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https://www.readbyqxmd.com/read/28323098/an-innovative-method-for-the-preparation-of-high-api-loaded-hollow-spherical-granules-for-use-in-controlled-release-formulation
#1
Takumi Asada, Mitsuaki Kobiki, Yasushi Ochiai, Yasunori Iwao, Shigeru Itai
The aim of this study was to prepare controlled-release (CR) granules with suitable particle strength, flowability, particle size distribution (PSD) and density characteristics for blending with other excipients. We also wanted these CR granules to contain large quantities of active pharmaceutical ingredient (API). A high shear mixer was used to mix an API with various polymers at various feed ratios, and the resulting granulated materials were sprayed with solvent. The wet granules were dried using a fluidized bed dryer to give CR granules...
March 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28315891/results-with-complementary-food-using-local-food-ingredients
#2
Tahmeed Ahmed, Munirul Islam, Nuzhat Choudhury, Iqbal Hossain, Sayeeda Huq, Mustafa Mahfuz, Shafiqul Alam Sarker
Appropriate complementary food is a must for optimum growth of infants and children. The food should be diverse and be given in sufficient quantities 2-4 times a day depending upon age. Poverty, food insecurity, and lack of awareness regarding the choice of nutritious food ingredients are deterrents to optimum complementary feeding. In Bangladesh, 77% of children do not receive appropriate complementary food and, hence, the high prevalence of childhood malnutrition. We developed ready-to-use complementary foods (RUCFs) using locally available food ingredients, rice/lentil and chickpea, which conform to standard specifications...
2017: Nestlé Nutrition Institute Workshop Series
https://www.readbyqxmd.com/read/28314373/structured-nanoparticles-from-the-self-assembly-of-polymer-blends-through-rapid-solvent-exchange
#3
Nannan Li, Athanassios Z Panagiotopoulos, Arash Nikoubashman
Molecular dynamics simulations were performed to study systematically the rapid mixing of a polymer blend in solution with a miscible non-solvent. In agreement with experiments, we observe that polymers self-assemble into complex nanoparticles, such as Janus and core-shell particles, when the good solvent is displaced by the poor solvent. The emerging structures can be predicted based on the surface tensions between the polymers, as well as between the polymers and the surrounding liquid. Furthermore, the size of the nanoparticles can be independently tuned through the mixing rate and the polymer concentration in the feed stream; meanwhile, the composition of the nanoparticles can be controlled by the polymer feed ratio...
March 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28303046/antioxidant-activity-and-polyphenolic-compound-stability-of-lentil-orange-peel-powder-blend-in-an-extrusion-process
#4
Rahul P Rathod, Uday S Annapure
Lentil contains substantial amount of protein, carbohydrate, fibre and other nutrients and orange peels powder rich in carbohydrate and fiber content The present study was aimed to investigate the effects of extrusion processing parameter on the level of total phenolic content (TPC), total flavonoid content (TFC), total tannin content and antioxidant activity of lentil-orange peel powder blend, also to investigate the possibility of blend as a candidate for production of protein rich extruded product by using response surface methodology...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28285981/novel-budesonide-particles-for-dry-powder-inhalation-dpi-prepared-using-a-microfluidic-reactor-coupled-with-ultrasonic-spray-freeze-drying
#5
Denis Saboti, Uroš Maver, Hak-Kim Chan, Odon Planinšek
Budesonide is a potent active pharmaceutical ingredient, often administered using respiratory devices such as metered dose inhalers (MDI), nebulizers and dry powder inhalers (DPI). Inhalable drug particles are conventionally produced by crystallization followed by milling. This approach tends to generate partially amorphous materials that require post-processing to improve the formulations' stability. Other methods involve homogenization or precipitation and often require the use of stabilizers, mostly surfactants...
