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https://www.readbyqxmd.com/read/28637322/predicting-perceived-isolation-among-midlife-and-older-lgbt-adults-the-role-of-welcoming-aging-service-providers
#1
Jie Yang, Yoosun Chu, Mary Anne Salmon
Background and Objectives: Older lesbian, gay, bisexual, and transgender (LGBT) adults are more likely to live alone and less likely to have children compared with their heterosexual counterparts. The lack of immediate family system can render older LGBT adults particularly vulnerable to social isolation and its consequences. The current study utilizes social exclusion theory, which asserts that not only material resources but also engagement with and inclusion into the society are necessary for marginalized people to be integrated into the mainstream...
June 16, 2017: Gerontologist
https://www.readbyqxmd.com/read/28637224/impact-of-a-macleaya-cordata-derived-alkaloid-extract-on-necrotic-enteritis-in-broilers
#2
G D Xue, S B Wu, M Choct, A Pastor, T Steiner, R A Swick
Necrotic enteritis (NE) causes significant economic losses in the broiler chicken industry, especially in birds raised without in-feed antibiotics. A standardized blend of plant-derived isoquinoline alkaloids (IQA) derived from Macleaya cordata has shown to have anti-inflammatory potency and promoted animal productivity. This study investigated the effects of IQA supplementation on broiler chickens under NE challenge. A 2 × 2 factorial arrangement of treatments was employed with factors: NE challenge (no or yes), and additives (no additive or IQA at 0...
June 20, 2017: Poultry Science
https://www.readbyqxmd.com/read/28637091/nurse-managers-determinants-and-behaviours-in-relation-to-patient-and-visitor-aggression-in-general-hospitals-a-qualitative-study
#3
Birgit Heckemann, Karin A Peter, Ruud Jg Halfens, Jos Mga Schols, Gerjo Kok, Sabine Hahn
AIM: 'To explore nurse managers' behaviours, attitudes, perceived social norms and behavioural control in the prevention and management of patient and visitor aggression in general hospitals. BACKGROUND: Patient and visitor aggression in general hospitals is a global problem that incurs substantial human suffering and organizational cost. Managers are key persons for creating low-aggression environments, yet their role and behaviour in reducing patient and visitor aggression remains unexplored...
June 21, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28637090/early-warning-systems-and-rapid-response-to-the-deteriorating-patient-in-hospital-a-realist-evaluation
#4
Jennifer Mcgaughey, Peter O'Halloran, Sam Porter, John Trinder, Bronagh Blackwood
AIM: To identify those contexts and mechanisms that enable or constrain the implementation of Rapid Response Systems on acute general hospital wards to recognise and respond to patient deterioration. BACKGROUND: Rapid Response Systems allow deteriorating patients to be recognised using Early Warning Systems, referred early via escalation protocols and managed at the bedside by competent staff. DESIGN: Realist Evaluation. METHODS: The research design was an embedded multiple case study approach of four wards in two hospitals in Northern Ireland which followed the principles of Realist Evaluation...
June 21, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28637086/climate-drives-plant-pollinator-interactions-even-along-small-scale-climate-gradients-the-case-of-the-aegean
#5
T Petanidou, A S Kallimanis, M Lazarina, T Tscheulin, J Devalez, A Stefanaki, E Ηanlidou, A Vujić, A Kaloveloni, S P Sgardelis
Plant-pollinator network structure is the outcome of ecological and evolutionary processes, and although the importance of environmental factors is beyond doubt, our knowledge of how abiotic factors (e.g. climate) shape plant-pollinator networks remains limited. This knowledge gap is critical, as climate change poses a major threat to ecosystems, especially in the Mediterranean. This study focuses on one of the hottest parts of the Basin, the Aegean Archipelago, Greece, and examines how climate affects species richness and network properties (e...
June 21, 2017: Plant Biology
https://www.readbyqxmd.com/read/28636997/an-optimized-hmgb1-expressed-by-recombinant-rabies-virus-enhances-immunogenicity-through-activation-of-dendritic-cells-in-mice
#6
Zhao Wang, Qian Liang, Yajing Zhang, Jie Yang, Mingming Li, Kunlun Wang, Min Cui, Huanchun Chen, Zhen F Fu, Ling Zhao, Ming Zhou
Rabies remains an important public health threat, killing approximately 59,000 people worldwide annually, most of which are from the developing countries of Africa and Asia where dog rabies are endemic. Therefore, developing an affordable and efficacious vaccine for dog-mediated rabies control is needful in these countries. Our previous studies indicated that over-expression of granulocyte-macrophage colony stimulating factor (GM-CSF) or macrophage inflammatory protein-1 (MIP-1α or CCL3) by recombinant rabies virus (rRABV) could enhance the immunogenicity by activating dendritic cells (DCs)...
