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metabolic surgery and diabetes

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https://www.readbyqxmd.com/read/29679334/metabolic-surgery-and-diabesity-a-systematic-review
#1
REVIEW
Lionel El Khoury, Elie Chouillard, Elias Chahine, Elias Saikaly, Tarek Debs, Radwan Kassir
Bariatric surgery is used to induce weight loss (baros = weight). Evidence has shown that bariatric surgery improves the comorbid conditions associated with obesity such as hypertension, hyperlipidemia, and type 2 diabetes mellitus T2DM. Hence, shifting towards using metabolic surgery instead of bariatric surgery is currently more appropriate in certain subset of patients. Endocrine changes resulting from operative manipulation of the gastrointestinal tract after metabolic surgery translate into metabolic benefits with respect to the comorbid conditions...
April 20, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29678347/the-incidence-and-risk-factors-associated-with-developing-symptoms-of-hypoglycemia-after-bariatric-surgery
#2
Clare J Lee, Todd T Brown, Michael Schweitzer, Thomas Magnuson, Jeanne M Clark
BACKGROUND: Hypoglycemia after bariatric surgery is an increasingly recognized metabolic complication associated with exaggerated secretion of insulin and gut hormones. OBJECTIVE: We sought to determine the incidence of hypoglycemic symptoms (hypo-sx) after bariatric surgery and characteristics of those affected compared with those unaffected. SETTING: University hospital. METHODS: We collected retrospective survey data from the patients who underwent bariatric surgery at a single center...
January 31, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29668809/anthropometric-and-clinical-profiles-of-post-bariatric-patients-submitted-to-procedures-in-plastic-surgery
#3
Simone Corrêa Rosa, Jefferson Lessa Soares DE Macedo, Luiz Augusto Casulari, Lucas Ribeiro Canedo, João Vitor Almeida Marques
OBJECTIVE: to evaluate the profile of patients submitted to post-bariatric plastic surgery at the North Wing Regional Hospital, Brasília, DF. METHODS: we conducted a prospective, descriptive and analytical study of patients submitted to Roux-en-Y gastroplasty, and subsequently to plastic surgery, from January 2011 to December 2016. We assessed body mass index before gastroplasty and after surgery plastic surgery, postoperative complications and comorbidities. RESULTS: we studied 139 patients (130 women and nine men), with a mean age of 41 years, who underwent 233 operations...
2018: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/29664527/-perioperative-nutrition-in-eras-protocols
#4
Andrés Sánchez C, Karin Papapietro V
The trauma involved in any surgical procedure, even if elective, causes a metabolic stress response characterized by postoperative insulin resistance (PIR). PIR is considered a surgical stress marker and is associated with increased morbidity and postoperative length of stay. PIR worsens when the patient is operated in a state of prolonged preoperative fasting or when postoperative feeding is delayed. The ERAS Protocols (Enhanced Recovery After Surgery) includes anesthetic, surgical, kinesiology, nutritional and nursing interventions aimed to modulate PIR...