March 9, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28273579/novel-modified-poly-vinyl-chloride-blend-membranes-for-removal-of-heavy-metals-from-mixed-ion-feed-sample
#6
Vignesh Nayak, M S Jyothi, R Geetha Balakrishna, Mahesh Padaki, Sebastien Deon
Herein, an attempt has been made to prepare a novel membrane with good efficiency for removal of heavy metal ions namely lead (Pb), cadmium (Cd) and chromium (Cr). 4-amino benzoic acid (ABA) was covalently grafted onto the poly vinyl chloride (PVC) backbone by CN bond to enhance the hydrophilicity. (1)H NMR and ATR-IR spectroscopy analysis confirmed the chemical modification of PVC. Further the modified polymer was blended in different compositions with polysulfone (PSf) for optimization. Morphological changes that occurred in blend membranes, due to the incorporation of modified PVC was studied by AFM and SEM techniques...
February 27, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28249605/cultivable-gut-bacteria-provide-a-pathway-for-adaptation-of-chrysolina-herbacea-to-mentha-aquatica-volatiles
#7
Graziano Pizzolante, Chiara Cordero, Salvatore M Tredici, Davide Vergara, Paola Pontieri, Luigi Del Giudice, Andrea Capuzzo, Patrizia Rubiolo, Chidananda N Kanchiswamy, Simon A Zebelo, Carlo Bicchi, Massimo E Maffei, Pietro Alifano
BACKGROUND: A chemical cross-talk between plants and insects is required in order to achieve a successful co-adaptation. In response to herbivory, plants produce specific compounds, and feeding insects respond adequately7 to molecules produced by plants. Here we show the role of the gut microbial community of the mint beetle Chrysolina herbacea in the chemical cross-talk with Mentha aquatica (or watermint). RESULTS: By using two-dimensional gas chromatography-mass spectrometry we first evaluated the chemical patterns of both M...
March 2, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28249376/effects-of-a-specific-blend-of-essential-oils-on-apparent-nutrient-digestion-rumen-fermentation-and-rumen-microbial-populations-in-sheep-fed-a-50-50-alfalfa-hay-concentrate-diet
#8
N Khateri, O Azizi, H Jahani-Azizabadi
OBJECTIVE: An experiment was conducted to investigate the effects of a specific mixture of essential oils (MEO), containing thyme, clove and cinnamon EO, on rumen microbial fermentation, nutrient apparent digestibility and blood metabolites in fistulated sheep. METHODS: Six sheep fitted with ruminal fistulas were used in a repeated measurement design with two 24-d periods to investigate the effect of adding MEO at 0 (control), 0.8, and 1.6 mL/d on apparent nutrient digestibility, rumen fermentation characteristics, rumen microbial population and blood chemical metabolites...
March 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28237592/enteric-methane-production-in-lactating-dairy-cows-with-continuous-feeding-of-essential-oils-or-rotational-feeding-of-essential-oils-and-lauric-acid
#9
G Klop, J Dijkstra, K Dieho, W H Hendriks, A Bannink
The rumen microbes can adapt to feed additives, which may make the decrease in enteric CH4 production upon feeding an additive a transient response only. This study investigated alternate feeding of 2 CH4 mitigating feed additives with a different mode of action on persistency of lowering CH4 production compared with feeding a single additive over a period of 10 wk. Four pairs of cows were selected, and within pairs, cows were randomly assigned to either the control (AR-AR) or the alternating (AR-LA) concentrate treatment...
February 22, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28231698/effect-of-feeding-of-blend-of-essential-oils-on-methane-production-growth-nutrient-utilization-in-growing-buffaloes
#10
M A Yatoo, L C Chaudhary, Neeta Agarwal, V B Chaturvedi, D N Kamra
Objective: An experiment was conducted to study the effect of a blend of essential oils (BEO) on enteric methane emission and growth performance of buffaloes (Bubalus bubalis). Methods: Twenty one growing male buffaloes (average body weight of 279 ± 9.3 kg) were divided in to three groups. The animals of all the three groups were fed on a ration consisting of wheat straw and concentrate mixture targeting 500g daily live weight gain. The three dietary groups were; Group1: control without additive, Group 2 and 3: supplemented with BEO @ 0...
