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https://www.readbyqxmd.com/read/28110482/the-evaluation-of-a-new-marker-of-transmyocardial-repolarization-parameters-in-ischemic-stroke-patients-t-peak-t-end-t-p-e-t-p-e-qtc
#1
Emine Emektar, Şeref Kerem Çorbacıoğlu, Osman Korucu, Selma Ramadan, Hüseyin Uzunosmanoğlu, Eda Kan, Yunsur Çevik
The cardiovascular manifestations of acute ischemic stroke have been well known. Several electrocardiography (ECG) abnormalities have been reported in patients following acute stroke, including QT interval prolongation, ST segment deviation and T-wave changes. This study aimed to investigate the changes in transmyocardial repolarization parameters, in ischemic stroke patients. The study is a prospective, blind, and controlled clinical study. The patients without cardiac disease who received ischemic stroke diagnoses were included in the study...
January 21, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28110433/a-comprehensive-analysis-of-cardiac-valve-plane-displacement-in-healthy-adults-age-stratified-normal-values-by-cardiac-magnetic-resonance
#2
Marco M Ochs, Thomas Fritz, Florian André, Johannes Riffel, Derliz Mereles, Matthias Müller-Hennessen, Evangelos Giannitsis, Hugo A Katus, Matthias G Friedrich, Sebastian J Buss
Cardiac valve plane displacement (CVPD) reflects longitudinal LV function. The purpose of the present study was to determine regional heterogeneity of CVPD in healthy adults to provide normal values by cardiac magnetic resonance (CMR). We measured the anterior aortic plane systolic excursion (AAPSE); the anterior, anterolateral, inferolateral, inferior, and inferoseptal mitral annular plane systolic excursion (MAPSE); and the lateral tricuspid annulus plane systolic excursion (TAPSE). Systolic excursion was measured as the distance from peak end-diastolic to peak end-sysstolic annular position (peak-to-peak) in cine images acquired in 2-, 3- and 4-chamber views...
January 21, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28110424/effects-of-caffeine-on-fractional-flow-reserve-values-measured-using-intravenous-adenosine-triphosphate
#3
Masafumi Nakayama, Taishiro Chikamori, Takashi Uchiyama, Yo Kimura, Nobuhiro Hijikata, Ryosuke Ito, Mikio Yuhara, Hideaki Sato, Yuichi Kobori, Akira Yamashina
We investigated the effects of caffeine intake on fractional flow reserve (FFR) values measured using intravenous adenosine triphosphate (ATP) before cardiac catheterization. Caffeine is a competitive antagonist for adenosine receptors; however, it is unclear whether this antagonism affects FFR values. Patients were evenly randomized into 2 groups preceding the FFR study. In the caffeine group (n = 15), participants were given coffee containing 222 mg of caffeine 2 h before the catheterization. In the non-caffeine group (n = 15), participants were instructed not to take any caffeine-containing drinks or foods for at least 12 h before the catheterization...
January 21, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28110000/drones-may-be-used-to-save-lives-in-out-of-hospital-cardiac-arrest-due-to-drowning
#4
A Claesson, L Svensson, P Nordberg, M Ringh, M Rosenqvist, T Djarv, J Samuelsson, O Hernborg, P Dahlbom, A Jansson, J Hollenberg
BACKGROUND: Drowning leading to out-of-hospital cardiac arrest (OHCA) and death is a major public health concern. Submersion with duration of less than 10minutes is associated with favourable neurological outcome and nearby bystanders play a considerable role in rescue and resuscitation. Drones can provide a visual overview of an accident scene, their potential as lifesaving tools in drowning has not been evaluated. AIM: The aim of this simulation study was to evaluate the efficiency of a drone for providing earlier location of a submerged possible drowning victim in comparison with standard procedure...
January 18, 2017: Resuscitation
https://www.readbyqxmd.com/read/28109998/impact-of-mean-arterial-pressure-on-clinical-outcomes-in-comatose-survivors-of-out-of-hospital-cardiac-arrest-insights-from-the-university-of-ottawa-heart-institute-regional-cardiac-arrest-registry-capital-care
#5
Juan J Russo, Tyler E James, Benjamin Hibbert, Altayyeb Yousef, Christina Osborne, George A Wells, Michael P V Froeschl, Derek Y So, Aun Yeong Chong, Marino Labinaz, Chris A Glover, Jean-François Marquis, Alexander Dick, Jordan Bernick, Michel R Le May
AIM: of the study We sought to assess the relationship between mean arterial pressure (MAP) and clinical outcomes in comatose survivors of out-of-hospital cardiac arrest (OHCA). METHODS: We identified consecutive comatose survivors of OHCA with an initial shockable rhythm treated with targeted temperature management. We examined clinical outcomes in relation to mean MAP (measured hourly) during the first 96hours of hospitalization. Mean MAP was examined as both a continuous variable and a categorical variable consisting of 3 pre-specified strata: <70mmHg, 70 to <80mmHg, and ≥80mmHg...
