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https://www.readbyqxmd.com/read/27899816/bariatric-surgery-for-obesity-and-metabolic-disorders-state-of-the-art
#1
REVIEW
Ninh T Nguyen, J Esteban Varela
Obesity is one of the most important public health conditions worldwide. Bariatric surgery for severe obesity is an effective treatment that results in the improvement and remission of many obesity-related comorbidities, as well as providing sustained weight loss and improvement in quality of life. Contemporary bariatric operations include Roux-en-Y gastric bypass, sleeve gastrectomy, adjustable gastric band and the duodenal switch. The vast majority of these procedures are now performed using laparoscopic technique, the main advantages of which include rapid recovery, the reduction of postoperative pain and the reduction of wound-related complications, compared with open surgery...
November 30, 2016: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27898680/a-core-outcome-set-for-the-benefits-and-adverse-events-of-bariatric-and-metabolic-surgery-the-bariact-project
#2
Karen D Coulman, James Hopkins, Sara T Brookes, Katy Chalmers, Barry Main, Amanda Owen-Smith, Robert C Andrews, James Byrne, Jenny L Donovan, Graziella Mazza, Barnaby C Reeves, Chris A Rogers, Janice L Thompson, Richard Welbourn, Sarah Wordsworth, Jane M Blazeby
BACKGROUND: Bariatric and metabolic surgery is used as a treatment for patients with severe and complex obesity. However, there is a need to improve outcome selection and reporting in bariatric surgery trials. A Core Outcome Set (COS), an agreed minimum set of outcomes reported in all studies of a specific condition, may achieve this. Here, we present the development of a COS for BARIAtric and metabolic surgery Clinical Trials-the BARIACT Study. METHODS AND FINDINGS: Outcomes identified from systematic reviews and patient interviews informed a questionnaire survey...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27896648/clinical-and-metabolic-effects-of-biliopancreatic-diversion-persist-after-reduction-of-the-gastric-pouch-and-elongation-of-the-common-alimentary-tract-preliminary-report-in-a-series-of-patients-with-a-10-year-follow-up
#3
Valerio Ceriani, Francesco Cetta, Tiziana Lodi, Ferdinando Pinna, Antonio E Pontiroli
BACKGROUND: Biliopancreatic diversion (BPD) is a bariatric technique burdened, in some instances, by clinical evidence of malabsorption and malnutrition, and by intractable diarrhea. OBJECTIVE: The objective of this study was to assess metabolic and nutritional effects on patients undergoing BPD and BPD plus revisional surgery because of side effects. METHODS: Thirty-five consecutive BPD patients underwent revisional surgery (elongation of the common limb from 50 to 200 cm and reduction of the gastric pouch from 500 to 40 ml) after a median 48-month period [48...
November 29, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27896516/the-differential-impact-of-body-mass-index-and-the-feature-of-metabolic-syndrome-on-oncological-outcomes-following-different-surgical-procedures-in-japanese-men-with-prostate-cancer
#4
Masaki Shiota, Ario Takeuchi, Masaaki Sugimoto, Eiji Kashiwagi, Takashi Dejima, Keijiro Kiyoshima, Junichi Inokuchi, Katsunori Tatsugami, Akira Yokomizo, Masatoshi Eto
PURPOSE: This study aimed to examine the differential impact of body mass index and the feature of metabolic syndrome (MetS; obesity, hypertension, diabetes mellitus, and dyslipidemia) on biochemical recurrence (BCR) following radical prostatectomy (RP) treatment for prostate cancer using different surgical procedures. METHODS: This study included 283 Japanese patients with clinically localized prostate cancer who were treated with RP between 2008 and 2012. The prognostic significance of overweight and the feature of MetS were analyzed according to surgical procedures...
November 28, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27893763/the-role-of-morbid-obesity-in-the-promotion-of-metabolic-disruptions-and-non-alcoholic-steatohepatitis-by-helicobacter-pylori
#5
Albert Lecube, Silvia Valladares, Carolina López-Cano, Liliana Gutiérrez, Andreea Ciudin, José Manuel Fort, Josep Maria Reñé, Xavier Matias-Guiu, Inés de Torres, Marta Bueno, Judit Pallarés, Juan Antonio Baena
BACKGROUND: Helicobacter pylory (HP) infection has been associated to an increased rate of type 2 diabetes (T2D) and liver disease through its effect on insulin resistance and systemic inflammation. However, results are inconstant and no studies exist in morbidly obese patients, in which both insulin resistance and inflammation coexist. MATERIAL AND METHODS: Cross-sectional study to evaluate the relationship between HP infection and alterations in carbohydrate metabolism, lipid profile, inflammation markers, and liver disease in patients awaiting for bariatric surgery...
