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Atrophie blanche

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https://www.readbyqxmd.com/read/27896899/characterization-of-a-novel-form-of-progressive-retinal-atrophy-in-whippet-dogs-a-clinical-electroretinographic-and-breeding-study
#1
André Tavares Somma, Juan Carlos Duque Moreno, Mario Teruo Sato, Blanche Dreher Rodrigues, Marianna Bacellar-Galdino, Laurence Mireille Occelli, Simon Michael Petersen-Jones, Fabiano Montiani-Ferreira
OBJECTIVE: To describe a form of progressive retinal atrophy (PRA) in Whippets including clinical, electroretinographic, optical coherence tomographic changes and pedigree analysis. ANIMALS STUDIED: Client-owned Whippet dogs (n = 51) living in Brazil. PROCEDURES: All animals were submitted for routine ophthalmic screening for presumed inherited ocular disease, which included the following: visual tests, such as obstacle course tests, in scotopic and photopic conditions, cotton ball test, dazzle reflex, ocular fundus evaluation by indirect ophthalmoscopy followed by fundus photography...
November 29, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27297279/livedoid-vasculopathy-a-review-of-pathogenesis-and-principles-of-management
#2
REVIEW
Biju Vasudevan, Shekhar Neema, Rajesh Verma
Livedoid vasculopathy is a rare cutaneous disease manifesting as recurrent ulcers on the lower extremities. The ulceration results in atrophic, porcelain white scars termed as atrophie blanche. The pathogenesis is yet to be understood with the main mechanism being hypercoagulability and inflammation playing a secondary role. The important procoagulant factors include protein C and S deficiency, factor V Leiden mutation, antithrombin III deficiency, prothrombin gene mutation and hyperhomocysteinemia. Histopathology of livedoid vasculopathy is characterized by intraluminal thrombosis, proliferation of the endothelium and segmental hyalinization of dermal vessels...
September 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/26876385/epidemiological-clinical-and-laboratory-profiles-of-cutaneous-polyarteritis-nodosa-patients-report-of-22-cases-and-literature-review
#3
REVIEW
Paulo Ricardo Criado, Gabriela Franco Marques, Thamara Cristiane Alves Batista Morita, Jozélio Freire de Carvalho
UNLABELLED: Cutaneous polyarteritis nodosa (CPAN) is a rare disease that affects small and middle caliber vessels of the deep dermis and subcutaneous tissue and its etiopathology remains yet to be understood. METHODS: Retrospective review of twenty two cases diagnosed as CPAN and confirmed by skin biopsy over the last 11 years was evaluated in our department. RESULTS: We found predominance in white woman, mean age of 39.4 years, showing no comorbidities in most of our sample...
June 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/26824005/autologous-fat-grafting-in-severe-lower-extremity-asymmetries-report-of-four-cases
#4
Juan Monreal
BACKGROUND: Lower extremity asymmetries are challenging problems in plastic and aesthetic surgery practice. Regardless of their origin, atrophies and asymmetries can be extremely varied and difficult to solve with simple techniques. OBJECTIVES:   The author reports his experience in the treatment of four patients suffering from severe lower extremity atrophy and asymmetry of different etiologies with autologous fat grafting. METHODS: A total of four cases are presented...
2015: Curēus
https://www.readbyqxmd.com/read/26639077/aetiology-and-management-of-atrophie-blanche-in-chronic-venous-insufficiency
#5
Elizabeth McVittie, Samantha Holloway
The presence of chronic venous insufficiency results in venous hypertension, which can lead to the development of venous leg ulceration. Patients often present with oedema of the lower limb and skin changes, for example, the presence of haemosiderin and lipodermatosclerosis, as well as ulceration. In some instances, patients can also develop atrophie blanche (AB)-white fibrotic areas on the skin adjacent to the ulcer. AB remains an ambiguous term owing to the use of many synonyms. Hence, health professionals need to be aware of the clinical presentation of AB and should be able to clearly differentiate between scarring caused by previous ulcers and that caused by the presence of AB...
