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https://www.readbyqxmd.com/read/28918340/-cervical-lift-an-update
#1
D Labbé, P Guerreschi
The neck is an aesthetic unit for which a rejuvenation request is sometimes very targeted or ore often encompassed in a global surgical project of face-lift. To obtain a long lasting outcome, the plastic surgeon has to make a full, detailed, and exhaustive analysis of the neck in order to choose the best indication within the multiple surgical tools. A full clinical examination is the key point, every aspects are outlined. The numerous surgical choices are described, illustrated, and sometimes revisited in the light of targeted anatomical studies...
September 13, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28918291/distinguished-cr-vi-capture-with-rapid-and-superior-capability-using-polydopamine-microsphere-behavior-and-mechanism
#2
Qingrui Zhang, Yixuan Li, Qinggang Yang, He Chen, Xinqing Chen, Tifeng Jiao, Qiuming Peng
Toxic heavy metal containing Cr(VI) species is a serious threat for ecological environment and human beings. In this work, a new mussel-inspired polydopamine microsphere (PDA-sphere) is prepared through in situ oxidative polymerization at air condition with controllable sizes. The adsorption of Cr(VI) ions onto PDA-sphere is highly pH dependent with the optimal pH ranging from 2.5 to 3.8. A rapid Cr(VI) removal can approach in 8min for equilibrium. More importantly, the prepared materials exhibit a remarkable sorption selectivity, coexisting SO4(2-), NO3(-) and Cl(-) ions at high levels; The applicability model further proves its effective performances with treated capacity of 42,000kg/kg sorbent, and the effluent can be reduced from 2000ppb to below 50ppb, which meets the drinking water criterions recommended by WHO...
August 26, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28918096/a-comprehensive-review-on-aurora-kinase-small-molecule-inhibitors-and-clinical-trial-studies
#3
REVIEW
Ankit C Borisa, Hardik G Bhatt
Aurora kinase belongs to serine/threonine kinase family which controls cell division. Therapeutic inhibition of Aurora kinase showed great promise as probable anticancer regime because of its important role during cell division. Here, in this review, we have carried out exhaustive study of various synthetic molecules reported as Aurora kinase inhibitors and developed as lead molecule at various stages of clinical trials from its discovery in 1995 to till date. We reported details of small molecules, specifically inhibiting all 3 types of Aurora kinases, which includes extensive literature search in various database like various scientific journals, patents, scifinder and PubMed database, internet resources, books, etc...
August 24, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28918033/six-highly-conserved-targets-of-rnai-revealed-in-hiv-1-infected-patients-from-russia-are-also-present-in-many-hiv-1-strains-worldwide
#4
Olga V Kretova, Daria M Fedoseeva, Maria A Gorbacheva, Natalya M Gashnikova, Maria P Gashnikova, Nataliya V Melnikova, Vladimir R Chechetkin, Yuri V Kravatsky, Nickolai A Tchurikov
RNAi has been suggested for use in gene therapy of HIV/AIDS, but the main problem is that HIV-1 is highly variable and could escape attack from the small interfering RNAs (siRNAs) due to even single nucleotide substitutions in the potential targets. To exhaustively check the variability in selected RNA targets of HIV-1, we used ultra-deep sequencing of six regions of HIV-1 from the plasma of two independent cohorts of patients from Russia. Six RNAi targets were found that are invariable in 82%-97% of viruses in both cohorts and are located inside the domains specifying reverse transcriptase (RT), integrase, vpu, gp120, and p17...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28917820/characterization-of-secondary-organic-aerosol-from-photo-oxidation-of-gasoline-exhaust-and-specific-sources-of-major-components
#5
Pengkun Ma, Peng Zhang, Jinian Shu, Bo Yang, Haixu Zhang
To further explore the composition and distribution of secondary organic aerosol (SOA) components from the photo-oxidation of light aromatic precursors (toluene, m-xylene, and 1,3,5-trimethylbenzene (1,3,5-TMB)) and idling gasoline exhaust, a vacuum ultraviolet photoionization mass spectrometer (VUV-PIMS) was employed. Peaks of the molecular ions of the SOA components with minimum molecular fragmentation were clearly observed from the mass spectra of SOA, through the application of soft ionization methods in VUV-PIMS...