January 18, 2017: Resuscitation
https://www.readbyqxmd.com/read/28109995/impact-of-cardiopulmonary-resuscitation-duration-on-neurologically-favourable-outcome-after-out-of-hospital-cardiac-arrest-a-population-based-study-in-japan
#6
Tasuku Matsuyama, Tetsuhisa Kitamura, Kosuke Kiyohara, Chika Nishiyama, Tatsuya Nishiuchi, Yasuyuki Hayashi, Takashi Kawamura, Bon Ohta, Taku Iwami
BACKGROUND: The optimal cardiopulmonary resuscitation (CPR) duration for patients with out-of-hospital cardiac arrest (OHCA) remains unclear. We aimed to assess the association between CPR duration and outcome after OHCA. METHODS: This prospective, population-based observational study conducted in Osaka, Japan enrolled 6,981 adult patients with non-traumatic witnessed OHCA who achieved return of spontaneous circulation (ROSC) from January 2005 through December 2012...
January 18, 2017: Resuscitation
https://www.readbyqxmd.com/read/28109936/precision-phenotyping-in-heart-failure-and-pattern-clustering-of-ultrasound-data-for-the-assessment-of-diastolic-dysfunction
#7
Alaa Mabrouk Salem Omar, Sukrit Narula, Mohamed Ahmed Abdel Rahman, Gianni Pedrizzetti, Hala Raslan, Osama Rifaie, Jagat Narula, Partho P Sengupta
OBJECTIVES: The aim of this study was to investigate whether cluster analysis of left atrial and left ventricular (LV) mechanical deformation parameters provide sufficient information for Doppler-independent assessment of LV diastolic function. BACKGROUND: Medical imaging produces substantial phenotyping data, and superior computational analyses could allow automated classification of repetitive patterns into patient groups with similar behavior. METHODS: The authors performed a cluster analysis and developed a model of LV diastolic function from an initial exploratory cohort of 130 patients that was subsequently tested in a prospective cohort of 44 patients undergoing cardiac catheterization...
January 11, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28109921/coronary-artery-pet-mr-imaging-feasibility-limitations-and-solutions
#8
Philip M Robson, Marc R Dweck, Maria Giovanna Trivieri, Ronan Abgral, Nicolas A Karakatsanis, Johanna Contreras, Umesh Gidwani, Jagat P Narula, Valentin Fuster, Jason C Kovacic, Zahi A Fayad
OBJECTIVES: The aims of this study were to describe the authors' initial experience with combined coronary artery positron emission tomographic (PET) and magnetic resonance (MR) imaging using (18)F-fluorodeoxyglucose ((18)F-FDG) and (18)F-sodium fluoride ((18)F-NaF) radiotracers, describe common problems and their solutions, and demonstrate the feasibility of coronary PET/MR imaging in appropriate patients. BACKGROUND: Recently, PET imaging has been applied to the aortic valve and regions of atherosclerosis...
January 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28109920/myocardial-blood-flow-and-inflammatory%C3%A2-cardiac-sarcoidosis
#9
Matthew J Kruse, Lara Kovell, Edward K Kasper, Martin G Pomper, David R Moller, Lilja Solnes, Edward S Chen, Thomas H Schindler
OBJECTIVES: This study sought to evaluate the effects of inflammatory sarcoid disease on coronary circulatory function and the response to immune-suppressive treatment. BACKGROUND: Although positron emission tomography assessment of myocardial inflammation is increasingly applied to identify active cardiac sarcoidosis, its effect on coronary flow and immune-suppressive treatment remains to be characterized. METHODS: Thirty-two individuals who were referred for positron emission tomography/computed tomography were evaluated for known or suspected cardiac sarcoidosis applying (18)F-fluorodeoxyglucose to determine inflammation and (13)N-ammonia to assess for perfusion deficits following a high-fat/low-carbohydrate diet and fasting state >12 h to suppress myocardial glucose uptake...