November 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29651097/unraveling-the-compromised-biomechanical-performance-of-type-2-diabetes-and-roux-en-y-gastric-bypass-bone-by-linking-mechanical-structural-and-physico-chemical-properties
#5
Carlos Marin, Georgios Papantonakis, Kathleen Sels, G Harry van Lenthe, Guillaume Falgayrac, Roman Vangoitsenhoven, Bart Van der Schueren, Guillaume Penel, Frank Luyten, Katleen Vandamme, Greet Kerckhofs
Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with obesity and hyperglycemia. Roux-en-Y gastric bypass (RYGB) surgery is a common treatment for severely obese patients and T2DM. Both RYGB and T2DM are linked to increased skeletal fragility, though the exact mechanisms are poorly understood. Our aim was to characterize the structural, mechanical and compositional properties of bones from diet-induced obese and RYGB-treated obese (bypass) mice to elucidate which the exact factors are contributing to the increased skeletal fragility...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29625459/beyond-hyperglycemia-evidence-for-retinal-neurodegeneration-in-metabolic-syndrome
#6
Cagatay Karaca, Zuleyha Karaca
Purpose: We evaluated the retinal effects of systemic metabolic changes clustered under the umbrella of metabolic syndrome (MetS) in comparison with age-matched healthy subjects. Methods: Spectral-domain optical coherence tomography (OCT) retinal segmentation analysis of 29 patients with MetS and 36 control subjects was performed. Patients with diabetes mellitus (DM), uncontrolled hypertension, retinopathy, high myopia or hyperopia, and posterior segment surgery, were excluded from analysis...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29617641/mechanisms-of-action-and-therapeutic-application-of-glucagon-like-peptide-1
#7
REVIEW
Daniel J Drucker
Glucagon-like peptide-1 (GLP-1) released from gut enteroendocrine cells controls meal-related glycemic excursions through augmentation of insulin and inhibition of glucagon secretion. GLP-1 also inhibits gastric emptying and food intake, actions maximizing nutrient absorption while limiting weight gain. Here I review the circuits engaged by endogenous versus pharmacological GLP-1 action, highlighting key GLP-1 receptor (GLP-1R)-positive cell types and pathways transducing metabolic and non-glycemic GLP-1 signals...
April 3, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29602992/updated-panel-report-best-practices-for-the-surgical-treatment-of-obesity
#8
Dana A Telem, Daniel B Jones, Philip R Schauer, Stacy A Brethauer, Raul J Rosenthal, David Provost, Stephanie B Jones
BACKGROUND: During the 2004 annual meeting of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), a panel of experts convened to provide updated information on best practices in bariatric surgery. The rapid evolution of endoluminal technologies, surgical indications, and training in bariatric surgery since 2004 has led to new questions and concerns about optimal treatment algorithms, patient selection, and the preparation of our current and future bariatric workforce...
March 30, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29593555/ileal-transposition-surgery-decreases-fat-mass-and-improves-glucose-metabolism-in-diabetic-gk-rats-possible-involvement-of-fgf21
#9
Kemin Yan, Weijie Chen, Huijuan Zhu, Guole Lin, Hui Pan, Naishi Li, Linjie Wang, Hongbo Yang, Meijuan Liu, Fengying Gong
Objective: Ileal transposition (IT) surgery has been reported to improve glucose and lipid metabolism, and fibroblast growth factor 21 (FGF21) is a powerful metabolic regulator. In the present study, we aimed to investigate the effects of IT surgery on metabolism and its possible relationship with the FGF21 signaling pathway in diabetic Goto-Kakizaki (GK) rats. Methods: Ten-week-old male GK rats were subjected to IT surgery with translocation of a 10 cm ileal segment to the proximal jejunum (IT group) or sham surgery without the ileum transposition (Sham-IT group)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29590379/increased-plasma-proneurotensin-levels-identify-nafld-in-adults-with-and-without-type-2-diabetes
#10
Ilaria Barchetta, Flavia Agata Cimini, Frida Leonetti, Danila Capoccia, Claudio Di Cristofano, Gianfranco Silecchia, Marju Orho-Melander, Olle Melander, Maria Gisella Cavallo
Context: Neurotensin (NT) is an intestinal peptide released by fat ingestion and promoting lipids absorption; higher circulating NT levels associate with type 2 diabetes (T2D), obesity and cardiovascular disease. Whether NT is related to non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) has not been fully investigated. Objective: To study the relationship between plasma proneurotensin1-117 (pro-NT), a stable fragment of the NT precursor hormone, and the presence/severity of NAFLD/NASH and to unravel correlates of increased pro-NT levels...