September 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28917793/multi-elemental-nd-sm-eu-gd-isotope-ratio-measurements-by-stop-flow-isotachophoresis-coupled-to-mc-icpms
#6
L Vio, B Martelat, H Isnard, A Nonell, F Chartier
In this study, a new analytical procedure based on isotachophoresis (ITP) coupled to a multi collector inductively coupled plasma mass spectrometer named Stop-Flow-ITP-MC-ICPMS is developed for exhaustive and high-precision multi-elemental isotopic characterization. We demonstrate that Stop-Flow-ITP makes it possible to stop the analytes migration several times for a duration compatible with the detector configuration changes without losing the separation performance. With this procedure, isotope ratio measurements of four lanthanides of interest for nuclear applications (Nd, Sm, Eu and Gd) were obtained with a reproducibility better than 0...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917757/innovative-thin-layer-chromatographic-method-combined-with-fluorescence-detection-for-specific-determination-of-febuxostat-application-in-biological-fluids
#7
Abdel-Maaboud I Mohamed, Mahmoud A Omar, Sayed M Derayea, Mohamed A Hammad, Abobakr A Mohamed
A newly developed thin-layer chromatographic (TLC) method coupled with fluorescence detection for specific determination of Febuxostat (FEB) was designed. The proposed method adopts exposure of FEB on a developed TLC plate to hydrochloric acid vapors, resulting in a large enhancement of its weak fluorescence, permitting its specific and sensitive determination in real human plasma and urine after excitation at 345nm on 60 F254 silica gel plates using toluene-ethyl acetate-methanol-glacial acetic acid; (30:10:5:0...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917721/low-levels-of-the-immunoregulator-semaphorin-4d-cd100-in-sera-of-hiv-patients
#8
Z Vadas, D Elbirt, S Radian, S Bezalel-Rosenberg, K Mahlab-Guri, E Toubi, I Asher, Z Sthoeger
INTRODUCTION: Semaphorin-4D (CD100), generated by CD4/CD8 cells, plays an important role in T cells activation. It also regulates B cell differentiation via its receptor the CD72. Both have soluble forms - sCD100/sCD72. METHODS: sCD100 and sCD72 levels were determined by ELISA (MyBioSource, USA). RESULTS: 28 chronic HIV patients and 50 matched healthy volunteers participated in our study. Before treatment, CD4 cell counts were 267±216cells/mcl and viral load (VL) was 586,675±1,897,431copies/ml...
September 13, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28917232/compressed-food-with-added-functional-oligopeptides-improves-performance-during-military-endurance-training
#9
Zhi-Qiang Zheng, Zhan-Hui Geng, Jia-Xi Liu, Shun-Tang Guo
BACKGROUND AND OBJECTIVES: Oligosaccharide or oligopeptide supplementation may have a significant impact on endurance performance. This study evaluated the effects of adding maltooligosaccharides (MO) or soy oligopeptides (SO) to compressed food (CF) on the physical response of soldiers to daily military training. METHODS AND STUDY DESIGN: Twelve soldiers were randomized to four diet groups: regular meals, CF, CFMO, and CFSO (crossover design). They participated in exercise tests including 90 minutes running at 55-65% VO2max and exhaustive running...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28917154/neural-activation-in-stress-related-exhaustion-cross-sectional-observations-and-interventional-effects
#10
Hanna Malmberg Gavelin, Anna Stigsdotter Neely, Micael Andersson, Therese Eskilsson, Lisbeth Slunga Järvholm, Carl-Johan Boraxbekk
The primary purpose of this study was to investigate the association between burnout and neural activation during working memory processing in patients with stress-related exhaustion. Additionally, we investigated the neural effects of cognitive training as part of stress rehabilitation. Fifty-five patients with clinical diagnosis of exhaustion disorder were administered the n-back task during fMRI scanning at baseline. Ten patients completed a 12-week cognitive training intervention, as an addition to stress rehabilitation...