December 2015: British Journal of Community Nursing
https://www.readbyqxmd.com/read/25744163/permanent-upper-trunk-plexopathy-after-interscalene-brachial-plexus-block
#6
Merce Avellanet, Xavier Sala-Blanch, Lidia Rodrigo, Miguel A Gonzalez-Viejo
Interscalene brachial plexus block (IBPB) has been widely used in shoulder surgical procedures. The incidence of postoperative neural injury has been estimated to be as high as 3 %. We report a long-term neurologic deficit after a nerve stimulator assisted brachial plexus block. A 55 year-old male, with right shoulder impingement syndrome was scheduled for elective surgery. The patient was given an oral dose of 10 mg of diazepam prior to the nerve stimulator assisted brachial plexus block. The patient immediately complained, as soon as the needle was placed in the interscalene area, of a sharp pain in his right arm and he was sedated further...
February 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/25325229/atrophie-blanche-is-it-associated-with-venous-disease-or-livedoid-vasculopathy
#7
Afsaneh Alavi, Jurg Hafner, Jan P Dutz, Dieter Mayer, R Gary Sibbald, Paulo Ricardo Criado, Patricia Senet, Jeffery P Callen, Tania J Phillips, Marco Romanelli, Robert S Kirsner
PURPOSE: The purpose of this learning activity is to provide information about the etiology and treatment of atrophie blanche. TARGET AUDIENCE: This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. OBJECTIVES: After participating in this educational activity, the participant should be better able to:1. Discuss the pathophysiology of atrophie blanche.2. Explore treatment options for livedoid vasculopathy...
November 2014: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/25259424/effective-topical-delivery-systems-for-corticosteroids-dermatological-and-histological-evaluations
#8
İpek Eroğlu, Erkan Azizoğlu, Mine Özyazıcı, Merve Nenni, Hande Gürer Orhan, Seda Özbal, Işıl Tekmen, İlgen Ertam, İdil Ünal, Özgen Özer
Atopic dermatitis (AD) is a chronic and relapsing skin disease with severe eczematous lesions. Long-term topical corticosteroid treatment can induce skin atrophy, hypopigmentation and transepidermal water loss (TEWL) increase. A new treatment approach was needed to reduce the risk by dermal targeting. For this purpose, Betamethasone valerate (BMV)/Diflucortolone valerate (DFV)-loaded liposomes (220-350 nm) were prepared and incorporated into chitosan gel to obtain adequate viscosity (∼13 000 cps). Drugs were localized in stratum corneum + epidermis of rat skin in ex-vivo permeation studies...
June 2016: Drug Delivery
https://www.readbyqxmd.com/read/24346927/livedoid-vasculopathy-associated-with-peripheral-neuropathy-a-report-of-two-cases
#9
Mariana Quirino Tubone, Gabriela Fortes Escobar, Juliano Peruzzo, Pedro Schestatsky, Gabriela Maldonado
Livedoid vasculopathy (LV) is a chronic and recurrent disease consisting of livedo reticularis and symmetric ulcerations, primarily located on the lower extremities, which heal slowly and leave an atrophic white scar ("atrophie blanche"). Neurological involvment is rare and presumed to be secondary to the ischemia from vascular thrombosis of the vasa nervorum. Laboratory evaluation is needed to exclude secondary causes such as hyper-coagulable states, autoimmune disorders and neoplasms. We present two patients with a rare association of peripheral neuropathy and LV, thereby highlighting the importance of a multidisciplinary approach to reach the correct diagnosis...
November 2013: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/24043683/unilateral-livedoid-vasculopathy-associated-with-involutional-phase-of-cutaneous-infantile-hemangioma-the-connection-to-coagulation-disorders
#10
Paulo Ricardo Criado, Afsaneh Alavi, Ilana Halpern, Mirian Nacagami Sotto, Robert S Kirsner
Livedoid vasculopathy is a bilateral painful and recurrent cutaneous ulcerative disorder of the legs that leads to atrophie blanche, atrophic white-porcelain scars, and is associated with disorders of fibrinolysis and/or coagulation. We present a young boy with an association between livedoid vasculopathy in the area of a previous involuted cutaneous hemangioma. We found 4 uncommon abnormalities associated with thrombo-occlusive events: heterozygous 20210 A→G genotype of prothrombin, reduced activity of anticoagulation proteins C and S, and elevated lipoprotein (a)...