June 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28636934/the-tmao-producing-enzyme-flavin-containing-monooxygenase-3-regulates-obesity-and-the-beiging-of-white-adipose-tissue
#7
Rebecca C Schugar, Diana M Shih, Manya Warrier, Robert N Helsley, Amy Burrows, Daniel Ferguson, Amanda L Brown, Anthony D Gromovsky, Markus Heine, Arunachal Chatterjee, Lin Li, Xinmin S Li, Zeneng Wang, Belinda Willard, YongHong Meng, Hanjun Kim, Nam Che, Calvin Pan, Richard G Lee, Rosanne M Crooke, Mark J Graham, Richard E Morton, Carl D Langefeld, Swapan K Das, Lawrence L Rudel, Nizar Zein, Arthur J McCullough, Srinivasan Dasarathy, W H Wilson Tang, Bernadette O Erokwu, Chris A Flask, Markku Laakso, Mete Civelek, Sathyamangla V Naga Prasad, Joerg Heeren, Aldons J Lusis, Stanley L Hazen, J Mark Brown
Emerging evidence suggests that microbes resident in the human intestine represent a key environmental factor contributing to obesity-associated disorders. Here, we demonstrate that the gut microbiota-initiated trimethylamine N-oxide (TMAO)-generating pathway is linked to obesity and energy metabolism. In multiple clinical cohorts, systemic levels of TMAO were observed to strongly associate with type 2 diabetes. In addition, circulating TMAO levels were associated with obesity traits in the different inbred strains represented in the Hybrid Mouse Diversity Panel...
June 20, 2017: Cell Reports
https://www.readbyqxmd.com/read/28636811/performance-evaluation-of-gpu-parallelization-space-time-adaptive-algorithms-and-their-combination-for-simulating-cardiac-electrophysiology
#8
Rafael S Oliveira, Bernardo M Rocha, Denise Burgarelli, Wagner Meira, Christakis Constantinides, Rodrigo Weber Dos Santos
The use of computer models as a tool for the study and understanding of the complex phenomena of cardiac electrophysiology has attained increased importance nowadays. At the same time, the increased complexity of the biophysical processes translates into complex computational and mathematical models. In order to speed up cardiac simulations and to allow more precise and realistic uses, two different techniques have been traditionally exploited: parallel computing and sophisticated numerical methods. In this work, we combine a modern parallel computing technique based on multicore and graphics processing units (GPUs), and a sophisticated numerical method based on a new space-time adaptive algorithm...
June 21, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28636808/diversity-and-abundance-of-human-pathogenic-fungi-associated-with-pigeon-feces-in-urban-environments
#9
Won Dong Lee, Jonathan J Fong, John A Eimes, Young Woon Lim
Pathogenic fungi are a growing health concern worldwide, particularly in large, densely populated cities. The dramatic upsurge of pigeon populations in cities has been implicated in the increased incidence of invasive fungal infections. In the current study, we used a culture-independent, high-throughput sequencing approach to describe the diversity of clinically relevant fungi (CRF) associated with pigeon feces and map the relative abundance of CRF across Seoul, Korea. In addition, we tested whether certain geographical, sociological, and meteorological factors were significantly associated with the diversity and relative abundance of CRF...
June 21, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28636802/2016-impact-factor-for-acta-physiologica-is-4-9
#10
EDITORIAL
P B Persson
How should we best measure journal quality? This never-ending-question remains to be resolved, yet the impact factor receives by far most attention.(1) Suggestions for better metrics (e.g. altmetrics(2) or the Eigenfactor(3) ) soon outnumbers the long list of impact factor flaws This article is protected by copyright. All rights reserved.