September 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28916279/the-role-of-il-6-released-from-pulmonary-epithelial-cells-in-diesel-ufp-induced-endothelial-activation
#11
Rossella Bengalli, Eleonora Longhin, Sara Marchetti, Maria C Proverbio, Cristina Battaglia, Marina Camatini
Diesel exhaust particles (DEP) and their ultrafine fraction (UFP) are known to induce cardiovascular effects in exposed subjects. The mechanisms leading to these outcomes are still under investigation, but the activation of respiratory endothelium is likely to be involved. Particles translocation through the air-blood barrier and the release of mediators from the exposed epithelium have been suggested to participate in the process. Here we used a conditioned media in vitro model to investigate the role of epithelial-released mediators in the endothelial cells activation...
September 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28915712/formation-function-and-exhaustion-of-notochordal-cytoplasmic-vacuoles-within-intervertebral-disc-current-understanding-and-speculation
#12
REVIEW
Feng Wang, Zeng-Xin Gao, Feng Cai, Arjun Sinkemani, Zhi-Yang Xie, Rui Shi, Ji-Nan Wei, Xiao-Tao Wu
Notochord nucleus pulposus cells are characteristic of containing abundant and giant cytoplasmic vacuoles. This review explores the embryonic formation, biological function, and postnatal exhaustion of notochord vacuoles, aiming to characterize the signal network transforming the vacuolated nucleus pulposus cells into the vacuole-less chondrocytic cells. Embryonically, the cytoplasmic vacuoles within vertebrate notochord originate from an evolutionarily conserved vacuolation process during neurulation, which may continue to provide mechanical and signal support in constructing a mammalian intervertebral disc...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28914816/energy-saving-traffic-scheduling-in-hybrid-software-defined-wireless-rechargeable-sensor-networks
#13
Yunkai Wei, Xiaohui Ma, Ning Yang, Yijin Chen
Software Defined Wireless Rechargeable Sensor Networks (SDWRSNs) are an inexorable trend for Wireless Sensor Networks (WSNs), including Wireless Rechargeable Sensor Network (WRSNs). However, the traditional network devices cannot be completely substituted in the short term. Hybrid SDWRSNs, where software defined devices and traditional devices coexist, will last for a long time. Hybrid SDWRSNs bring new challenges as well as opportunities for energy saving issues, which is still a key problem considering that the wireless chargers are also exhaustible, especially in some rigid environment out of the main supply...
September 15, 2017: Sensors
https://www.readbyqxmd.com/read/28914068/-the-extent-of-the-burnout-syndrome-among-pharmacists-partial-study
#14
Markéta Saligerová, Jozef Kolář
The paper deals with the possibilities of investigating the susceptibility to burnout syndrome in pharmacists and pharmaceutical assistants working in pharmacies. By using the Maslach Burnout Inventory, between November 2015 and January 2016, 53 healthcare professionals were contacted in 11 pharmacies (Brno, Vyškov). The results of the research show that with an increasing length of practice the average EE factor (emotional exhaustion) increases. The DP (depersonalization) factor does not increase significantly with the increase in the length of practice...
