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https://www.readbyqxmd.com/read/29154418/measuring-non-polyaminated-lipocalin-2-for-cardiometabolic-risk-assessment
#1
Kangmin Yang, Han-Bing Deng, Andy W C Man, Erfei Song, Jialiang Zhang, Cuiting Luo, Bernard M Y Cheung, Kwok-Yung Yuen, Pia Søndergaard Jensen, Akhmadjon Irmukhamedov, Atlanta G I M Elie, Paul M Vanhoutte, Aimin Xu, Jo G R De Mey, Yu Wang
AIMS: Lipocalin-2 is a pro-inflammatory molecule characterized by a highly diversified pattern of expression and structure-functional relationships. In vivo, this molecule exists as multiple variants due to post-translational modifications and/or protein-protein interactions. Lipocalin-2 is modified by polyamination, which enhances the clearance of this protein from the circulation and prevents its excessive accumulation in tissues. On the other hand, animal studies suggest that non-polyaminated lipocalin-2 (npLcn2) plays a causal role in the pathogenesis of obesity-associated medical complications...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29152244/effect-of-dietary-protein-intake-on-the-body-composition-and-metabolic-parameters-of-neutered-dogs
#2
Iris Mayumi Kawauchi, Juliana Toloi Jeremias, Paula Takeara, Danilo Ferreira de Souza, Júlio Cesar de Carvalho Balieiro, Karina Pfrimer, Marcio Antonio Brunetto, Cristiana Fonseca Ferreira Pontieri
Neutering is a common veterinary recommendation and is often associated with obesity development. Thus, the aim of the present study was to evaluate the effects of two different amounts of protein intake by neutered dogs regarding maintenance energy requirement (MER), body composition, and biochemical and hormonal parameters. A total of fourteen healthy adult dogs were fed either a diet containing 59·7 g protein/1000 kcal (4184 kJ) (P60) or a diet with 94·0 g protein/1000 kcal (4184 kJ) (P94) for 26 weeks after neutering to maintain their body weight prior to neutering...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29151065/the-mrna-expression-levels-of-uncoupling-proteins-1-and-2-in-mononuclear-cells-from-patients-with-metabolic-disorders-obesity-and-type-2-diabetes-mellitus
#3
Sona Margaryan, Agata Witkowicz, Anna Partyka, Levon Yepiskoposyan, Gayane Manukyan, Lidia Karabon
INTRODUCTION: Type 2 diabetes mellitus (T2DM) and obesity are metabolic disorders whose major hallmark is insulin resistance. Impaired mitochondrial activity, such as reduced ratio of energy production to respiration, has been implicated in the development of insulin resistance. Uncoupling proteins (UCPs) are proton carriers, expressed in the mitochondrial inner membrane, that uncouple oxygen consumption by the respiratory chain from ATP synthesis. AIM: The aim of the study was to determine transcriptional levels of UCP1 and UCP2 in peripheral blood mononuclear cells (PBMCs) from patients with metabolic disorders: T2DM, obesity and from healthy individuals...
October 19, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/29148120/mapping-brown-adipose-tissue-based-on-fat-water-fraction-provided-by-z-spectral-imaging
#4
Alessandro Scotti, Rong-Wen Tain, Weiguo Li, Victoria Gil, Chong Wee Liew, Kejia Cai
BACKGROUND: Brown adipose tissue (BAT) has a great relevance in metabolic diseases and has been shown to be reduced in obesity and insulin resistance patients. Currently, Dixon MRI is used to calculate fat-water fraction (FWF) and differentiate BAT from white adipose tissue (WAT). However, it may fail in areas of phase wrapping and introduce fat-water swapping artifacts. PURPOSE: To investigate the capacity of the Z-spectrum imaging (ZSI) for the identification of BAT in vivo...
November 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29146142/visceral-adiposity-index-as-a-predictor-of-chronic-kidney-disease-in-a-relatively-healthy-population-in-taiwan
#5
Yi-Chuan Chen, Shih-Han Lai, Yi-Wen Tsai, Shy-Shin Chang
OBJECTIVES: Abdominal obesity is an independent risk factor for cardiovascular disease and chronic kidney disease (CKD). Visceral adiposity index (VAI), a simple formula representing visceral adipose dysfunction, has already been proven to have a strong correlation with various cardiometabolic disorders. Limited studies are available regarding the relationship between VAI and renal function decline. Therefore, the purpose of this study was to evaluate the relationship between VAI and renal function and to estimate the risk of chronic kidney disease in a relatively healthy adult population in Taiwan...