2016: PloS One
https://www.readbyqxmd.com/read/27890326/the-effect-of-metabolic-comorbidities-and-commonly-used-drugs-on-the-prognosis-of-patients-with-ovarian-cancer
#6
Daniel Bar, Ofer Lavie, Nili Stein, Ido Feferkorn, Ayelet Shai
BACKGROUND: Diabetes mellitus is associated with an increased risk of recurrence in patients with ovarian cancer. Retrospective studies suggested that the use of statins, metformin and beta blockers is associated with improved prognosis in these patients. Patients with diabetes often suffer from hypertension and are usually treated concomitantly by several classes of drugs. Our aim was to assess the independent contribution of diabetes mellitus and hypertension and of the use of aspirin, statins, metformin and beta blockers on the risk of ovarian cancer recurrence and mortality...
October 14, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27875417/the-utility-of-routinely-obtaining-postoperative-laboratory-studies-following-a-minimally-invasive-transforaminal-lumbar-interbody-fusion
#7
Junyoung Ahn, Dustin H Massel, Benjamin C Mayo, Fady Y Hijji, Ankur S Narain, Khaled Aboushaala, Daniel D Bohl, Islam M Elboghdady, Jacob V DiBattista, Kern Singh
STUDY DESIGN: This is a retrospective analysis. OBJECTIVE: To test the hypothesis that there is limited utility in routinely obtaining postoperative laboratory values following minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). BACKGROUND DATA: At many institutions, it is routine to obtain a complete blood count and basic metabolic profile (BMP) following a MIS TLIF. However, the utility of this practice has not been well characterized...
November 21, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27867860/laparoscopic-sleeve-gastrectomy-for-the-treatment-of-diabetes-mellitus-type-2-patients-single-center-early-experience
#8
Piotr Major, Michal Wysocki, Michał Pędziwiatr, Piotr Małczak, Magdalena Pisarska, Andrzej Budzyński
BACKGROUND: In recent years, laparoscopic sleeve gastrectomy (LSG) has become one of the most commonly used primary bariatric procedures for morbid obesity. While laparoscopic Roux-en-Y gastric bypass (LRYGB) has well documented positive clinical influence on type 2 diabetes, the role of LSG in diabetes treatment is debatable. The main aim of this study is to present our early experience in LSG as a method of bariatric treatment in patients with type 2 diabetes or abnormalities in glucose homeostasis...
October 2016: Gland Surgery
https://www.readbyqxmd.com/read/27866938/ovulation-induction-in-polycystic-ovary-syndrome-current-options
#9
REVIEW
Richard S Legro
There are a variety of effective treatment options to induce ovulation in women with polycystic ovary syndrome (PCOS). The most effective treatments are primarily reproductive and target the hypothalamic-pituitary-ovarian (HPO) axis. Letrozole, an aromatase inhibitor, is headed toward replacing clomiphene, a selective estrogen receptor modulator, as the first-choice option. Metabolic treatments likely work indirectly through the HPO axis. Many metabolic treatments have shown initial promise and later failed (troglitozone or d-chiro-inositol) or disappointed (metformin); further studies are needed of newer agents to treat type 2 diabetes...
September 21, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27864670/relationship-between-vitamin-d-deficiency-and-the-components-of-metabolic-syndrome-in-patients-with-morbid-obesity-before-and-1%C3%A2-year-after-laparoscopic-roux-en-y-gastric-bypass-or-sleeve-gastrectomy
#10
Ana Obispo Entrenas, David Legupin Tubio, Fabiola Lucena Navarro, Francisco Martin Carvajal, Norberto Gandara Adan, Maximino Redondo Bautista, Jimena Abiles Osinaga
BACKGROUND: Vitamin D deficiency (VDD) is associated with obesity and metabolic syndrome (MS). After bariatric surgery (BS), high rates of VDD often persist and some patients are refractory to the resolution of comorbidities. The aim of the present study is to analyse the relationship between the levels of vitamin D and the persistence of MS components at 12 months after BS, according to the surgical technique used. METHODS: We performed a retrospective study of 46 patients undergoing BS: 23 underwent laparoscopic Roux-en-Y gastric bypass (LRYGBP) and 23 laparoscopic sleeve gastrectomy (LSG)...