December 2013: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/24028907/livedoid-vasculopathy-an-in-depth-analysis-using-a-modified-delphi-approach
#11
REVIEW
Afsaneh Alavi, Jürg Hafner, Jan P Dutz, Dieter Mayer, R Gary Sibbald, Paulo Ricardo Criado, Patricia Senet, Jeffery P Callen, Tania J Phillips, Marco Romanelli, Robert S Kirsner
Livedoid vasculopathy (LV) is a noninflammatory thrombotic condition presenting in a primary idiopathic or secondary subtype associated with abnormal coagulation factors. Different from atrophie blanche (AB), which is a clinical manifestation of certain scars, LV may have AB in combination with recurrent livedo reticularis with chronic and painful skin ulcers particularly around the ankle region, and at the back of the feet. Histology is characterized by segmental hyalinizing changes at the subintimal region of small dermal vessels with thrombotic occlusions...
December 2013: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/23989066/livedoid-vasculopathy-a-thrombotic-disease
#12
REVIEW
Nina Kerk, Tobias Goerge
Livedoid vasculopathy is a rare, chronic occlusive disease of vessels supporting the upper layers of the skin. It is characterized by purpuric maculae and recurrent painful ulcerations mostly affecting the lower leg. These ulcerations occur episodically especially in summer time and heal slowly, leaving characteristic porcelain-white scars called ’atrophie blanche’.This review is focused on the current knowledge on livedoid vasculopathy and modern therapy strategies resulting from its etiopathogenetic associations with prothrombotic states...
September 2013: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/23821447/-recurrent-leg-ulcers-due-to-livedoid-vasculopathy-successful-treatment-with-low-molecular-weight-heparin
#13
A Becker, M Stoffels-Weindorf, T Schimming, J Dissemond
HISTORY AND ADMISSION FINDINGS: A 50-year-old women had suffered from recurrent and extremely painful ulcerations of both legs and the back of her feet for about 3 weeks. The clinical examination showed multiple hemorrhagic and bizarre configured ulcerations with a surrounding livid-erythematous discoloration, hyperpigmentation and extensive atrophie blanche. INVESTIGATIONS: Neither instrument-based nor serological tests revealed specific pathological findings. Histological results from the border area of the ulceration confirmed the diagnosis of livedoid vasculopathy...
July 2013: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/23582572/the-skin-and-hypercoagulable-states
#14
REVIEW
Laura A Thornsberry, Kristen I LoSicco, Joseph C English
Hypercoagulable states (HS) are inherited or acquired conditions that predispose an individual to venous and/or arterial thrombosis. The dermatologist can play a vital role in diagnosing a patient's HS by recognizing the associated cutaneous manifestations, such as purpura, purpura fulminans, livedo reticularis, livedo vasculopathy (atrophie blanche), anetoderma, chronic venous ulcers, and superficial venous thrombosis. The cutaneous manifestations of HS are generally nonspecific, but identification of an abnormal finding can warrant a further workup for an underlying thrombophilic disorder...
September 2013: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/23437985/livedoid-vasculopathy-current-aspects-of-diagnosis-and-treatment-of-cutaneous-infarction
#15
REVIEW
Nina Kerk, Tobias Goerge
Livedoid vasculopathy is a rare, chronic, recurrent disease of the cutaneous microcirculation. Its typical clinical manifestation is a triad which consists of livedo racemosa of the skin, episodic painful ulcerations of the distal aspects of the legs and a healing process leaving small porcelain-white scars called atrophie blanche. As an important result of recent research, livedoid vasculopathy has been defined as a coagulation disorder classified as a vasculopathy different from inflammatory vasculitis. This differentiation adds to the current pathophysiologic understanding and supports the therapeutic rationale with respect to the use of new systemic anticoagulants...