November 14, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29142342/prevalence-of-subclinical-peripheral-vascular-disease-in-obese-egyptian-patients
#6
Jehan Ahmed Younes, Nahla Dessoki El-Sayed, Ayman Ismail Kamel
Objective: To detect subclinical peripheral vascular disease in obese Egyptian patients and establish relations between obesity, metabolic risk factors, and PVD. Methods: This was a prospective case-control study including 100 obese patients (BMI >30) (G1). In addition, 100 age and sex matched non-obese healthy subjects as a control group (G2). Both groups were subjected to duplex ultrasound, Radionuclide muscle scan. Angiography was done for 17 patients. Results: The image pattern of 99mTc-MIBI muscles uptake was studied and perfusion reserve (PR%) was calculated in (G1) and (G2)...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29140513/amino-acid-and-fatty-acid-levels-affect-hepatic-phosphorus-metabolite-content-in-metabolically-healthy-humans
#7
Sabine Kahl, Bettina Nowotny, Klaus Straßburger, Alessandra Bierwagen, Birgit Klüppelholz, Barbara Hoffmann, Guido Giani, Peter J Nowotny, Franziska Wallscheid, Erifili Hatziagelaki, Giovanni Pacini, Jong-Hee Hwang, Michael Roden
Objective: Hepatic energy metabolism negatively relates to insulin resistance and liver fat content in type 2 diabetes patients, but its role in metabolically healthy humans is unclear. We hypothesized that intrahepatocellular γ-adenosine triphosphate (γATP) and inorganic phosphate (Pi) concentrations exhibit similar associations with insulin sensitivity in non-diabetic non-obese volunteers. Research Design and methods: A total of 76 participants underwent a 4-point sampling 75-g OGTT as well as in vivo31P/1H magnetic resonance spectroscopy...
November 13, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29140289/cats-and-carbohydrates-the-carnivore-fantasy
#8
REVIEW
Adronie Verbrugghe, Myriam Hesta
The domestic cat's wild ancestors are obligate carnivores that consume prey containing only minimal amounts of carbohydrates. Evolutionary events adapted the cat's metabolism and physiology to this diet strictly composed of animal tissues and led to unique digestive and metabolic peculiarities of carbohydrate metabolism. The domestic cat still closely resembles its wild ancestor. Although the carnivore connection of domestic cats is well recognised, little is known about the precise nutrient profile to which the digestive physiology and metabolism of the cat have adapted throughout evolution...
November 15, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/29130065/metabolic-syndrome-in-apparently-healthy-ghanaian-adults-a-systematic-review-and-meta-analysis
#9
REVIEW
Richard Ofori-Asenso, Akosua Adom Agyeman, Amos Laar
Background: Metabolic syndrome (MetS) is a major public health problem in Sub-Saharan Africa. We systematically reviewed the literature towards estimating the prevalence of MetS among apparently "healthy" Ghanaian adults. Methods: We searched PubMed, Web of Science, Scopus, Africa Journals Online, African Index Medicus, and Google scholar as well as the websites of the Ministry of Health and Ghana Health service through September 2016. Only studies conducted among apparently "healthy" (no established disease, e...
2017: International Journal of Chronic Diseases
https://www.readbyqxmd.com/read/29128417/exercise-more-or-sit-less-a-randomized-trial-assessing-the-feasibility-of-two-advice-based-interventions-in-obese-inactive-adults
#10
Kristian Overgaard, Kirstine Nannerup, Mette Kirstine Birk Lunen, Helle Terkildsen Maindal, Ryan G Larsen
OBJECTIVES: The risk of metabolic and cardiovascular disease may be reduced by a healthy pattern of daily physical activity. We investigated the feasibility and preliminary effectiveness of advice-based interventions aiming at either increasing moderate-to-vigorous intensity physical activity (MVPA) or reducing sedentary time (ST) in obese volunteers. DESIGN: Randomized non-blinded two-armed trial. METHOD: Inactive, obese adults were randomly assigned to reduce sedentary behavior (SitLess) (n=30) or increase MVPA (ExMore) (n=29) for 4 weeks...
