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https://www.readbyqxmd.com/read/28346904/single-particle-mass-spectral-signatures-from-vehicle-exhaust-particles-and-the-source-apportionment-of-on-line-pm2-5-by-single-particle-aerosol-mass-spectrometry
#1
Jian Yang, Shexia Ma, Bo Gao, Xiaoying Li, Yanjun Zhang, Jing Cai, Mei Li, Ling'ai Yao, Bo Huang, Mei Zheng
In order to accurately apportion the many distinct types of individual particles observed, it is necessary to characterize fingerprints of individual particles emitted directly from known sources. In this study, single particle mass spectral signatures from vehicle exhaust particles in a tunnel were performed. These data were used to evaluate particle signatures in a real-world PM2.5 apportionment study. The dominant chemical type originating from average positive and negative mass spectra for vehicle exhaust particles are EC species...
March 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28346701/effect-of-resistance-training-with-vibration-and-compression-on-the-formation-of-muscle-and-bone
#2
Christoph Zinner, Bettina Baessler, Kilian Weiss, Jasmine Ruf, Guido Michels, Hans-Christer Holmberg, Billy Sperlich
INTRODUCTION: In this study we investigated the effects of resistance training with vibration in combination with leg compression to restrict blood flow on strength, muscle oxygenation, muscle mass, and bone formation. METHODS: Twelve participants were tested before and after 12 weeks of resistance training with application of vibration (VIBRA; 1-2 mm, 30 Hz) to both legs and compression (∼35 mm Hg, VIBRA+COMP) to only 1 leg. RESULTS: VIBRA+COMP and VIBRA improved 1 repetition maximum (1-RM), increased the number of repetitions preceding muscle exhaustion, enhanced cortical bone mass, and lowered the mass and fat fraction in the thigh, with no changes in total muscle mass...
March 27, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28345650/rational-combination-of-oncolytic-vaccinia-virus-and-pd-l1-blockade-works-synergistically-to-enhance-therapeutic-efficacy
#3
Zuqiang Liu, Roshni Ravindranathan, Pawel Kalinski, Z Sheng Guo, David L Bartlett
Both anti-PD1/PD-L1 therapy and oncolytic virotherapy have demonstrated promise, yet have exhibited efficacy in only a small fraction of cancer patients. Here we hypothesized that an oncolytic poxvirus would attract T cells into the tumour, and induce PD-L1 expression in cancer and immune cells, leading to more susceptible targets for anti-PD-L1 immunotherapy. Our results demonstrate in colon and ovarian cancer models that an oncolytic vaccinia virus attracts effector T cells and induces PD-L1 expression on both cancer and immune cells in the tumour...
March 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28345636/viral-infections-reinvigorating-exhausted-t-cells-in-hepatitis-b-infection
#4
Megan Cully
No abstract text is available yet for this article.
March 27, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28345535/photoactivated-processes-in-optical-fibers-generation-and-conversion-mechanisms-of-twofold-coordinated-si-and-ge-atoms
#5
Luigi Giacomazzi, Layla Martin-Samos, Aziz Boukenter, Youcef Ouerdane, Sylvain Girard, Antonino Alessi, Nicolas Richard, Stefano de Gironcoli
In this work we present an extensive investigation of nanoscale physical phenomena related to oxygen-deficient centers (ODC) in silica and Ge-doped silica by means of first-principles calculations, including nudged-elastic band (NEB), electron paramagnetic resonance (EPR) parameters calculations, and many-body perturbation theory (GW and Bethe-Salpeter Equation) techniques. We show that by neutralizing positively charged oxygen monovacancies we can obtain model structures of twofold Si and Ge defects of which the calculated absorption spectra and singlet-to-triplet transitions are in excellent agreement with the experimental optical absorption and photo-luminescence data...
March 27, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28345090/exhaustive-suzuki-miyaura-reactions-of-polyhalogenated-heteroarenes-with-alkyl-boronic-pinacol-esters
#6
Sébastien Laulhé, J Miles Blackburn, Jennifer L Roizen
A novel Suzuki-Miyaura protocol is described that enables the exhaustive alkylation of polychlorinated pyridines. This method facilitates a formal synthesis of normuscopyridine and the rapid assembly of a dumbbell shaped portion of a [2]rotaxane.