March 23, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29580352/weight-loss-and-glycemic-control-after-sleeve-gastrectomy-results-from-a-middle-eastern-center-of-excellence
#11
Khalid Al Khalifa, Ahmed Al Ansari, May Showaiter
Obesity and its associated metabolic disorders are strongly linked to both morbidity and mortality. Sleeve gastrectomy (SG) has been established as an effective means of weight loss for obese patients as well as a treatment for type 2 diabetes mellitus (T2DM). This study was designed to examine the short- and midterm outcomes of patients who underwent SG in a Middle Eastern Center of Excellence, a military training teaching hospital. The clinical outcomes of 59 patients with impaired glucose tolerance and T2DM who underwent SG between 2011 and 2014 with at least one and up to four years of follow-up were studied...
February 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29579172/micrornas-in-the-mammalian-gut-endocrine-lineage
#12
Yu-Han Hung, Praveen Sethupathy
MicroRNAs (miRNAs) are small noncoding RNA molecules that modulate gene expression at the posttranscriptional level. Numerous reports have elucidated the importance of miRNAs in the regulation of a wide array of biological processes including metabolism and energy homeostasis. miRNAs in the endocrine pancreas have been intensively studied over the last 15 years and linked to pancreatic islet development and function. In comparison, knowledge of miRNAs in gut endocrine cells, or enteroendocrine cells (EECs), is severely lacking...
February 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29571634/the-effect-of-metabolic-surgery-on-nonobese-patients-bmi-30-kg-m-2-with-type-2-diabetes-a-systematic-review
#13
Zhi-Ping Huang, Yan Guo, Chao-Qian Liu, Lin Qi, Da-Jin Zou, Wei-Ping Zhou
BACKGROUND: The influence of metabolic surgery on the glucose and lipid profiles of nonobese body mass index<30 kg/m2 patients with type 2 diabetes, particularly the effect ≥1 year, remains unknown. METHODS: PubMed and Ovid Embase were used. SETTING: University hospitals. RESULTS: In total, 21 studies including 921 patients were examined in this systematic review, the results of which revealed decrease in body mass index, waist circumference, fasting plasma glucose, glycosylated hemoglobin A1C, fasting C-peptide, fasting insulin, homeostasis model of assessment for insulin resistance index, triglycerides, total cholesterol, and low-density lipoprotein cholesterol...
February 15, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29561982/comparison-of-the-levels-of-c-reactive-protein-glp-1-and-glp-2-among-individuals-with-diabetes-morbid-obesity-and-healthy-controls-an-exploratory-study
#14
Everton Cazzo, José Carlos Pareja, Elinton Adami Chaim, Cláudio Saddy Rodrigues Coy, Daniéla Oliveira Magro
BACKGROUND: The glucagon-like peptides 1 and 2 (GLP-1/GLP-2) are gut hormones that may directly affect the glucose homeostasis and their activity seems to be significantly affected by chronic inflammation. OBJECTIVE: To evaluate the postprandial levels of glucagon-like peptides 1 and 2 (GLP-1/GLP-2), C-reactive protein (CRP), and the postprandial glucose and insulin levels among individuals with obesity, type 2 diabetes, and healthy controls. METHODS: An exploratory cross-sectional study, which involved individuals awaiting for bariatric/metabolic surgery and healthy controls...
January 2018: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/29560648/metabolic-and-nutritional-complications-of-bariatric-surgery-a-review
#15
REVIEW
L Mesureur, M Arvanitakis
Bariatric surgery is considered as the only effective durable weight-loss therapy and may be curative for obesity-related comorbidities such as diabetes. Nevertheless this surgery is not devoid of potential long-term complications such as dumping syndrome, gastroesophageal reflux disease and nutrient deficiencies. For this reason, preoperative nutritional assessment and rigorous postoperative follow-up with administration of multi-vitamins supplements and assessment of serum levels is recommended for each patient who is undergoing a bariatric surgery...
October 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29556514/determinant-factors-for-chronic-kidney-disease-after-partial-nephrectomy
#16
REVIEW
Oscar D Martín, Heilen Bravo, Marcos Arias, Diego Dallos, Yesica Quiroz, Luis G Medina, Giovanni E Cacciamani, Raul G Carlini
The objective of this review is to evaluate the factors that determine the development or deterioration of Chronic Kidney Disease (CKD) after partial nephrectomy (PN). When current literature is reviewed, it is found that factors that influence renal function after partial nephrectomy, are multifactorial. Those are divided into pre-surgical factors, such as hypertension, diabetes mellitus, urolithiasis, obesity, metabolic syndrome among others; intra-surgical factors, like the surgical technique used, the remaining healthy tissue, the experience of the surgeon, the time and type of ischemia among others...
