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https://www.readbyqxmd.com/read/28727756/dysregulation-of-micrornas-and-renin-angiotensin-system-in-high-salt-diet-induced-cardiac-dysfunction-in-uninephrectomized-rats
#1
Venkateswara Rao Amara, Sunil Kumar Surapaneni, Kulbhushan Tikoo
Uninephrectomy is not associated with major adverse events in cardiovascular and renal functions of live kidney donors. The effect of high salt diet on the quality of life of live kidney donors is largely unknown. Hence in this study, we aimed to determine the effect of high salt diet on the alterations of renin-angiotensin system and microRNAs leading to CV and renal dysfunction in uninephrectomized rats. In order to mimic clinical scenario, uninephrectomized male Sprague Dawley rats were fed initially with normal pellet diet for 12 weeks and then for 20 weeks with high salt (10% w/w NaCl) diet...
2017: PloS One
https://www.readbyqxmd.com/read/28716819/effect-of-type-2-diabetes-surgical-incision-and-volatile-anesthesia-on-hemodynamics-in-the-rat
#2
Carol T Bussey, Regis R Lamberts
Diabetic patients have increased cardiac complications during surgery, possibly due to impaired autonomic regulation. Anesthesia lowers blood pressure and heart rate (HR), whereas surgical intervention has opposing effects. The interaction of anesthesia and surgical intervention on hemodynamics in diabetes is unknown, despite being a potential perioperative risk factor. We aimed to determine the effect of diabetes on the integrative interaction between hemodynamics, anesthesia, and surgical incision. Zucker type 2 diabetic rats (DM) and their nondiabetic littermates (ND) were implanted with an intravenous port for drug delivery, and a radiotelemeter to measure mean arterial blood pressure (MAP) and derive HR (total n = 50)...
July 2017: Physiological Reports
https://www.readbyqxmd.com/read/28716522/exercise-individualized-by-trimpi-method-reduces-arterial-stiffness-in-early-onset-type-2-diabetic-patients-a-randomized-controlled-trial-with-aerobic-interval-training
#3
Alfonso Bellia, Ferdinando Iellamo, Elisa De Carli, Aikaterini Andreadi, Elvira Padua, Mauro Lombardo, Giuseppe Annino, Francesca Campoli, Sara Tartaglione, Stefano D'Ottavio, David Della-Morte, Davide Lauro
BACKGROUND: Arterial stiffness (AS) and baroreflex sensitivity (BRS) are subclinical markers of vascular diseases in type 2 diabetes (T2D). We evaluated the effects of aerobic interval training (AIT), with loads prescribed according to individual heart rate and lactate profiling obtained during a baseline treadmill test (TRIMPi method), on AS and BRS in patients with early-onset T2D without cardiovascular complications. POPULATION STUDY AND METHODS: Twenty-two sedentary overweight T2D patients (aged 57±7years) were randomized to 12-weeks open-label of supervised AIT by TRIMPi (n=8) or unsupervised physical activity as per usual care (SOC) (n=11)...
June 17, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28714262/baroreflex-mediated-sympathetic-overactivation-induced-by-mental-stress-in-post-traumatic-stress-disorder-depends-on-the-type-of-stressor
#4
Luiz Eduardo Virgilio Silva, Pedro Lourenço Katayama
Sympathetic overactivation has long been recognized as a deleterious condition, involved in the physiopathology of several diseases. The overactivity of sympathetic nervous system (SNS) may be the consequence of different conditions and an intriguing question that still remains is whether diseases, such as hypertension and heart failure, are induced by increased SNS or increased SNS is a consequence of the disease progression. This article is protected by copyright. All rights reserved.
July 17, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28710030/differences-of-sympathetic-and-parasympathetic-modulation-in-major-depression
#5
Andy Schumann, Caroline Andrack, Karl-Jürgen Bär
Inconsistent results have been reported with respect to cardiac autonomic function in major depression. The aim of our study was to investigate autonomic function in various branches of the autonomic nervous system in order to better understand parasympathetic and sympathetic modulation in the disease. We investigated 29 unmedicated patients suffering from major depression (MD) in comparison to matched control subjects (gender, age, BMI). The autonomic assessment at rest included values of heart rate variability (HRV), blood pressure variability (BPV), baroreflex sensitivity (BRS), respiration, skin conductance (SC) as well as the calculation of pupillary diameter and the unrest index (PUI)...
