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metabolically healthy obesity

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https://www.readbyqxmd.com/read/28077863/what-have-human-experimental-overfeeding-studies-taught-us-about-adipose-tissue-expansion-and-susceptibility-to-obesity-and-metabolic-complications
#1
REVIEW
D J Cuthbertson, T Steele, J P Wilding, J C G Halford, J A Harrold, M Hamer, F Karpe
Overfeeding experiments, in which we impose short-term positive energy balance, help unravel the cellular, physiological and behavioural adaptations to nutrient excess. These studies mimic longer-term mismatched energy expenditure and intake. There is considerable inter-individual heterogeneity in the magnitude of weight gain when exposed to similar relative caloric excess reflecting variable activation of compensatory adaptive mechanisms. Significantly, given similar relative weight gain, individuals may be protected from/predisposed to metabolic complications (insulin resistance, dyslipidaemia, hypertension), non-alcoholic fatty liver disease and cardiovascular disease...
January 12, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28077341/irisin-and-oxytocin-as-predictors-of-metabolic-parameters-in-obese-children
#2
Ciğdem Binay, Cem Paketçi, Savaş Güzel, Nedim Samancı
OBJECTIVE: Irisin and oxytocin can affect energy homeostasis and have been proposed to play an important role in reducing obesity and diabetes. We aimed to determine the relationship between metabolic parameters (including irisin and oxytocin levels) and anthropometric parameters in obese children. METHODS: Ninety obese children (mean age, 13.85 ± 1.63 years) and 30 healthy controls (mean age, 14.32 ± 1.58 years) were enrolled in this study. Anthropometric and laboratory parameters (glucose, insulin, lipid, oxytocin, and irisin levels) were analysed...
January 12, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28073639/association-between-volume-and-glucose-metabolism-of-abdominal-adipose-tissue-in-healthy-population
#3
Hyun Woo Kwon, Sang Mi Lee, Jeong Won Lee, Jung-Eun Oh, Se-Whan Lee, Shin Young Kim
OBJECTIVE: We investigated the association of adipose tissue volume and metabolic activity with cardiometabolic risk factors. METHODS: 232 healthy subjects (43.23±4.09y) having (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) results were included. Clinical information, anthropometry and laboratory results were obtained. Volume and metabolic activity of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) was obtained from FDG PET/CT...
January 7, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28067891/an-interactive-web-based-intervention-on-nutritional-status-physical-activity-and-health-related-quality-of-life-in-patient-with-metabolic-syndrome-a-randomized-controlled-trial-the-red-ruby-study
#4
L Jahangiry, A Montazeri, M Najafi, M Yaseri, M A Farhangi
BACKGROUND/OBJECTIVES: Physical inactivity and unhealthy nutritional behaviors are recognized as the key factors in the cause and management of metabolic syndrome (MetS). The effectiveness of interactive web-based interventions on dietary intakes, physical activity and health-related quality of life (HRQOL) among people with MetS is currently unknown. METHODS: The two-arm randomized-controlled trial was conducted for patients with MetS from June through December 2012 in Tehran, Iran...
January 9, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28066877/central-noradrenaline-transporter-availability-in-highly-obese-non-depressed-individuals
#5
Swen Hesse, Georg-Alexander Becker, Michael Rullmann, Anke Bresch, Julia Luthardt, Mohammed K Hankir, Franziska Zientek, Georg Reißig, Marianne Patt, Katrin Arelin, Donald Lobsien, Ulrich Müller, S Baldofski, Philipp M Meyer, Matthias Blüher, Mathias Fasshauer, Wiebke K Fenske, Michael Stumvoll, Anja Hilbert, Yu-Shin Ding, Osama Sabri
PURPOSE: The brain noradrenaline (NA) system plays an important role in the central nervous control of energy balance and is thus implicated in the pathogenesis of obesity. The specific processes modulated by this neurotransmitter which lead to obesity and overeating are still a matter of debate. METHODS: We tested the hypothesis that in vivo NA transporter (NAT) availability is changed in obesity by using positron emission tomography (PET) and S,S-[(11)C]O-methylreboxetine (MRB) in twenty subjects comprising ten highly obese (body mass index BMI > 35 kg/m(2)), metabolically healthy, non-depressed individuals and ten non-obese (BMI < 30 kg/m(2)) healthy controls...
