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JOURNAL ARTICLE
F C Silva, Patrícia Alves Maia Guidine, Natalia Lima Machado, Carlos Henrique Xavier, R C de Menezes, Tasso Moraes-Santos, Márcio Flávio Moraes, Deoclécio Alves Chianca
The scorpion envenoming syndrome is an important worldwide public health problem due to its high incidence and potential severity of symptoms. Some studies address the high sensitivity of the central nervous system to this toxin action. It is known that cardiorespiratory manifestations involve the activation of the autonomic nervous system. However, the origin of this modulation remains unclear. Considering the important participation of the dorsomedial hypotalamus (DMH) in the cardiovascular responses during emergencial situations, the aim of this work is to investigate the involvement of the DMH on cardiovascular responses induced by intracerebroventricular (icv) injection of Tityustoxin (TsTX, a α-type toxin extracted from the Tityus serrulatus scorpion venom)...
March 2015: Neurotoxicology
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