November 7, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29121861/transcriptomics-metabolomics-and-histology-indicate-that-high-carbohydrate-diet-negatively-affects-the-liver-health-of-blunt-snout-bream-megalobrama-amblycephala
#11
Wassana Prisingkorn, Panita Prathomya, Ivan Jakovlić, Han Liu, Yu-Hua Zhao, Wei-Min Wang
BACKGROUND: Global trend of the introduction of high levels of relatively cheap carbohydrates to reduce the amount of costly protein in the aquatic animal feed production has affected the aquaculture of an economically important cyprinid fish, blunt snout bream (Megalobrama amblycephala). This dietary shift has resulted in increased prevalence of metabolic disorders, often causing economic losses. High dietary intake of carbohydrates, associated with obesity, is one of the major causes of non-alcoholic fatty liver disease (NAFLD) in humans...
November 9, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29119718/glucocorticoids-suppress-brown-adipose-tissue-function-in-humans-a-double-blind-placebo-controlled-study
#12
Moe Thuzar, W Phillip Law, Jeyakantha Ratnasingam, Christina Jang, Goce Dimeski, Ken Ky Ho
AIM: To investigate the effect of glucocorticoids on BAT function in humans MATERIALS & METHODS: In a randomised double-blind cross-over design, 13 healthy adults underwent 1 week of oral prednisolone (15mg/day) and placebo treatment with an intervening 2-week wash-out period. BAT function was assessed in response to cooling (19(0) C) and to a standardised meal, by measuring fluoro-deoxyglucose (FDG) uptake using Positron Emission Tomography-Computed Tomography and skin temperatures overlying the supraclavicular (SCL) BAT depots using infrared thermography...
November 8, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29117797/obesity-and-metabolic-syndrome-in-copd-is-exercise-the-answer
#13
Benjamin D James, Amy V Jones, Ruth E Trethewey, Rachael A Evans
Approximately half of all patients with chronic obstructive pulmonary disease (COPD) attending pulmonary rehabilitation (PR) programmes are overweight or obese which negatively impacts upon dyspnoea and exercise tolerance particularly when walking. Within the obese population (without COPD), the observed heterogeneity in prognosis is in part explained by the variability in the risk of developing cardiovascular disease or diabetes (cardiometabolic risk) leading to the description of metabolic syndrome. In obesity alone, high-intensity aerobic training can support healthy weight loss and improve the constituent components of metabolic syndrome...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29117621/gender-differences-in-cardiometabolic-risk-factors-in-metabolically-healthy-normal-weight-adults-with-central-obesity
#14
Katarína Šebeková, Melinda Csongová, Radana Gurecká, Zora Krivošíková, Jozef Šebek
We investigated whether metabolically healthy normal weight adults with central obesity display worse cardiometabolic profile compared with their centrally lean counterparts. This retrospective, cross-sectional study, comprised 1 135 subjects (64% females) aged 18-to-81 years, presenting ≤2 components of metabolic syndrome. They were classified as centrally lean (waist-to-height ratio (WHtR)<0.5 and waist circumference<80 cm in females and<94 cm in males) or presenting central obesity (WHtR ≥0...
November 8, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29113498/decreased-serum-microrna-21-level-is-associated-with-obesity-in-healthy-and-type-2-diabetic-subjects
#15
Samira Ghorbani, Roya Mahdavi, Behnam Alipoor, Ghodratollah Panahi, Ensieh Nasli Esfahani, Farideh Razi, Mohhammad Taghikhani, Reza Meshkani
BACKGROUND: Recently, much attention has been paid to the role of circulating microRNAs (miRNAs) as novel biomarkers for various diseases. The aim of this study was to investigate the level of a subset of miRNAs in serum samples of the diabetic and healthy subjects. METHODS: Forty two healthy and 45 T2D subjects participated in this study. Serum miR-21, miR-126, and miR-146a levels were measured using real-time PCR. RESULTS: There was no significant difference in the serum level of miR-21, miR-126, and miR-146a between the diabetic and non-diabetic groups...