January 11, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28109874/comparison-of-durable-polymer-zotarolimus-eluting-and-biodegradable-polymer-biolimus-eluting-coronary-stents-in-patients-with-coronary-artery-disease-3-year-clinical-outcomes-in-the-randomized-sort-out-vi-trial
#10
Bent Raungaard, Evald H Christiansen, Hans Erik Bøtker, Henrik S Hansen, Jan Ravkilde, Leif Thuesen, Jens Aarøe, Anton B Villadsen, Christian J Terkelsen, Lars R Krusell, Michael Maeng, Steen D Kristensen, Karsten T Veien, Knud N Hansen, Anders Junker, Morten Madsen, Søren L Andersen, Svend E Jensen, Lisette O Jensen
OBJECTIVES: The authors sought to compare the safety and efficacy of the biocompatible durable-polymer zotarolimus-eluting stent with the biodegradable-polymer biolimus-eluting stent in unselected coronary patients. BACKGROUND: Biodegradable-polymer biolimus-eluting stents are superior to first-generation durable-polymer drug-eluting stents in long-term randomized all-comer trials. Long-term data comparing them to second-generation durable-polymer drug-eluting stents are lacking...
January 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28109872/5-year-safety-and-efficacy-of-resolute%C3%A2-zotarolimus-eluting-stent-the-resolute-global-clinical-trial-program
#11
Robert W Yeh, Sigmund Silber, Lianglong Chen, Shaoliang Chen, Shirish Hiremath, Franz-Josef Neumann, Shubin Qiao, Shigeru Saito, Bo Xu, Yuejin Yang, Laura Mauri
OBJECTIVES: The authors evaluated the 5-year cumulative incidence of cardiovascular events following Resolute zotarolimus-eluting stent (R-ZES) implantation. BACKGROUND: Individual trials are often underpowered to show differences for low-frequency adverse events. The R-ZES was studied in 10 prospective clinical trials, designed with identical adverse event definitions, ascertainment, and adjudication. METHODS: The RESOLUTE Global Clinical Trial Program includes 7,618 patients treated with R-ZES: RESOLUTE first-in-human study (N = 139), RESOLUTE All Comers (N = 1,140), RESOLUTE International (N = 2,349), RESOLUTE US (N = 1,402), RESOLUTE US 38 mm (N = 114), RESOLUTE Japan (N = 100), RESOLUTE Japan Small Vessel Study (N = 65), RESOLUTE Asia (N = 311), RESOLUTE China Randomized Controlled Trial (N = 198), and RESOLUTE China Registry (N = 1,800)...
January 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28109865/a-survey-of-membrane-receptor-regulation-in-valvular-interstitial-cells-cultured-under-mechanical-stresses
#12
Mir S Ali, Xinmei Wang, Carla M R Lacerda
Degenerative valvular diseases have been linked to the action of abnormal forces on valve tissues during each cardiac cycle. It is now accepted that the degenerative behavior of valvular cells can be induced mechanically in vitro. This approach of in vitro modeling of valvular cells in culture constitutes a powerful tool to study, characterize, and develop predictors of heart valve degeneration in vivo. Using such in vitro systems, we expect to determine the exact signaling mechanisms that trigger and mediate propagation of degenerative signals...
January 18, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28109683/incidence-and-risk-factors-of-delirium-in-patients-after-type-a-aortic-dissection-surgery
#13
Zhengqin Liu, Xinyan Pang, Xiquan Zhang, Guangqing Cao, Changcun Fang, Shuming Wu
OBJECTIVE: To study the incidence and related risk factors for postoperative delirium after type-A aortic dissection in patients who underwent Sun's procedure (total arch replacement using a tetrafurcate graft with stented elephant trunk implantation). DESIGN: A retrospective study. SETTING: A cardiac surgical intensive care unit. PARTICIPANTS: The study comprised 100 patients admitted to the intensive care unit for type-A aortic dissection...
November 3, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28109620/effect-of-pre-operative-octenidine-nasal-ointment-and%C3%A2-showering-on-surgical-site-infections-in-patients-undergoing-cardiac-surgery
#14
M Reiser, A Scherag, C Forstner, F M Brunkhorst, S Harbarth, T Doenst, M W Pletz, S Hagel
OBJECTIVE: To evaluate the effect of pre-operative octenidine (OCT) decolonization on surgical site infection (SSI) rates. DESIGN: Before-and-after cohort study. PATIENTS: Patients undergoing an elective isolated coronary artery bypass graft (CABG) procedure: control group (1(st) January to 31(st) December 2013), N=475; intervention group (1(st) January to 31(st) December 2014), N=428. INTERVENTIONS: The intervention consisted of nasal application of OCT ointment three times daily, beginning on the day before surgery, and showering the night before and on the day of surgery with OCT soap...
