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Stylianos Fragidis, Konstantinos Sombolos, Elias Thodis, Stylianos Panagoutsos, Euthymia Mourvati, Maria Pikilidou, Aikaterini Papagianni, Ploumis Pasadakis, Vasilios Vargemezis
AIM: To investigate the predictive value of low freeT3 for long-term mortality in chronic hemodialysis (HD) patients and explore a possible causative role of chronic inflammation. METHODS: One hundred fourteen HD patients (84 males) consecutively entered the study and were assessed for thyroid function and two established markers of inflammation, high sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6). Monthly blood samples were obtained from all patients for three consecutive months during the observation period for evaluation of thyroid function and measurement of inflammatory markers...
July 6, 2015: World Journal of Nephrology
P Sathi, S Kalyan, C L Hitchcock, M Pudek, J C Prior
OBJECTIVE: Thyroid hormones and progesterone both influence core temperature, metabolism and are crucial during pregnancy. Our objective was to discover whether progesterone therapy caused changes in thyroid physiology compared with placebo. DESIGN: Post hoc analysis from a randomized (1:1) placebo-controlled 12-week trial of oral micronized progesterone (Progesterone, 300 mg/d at bedtime) for hot flushes (vasomotor symptoms, VMS) conducted in an academic medical centre...
August 2013: Clinical Endocrinology
Krzysztof Lewandowski, Piotr Hincz, Mariusz Grzesiak, Agata Cajdler-Łuba, Ireneusz Salata, Jan Wilczyński, Andrzej Lewiński
UNLABELLED: A 32-year-old Caucasian was admitted at 14 weeks of gestation with hypotension and weight loss. Family members noted that she appeared "tired" prior to pregnancy Past medical history included primary hypothyroidism treated with thyroxine (100 microg/day). She had a healthy daughter aged 2.5 years who had been born small for gestational age. At about 8 weeks of gestation she started to vomit several times a day. She was treated with antiemetics and intravenous fluids. Following discharge she remained nauseated, weak and lightheaded and lost about 8 kg of weight...
July 2010: Ginekologia Polska
V Durovcová, J Marek, V Hána, M Matoulek, V Zikán, D Haluzíková, P Kaválková, Z Lacinová, M Kršek, M Haluzík
Serum adipocyte fatty acid-binding protein (FABP-4) concentrations are linked to human obesity and other features of metabolic syndrome. Patients with Cushing´s syndrome (CS) develop numerous features of metabolic syndrome due to chronic cortisol excess. Here we tested the hypothesis that chronically increased cortisol levels in CS patients may alter circulating levels of FABP-4. Fourteen patients with CS, 19 patients with simple obesity (OB) and 36 healthy control subjects (C) were included in the study. Serum FABP-4 concentrations were significantly higher in both CS and OB patients relative to C group, but they did not differ between CS and OB groups...
2010: Physiological Research
J Drobnik, J Ciosek, D Slotwinska, B Stempniak, D Zukowska, A Marczynski, D Tosik, H Bartel, R Dabrowski, A Szczepanowska
The connective tissue matrix of the heart remains under regulatory influence of the thyroid hormones. Some conflicting data describe the connective tissue changes in subjects with thyroid gland disorders. The aim of the study was to assess the changes of the connective tissue accumulation in the heart of rats in the state of hypothyroidism and to answer the question whether TSH is involved in mechanism of the observed phenomena. Hypothyroidism in rats was induced by methylotiouracil treatment or by thyreoidectomy...
September 2009: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Hisashi Ota, Nobuyuki Amino, Shinji Morita, Kaoru Kobayashi, Sumihisa Kubota, Shuji Fukata, Naohisa Kamiyama, Akira Miyauchi
OBJECTIVE: Differentiation between destruction-induced thyrotoxicosis and Graves' thyrotoxicosis is important for selection of proper therapy. It is, however, often difficult to make this distinction without measurement of radioactive iodine uptake. We investigated the possibility that assessment of thyroid blood flow would allow differentiation between the two entities. PATIENTS AND MEASUREMENTS: One hundred and fourteen untreated patients with thyrotoxicosis (56 Graves' disease, 28 painless thyroiditis, 30 subacute thyroiditis) and 25 normal controls were examined...
July 2007: Clinical Endocrinology
B Galusca, C Bossu, N Germain, M Kadem, D Frere, M H Lafage-Proust, F Lang, B Estour
INTRODUCTION: In anorexia nervosa (AN) patients osteoporosis occurs within a framework of multiple hormonal abnormalities as a result of bone turnover uncoupling, with decreased bone formation and increased bone resorption. The aim of study was to evaluate the hormonal and nutritional relationships with both of these bone remodeling compartments and their eventual modifications with age. PATIENTS AND MEASUREMENTS: In a cohort of 115 AN patients (mean BMI:14.6 kg/m2) that included 60 mature adolescents (age: 15...
2006: Osteoporosis International
John K Triantafillidis, Dimitrios Georgakopoulos, Aristofanis Gikas, Emmanuel Merikas, George Peros, Kyriaki Sofroniadou, Petros Cheracakis, Maria Sklavaina, Georgios Tzanidis, Evangelia Konstantellou
The aim of this study was to assess the relationship between Helicobacter pylori (Hp) infection, serum thyroid hormone levels and certain cardiovascular risk factors in normal volunteers. In 110 blood donors (85 men, 25 women, aged 35.6 +/- 9.76) the serum levels of IgG antibodies against Hp were estimated using a sensitive immunoassay. Serum estimation of T3, T4, TSH, FT3, FT4, thyroid (microsomial) autoantibodies, C-Reactive-Protein, a1-acid-glycoprotein, vitamin B12, folic acid, cholesterol, triglycerides, total lipids, HDL, LDL, and antibodies against hepatitis A, was also carried-out...
December 2003: Hepato-gastroenterology
P P Vescovi, A Pezzarossa
During cocaine addiction the hypothalamus-pituitary axis is widely affected and a blunted response of thyroid stimulating hormone (TSH) to thyroid releasing hormone (TRH) consistent with a hyperthyroid state has been observed. Since the thyroid status can affect the release of growth hormone (GH) the authors evaluated TSH and GH responses to TRH in cocaine addicts at the time of drug withdrawal and 30 days after. Twenty-six male cocaine addicts and 11 healthy male control subjects agreed to participate in the study...
December 1999: Neuropeptides
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