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https://www.readbyqxmd.com/read/28932330/is-male-rheumatoid-arthritis-an-occupational-disease-a-review
#1
Dan Murphy, David Hutchinson
BACKGROUND: Rheumatoid arthritis (RA) is a systemic, inflammatory disease with an estimated global prevalence of 0.3-1.0%. An unexplained association exists between low formal education and the development of RA independent of smoking. It is established that RA is initiated in the lungs and that various occupations associated with dust, fume and metal inhalation can increase the risk of RA development. OBJECTIVE: The objective of this review is to evaluate published clinical reports related to occupations associated with RA development...
2017: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28929749/copper-catalyzed-tandem-aerobic-oxidative-cyclization-for-the-synthesis-of-polysubstituted-quinolines-via-c-sp3-c-sp2-h-bonds-functionalization
#2
Xiaobo Pang, Mingzhong Wu, Jixiang Ni, Fuming Zhang, Jingfeng Lan, Baohua Chen, Rulong Yan
One-pot Cu-catalyzed tandem aerobic oxidative cyclization for the synthesis of quinolines from 2-vinylanilines/2-aryl anilines and 2-methylquinolines via C(sp3)-H/C(sp2)-H bonds functionalization has been developed. Dioxygen as an ideal oxidant has been employed for this transformation. The substrates bearing various functional groups are performed well in this process and generate the desired products in moderate to good yields.
September 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28925728/impact-of-consumption-of-repeatedly-heated-cooking-oils-on-the-incidence-of-various-cancers-a-critical-review
#3
Kumar Ganesan, Kumeshini Sukalingam, Baojun Xu
Repeated heating of vegetable oils at high temperatures during cooking is a very common cooking practice. Repeatedly heated cooking oils (RCO) can generate varieties of compounds, including polycyclic aromatic hydrocarbons (PAH), some of which have been reported as carcinogenic. RCO is one of the commonly consumed cooking and frying medium. These RCO consumption and inhalation of cooking fumes can pose a serious health hazard. Taking into account exploratory study, the present review aims to provide the consumption of RCO and its fumes cause the high incidence of genotoxic, mutagenic, tumorogenic and various cancers...
September 19, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28916653/yap-suppresses-lung-squamous-cell-carcinoma-progression-via-deregulation-of-the-dnp63-gpx2-axis-and-ros-accumulation
#4
Hsinyi Huang, Wenjing Zhang, Yafang Pan, Yijun Gao, Lei Deng, Fuming Li, Fei Li, Xueyan Ma, Shenda Hou, Jing Xu, Peixue Li, Xiaoxun Li, Guohong Hu, Cheng Li, Haiquan Chen, Lei Zhang, Hongbin Ji
Lung squamous cell carcinoma (SCC), accounting for approximately 30% of non-small cell lung cancer, is often refractory to therapy. Screening a small molecule library, we identified digitoxin as a high potency compound for suppressing human lung SCC growth in vitro and in vivo. Mechanistic investigations revealed that digitoxin attenuated YAP phosphorylation and promoted YAP nuclear sequestration. YAP activation led to excessive accumulation of reactive oxygen species (ROS) by downregulating the antioxidant enzyme GPX2 in a manner related to p63 blockade...
September 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28910727/gene-environment-interaction-does-fluoride-influence-the-reproductive-hormones-in-male-farmers-modified-by-er%C3%AE-gene-polymorphisms
#5
Qiang Ma, Hui Huang, Long Sun, Tong Zhou, Jingyuan Zhu, Xuemin Cheng, Lijv Duan, Zhiyuan Li, Liuxin Cui, Yue Ba
The occurrence of endemic fluorosis is derived from high fluoride levels in drinking water and industrial fumes or dust. Reproductive disruption is also a major harm caused by fluoride exposure besides dental and skeletal lesions. However, few studies focus on the mechanism of fluoride exposure on male reproductive function, especially the possible interaction of fluoride exposure and gene polymorphism on male reproductive hormones. Therefore, we conducted a cross-sectional study in rural areas of Henan province in China to explore the interaction between the estrogen receptor alpha (ERα) gene and fluoride exposure on reproductive hormone levels in male farmers living in the endemic fluorosis villages...