November 18, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27843182/association-between-components-of-metabolic-syndrome-and-prostatic-enlargement-an-indian-perspective
#11
P R Nandy, Sabyasachi Saha
BACKGROUND: To find association between prostate gland volume to components of the metabolic syndrome. METHODS: Cross-sectional, observational study in a tertiary care hospital of the Armed Forces of India. A total of 115 male patients aged 50-65 years attending the Urology OPD between Jan 2014 and July 2015 with lower urinary tract symptoms (LUTS) were included. Men with known malignant disease including carcinoma prostate, those on medical management for BPH and individuals with previous history of surgery related to urinary bladder/prostate were excluded...
October 2016: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/27843076/evolution-of-subcutaneous-adipose-tissue-fibrosis-after-bariatric-surgery
#12
K Chabot, M-S Gauthier, P Y Garneau, R Rabasa-Lhoret
AIM: Obesity is associated with the development of metabolic complications such as insulin resistance (IR). The mechanisms leading to IR remain unclear. This study aimed to investigate the relationship between adipose tissue fibrosis and IR in obese patients before and after bariatric surgery. METHODS: Thirty-five obese patients awaiting bariatric surgery (12 with type 2 diabetes) were included in the study. Non-diabetic patients were classified as either insulin-sensitive (n=11) or insulin-resistant (n=12), based on the Matsuda insulin sensitivity index (ISIMatsuda)...
November 11, 2016: Diabetes & Metabolism
https://www.readbyqxmd.com/read/27842762/-evolution-of-type-2-diabetes-and-carbohydrate-intolerance-following-bariatric-surgery-in-a-mexican-mestizo-population
#13
Eva Ramírez-Avilés, Omar Espinosa-González, Mónica Amado-Galván, Hernán Maydón-González, Elisa Sepúlveda-Guerrero, Carlos Zerrweck-López
BACKGROUND: Bariatric surgery continues to be the best treatment for weight loss and control of obesity related comorbidities. Gastric bypass and sleeve gastrectomy have demonstrated to be the most effective surgeries, but this has not been established in a Mexican (non-American) population. OBJECTIVE: To analyse the improvement in type 2 diabetes mellitus and carbohydrate intolerance in obese patients after bariatric surgery. MATERIAL AND METHODS: A retrospective analysis was performed on the data collected prospectively between 2013 and 2015 on every obese patient with diabetes and carbohydrate intolerance submitted for bariatric surgery...
November 11, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27834300/the-surmetagit-study-design-and-rationale-for-a-prospective-pan-omics-examination-of-the-gastrointestinal-response-to-roux-en-y-gastric-bypass-surgery
#14
Priscila Sala, Giliane Belarmino, Natasha Mendonça Machado, Camila Siqueira Cardinelli, Karina Al Assal, Mariane Marques Silva, Danielle Cristina Fonseca, Robson Kiyoshi Ishida, Marco Aurélio Santo, Eduardo Guimarães Hourneaux de Moura, Paulo Sakai, Ismael Francisco Mota Siqueira Guarda, Ismael Dale Cotrim Guerreiro da Silva, Agatha Sacramento Rodrigues, Carlos Alberto de Bragança Pereira, Steven Heymsfield, Joel Doré, Raquel Susana Matos de Miranda Torrinhas, Daniel Giannella-Neto, Dan Linetzky Waitzberg
OBJECTIVE: To describe the protocol of the SURgically induced Metabolic effects on the Human GastroIntestinal Tract (SURMetaGIT) study, a clinical pan-omics study exploring the gastrointestinal tract as a central organ driving remission of type 2 diabetes mellitus (T2DM) after Roux-en-Y gastric bypass (RYGB). The main points considered in the study's design and challenges faced in its application are detailed. METHODS: This observational, longitudinal, prospective study involved collection of gastrointestinal biopsy specimens, faeces, urine, and blood from 25 obese women with T2DM who were candidates for RYGB (20 patients for omics assessment and 5 for omics validation)...
November 10, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27829412/gastric-bypass-surgery-reveals-independency-of-obesity-and-diabetes-melitus-type-2
#15
Mogens Fenger, Dorte Lindqvist Hansen, Dorte Worm, Lisbeth Hvolris, Viggo B Kristiansen, Elin Rebecka Carlsson, Sten Madsbad
BACKGROUND: Roux-en-Y gastric bypass surgery is widely applied to ameliorate morbid obesity, including diabetes in people with type 2 diabetes. The latter vanish a few days after surgery for many, but not in all patients before any weight reduction has occurred. The explanation for this change in metabolic status is poorly understood, but the observation may suggest that the fate obesity and diabetes is only partly linked after surgery. METHODS: The trajectories of weight reduction measured as reduced body mass index (BMI) in 741obese subjects with and without diabetes were evaluated...