February 23, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28215897/effects-of-body-condition-monensin-and-essential-oils-on-ruminal-lipopolysaccharide-concentration-inflammatory-markers-and-endoplasmatic-reticulum-stress-of-transition-dairy-cows
#11
C Drong, S Bühler, J Frahm, L Hüther, U Meyer, D von Soosten, D K Gessner, K Eder, H Sauerwein, S Dänicke
Evidence exists that dairy cows experience inflammatory-like phenomena in the transition period. Rumen health and alterations in metabolic processes and gene networks in the liver as the central metabolic organ might be key factors for cows' health and productivity in early lactation. This study made use of an animal model to generate experimental groups with different manifestations of postpartal fat mobilization and ketogenesis. In total, 60 German Holstein cows were allocated 6 wk antepartum to 3 high-body condition score (BCS) groups (BCS 3...
February 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28134434/herbivore-induced-plant-volatiles-accurately-predict-history-of-coexistence-diet-breadth-and-feeding-mode-of-herbivores
#12
Holger Danner, Gaylord A Desurmont, Simona M Cristescu, Nicole M van Dam
Herbivore-induced plant volatiles (HIPVs) serve as specific cues to higher trophic levels. Novel, exotic herbivores entering native foodwebs may disrupt the infochemical network as a result of changes in HIPV profiles. Here, we analysed HIPV blends of native Brassica rapa plants infested with one of 10 herbivore species with different coexistence histories, diet breadths and feeding modes. Partial least squares (PLS) models were fitted to assess whether HIPV blends emitted by Dutch B. rapa differ between native and exotic herbivores, between specialists and generalists, and between piercing-sucking and chewing herbivores...
January 30, 2017: New Phytologist
https://www.readbyqxmd.com/read/28129937/determination-of-cinnamaldehyde-carvacrol-and-thymol-in-feedstuff-additives-by-pressurized-liquid-extraction-followed-by-gas-chromatography-mass-spectrometry
#13
Marta Jiménez-Salcedo, María Teresa Tena
Specific blends of essential oils (BEOs) are promising substitutes for antibiotics to promote livestock performance and to reduce the incidence of intestinal disorders. Microencapsulation of BEOs has shown to improve their stability, bioavailability and to control their release rate once they are added to the feedstuff. The development and validation of a method for determining essential oil components such as carvacrol, thymol and cinnamaldehyde in a microencapsulated material used as feed additive is presented...
March 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28117827/film-extrusion-of-crambe-abyssinica-wheat-gluten-blends
#14
Mikael Gällstedt, Henrik Pettersson, Therese Johansson, William R Newson, Eva Johansson, Mikael S Hedenqvist
Crambe abyssinica is a plant with potential for use in industrial (non-food) plant oil production. The side stream from this oil production is a high-protein crambe meal that has limited value, as it is not fit for food or feed use. However, it contains proteins that could potentially make it a suitable raw material for higher-value products. The purpose of this study was to find methods of making this side stream into extruded films, showing that products with a higher value can be produced. The study mainly considered the development of material compositions and methods of preparing and extruding the material...
January 17, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28114992/a-maize-ing-attraction-gravid-anopheles-arabiensis-are-attracted-and-oviposit-in-response-to-maize-pollen-odours
#15
Betelehem Wondwosen, Sharon R Hill, Göran Birgersson, Emiru Seyoum, Habte Tekie, Rickard Ignell
BACKGROUND: Maize cultivation contributes to the prevalence of malaria mosquitoes and exacerbates malaria transmission in sub-Saharan Africa. The pollen from maize serves as an important larval food source for Anopheles mosquitoes, and females that are able to detect breeding sites where maize pollen is abundant may provide their offspring with selective advantages. Anopheles mosquitoes are hypothesized to locate, discriminate among, and select such sites using olfactory cues, and that synthetic volatile blends can mimic these olfactory-guided behaviours...