September 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/28905957/correction-a-dual-ion-electrochemistry-deionization-system-based-on-agcl-na0-44mno2-electrodes
#6
Fuming Chen, Yinxi Huang, Lu Guo, Meng Ding, Hui Ying Yang
Correction for 'A dual-ion electrochemistry deionization system based on AgCl-Na0.44MnO2 electrodes' by Fuming Chen et al., Nanoscale, 2017, 9, 10101-10108.
September 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28901575/fuming-with-rage-do-members-of-low-status-groups-signal-anger-more%C3%A2-than-members-of-high-status-groups
#7
Chuma Kevin Owuamalam, Mark Rubin
Owuamalam, Weerabangsa, Karunagharan and Rubin found that Malaysians associate people in low status groups with anger more than their higher status counterparts: the hunchback heuristic. But is this belief accurate? Here, we propose the alternative possibility that members of low-status groups might deliberately suppress anger to counter this stigma, while members of high-status groups might disinhibit their anger to assert their superiority. To test these propositions, we manipulated undergraduate students' relative group status by leading them to believe that provocative comments about their undergraduate social identity came from a professor (low-status condition) or a junior foundation year student (high-status condition)...
October 2017: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/28899966/factors-associated-with-work-productivity-among-people-with-copd-birmingham-copd-cohort
#8
Kiran K Rai, Peymané Adab, Jon G Ayres, W Stanley Siebert, Steven S Sadhra, Alice J Sitch, David A Fitzmaurice, Rachel E Jordan
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) are more likely to take time off work (absenteeism) and report poor performance at work (presenteeism) compared to those without COPD. Little is known about the modifiable factors associated with these work productivity outcomes. AIM: To assess the factors associated with work productivity among COPD patients. METHODS: Cross-sectional analysis of baseline data from a subsample (those in paid employment) of the Birmingham COPD Cohort study...
September 12, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28898733/manipulation-of-pickering-emulsion-rheology-using-hydrophilically-modified-silica-nanoparticles-in-brine
#9
Christopher Griffith, Hugh Daigle
HYPOTHESIS: Previous work on Pickering emulsions has shown that bromohexadecane-in-water emulsions (50% oil) stabilized with fumed and spherical particles modified with hexadecyl groups develop a noticeable zero shear elastic storage modulus (G'0) of 200Pa and 9Pa, respectively, while in just 50mM NaCl. This high G'0 can be problematic for subsurface applications where brine salinities are higher and on the order of 600mM NaCl. High reservoir salinity coupled with low formation pressure drops could prevent an emulsion with a high G'0 from propagating deep into formation...
September 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28886565/size-separated-particle-fractions-of-stainless-steel-welding-fume-particles-a-multi-analytical-characterization-focusing-on-surface-oxide-speciation-and-release-of-hexavalent-chromium
#10
N Mei, L Belleville, Y Cha, U Olofsson, I Odnevall Wallinder, K-A Persson, Y S Hedberg
Welding fume of stainless steels is potentially health hazardous. The aim of this study was to investigate the manganese (Mn) and chromium (Cr) speciation of welding fume particles and their extent of metal release relevant for an inhalation scenario, as a function of particle size, welding method (manual metal arc welding, metal arc welding using an active shielding gas), different electrodes (solid wires and flux-cored wires) and shielding gases, and base alloy (austenitic AISI 304L and duplex stainless steel LDX2101)...