January 9, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28066005/metabolic-syndrome-and-central-obesity-in-depression-a-cross-sectional-study
#6
Anju Agarwal, Manu Agarwal, Kabir Garg, Pronob Kumar Dalal, Jitendra Kumar Trivedi, J S Srivastava
INTRODUCTION: The current epidemiological data and meta-analyses indicate a bidirectional association between depression and metabolic syndrome (MetS). AIMS: To assess the prevalence of metabolic syndrome and obesity in drug naïve patients (in current episode) having Recurrent Major Depressive Disorder and Bipolar Depression. METHOD: This was a single point cross sectional observational study that involved administration of diagnostic and assessment tools and blood investigations...
July 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28065384/the-effects-of-fat-induced-obesity-on-bone-metabolism-in-rats
#7
Wei Li, Peng Xu, Cuizhe Wang, Xiaodan Ha, Yajuan Gu, Yan Wang, Jun Zhang, Jianxin Xie
OBJECTIVE: The aim of the current study was to investigate the effects of obesity, induced via a high-fat diet, on bone metabolism in rats. METHODS: Two hundred healthy Wistar male rats aged 4 weeks were fed a standard diet and a high-fat diet. At specific time points (week 0, 4, 6, 8, and 10), plasma was collected to determine the levels of glucose and lipid metabolism. Additionally, enzyme-linked immunoassays were performed to determine the plasma levels of adipocyte and bone metabolism factors...
January 3, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28064520/menopause-hormone-therapy-and-diabetes
#8
C A Stuenkel
Over the past three decades, the prevalence of diabetes has increased four-fold. Coupled with the global obesity epidemic and aging of the world's population, a perfect metabolic storm is brewing. The influence of menopause and exogenous estrogen and progestogens must be included in this equation. In this review, criteria for diagnosing diabetes and recommendations for screening are described. The reported effects of menopause on diabetes risk in healthy women are reviewed as well as the relationship between established diabetes and the timing of menopause...
January 8, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28064116/sex-specific-and-inter-individual-differences-in-biomarkers-of-selenium-status-identified-by-a-calibrated-elisa-for-selenoprotein-p
#9
Sandra Hybsier, Torsten Schulz, Zida Wu, Ilja Demuth, Waldemar B Minich, Kostja Renko, Eddy Rijntjes, Josef Köhrle, Christian J Strasburger, Elisabeth Steinhagen-Thiessen, Lutz Schomburg
Selenoprotein P (SELENOP) is a liver-derived transporter of selenium (Se) in blood, and a meaningful biomarker of Se status. Se is an essential trace element for the biosynthesis of enzymatically-active selenoproteins, protecting the organism from oxidative damage. The usage of uncalibrated assays hinders the comparability of SELENOP concentrations and their pathophysiological interpretation across different clinical studies. On this account, we established a new sandwich SELENOP-ELISA and calibrated against a standard reference material (SRM1950)...
December 29, 2016: Redox Biology
https://www.readbyqxmd.com/read/28053538/inverse-relationship-of-cardioankle-vascular-index-with-bmi-in-healthy-japanese-subjects-a-cross-sectional-study
#10
Daiji Nagayama, Haruki Imamura, Yuta Sato, Takashi Yamaguchi, Noriko Ban, Hidetoshi Kawana, Masahiro Ohira, Atsuhito Saiki, Kohji Shirai, Ichiro Tatsuno
OBJECTIVE: The objective of this study is to investigate the association of body mass index (BMI) with arterial stiffness assessed by cardioankle vascular index (CAVI). SUBJECTS AND METHODS: A retrospective cross-sectional study was conducted in 23,257 healthy Japanese subjects (12,729 men and 10,528 women, aged 47.1 ± 12.5 years, BMI 22.9 ± 3.4 kg/m(2)) who underwent health screening between 2004 and 2006 in Japan. Exclusion criteria were current medication use and a past history of cardiovascular disease, hypertension, stroke, diabetes, and nephritis...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28050048/editorial-lean-nafld-metabolic-obesity-with-normal-bmi%C3%A2-is-it-in-the-genes
#11
Curtis K Argo, Zachary H Henry
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. "Lean" NAFLD represents a patient subpopulation with hepatic steatosis evident on imaging with normal BMI. This paper by Feldman and Eder et al. illustrates the mild but clear metabolic differences and genetic connections in Caucasian lean NAFLD patients compared with obese NAFLD and healthy controls. Their findings highlight key similarities of lean and obese NAFLD compared with lean healthy subjects. This paper characterizes "lean" NAFLD as a unique phenotype with specific genetic associations deserving of further investigation in the greater scheme of elucidating the pathophysiology of fatty liver...