January 2018: Oncoscience
https://www.readbyqxmd.com/read/29555031/laparoscopic-gastric-bypass-for-the-treatment-of-type-2-diabetes-a-comparison-of-roux-en-y-versus-single-anastomosis-gastric-bypass
#17
Owaid M Almalki, Wei-Jei Lee, Keong Chong, Kong-Han Ser, Yi-Chih Lee, Shu-Chun Chen
BACKGROUND: In recent years, gastric bypass surgery has been found to have therapeutic potential for the treatment of type 2 diabetes (T2D). However, the difference between 2 bypass procedures, Roux-en-Y gastric bypass (RYGB) and another single anastomosis gastric bypass (SAGB), is not clear. OBJECTIVE: To evaluate the differences between SAGB and RYGB in the efficacy of T2D remission in obese patients. SETTING: Tertiary teaching hospital...
April 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29554811/early-glycaemic-control-for-maintaining-visual-function-in-type-1-diabetes-the-oulu-cohort-study-of-diabetic-retinopathy
#18
Nina Hautala, Mira Siiskonen, Virva Hannula, Kaisu Järvinen, Aura Falck
PURPOSE: The purpose of this study was to evaluate the visual function and the ophthalmic status of young Finnish adults with long duration of type 1 diabetes in relation to the history of the metabolic control. METHODS: A population-based cohort of children with type 1 diabetes examined in the Northern Ostrobothnia hospital district in 1989 (n = 216) was re-examined 18 years later. High-contrast visual acuity (best-corrected visual acuity), contrast sensitivity, refractive error, lens status, intraocular pressure, stage of diabetic retinopathy and received treatments were evaluated...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29554135/thermogenic-capacity-of-human-periaortic-adipose-tissue-is-transformed-by-body-weight
#19
Diana Vargas, Carolina López, Edward Acero, Edgar Benitez, Angélica Wintaco, Jaime Camacho, Marisol Carreño, Juan Umaña, Daniela Jimenez, Said Díaz, Fernando Lizcano
The anatomical location of adipose tissue might have direct implications for its functionality and risk of cardiovascular disease. Adipose tissue surrounding blood vessels may be thermogenically more active in specific areas of the body, releasing substances that regulate vascular metabolism. In humans, the phenotypic characteristics of adipose tissue surrounding the aorta and the cardiovascular disease risk that it might entail remain largely unknown. Here, we compared thermogenesis-related molecular features of human periaortic adipose tissue samples with those of subcutaneous adipose tissue, obtained by sternotomy from 42 patients undergoing cardiovascular surgery...
2018: PloS One
https://www.readbyqxmd.com/read/29548899/inflammatory-cytokine-profiles-in-visceral-and-subcutaneous-adipose-tissues-of-obese-patients-undergoing-bariatric-surgery-reveal-lack-of-correlation-with-obesity-or-diabetes
#20
Volatiana Rakotoarivelo, Gregory Lacraz, Marian Mayhue, Christine Brown, Diane Rottembourg, Julie Fradette, Subburaj Ilangumaran, Alfredo Menendez, Marie-France Langlois, Sheela Ramanathan
Population studies have linked insulin resistance to systemic low-grade chronic inflammation and have reported elevated levels of inflammatory cytokines such as TNFα, IL-1β and IL-6, individually or in certain combinations, in adipose tissues or in the serum. We undertook this comprehensive study to simultaneously evaluate the expression of several pro-inflammatory and anti-inflammatory cytokines in serum and in the visceral and subcutaneous adipose tissues from obese patients undergoing bariatric surgery...
March 8, 2018: EBioMedicine
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