August 31, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28883490/in-vitro-exposure-of-simulated-meat-cooking-fumes-to-assess-adverse-biological-effects
#11
Bijay Kumar Poudel, Jungwook Choi, Jae Hong Park, Kyung-Oh Doh, Jeong Hoon Byeon
The heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is considered as a human carcinogenic or mutagenic compound that is produced from the co-condensation of creatinine and amino acids as meats cook at high temperatures. The cooking of meats at high temperatures produces fumes, and these fumes can be suspended as aerosols via the vapor-to-particle (or -droplet) process in a temperature gradient field. Size distributions of the aerosols included a significant portion of nano- and submicron-sized particles, and these can be directly deposited in the lungs and on skin by particle transport phenomena near cooking areas...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28881305/the-association-between-cooking-oil-fume-exposure-during-pregnancy-and-birth-weight-a-prospective-mother-child-cohort-study
#12
Lingling Wang, Weiyue Hu, Quanquan Guan, Guizhen Du, Ting Chen, Wei Wu, Yun Wang, Xinru Wang, Yankai Xia
Effects of indoor air pollution on neonatal birth weight has been studied for many years. In China, cooking oil fumes are important parts of indoor air pollution. However, whether cooking oil fume exposure during pregnancy affects birth weight in China remains poorly understood. The objective of this study was to examine the association between pregnancy exposure to cooking oil fumes and birth weight in a newly established prospective mother-child cohort in China. We finally included 1420 pregnant women from 2013 to 2015 and follow up for one year until the offspring was born...
September 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28873337/thalamic-gaba-levels-and-occupational-manganese-neurotoxicity-association-with-exposure-levels-and-brain-mri
#13
Ruoyun E Ma, Eric J Ward, Chien-Lin Yeh, Sandy Snyder, Zaiyang Long, Fulya Gokalp Yavuz, S Elizabeth Zauber, Ulrike Dydak
Excessive occupational exposure to Manganese (Mn) has been associated with clinical symptoms resembling idiopathic Parkinson's disease (IPD), impairing cognitive and motor functions. Several studies point towards an involvement of the brain neurotransmitter system in Mn intoxication, which is hypothesized to be disturbed prior to onset of symptoms. Edited Magnetic Resonance Spectroscopy (MRS) offers the unique possibility to measure γ-amminobutyric acid (GABA) and other neurometabolites in vivo non-invasively in workers exposed to Mn...
September 2, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28871212/evaluation-of-consumer-monitors-to-measure-particulate-matter
#14
Sinan Sousan, Kirsten Koehler, Laura Hallett, Thomas M Peters
Recently, inexpensive (<$300) consumer aerosol monitors (CAMs) targeted for use in homes have become available. We evaluated the accuracy, bias, and precision of three CAMs (Foobot from Airoxlab, Speck from Carnegie Mellon University, and AirBeam from HabitatMap) for measuring mass concentrations in occupational settings. In a laboratory study, PM2.5 measured with the CAMs and a medium-cost aerosol photometer (personal DataRAM 1500, Thermo Scientific) were compared to that from reference instruments for three aerosols (salt, welding fume, and Arizona road dust, ARD) at concentrations up to 8500 μg/m(3)...
May 2017: Aerosol Science and Technology: the Journal of the American Association for Aerosol Research
https://www.readbyqxmd.com/read/28871124/cell-division-cycle-42-plays-a-cell-type-specific-role-in-lung-tumorigenesis
#15
Chao Zheng, Yuetong Wang, Liu Yang, Shuhua Zhou, Yijun Gao, Fuming Li, Yan Feng, Zuoyun Wang, Lixing Zhan, Qin Yan, Xueliang Zhu, Kwok-Kin Wong, Zhengjun Chen, Hongbin Ji
Cell division cycle 42 (CDC42) plays important roles in polarity establishment and maintenance as well as cell cycle progression and cell division. Although disruption of cell polarity is a prerequisite in epithelial tumor initiation, the roles of CDC42 in tumorigenesis are still poorly understood. Here we find that Cdc42 deficiency inhibits the Kras (G12D) -induced lung alveoli tumor formation, while conversely promotes bronchiole tumor formation in mice. Bronchial Cdc42 loss destroys contact inhibition potentially through cell polarity disruption, and results in increased tumor formation...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28862493/an-official-american-thoracic-society-workshop-report-presentations-and-discussion-of-the-sixth-jack-pepys-workshop-on-asthma-in-the-workplace
#16
Susan M Tarlo, Jean-Luc Malo, Frédéric de Blay, Nicole Le Moual, Paul Henneberger, Dick Heederik, Monika Raulf, Christopher Carlsten, André Cartier
The Sixth Jack Pepys Workshop on Asthma in the Workplace focused on six key themes regarding the recognition and assessment of work-related asthma and airway diseases: (1) cleaning agents and disinfectants (including in swimming pools) as irritants and sensitizers: how to evaluate types of bronchial reactions and reduce risks; (2) population-based studies of occupational obstructive diseases: use of databanks, advantages and pitfalls, what strategies to deal with biases and confounding?; (3) damp environments, dilapidated buildings, recycling processes, and molds, an increasing problem: mechanisms, how to assess causality and diagnosis; (4) diagnosis of occupational asthma and rhinitis: how useful are recombinant allergens (component-resolved diagnosis), metabolomics, and other new tests?; (5) how does exposure to gas, dust, and fumes enhance sensitization and asthma?; and (6) how to determine probability of occupational causality in chronic obstructive pulmonary disease: epidemiological and clinical, confirmation, and compensation aspects...