July 11, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28707593/effects-of-some-indigenous-plants-of-north-karnataka-india-on-cardiovascular-and-glucose-regulatory-systems-in-diabetic-rats
#6
Kusal K Das, Kailash S Chadchan, R Chandramouli Reddy, M S Biradar, Pallavi S Kanthe, Bheemshetty S Pati, Jeevan G Ambekar, Ishwar B Bagoji, Swastika Das
BACKGROUND: The medicinal plants of north Karnataka, India are always researchers delight as many of these plants are rarely found in elsewhere other than this part of India. Kenaf leaves (Hibiscus cannabinus Linn, Pundi), Chick pea leaves (Cicer arietinum Linn, Chana) and Prickly lettuce leaves (Lactuca scariola Linn, Hattaraki.) are a few of these indigenous plants which are routinely consumed by the people as diet in this part of India. Various studies were done on these plants to find out some potential anti diabetic efficacies but reports are still not encouraging...
July 12, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28702747/management-of-supine-hypertension-complicating-neurogenic-orthostatic-hypotension
#7
Jacquie Baker, Kurt Kimpinski
Neurogenic orthostatic hypotension (NOH) can be present in a number of disorders, including synucleinopathies, autoimmune disorders, and various genetic disorders. All are characterized by defective norepinephrine release from sympathetic terminals upon standing, resulting in impaired vasoconstriction. NOH is defined as a drop in systolic blood pressure ≥20 mmHg or diastolic blood pressure ≥10 mmHg, or both, within 3 minutes of standing or head up-tilt at a minimum of 60°. However, approximately 50% of patients have associated supine hypertension, which greatly complicates treatment...
July 12, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28699532/modulation-of-heart-rate-by-acute-or-chronic-aerobic-exercise-potential-effects-on-blood-pressure-control
#8
Carme Perez-Quilis, J Derek Kingsley, Kabir Malkani, Gianfranco Cervellin, Giuseppe Lippi, Fabian Sanchis-Gomar
It was initially assumed that heart rate and arterial blood pressure were modulated by normal respiration and muscle contraction. The arterial baroreflex, an inverse relationship between blood pressure and heart rate, was later reported. Nonetheless, it was then assumed that those responses involved vagal modulation. We summarize available evidence on the modulation of heart rate by acute or chronic aerobic exercise as well as its potential implications on BP control. Numerous studies have tried to clarify whether aerobic exercise modifies neurally-mediated vasoconstriction, but they report contradictory results...
July 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28693357/effect-of-acute-ambient-temperature-exposure-on-cardio-pulmonary-and-respiratory-kinetics-in-men
#9
U Drescher, J Koschate, U Hoffmann, S Schneider, A Werner
PURPOSE: The goal of the study was to compare the kinetics responses of heart rate (HR) and pulmonary (V'O2pulm) and muscular (V'O2musc) oxygen uptake during dynamic leg exercise across different acute ambient temperature conditions in a climatic chamber. METHODS: Thirteen physically healthy, active male volunteers performed pseudo-random binary sequence (PRBS) work rate (WR) changes between 30 W and 80 W at 15°C, 25°C and 35°C, respectively. HR was measured beat-to-beat by echocardiogram and V'O2pulm by breath-by-breath gas exchange, and V'O2musc estimations were assessed by applying a circulatory model and cross-correlation functions based on the approach of Hoffmann et al...
July 10, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28687588/the-carotid-baroreflex-modifies-the-pressor-threshold-of-the-muscle-metaboreflex-in-humans
#10
Masashi Ichinose, Tomoko K Ichinose-Kuwahara, Kazuhito Watanabe, Narihiko Kondo, Takeshi Nishiyasu
The purpose of present study was to test our hypothesis that unloading the carotid baroreceptors alters the threshold and gain of the muscle metaboreflex in humans. Ten healthy subjects performed a static handgrip exercise at 50% of maximum voluntary contraction. Contraction was sustained for 15, 30, 45 and 60 s, and was followed by 3 min of forearm circulatory arrest, during which forearm muscular pH is known to decrease linearly with increasing contraction time. The carotid baroreceptors were unloaded by applying 0...