2017: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/28913794/wheat-improvement-in-india-present-and-future
#15
Sonia Goel, Kalpana Singh, N K Singh
Wheat (Triticum aestivum L.) contributes substantially to global food and nutritional security. With the growing demands under the constraints of depleting natural resources, environmental fluctuation, and increased risk of epidemic outbreaks, the task of increasing wheat production has become daunting. The factors responsible for first green revolution seem to be exhausting rapidly, and there is an immediate need to develop the technologies which can not only increase the wheat production but also sustain the same at a higher level without adversely affecting the natural resources...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28912802/chaotic-image-encryption-algorithm-based-on-bit-permutation-and-dynamic-dna-encoding
#16
Xuncai Zhang, Feng Han, Ying Niu
With the help of the fact that chaos is sensitive to initial conditions and pseudorandomness, combined with the spatial configurations in the DNA molecule's inherent and unique information processing ability, a novel image encryption algorithm based on bit permutation and dynamic DNA encoding is proposed here. The algorithm first uses Keccak to calculate the hash value for a given DNA sequence as the initial value of a chaotic map; second, it uses a chaotic sequence to scramble the image pixel locations, and the butterfly network is used to implement the bit permutation...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28912741/daily-use-of-energy-management-strategies-and-occupational-well-being-the-moderating-role-of-job-demands
#17
Stacey L Parker, Hannes Zacher, Jessica de Bloom, Thomas M Verton, Corine R Lentink
We examine the relationships among employees' use of energy management strategies and two occupational well-being outcomes: job satisfaction and emotional exhaustion. Based on conservation of resources theory, it was hypothesized that employees with high job demands would benefit more from using energy management strategies (i.e., including prosocial, organizing, and meaning-related strategies), compared to employees with low job demands. We tested this proposition using a quantitative diary study. Fifty-four employees provided data twice daily across one work week (on average, 7 daily entries)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28912581/secretory-phospholipase-a2-iia-overexpressing-mice-exhibit-cyclic-alopecia-mediated-through-aberrant-hair-shaft-differentiation-and-impaired-wound-healing-response
#18
Gopal L Chovatiya, Rahul M Sarate, Raghava R Sunkara, Nilesh P Gawas, Vineet Kala, Sanjeev K Waghmare
Secretory phospholipase A2 Group-IIA (sPLA2-IIA) is involved in lipid catabolism and growth promoting activity. sPLA2-IIA is deregulated in many pathological conditions including various cancers. Here, we have studied the role of sPLA2-IIA in the development of cyclic alopecia and wound healing response in relation to complete loss of hair follicle stem cells (HFSCs). Our data showed that overexpression of sPLA2-IIA in homozygous mice results in hyperproliferation and terminal epidermal differentiation followed by hair follicle cycle being halted at anagen like stage...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912506/role-of-tumor-necrosis-factor-%C3%AE-and-its-receptors-in-diesel-exhaust-particle-induced-pulmonary-inflammation
#19
Smitha Kumar, Guy Joos, Louis Boon, Kurt Tournoy, Sharen Provoost, Tania Maes
Inhalation of diesel exhaust particles (DEP) induces an inflammatory reaction in the lung. However, the underlying mechanisms remain to be elucidated. Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine that operates by binding to tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2). The role of TNF-α signaling and the importance of either TNFR1 or TNFR2 in the DEP-induced inflammatory response has not yet been elucidated. TNF-α knockout (KO), TNFR1 KO, TNFR2 KO, TNFR1/TNFR2 double KO (TNFR-DKO) and wild type (WT) mice were intratracheally exposed to saline or DEP...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912206/clinical-yield-of-familial-screening-after-sudden-death-in-young-subjects-the-french-experience
#20
Pauline Quenin, Florence Kyndt, Philippe Mabo, Jacques Mansourati, Dominique Babuty, Aurélie Thollet, Béatrice Guyomarch, Richard Redon, Julien Barc, Jean-Jacques Schott, Frederic Sacher, Vincent Probst, Jean Baptiste Gourraud
BACKGROUND: After sudden cardiac death with negative autopsy, clinical screening of relatives identifies a high proportion of inherited arrhythmia syndrome. However, the efficacy of this screening in families not selected by autopsy has never been assessed. We aim to investigate the value of clinical screening in relatives of all subjects who died suddenly before 45 years of age. METHODS AND RESULTS: One hundred and three consecutive families who experienced unexplained sudden cardiac death before 45 years of age were included from May 2009 to December 2014 in a prospective multicenter registry...
September 2017: Circulation. Arrhythmia and Electrophysiology
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