November 9, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27829330/diabetes-and-nutritional-screening-in-post-bariatric-patients
#16
Maria E Pena, Trisha B Newaz
With the rise of obesity there has been a concomitant increase in the incidence of type 2 diabetes (T2DM). As a result, the term "diabesity" has become a popular disease entity in the past several years. When lifestyle modification and pharmacotherapy fail to achieve successful weight loss and diabetes control, bariatric surgery is a recommended treatment option. Bariatric surgery has been shown to promote sustained T2DM remission in 30-63% of patients and improve other components of metabolic syndrome; thus a preferred term has been "metabolic surgery"...
November 7, 2016: Current Diabetes Reviews
https://www.readbyqxmd.com/read/27823611/bariatric-surgery-pathophysiology-and-outcomes
#17
REVIEW
Sidra Azim, Sangeeta R Kashyap
Diabetes mellitus and obesity are closely interrelated and pose a major burden on health care in terms of morbidity and mortality. Weight loss has favorable metabolic benefits for glycemic control and improvement of metabolic syndrome. Bariatric surgery (BS) is the most effective treatment for weight loss with durable results as compared to lifestyle modification. BS procedures have been associated with significant reduction in abdominal obesity, metabolic syndrome components, and glycemic control requiring fewer medications...
December 2016: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/27818587/improved-glucose-metabolism-following-bariatric-surgery-is-associated-with-increased-circulating-bile-acid-concentrations-and-remodeling-of-the-gut-microbiome
#18
REVIEW
Lukasz Kaska, Tomasz Sledzinski, Agnieszka Chomiczewska, Agnieszka Dettlaff-Pokora, Julian Swierczynski
Clinical studies have indicated that circulating bile acid (BA) concentrations increase following bariatric surgery, especially following malabsorptive procedures such as Roux-en-Y gastric bypasses (RYGB). Moreover, total circulating BA concentrations in patients following RYGB are positively correlated with serum glucagon-like peptide-1 concentrations and inversely correlated with postprandial glucose concentrations. Overall, these data suggest that the increased circulating BA concentrations following bariatric surgery - independently of calorie restriction and body-weight loss - could contribute, at least in part, to improvements in insulin sensitivity, incretin hormone secretion, and postprandial glycemia, leading to the remission of type-2 diabetes (T2DM)...
October 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27818311/changes-in-bone-metabolism-after-bariatric-surgery-by-gastric-bypass-or-sleeve-gastrectomy
#19
Kaisa K Ivaska, Ville Huovinen, Minna Soinio, Jarna C Hannukainen, Virva Saunavaara, Paulina Salminen, Mika Helmiö, Riitta Parkkola, Pirjo Nuutila, Riku Kiviranta
Bariatric surgery results in rapid weight loss and beneficial metabolic effects, but may have negative effects on the skeleton. The objective of this prospective study was to evaluate changes in bone metabolism in response to bariatric surgery with two surgical techniques. 46 morbidly obese subjects (mean 44.9years, BMI 42.1) with (n=19) or without (n=27) type 2 diabetes (T2DM) at baseline underwent either Roux-en-Y gastric bypass (RYGB, n=21) or sleeve gastrectomy (SG, n=25). Bone turnover markers (CTX, PINP, TRAcP5b, TotalOC and ucOC) were measured before and six months after surgery...
November 3, 2016: Bone
https://www.readbyqxmd.com/read/27811445/a-retrospective-analysis-of-blood-gases-with-two-different-insulin-infusion-protocols-in-patients-undergoing-cardiovascular-surgery
#20
S M Kuskonmaz, Ö Kurtipek, M E Aydın, M E Erbatur, M Alkan, Y Ünal, M Arslan
AIM: Intraoperative blood glucose concentration is known to be an independent risk factor for morbidity and mortality in patients undergoing cardiovascular surgery. Arterial blood gas analysis is an important investigation to monitor the acid-base balance and gas exchange in these patients. Hyperglycemia leads to a series of metabolic changes which affect acid-base balance and serum electrolytes. In this study, we aimed to look into the effect of glycemic control on arterial blood gas parameters, serum electrolytes, and hemoglobin (Hb)...
November 2016: Nigerian Journal of Clinical Practice
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