July 7, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28679109/investigation-of-vagal-afferent-functioning-using-the-heartbeat-event-related-potential
#11
Christina Huang, R N Gevirtz, Julie Onton, Jose R Criado
Although there has been much support for HRV Biofeedback as an effective intervention for various disorders, there is a lack of comprehension of the underlying mechanisms. The predominant theories of increased vagal efferents and baroreflex gain are insufficient in explaining the frequent observations that HRV Biofeedback impacts changes in constructs beyond ANS mediation, such as emotion regulation, attentional control, and self-regulatory reserve. It has been suspected that vagal afferent functioning may be the underlying mechanism, but little research has explored this...
July 2, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28675547/baroreceptor-reflex-failure-review-of-the-literature-and-the-potential-impact-on-patients-with-head-and-neck-cancer
#12
Shivani Shah-Becker, Michael Pennock, Lawrence Sinoway, David Goldenberg, Neerav Goyal
BACKGROUND: Baroreceptor dysfunction and reflex failure may occur after surgery affecting the carotid artery. The implications for patients undergoing treatment for head and neck cancer are not well described. METHODS: A literature search of PubMed was performed between March 2016 and May 2016. Search terms used individually and in combination included: "baroreflex failure," "carotid sinus sensitivity," "carotid endarterectomy," "carotid body tumor," and "head and neck cancer...
July 4, 2017: Head & Neck
https://www.readbyqxmd.com/read/28674869/muscle-sympathetic-nerve-activity-peaks-in-the-first-trimester-in-healthy-pregnancy-a-longitudinal-case-study
#13
Sarah L Hissen, Khadigeh El Sayed, Vaughan G Macefield, Rachael Brown, Chloe E Taylor
OBJECTIVE AND METHODS: Muscle sympathetic nerve activity and baroreflex sensitivity were examined at rest before, during (weeks 6, 11, 17, 22, 25, 33 and 36) and after a normotensive pregnancy. RESULTS: Muscle sympathetic nerve activity is elevated during pregnancy with a large peak in the first trimester (Δ17 bursts/min) and a secondary peak in the third trimester (Δ11 bursts/min). Cardiac baroreflex sensitivity peaked in the first trimester (10 vs. 6 ms/mmHg pre-pregnancy), whereas sympathetic baroreflex sensitivity was greater throughout...
July 3, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28666602/integrated-cardiovascular-respiratory-control-in-type-1-diabetes-evidences-functional-imbalance-possible-role-of-hypoxia
#14
L Bianchi, C Porta, A Rinaldi, C Gazzaruso, P Fratino, P DeCata, P Protti, R Paltro, L Bernardi
BACKGROUND: Cardiovascular (baroreflex) and respiratory (chemoreflex) control mechanisms were studied separately in diabetes, but their reciprocal interaction (well known for diseases like heart failure) had never been comprehensively assessed. We hypothesized that prevalent autonomic neuropathy would depress both reflexes, whereas prevalent autonomic imbalance through sympathetic activation would depress the baroreflex but enhance the chemoreflexes. METHODS: In 46 type-1 diabetic subjects (7...
June 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28665712/left-ventricular-end-diastole-hemodynamics-is-strongly-associated-with-spontaneous-cardiac-baroreflex-in-humans
#15
Karol Makowski, Elżbieta Kramarz, Grzegorz Kamiński, Monika Grzęda, Paulina Kramarz, Grzegorz Kade
BACKGROUND: In animals, hemodynamic conditions during left ventricular (LV) end-diastole are crucial for the excitation of autonomic afferents distributed throughout cardiac chambers and large thoracic vessels. The objective of the study was to select the echocardiographic indices of LV diastolic function that are the most potent predictors of the heart's spontaneous baroreflex in humans. METHODS: In 47 untreated hypertensive patients (26 with normal and 21 with increased left atrium diameter) and 24 healthy controls, baroreflex sensitivity (BRS) was assessed in the low (αLF; 0...