November 18, 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28109619/obesity-and-heart-failure-focus-on-the-obesity-paradox
#15
REVIEW
Salvatore Carbone, Carl J Lavie, Ross Arena
The escalating prevalence of obesity has been linked to substantial increases in both metabolic and cardiovascular disease. Nevertheless, the direct effects of obesity on cardiovascular health and function require further exploration. In particular, the relationship between obesity and cardiac function has received intense scrutiny. Although obesity increases the risk for development of heart failure (HF), it appears to exert a protective effect in patients in whom HF has already been diagnosed (the "obesity paradox")...
January 5, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28109576/beta-blockers-reduced-the-risk-of-cardiac-rupture-in-patients-with-acute-myocardial-infarction-a-meta-analysis-of-randomized-control-trials
#16
Wei Gong, Siting Feng, Xiao Wang, Jingyao Fan, Aobo Li, Shao-Ping Nie
BACKGROUND: Cardiac rupture (CR) is a catastrophic complication that occurs after acute myocardial infarction (MI) and, at present, there are no effective pharmacological strategies for preventing this condition. The objective of this meta-analysis was to assess the effect of beta-blockers on CR in patients with acute MI. METHODS: An extensive search of the PUBMED, EMBASE, ISI Web of Science, MEDLINE and Cochrane was performed to retrieve the studies of beta-blockers treatment in patients with acute MI...
January 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28109570/osteopathic-manipulative-treatment-improves-heart-surgery-outcomes-a-randomized-controlled-trial
#17
Vittorio Racca, Bruno Bordoni, Paolo Castiglioni, Maddalena Modica, Maurizio Ferratini
BACKGROUND: Controlling sternal pain after heart surgery is important to reduce the risk of postoperative complications, but pain is often undertreated because of contraindications and side effects of analgesic drugs. Recently, osteopathic manipulative treatment (OMT) was demonstrated to reduce pain in different clinical contexts, suggesting its potential utility after cardiac surgery. The aim of this open-label, controlled study is to assess whether OMT contributes to sternal pain relief and improves postoperative outcomes...
January 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28109568/one-or-two-internal-thoracic-grafts-long-term-follow-up-of-957-off-pump-coronary-bypass-surgeries
#18
Dmitry Pevni, Yanai Ben-Gal, Rephael Mohr, Amir Ganiel, Yosef Paz, Amir Kramer, Nahum Nesher
BACKGROUND: The potential survival benefit of bilateral internal thoracic artery (BITA) grafting in patients undergoing off-pump coronary artery bypass graft surgery (OPCABG) is controversial owing to the technical complexity of these operations. Our objective was to compare the outcome of patients undergoing OPCABG with BITA to the outcome of patients undergoing OPCABG with a single internal thoracic artery (SITA) and saphenous vein grafts or radial artery. METHODS: Five hundred and thirty-five consecutive patients who underwent OPCABG BITA at our institute between 2000 and 2008 were compared with 422 patients who underwent OPCABG with SITA...
January 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28109560/etiologies-trends-and-predictors-of-30-day-readmission-in-patients-with-heart-failure
#19
Shilpkumar Arora, Prashant Patel, Sopan Lahewala, Nilay Patel, Nileshkumar J Patel, Kosha Thakore, Aditi Amin, Byomesh Tripathi, Varun Kumar, Harshil Shah, Mahek Shah, Sidakpal Panaich, Abhishek Deshmukh, Apurva Badheka, Umesh Gidwani, Radha Gopalan
Heart failure (HF) is the most common discharge diagnosis across the United States, and these patients are particularly vulnerable to readmissions, increasing attention to potential ways to address the problem. The study cohort was derived from the Healthcare Cost and Utilization Project's National Readmission Data 2013, sponsored by the Agency for Healthcare Research and Quality. HF was identified using appropriate International Classification of Diseases, Ninth Revision, Clinical Modification codes. Readmission was defined as a subsequent hospital admission within 30 days after discharge day of index admission...
December 14, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28109343/involvement-of-wnt-pathway-in-ethanol-induced-inhibition-of-mouse-embryonic-stem-cell-differentiation
#20
Qian Wang, Jing-Wen Song, Yang Liu, Xian-Xian Zhao
Ethanol has been reported to have toxicity on embryonic stem cells (ESCs). The present study aims to address the teratogenic effects of ethanol on the growth and cardiac differentiation of ESCs. Mouse embryonic stem D3 cells were employed. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays were used to determine cytotoxicity. Quantitative real time polymerase chain reaction (qRT-PCR) and Western blotting were used to analyze the expressions of cardiac differentiation-related and Wnt signaling factors...
February 2017: Alcohol
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