September 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28858348/a-prussian-blue-anode-for-high-performance-electrochemical-deionization-promoted-by-the-faradaic-mechanism
#17
Lu Guo, Runwei Mo, Wenhui Shi, Yinxi Huang, Zhi Yi Leong, Meng Ding, Fuming Chen, Hui Ying Yang
Desalination is a sustainable process that removes sodium and chloride ions from seawater. Herein, we demonstrate a faradaic mechanism to promote the capacity of capacitive deionization in highly concentrated salt water via an electrochemical deionization device. In this system, ion removal is achieved by the faradaic mechanism via a constant current operation mode, which is improved based on the constant voltage operation mode used in the conventional CDI operation. Benefiting from the high capacity and excellent rate performance of Prussian blue as an active electrochemical reaction material, the designed unit has revealed a superior removal capacity with an ultrafast ion removal rate...
September 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/28857088/-health-hazards-resulting-from-exposure-to-zinc-and-its-inorganic-compounds-in-industry
#18
REVIEW
Daria Pakulska, Sławomir Czerczak
This article deals with health risks resulting from exposure to zinc and its inorganic compounds in industry. The main source of zinc exposure are fumes generated during thermal and chemical processes, mainly zinc oxide fume formed by immediate oxidation of metallic zinc vapor formed during high-temperature processes, as well as dust generated during the mechanical processing of zinc-containing materials. It is recognized that zinc ions are responsible for health effects of exposure to dust/fumes of the majority of zinc compounds, and the final effect of exposure depends on the degree of dispersion of dusts/fumes suspended in the air...
August 31, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28855823/microbiological-and-molecular-identification-of-bacterial-species-isolated-from-nasal-and-oropharyngeal-mucosa-of-fuel-workers-in-riyadh-saudi-arabia
#19
Suaad S AlWakeel
This study aimed to determine the bacterial species colonizing the nasal and oropharyngeal mucosa of fuel workers in Central Riyadh, Saudi Arabia on a microbiological and molecular level. Throat and nasal swab samples were obtained from 29 fuel station attendants in the period of time extending from March to May 2014 in Riyadh, Saudi Arabia. Microbiological identification techniques were utilized to identify the bacterial species isolated. Antibiotic sensitivity was assessed for each of the bacterial isolates...
September 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28853235/efficiency-of-different-storage-media-for-avulsed-teeth-in-animal-models-a-systematic-review
#20
Daniele L Longo, Ana C Fumes, Erika C Küchler, Francisco W G Paula-Silva, Paulo Nelson Filho, Léa A B Silva
BACKGROUND/AIMS: Tooth avulsion consists of the complete displacement of a tooth from the alveolar socket. When immediate replantation is not possible, the avulsed tooth should be kept in a storage medium capable of maintaining the viability of periodontal ligament (PDL) cells on the root surface. However, there is no consensus on the best storage medium able to prevent sequels such as ankylosis and tooth resorption. The aim of this study was to perform a systematic review to evaluate the in vivo effectiveness of different storage media for avulsed teeth...
August 29, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
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