May 2013: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/23299272/effect-of-amelogenin-ecm-protein-on-the-healing-of-chronic-leg-ulcers-with-atrophie-blanche
#16
K Fogh, C B Nielsen, W Dam
OBJECTIVE: To determine the effect of topically applied amelogenin extracellular matrix protein(AEMP) in patients with non-healing venous leg ulcers combined with atrophie blanche. METHOD: This retrospective case series of patients with non-healing venous leg ulcers with atrophie blanche of the distal proportion of their lower legs, where non-healing was defined as no progress toward healing for 3 months previously, under standard therapy. Patient records were reviewed for associated diseases, wound diagnoses, distal blood pressure, previous treatments and changes in wound area...
December 2012: Journal of Wound Care
https://www.readbyqxmd.com/read/23193816/-vasculitis-and-vasculopathy
#17
REVIEW
Asjastipić Marković
Many pathophysiological process components are known to be implicated in lower limb ulcerations, among which vascular lesions have a major role. Vasculitis denotes a heterogeneous group of clinical entities which all are characterized by the inflammatory process of arterial and venous walls of any size and in any organ, quite frequently in the skin. Vasculopathy, on the other hand, refers to vascular and capillary lesions caused by, for example, some medications. The classification of vasculitides according to the size of the blood vessels involved serves for proper understanding the issue among clinicians and researchers, and not as a diagnostic tool...
October 2012: Acta Medica Croatica: C̆asopis Hravatske Akademije Medicinskih Znanosti
https://www.readbyqxmd.com/read/23052434/a-ten-year-retrospective-study-on-livedo-vasculopathy-in-asian-patients
#18
Emily Y Gan, Mark B Y Tang, Suat Hoon Tan, Sze Hon Chua, Audrey W H Tan
INTRODUCTION: This study aims to analyse the clinico-epidemiological characteristics of Asian patients diagnosed with livedo vasculopathy (LV). MATERIALS AND METHODS: We performed a retrospective analysis of all patients diagnosed with LV from 1997 to 2007 at our centre. RESULTS: Seventy patients were diagnosed with LV with a mean age of 39 years, female: male ratio of 3:1 and no racial predilection. Most cases remained purely cutaneous, presenting with painful leg ulcers and atrophie blanche...
September 2012: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/22291497/rituximab-in-severe-skin-diseases-target-disease-and-dose
#19
Daniel D Bennett, Maro Ohanian, Christian T Cable
New clinical indications for rituximab seem to appear every day. This review will trace the use of this monoclonal antibody from lymphoid malignancy, to classic autoimmune disease, and specifically severe autoimmune skin diseases. The history leading to different dosing schema with associated pharmacokinetic data will be discussed. A case of livedoid vasculopathy (atrophie blanche) responding to rituximab will illustrate how the response to therapy can help to elucidate previously obscure pathophysiology.
2010: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/22147037/livedoid-vasculopathy-an-intringuing-cutaneous-disease
#20
REVIEW
Paulo Ricardo Criado, Evandro Ararigboia Rivitti, Mirian Nacagami Sotto, Neusa Yuriko Sakai Valente, Valeria Aoki, Jozelio Freire de Carvalho, Cidia Vasconcellos
Livedoid vasculopathy is a skin disease that occludes the blood vessels of the dermis. It has a pauciinflammatory or non-inflammatory nature. It is characterized by the presence of macular or papular, erythematous-purpuric lesions affecting the legs, especially the ankles and feet, and producing intensely painful ulcerations, which cause white atrophic scars called "atrophie blanche". This review includes studies and case reports found in the medical literature regarding the etiopathogenic associations of the disease, particularly those related to thrombophilia, their histopathological findings and the therapeutic approaches used in the difficult clinical management of these cases...
September 2011: Anais Brasileiros de Dermatologia
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