March 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28344863/tumor-infiltrating-lymphocytes-tils-from-patients-with-glioma
#7
Zhenjiang Liu, Qingda Meng, Jiri Bartek, Thomas Poiret, Oscar Persson, Lalit Rane, Elena Rangelova, Christopher Illies, Inti Harvey Peredo, Xiaohua Luo, Martin Vijayakumar Rao, Rebecca Axelsson Robertson, Ernest Dodoo, Markus Maeurer
Tumor-infiltrating lymphocytes (TILs) may represent a viable source of T cells for the biological treatment of patients with gliomas. Glioma tissue was obtained from 16 patients, tumor cell lines were established, and TILs were expanded in 16/16 cases using a combination of IL-2/IL-15/IL-21. Intracellular cytokine staining (ICS, IL-2, IL-17, TNFα and IFNγ production) as well as a cytotoxicity assay was used to detect TIL reactivity against autologous tumor cells or shared tumor-associated antigens (TAAs; i...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28344838/establishing-a-policy-framework-for-the-primary-prevention-of-occupational-cancer-a-proposal-based-on-a-prospective-health-policy-analysis
#8
Amanda Veglia, Manisha Pahwa, Paul A Demers
BACKGROUND: Despite our knowledge of the causes of cancer, millions of workers are involuntarily exposed to a wide range of known and suspected carcinogens in the workplace. To address this issue from a policy perspective, we developed a policy framework based on a prospective health policy analysis. Use of the framework was demonstrated for developing policies to prevent cancers associated with diesel engine exhaust (DEE), asbestos, and shift work, three occupational carcinogens with global reach and large cancer impact...
March 2017: Safety and Health At Work
https://www.readbyqxmd.com/read/28344737/non-invasive-measures-of-core-temperature-versus-ingestible-thermistor-during-exercise-in-the-heat
#9
Donovan L Fogt, Andrea L Henning, Adam S Venable, Brian K McFarlin
The accuracy of core temperature (Tc) thermometry from temporal, tympanic, and oral thermometry devices has been variable during exercise in a hot, humid environment. The purpose of the present study was to cross-validate temporal, two tympanic devices, and oral devices compared to an ingestible thermistor during exercise in a hot, humid environment. Fourteen young, active adults (6 women) completed a graded exercise test until voluntary exhaustion in an environmental chamber (35.5 ± 0.6 °C, 53.9 ± 5.8 % RH)...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28344714/moral-distress-and-burnout-in-internal-medicine-residents
#10
Sharareh Sajjadi, Monica Norena, Hubert Wong, Peter Dodek
BACKGROUND: Residents frequently encounter situations in their workplace that may induce moral distress or burnout. The objective of this study was to measure overall and rotation-specific moral distress and burnout in medical residents, and the relationship between demographics and moral distress and burnout. METHODS: The revised Moral Distress Scale and the Maslach Burnout Inventory (Human Service version) were administered to Internal Medicine residents in the 2013-2014 academic year at the University of British Columbia...
February 2017: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/28344515/burnout-among-nurses-working-in-social-welfare-centers-for-the-disabled
#11
Eleni Lahana, Konstantina Papadopoulou, Olga Roumeliotou, Andreas Tsounis, Pavlos Sarafis, Dimitris Niakas
BACKGROUND: In the healthcare sector, we often come across the burnout syndrome. It is an occupational syndrome which causes, physical and emotional exhaustion. More information is needed on the dangers of burnout and how often it occurs in healthcare. The purpose of this study was to investigate burnout and factors associated with the syndrome among nurses working with people that are mentally challenged. METHODS: A cross-sectional survey was conducted, among 180 nurses working in public health centers for the disabled in multiple regions of Greece...
2017: BMC Nursing
https://www.readbyqxmd.com/read/28344458/the-effects-of-non-contingent-feedback-on-the-incidence-of-plateau-at-v%C3%AC-o2max
#12
Dan Gordon, Marie Gernigon, James Baker, Viviane Merzbach, Adrian Scruton
The purpose of this study was to examine the effects of non-contingent feedback in the form of heart rate (HR) on the incidence of plateau at V̇O2max. Ten physically active males (age 24.8 yrs ± 4.2; mass 81.4 ± 9.0 kg; stature 1.80 ± 0.11 m, V̇O2max 53.2 ± 5.8 ml·kg(-1.)min(-1)) who were V̇O2max testing naïve but were cognisant as to the heart rate responses to exercise completed four incremental tests to volitional exhaustion, separated by ~72 h for the determination of V̇O2max and gas exchange threshold...
March 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28344184/arteriovenous-hybrid-graft-with-outflow-in-the-proximal-axillary-vein
#13
Allen G Murga, Jason Chiriano, Sharon C Kiang, Sheela Patel, Christian Bianchi, Ahmed M Abou-Zamzam, Theodore H Teruya
INTRODUCTION: The patency of long-term hemodialysis access in end-stage renal disease (ESRD) patients remains a significant challenge. Often these patients are affected with limited venous outflow options, requiring limb abandonment and creation of new access in the contralateral arm. Vascular surgeons are familiar with the exposure of the proximal axillary artery via an infraclavicular incision. The axillary vein is easily exposed through this technique. The use of the hybrid Gore graft can make the venous anastomosis easier...