January 23, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28110126/effect-of-supplementation-with-linseed-or-a-blend-of-aromatic-spices-and-time-on-feed-on-fatty-acid-composition-meat-quality-and-consumer-liking-of-meat-from-lambs-fed-dehydrated-alfalfa-or-corn
#16
C E Realini, G Bianchi, O Bentancur, G Garibotto
Cross-bred lambs (n=72) were fed finishing diets using a factorial arrangement of treatments: BASAL DIET (alfalfa pellets or corn), SUPPLEMENT (none, linseed or aromatic spices), TIME ON FEED (41 or 83days). Carcass and meat quality traits, fatty acid composition, color stability and consumer liking were determined. Feeding alfalfa improved sensory ratings and fatty acid composition of lamb. However, corn or longer alfalfa feeding would be recommended if heavier and fatter carcasses are sought. Consumer liking and fatty acid composition of lamb were improved with addition of spices and linseed, respectively...
December 29, 2016: Meat Science
https://www.readbyqxmd.com/read/28107993/using-multiple-process-analytical-technology-probes-to-monitor-multivitamin-blends-in-a-tableting-feed-frame
#17
Pedro Durão, Clémence Fauteux-Lefebvre, Jean-Maxime Guay, Nicolas Abatzoglou, Ryan Gosselin
As Process Analytical Technology (PAT) implementation grows in the pharmaceutical industry, more studies are being performed to evaluate its suitability in new applications and processes within the manufacturing chain. As the last step in tablet production, the compression stage represents a critical phase that ensures product quality. In-line control put in place at this stage has the potential to detect powder blends that are out of specification limits and, thus, help to improve product quality. The objectives of the present project are to quantify the composition of a commercial 31-component multivitamin powder blend in real time on an industrial feed frame, using 3 different PAT tools: light-induced fluorescence spectroscopy, near infrared spectroscopy and red, green and blue color imaging...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107878/effect-of-strategic-administration-of-an-encapsulated-blend-of-formic-acid-citric-acid-and-essential-oils-on-salmonella-carriage-seroprevalence-and-growth-of-finishing-pigs
#18
Kavita Walia, Hector Argüello, Helen Lynch, Finola C Leonard, Jim Grant, Dermot Yearsley, Sinead Kelly, Geraldine Duffy, Gillian E Gardiner, Peadar G Lawlor
Controlling Salmonella at farm level can act as the first line of defence in reducing salmonellosis from pork. This study investigated the efficacy of an encapsulated blend of formic acid, citric acid, and essential oils (FormaXOL™) administered to finisher pigs for 28days prior to slaughter in controlling Salmonella shedding on a commercial farm with a history of high Salmonella seroprevalence. Fourteen pens of 8-10 pigs/pen were randomly assigned to a control (finisher diet without additive) or a treatment group (the same diet with 4kg/t of FormaXOL™) for 28 days...
February 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28099982/-e-learning-in-ent-usage-in-university-medical-centers-in-germany
#19
Peter Freiherr von Saß, Thomas Klenzner, Kathrin Scheckenbach, Adam Chaker
E-learning is an essential part of innovative medical teaching concepts. The challenging anatomy and physiology in ENT is considered particularly suitable for self-assessed and adaptive e-learning. Usage and data on daily experience with e-learning in German ENT-university hospitals are currently unavailable and the degree of implementation of blended learning including feed-back from medical students are currently not known. We investigated the current need and usage of e-learning in academic ENT medical centers in Germany...
January 18, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28099453/elimination-of-porcine-epidemic-diarrhea-virus-in-an-animal-feed-manufacturing-facility
#20
Anne R Huss, Loni L Schumacher, Roger A Cochrane, Elizabeth Poulsen, Jianfa Bai, Jason C Woodworth, Steve S Dritz, Charles R Stark, Cassandra K Jones
Porcine Epidemic Diarrhea Virus (PEDV) was the first virus of wide scale concern to be linked to possible transmission by livestock feed or ingredients. Measures to exclude pathogens, prevent cross-contamination, and actively reduce the pathogenic load of feed and ingredients are being developed. However, research thus far has focused on the role of chemicals or thermal treatment to reduce the RNA in the actual feedstuffs, and has not addressed potential residual contamination within the manufacturing facility that may lead to continuous contamination of finished feeds...
2017: PloS One
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