-matching operations, (7) snoopy caches and intelligent memory systems, and (8) media-access control functions...
March 10, 1996: Applied Optics
Christian Rohr, Wolfgang Marwan, Monika Heiner
SUMMARY: To investigate biomolecular networks, Snoopy provides a unifying Petri net framework comprising a family of related Petri net classes. Models can be hierarchically structured, allowing for the mastering of larger networks. To move easily between the qualitative, stochastic and continuous modelling paradigms, models can be converted into each other. We get models sharing structure, but specialized by their kinetic information. The analysis and iterative reverse engineering of biomolecular networks is supported by the simultaneous use of several Petri net classes, while the graphical user interface adapts dynamically to the active one...
April 1, 2010: Bioinformatics
G Patrick Maxwell, Shawn A Birchenough, Allen Gabriel
BACKGROUND: An increasing number of patients present today with volume-depleted breasts from large saline or silicone gel-filled implants most commonly placed under the pectoral muscle. Revisionary (secondary or tertiary) surgeries are performed for late complications of breast augmentation, such as implant extrusion, gel bleed, rupture with extravasation of the gel, saline implant deflation, capsular contracture, palpability, rippling, "double- bubble," "Snoopy breast," symmastia, and implant malposition...
September 2009: Aesthetic Surgery Journal
G Patrick Maxwell, Allen Gabriel
Increasing numbers of patients are presenting with volume-depleted breasts as a result of large saline implants that were placed under the pectoral muscle. To treat this problem, the authors introduce a revisionary surgery technique, called the neopectoral pocket, designed for patients with subpectoral implants. This technique is useful for the management of late breast augmentation complications, such as capsular contracture and implant malposition, including "double bubble" breast deformity, "Snoopy breast", and symmastia...
July 2008: Aesthetic Surgery Journal
L Jemtå, K S Fugl-Meyer, K Oberg, M Dahl
AIM: The first aim was to investigate dimension-specific and global self-esteem in children and adolescents with mobility impairment and to analyse the relation between self-esteem and demographic data and disability characteristics. The second aim was to identify the impact of five self-esteem dimensions on well-being and coping strategies. METHODS: A total of 138 children and adolescents aged 7-18 years with mobility impairment took part in a semi-structured interview...
March 2009: Acta Paediatrica
Stefanie Grunwald, Astrid Speer, Jörg Ackermann, Ina Koch
UNLABELLED: Searching for therapeutic strategies for Duchenne muscular dystrophy, it is of great interest to understand the responsible molecular pathways down-stream of dystrophin completely. For this reason we have performed real-time PCR experiments to compare mRNA expression levels of relevant genes in tissues of affected patients and controls. To bring experimental data in context with the underlying pathway theoretical models are needed. Modelling of biological processes in the cell at higher description levels is still an open problem in the field of systems biology...
May 2008: Bio Systems
Lisa A Cerilli, Alexis Harris
No abstract text is available yet for this article.
October 2005: International Journal of Surgical Pathology
Lena Jemtå, M Dahl, Kerstin S Fugl-Meyer, Richard Stensman
AIM: To describe the well-being of children and adolescents with mobility impairment in relation to demographic data and disability characteristics. METHODS: The present study is based on interviews with 141 subjects aged 7 to 18?y with impaired mobility. Perceived overall well-being was measured by a nine-grade visual scale, the Snoopy scale. Independence or dependence was evaluated by the Index of Independence in Activities of Daily Living. Motor capacity was assessed with an instrument including active movements, rapidity, locomotion and balance as well as the presence and localization of pain...
May 2005: Acta Paediatrica
N Principi, S Esposito, R Cavagna, S Bosis, R Droghetti, N Faelli, S Tosi, E Begliatti et al.
In order to evaluate the efficacy of macrolides in pediatric patients with recurrent respiratory tract infections (RRTIs), we enrolled 1,706 children (783 females) aged between 6 months and 14 years (median: 4 years) with an acute respiratory infection and a history of RRTIs (> or = 8 episodes per year if aged < 3 years; > or = 6 episodes per year if aged > or = 3 years). The therapies were chosen by the primary care pediatricians and their effects on respiratory relapses were blindly analyzed. Regardless of age and clinical diagnosis, the children treated with macrolides showed a significantly higher rate of short- and long-term clinical success than those receiving beta-lactams (p<0...
February 2003: Journal of Chemotherapy
F Abu-Jarad, Fazal-ur-Rehman, M N Al-Haddad, M I Al-jarallah
Area passive neutron dosemeters based on nuclear track detectors (NTDs) have been used for 13 days to assess accumulated low doses of thermal neutrons around neutron source storage area of the King Fahd University of Petroleum and Minerals (KFUPM). Moreover, the aim of this study is to check the effectiveness of shielding of the storage area. NTDs were mounted with the boron converter on their surface as one compressed unit. The converter is a lithium tetraborate (Li2B4O7) layer for thermal neutron detection via 10B(n,alpha)7Li and 6Li(n,alpha)3H nuclear reactions...
2002: Radiation Protection Dosimetry
No abstract text is available yet for this article.
April 24, 1999: BMJ: British Medical Journal
R P Gruber, H W Jones
A previously described technique of mastopexy is employed whereby a donut-shaped portion of periareolar skin is deepithelized. The radius of the skin to be removed is usually 2 to 3 cm and includes a portion of the areola. The resulting wound is closed, leaving only a periareolar scar. The primary motivation for such a mastopexy was (1) minimizing scar to the periareolar area, (2) complete preservation of nipple sensation, and (3) ease and short duration of surgery. It is often used to correct a protuberant nipple-areolar complex ("Snoopy" deformity)...
January 1980: Plastic and Reconstructive Surgery
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