November 7, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29110650/group-based-developmental-bmi-trajectories-polycystic-ovary-syndrome-and-gestational-diabetes-a-community-based-longitudinal-study
#16
Nadira Sultana Kakoly, Arul Earnest, Lisa J Moran, Helena J Teede, Anju E Joham
BACKGROUND: Obesity is common in young women, increasing insulin resistance (IR) and worsening pregnancy complications, including gestational diabetes (GDM). Women with polycystic ovary syndrome (PCOS) are commonly obese, which aggravates the severity of PCOS clinical expression. Relationships between these common insulin-resistant conditions, however, remain unclear. METHODS: We conducted a secondary analysis of the Australian Longitudinal Study on Women's Health (ALSWH) database, including data from 8009 women aged 18-36 years across six surveys...
November 6, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29108814/waist-to-height-ratio-and-sedentary-lifestyle-as-predictors-of-metabolic-syndrome-in-children-in-ecuador
#17
F Aguirre P, A Coca, M F Aguirre, G Celis
OBJECTIVE: To determine the predictors and prevalence of metabolic syndrome (MS) and the presence of vascular inflammation in apparently-normal children (10-15 years) of both sexes in Guayaquil, Ecuador. STUDY DESIGN AND METHODS: We included 395 apparently-healthy students from a middle-income school in a cross-sectional survey. Informed consent was obtained from students and parents. Anthropometric measurements including blood pressure (BP), body mass index (BMI) and waist-to-height ratio (WHtR), and blood tests were recorded...
November 3, 2017: Hipertensión y Riesgo Vascular
https://www.readbyqxmd.com/read/29106481/blood-concentrations-of-persistent-organic-pollutants-and-unhealthy-metabolic-phenotypes-in-normal-weight-overweight-and-obese-individuals
#18
Magda Gasull, Conxa Castell, Natàlia Pallarès, Carme Miret, José Pumarega, María Te Llez-Plaza, Tomàs López, Jordi Salas-Salvadó, Duk-Hee Lee, Albert Goday, Miquel Porta
Factors underlying metabolic phenotypes, such as the metabolically healthy but obese phenotype, remain unclear. Differences in metabolic phenotypes -particularly, among individuals with a similar body mass index- could be related to concentrations of persistent organic pollutants (POPs). No studies have analyzed POPs and metabolic phenotypes in normal-weight persons. The authors investigated the relationships between serum concentrations of POPs and metabolic phenotypes in 860 normal-weight, overweight, and obese participants in the 2002 Catalan Health Interview Survey (Spain)...
June 30, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29100915/dynamic-status-of-metabolically-healthy-overweight-obesity-and-metabolically-unhealthy-and-normal-weight-and-the-risk-of-type-2-diabetes-mellitus-a-cohort-study-of-a-rural-adult-chinese-population
#19
Bingyuan Wang, Ming Zhang, Shu Wang, Chongjian Wang, Jinjin Wang, Linlin Li, Lu Zhang, Yongcheng Ren, Chengyi Han, Yang Zhao, Junmei Zhou, Guo'an Wang, Yanxia Shen, Dongting Wu, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Xinping Luo, Dongsheng Hu
OBJECTIVE: We aimed to determine dynamic status of metabolically healthy overweight or obesity (MHO) and metabolically unhealthy and normal weight (MUNW) and the risk of incident type 2 diabetes mellitus (T2DM). METHODS: Body mass index and metabolic health were assessed on 11,865 eligible participants ≥18 years from 6-year follow-up cohort study of a rural Chinese population. Participants were classified as metabolically healthy and normal weight (MHNW), MHO, MUNW and metabolically unhealthy overweight or obesity (MUO) at both baseline and follow-up examinations...
October 31, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/29100781/estrogens-and-female-liver-health
#20
Karen L Chen, Zeynep Madak-Erdogan
Due to declining estrogen levels during menopause, NAFLD prevalence is higher in postmenopausal women compared to in premenopausal women or in men. Postmenopausal women are more susceptible to weight gain, fat redistribution and dyslipidemia, all major hallmarks of metabolic syndrome associated with increased NAFLD risk. Gut microbiota plays important roles in development of gastrointestinal tract, metabolism and immunity. Host-microbe interactions allows regulation of a wide range of pathways that affect healthy and diseased physiology...
November 1, 2017: Steroids
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