March 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28343846/higher-levels-of-il-6-cd4-turnover-and-treg-frequency-are-already-present-before-cart-in-hiv-infected-subjects-with-later-low-cd4-recovery
#14
Isaac Rosado-Sánchez, Inmaculada Jarrín, María M Pozo-Balado, Rebeca S de Pablo-Bernal, Inés Herrero-Fernández, Ana I Alvarez-Ríos, Esther Rodríguez-Gallego, Miguel Genebat, Mar Vera, Juan Berenguer, María L Martín, Enrique Bernal, Francesc Vidal, Julià Blanco, Manuel Leal, Yolanda M Pacheco
Immunological characterization of HIV-infected subjects with low CD4-recovery (LR-subjects) has been extensively performed after a variable period of combined antiretroviral therapy (cART). We now explore immunological alterations present before the cART onset. In a case-control study, we selected pre-cART samples of HIV-subjects with and without low CD4-recovery after cART (n = 21 per group). CD4 T-cell activation, senescence and exhaustion related markers were not found specifically altered before cART initiation...
March 24, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28343572/effect-of-the-timing-of-ice-slurry-ingestion-for-precooling-on-endurance-exercise-capacity-in-a-warm-environment
#15
Keisuke Takeshima, Sumire Onitsuka, Zheng Xinyan, Hiroshi Hasegawa
It has been demonstrated that precooling with ice slurry ingestion enhances endurance exercise capacity in the heat. However, no studies have yet evaluated the optimal timing of ice slurry ingestion for precooling. This study aimed to investigate the effects of varying the timing of ice slurry ingestion for precooling on endurance exercise capacity in a warm environment. Ten active male participants completed 3 experimental cycling trials to exhaustion at 55% peak power output (PPO) after 15min of warm-up at 30% PPO at 30°C and 80% relative humidity...
April 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28343286/a-mimic-of-sexually-motivated-homicide-insect-stings-and-heat-exhaustion-in-a-forest
#16
Nancy X Liu, Michael S Pollanen
We report the case a woman who was found dead in a forest. The body was nude and the position of the body suggested a sexually motivated homicide. We concluded that death was not related to homicide, but was related to the conjunction of environmental factors, including insect stings, and acute psychosis. A medicolegal death investigation with postmortem examination was undertaken to determine cause of death. At the scene, the body was supine with legs spread apart and the knees flexed, exposing the external genitalia...
March 25, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28343184/regulatory-role-of-ngfs-in-neurocognitive-functions
#17
Ashutosh Kumar, Vikas Pareek, Muneeb A Faiq, Pavan Kumar, Khursheed Raza, Pranav Prasoon, Subrahamanyam Dantham, Sankat Mochan
Nerve growth factors (NGFs), especially the prototype NGF and brain-derived neurotrophic factor (BDNF), have a diverse array of functions in the central nervous system through their peculiar set of receptors and intricate signaling. They are implicated not only in the development of the nervous system but also in regulation of neurocognitive functions like learning, memory, synaptic transmission, and plasticity. Evidence even suggests their role in continued neurogenesis and experience-dependent neural network remodeling in adult brain...
March 27, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28342622/an-analysis-of-the-relationship-between-burnout-socio-demographic-and-workplace-factors-and-job-satisfaction-among-emergency-department-health-professionals
#18
Menderes Tarcan, Neşet Hikmet, Benjamin Schooley, Mehmet Top, Gamze Yorgancıoglu Tarcan
INTRODUCTION: Burnout among emergency medical practitioners and personnel negatively affects career satisfaction and job performance and can lead to mental health issues, including anxiety, depression, and suicide. PURPOSE: This study investigated the relationship between the perceptions of burnout and job satisfaction of those working in two different hospital's emergency departments assessing the effect of burnout dimensions and additional factors (age, position, marital status, annual income, employment type, gender, patient encounters, and household economic well-being) on job satisfaction...
April 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28341666/pd-1-blockade-mediated-rescue-of-exhausted-t-cells-requires-cd28
#19
(no author information available yet)
PD-1 suppresses T cell activity by inhibiting the T cell costimulatory receptor CD28.
March 24, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28341536/the-role-of-cpla2-in-methylglyoxal-induced-cell-apoptosis-of-huvecs
#20
Jie Yuan, Chao Zhu, Yali Hong, Zongxing Sun, Xianjun Fang, Biao Wu, Shengnan Li
Methylglyoxal (MGO), a highly reactive dicarbonyl compound, is mainly formed as a byproduct of glycolysis. Elevated MGO level is known to induce apoptosis of vascular endothelial cells, which is implicated with progression of atherosclerosis and diabetic complications. However, the underlying mechanisms have not been exhaustively investigated yet. Here, we further characterized the mechanisms how MGO induced apoptosis in human umbilical vein endothelial cells (HUVECs). Our data revealed that cytosolic phospholipase A2 (cPLA2) played an important role in MGO-induced cell apoptosis...
March 21, 2017: Toxicology and Applied Pharmacology
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