January 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28049882/the-relationship-between-circulating-neutrophil-gelatinase-associated-lipocalin-and-early-alteration-of-metabolic-parameters-is-associated-with-dietary-saturated-fat-intake-in-non-diabetic-korean-women
#12
Ga Yoon Na, So Ra Yoon, Juhyun An, Rimkyo Yeo, Juhyun Song, Mi-Na Jo, Seongho Han, Oh Yoen Kim
Circulating neutrophil gelatinase-associated lipocalin (NGAL) is associated with obesity-related metabolic disorders. This study investigated the relationship between serum NGAL and early alteration of metabolic parameters in non-diabetic Korean women, particularly with respect to saturated fat (SFA) intake. Anthropometric parameters, fasting glycemic status, and levels of lipids, oxidative stress/inflammatory markers, and NGAL were measured in 82 non-diabetic Korean women [Super-healthy group (n=57) with 0 metabolic syndrome risk factor (MetS RF) and MetS-risk group (n=25) with MetS RF≥1]...
December 30, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/28043708/emerging-roles-of-sodium-glucose-cotransporter-2-inhibitors-in-cardiology
#13
REVIEW
Atsushi Tanaka, Koichi Node
The ultimate goal of treatment in people with diabetes mellitus is to prevent development of cardiovascular (CV) disease, resulting in prolongation of healthy life expectancy. Although impaired glycemic metabolism has a central role in its pathology, a number of studies have demonstrated that remedy for its imbalance cannot necessarily be accomplished as a therapeutic goal. A comprehensive medical approach against multi-factorial pathologies in diabetes, such as insulin resistance, obesity, hypertension, and dyslipidemia, in addition to diet and exercise therapy should be rather performed in the routine clinical setting...
December 30, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/28042926/the-potential-impact-of-gut-microbiota-on-your-health-current-status-and-future-challenges
#14
Stitaya Sirisinha
Our health and probably also our behaviors and mood depend not only on what we eat or what we do (lifestyle behaviors), but also on what we host. It is well established for decades that all vertebrates including humans are colonized by a wide array of bacteria, fungi, eukaryotic parasites and viruses, and that, at steady state (homeostasis), this community of microbes establishes a friendly mutual relationship with the host. The term microbiota was originally meant to represent an ecological community of commensals and potentially pathogenic microbes that live within our bodies, but it is now used interchangeably with the term microbiome which was initially meant to represent a collective genome of the microbiota...
December 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28041735/beneficial-effects-of-probiotic-cholesterol-lowering-strain-of-enterococcus-faecium-wefa23-from-infants-on-diet-induced-metabolic-syndrome-in-rats
#15
Fen Zhang, Liang Qiu, Xiongpeng Xu, Zhengqi Liu, Hui Zhan, Xueying Tao, Nagendra P Shah, Hua Wei
The aim of this study was to select probiotic Enterococcus strains which have the potential to improve metabolic syndrome (MS). Ten Enterococcus strains isolated from healthy infants were evaluated for their probiotic properties in vitro, and Enterococcus faecium WEFA23 was selected due to its cholesterol removal ability (1.89 ± 0.07 mg/10(10) cfu), highest glycodeoxycholic acid-hydrolase activity (1.86 ± 0.01 U/mg), and strong adhesion capacity to Caco-2 cells (17.90 ± 0.19%). The safety of E. faecium WEFA23 was verified by acute oral administration in mice, and it was found to have no adverse effects on general health status, bacterial translocation, and gut mucosal histology...