June 30, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28663324/new-indices-from-microneurography-to-investigate-the-arterial-baroreflex
#16
Alexandre Laurin, Matthew G Lloyd, Tesshin Hachiya, Mitsuru Saito, Victoria E Claydon, Andrew Blaber
Baroreflex-mediated changes in heart rate and vascular resistance in response to variations in blood pressure are critical to maintain homeostasis. We aimed to develop time domain analysis methods to complement existing cross-spectral techniques in the investigation of the vascular resistance baroreflex response to orthostatic stress. A secondary goal was to apply these methods to distinguish between levels of orthostatic tolerance using baseline data. Eleven healthy, normotensive males participated in a graded lower body negative pressure protocol...
June 2017: Physiological Reports
https://www.readbyqxmd.com/read/28658603/physiological-approaches-to-assess-diminished-sympathetic-activity-in-the-conscious-rat
#17
Matthew R Zahner, Chang-Ning Liu, Vincent Bernardo, Carrie Northcott, Cheryl Tyszkiewicz, Carlin Okerberg, Magalie Boucher, Ingrid Pardo, Chris J Somps
The purpose of this study was to evaluate functional measures of diminished sympathetic activity after postganglionic neuronal loss in the conscious rat. To produce variable degrees of sympathetic postganglionic neuronal loss, adult rats were treated daily with toxic doses of guanethidine (100mg/kg) for either 5days or 11days, followed by a recovery period of at least 18days. Heart rate, blood pressure, cardiac baroreflex responsiveness, urinalysis (for catecholamine metabolite, 3-methoxy-4-hydroxyphenylethylenglycol; MHPG), and pupillometry were performed during the recovery period...
June 25, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28658076/recovery-time-profiling-after-short-middle-and-long-distance-swimming-performance
#18
Alessandro Piras, Matteo Cortesi, Francesco Campa, Monica Perazzolo, Giorgio Gatta
We investigated cardiac autonomic responses and hemodynamic parameters on recovery time following short-, middle- and long-swimming performance. Ten male regional-level swimmers were tested to estimate time and frequency domains of arterial baroreflex sensitivity and heart rate variability after 100-, 200-, and 400-m of front crawl. We found a BRS reduction for 90 min after a maximal 100- and 200-m front crawl event, meanwhile the reflex was restored back to the baseline value about 70 min after 400-m. The vagally mediated HF power of R-R intervals was significantly reduced for 30 min after 400-m, and more than 90 min after 100- and 200-m, with a concomitant increase of sympathetic modulation...
June 22, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28650915/the-brainstem-network-controlling-blood-pressure-an-important-role-for-pressor-sites-in-the-caudal-medulla-and-cervical-spinal-cord
#19
Michael G Z Ghali
: Although medullary control of blood pressure (BP) has been extensively studied, the contribution of critical regions, such as pressor sites in the caudal medulla and upper cervical spinal cord and the lateral tegmental field, remains controversial and underappreciated. A series of pressor sites caudal to the caudal ventrolateral medulla (CVLM), including the caudal pressor area (CPA) and medullocervical pressor area, play an important role in control of BP. Activation and inhibition of these sites elicits pressor and depressor responses, respectively...
June 24, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28648674/hemodynamic-changes-in-patients-with-influenza-a-after-propacetamol-infusion-in-the-emergency-department
#20
Hyun Jong Lee, Young Ju Suh, Ah Jin Kim, Seung Baik Han, Areum Durey
OBJECTIVES: Recently, there has been an emerging clinical data suggesting that intravenous propacetamol may cause iatrogenic hypotension. The primary objective of this study was to evaluate hemodynamic changes after propacetamol infusion in the emergency department (ED) with the patients of influenza A. Secondary objective was to assess the incidence of propacetamol-induced significant hypotension and to evaluate factors associated with this adverse effect by comparing two groups of patients with or without a significant reduction in blood pressure (BP)...
June 21, 2017: American Journal of Emergency Medicine
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