December 29, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/28040833/insights-into-the-relationships-between-diabetes-prediabetes-and-cancer
#16
REVIEW
Lorenzo Scappaticcio, Maria Ida Maiorino, Giuseppe Bellastella, Dario Giugliano, Katherine Esposito
Diabetes mellitus and cancer are two growing health problems. They have in common many modifiable risk factors including sex, age, obesity, physical activity, diet, alcohol, and smoking, and have a long latency before overtly manifesting. Patients with diabetes experience a roughly 20-25% higher cancer incidence compared to individuals without diabetes, and it depends on cancer site. Moreover, patients with diabetes who further develop cancer have increased early and late mortality in comparison with cancer patients without diabetes...
December 31, 2016: Endocrine
https://www.readbyqxmd.com/read/28039871/high-salivary-testosterone-to-androstenedione-t-a4-ratio-and-adverse-metabolic-phenotypes-in-women-with-pcos
#17
J Münzker, L Lindheim, J Adaway, C Trummer, E Lerchbaum, T R Pieber, B Keevil, B Obermayer-Pietsch
BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by a combination of hormonal and metabolic disturbances, such as insulin resistance, glucose intolerance, anovulation and hyperandrogenism. Clinical phenotypes of PCOS show different patterns of steroid hormones that have been investigated to some extent. This study aimed to establish a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of salivary testosterone and androstenedione, and to describe the salivary testosterone to androstenedione (T/A4) ratio as a new tool for the assessment of hyperandrogenism and metabolic health...
December 31, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/28039702/serum-apelin-levels-and-body-composition-changes-in-breast-cancer-patients-treated-with-an-aromatase-inhibitor
#18
Tarik Salman, Leyla Demir, Umut Varol, Murat Akyol, Utku Oflazoglu, Yasar Yildiz, Halil Taskaynatan, Hakan Cengiz, Guven Guvendi, Yuksel Kucukzeybek, Ahmet Alacacioglu, Oktay Tarhan
PURPOSE: The adipose tissue plays a role in carcinogenesis with the adipokines it generates. Apelin is an anti-obesigenic adipokine, and assumes roles in both vascularization and tumor cell proliferation. The present study aimed to investigate changes in apelin levels, in postmenopausal breast cancer (BC) patients receiving aromatase inhibitors (AIs). METHODS: Forty early-stage postmenopausal BC patients treated with AIs with no history of chemotherapy administration were included in the study...
November 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28035344/dietary-olive-oil-induces-cannabinoid-cb2-receptor-expression-in-adipose-tissue-of%C3%A2-apc-min-transgenic-mice
#19
Maria Notarnicola, Valeria Tutino, Angela Tafaro, Giusy Bianco, Emilia Guglielmi, Maria Gabriella Caruso
BACKGROUND: Cannabinoid- 2 (CB2) receptor is known for its anti-obesity effects silencing the activated immune cells that are key drivers of metabolic syndrome and inflammation. Nutritional interventions in experimental models of carcinogenesis have been demonstrated to modulate tissue inflammation state and proliferation. OBJECTIVE: Aim of this study was to test, in Apc(Min/+) mice, whether a diet enriched with olive oil, omega- 3 and omega-6- PUFAs affects the adipose tissue inflammation status. METHODS: Four groups of animal were studied: ST group, receiving a standard diet; OO group, receiving the standard diet in which soybean oil (source of fats) was replaced with olive oil; OM-3 group, receiving the standard diet in which soybean oil was replaced with salmon oil; OM-6 group, receiving the standard diet in which soybean oil was replaced with oenothera oil...
October 27, 2016: Nutr Healthy Aging
https://www.readbyqxmd.com/read/28034467/maternal-health-and-the-placental-microbiome
#20
REVIEW
Elise Pelzer, Luisa F Gomez-Arango, Helen L Barrett, Marloes Dekker Nitert
Over the past decade, the role of the microbiome in regulating metabolism, immune function and behavior in humans has become apparent. It has become clear that the placenta is not a sterile organ, but rather has its own endogenous microbiome. The composition of the placental microbiome is distinct from that of the vagina and has been reported to resemble the oral microbiome. Compared to the gut microbiome, the placental microbiome exhibits limited microbial diversity. This review will focus on the current understanding of the placental microbiota in normal healthy pregnancy and also in disease states including preterm birth, chorioamnionitis and maternal conditions such as obesity, gestational diabetes mellitus and preeclampsia...
December 2, 2016: Placenta
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