June 21, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28636792/mtf-and-dqe-enhancement-using-an-apodized-aperture-x-ray-detector-design
#11
Tomi F Nano, Terenz Escartin, Elina Ismailova, Karim S Karim, Jan Lindstrȍm, Ho Kyung Kim, Ian A Cunningham
PURPOSE: Acquisition of high-quality x-ray images using low patient exposures requires detectors with high detective quantum efficiency (DQE). We describe a novel apodized-aperture pixel (AAP) design that increases high-frequency modulation transfer function (MTF) and DQE values. The AAP design makes a separation of physical sensor elements from image pixels by using very small sensor elements (e.g. 0.010-0.025 mm) to synthesize desired larger image pixels (e.g. 0.1-0.2 mm). METHODS: A cascaded systems model of signal and noise propagation is developed to describe the benefits of the AAP approach in terms of the MTF, Wiener noise power spectrum (NPS) and DQE...
June 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28636786/exacta-the-complement-system-in-kidney-diseases
#12
S Reuter, R Mrowka
The complement system, a plasma component, was described upon its discovery to augment the opsonisation of bacteria by antibodies, 'complementing' said antibodies' antibacterial activity. In its first and foremost role, the complement cascade helps convert pathogen recognition into an effective host defence. Two recent publications in Acta Physiologica have highlighted the role of complement factors in immune cell function, namely monoamine transmitter release from immune cells during immune response and inflammation(1, 2) This article is protected by copyright...
June 21, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28636783/normal-neonatal-hearing-screening-did-not-preclude-sensorineural-hearing-loss-in-two-year-old-very-preterm-infants
#13
Inge L van Noort-van der Spek, André Goedegebure, Nico G Hartwig, René F Kornelisse, Marie-Christine J P Franken, Nynke Weisglas-Kuperus
AIM: Very preterm infants are at risk of neonatal hearing loss. However, it is unknown whether infants with a normal neonatal hearing screening result risk sensorineural hearing loss (SNHL) at a later age. METHODS: This cohort study was conducted at the Erasmus Medical University Center Rotterdam, the Netherlands, on 77 very preterm infants born between October 2005 and September 2008. All infants underwent auditory brainstem response audiometry during neonatal hearing screening and at two years of corrected age...
June 21, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28636779/comparative-study-shows-differences-in-screen-exposure-sleep-patterns-and-sleep-disturbances-between-jewish-and-muslim-children-in-israel
#14
Tzischinsy Orna, Haimov Iris
AIM: This study determined the differences in screen exposure, sleep patterns and sleep disturbances, and the associations between these factors, among Jewish and Muslim children in Israel. METHODS: The participants were 1,049 school children - 499 Jewish and 550 Muslim - with a mean age of 9.20 ±0.71 years, who attended public schools in both urban and residential settings in 2014. They all completed the Sleep Self-Report questionnaire and the Screen Exposure Questionnaire...
June 21, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28636775/role-of-the-tumour-necrosis-factor-like-weak-inducer-of-apoptosis-tweak-fibroblast-growth-factor-inducible-14-fn14-axis-in-autoimmune-thyroid-disease
#15
Shiqiao Peng, Xiaohui Yu, Xuemin Zhao, Xinyi Wang, Xuren Sun, Cheng Han, Zhongyan Shan, Chenyan Li, Weiping Teng
BACKGROUND: TNF-like weak inducer of apoptosis (TWEAK), its receptor fibroblast growth factor-inducible 14 (Fn14) and its scavenger receptor CD163 (sCD163) have known associations with many autoimmune diseases. However, the role of the TWEAK axis in autoimmune thyroid disease (AITD) remains unclear. Therefore, the aim of this study was to investigate the role of the TWEAK-Fn14 axis in the pathogenesis of AITD. METHODS: Serum levels of soluble TWEAK (sTWEAK) and sCD163 were measured in 38 patients with Graves' disease (GD), 40 patients with Hashimoto's thyroiditis (HT), and 40 healthy controls (HCs)...
June 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28636763/sensitive-volume-effects-on-monte-carlo-calculated-ion-chamber-response-in-magnetic-fields
#16
Victor N Malkov, David W O Rogers
PURPOSE: The development of magnetic resonance guided radiation therapy (MR-gRT) necessitates accurate Monte Carlo (MC) models of ion chambers for computing ion chamber corrections to compensate for the presence of the magnetic field. This study evaluates the sensitivity of the ion chamber dose response in a magnetic field on the collection volume used in the MC simulation METHODS: The EGSnrc system's egs_chamber application is used with a recently developed and validated magnetic field transport code...
June 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28636755/technical-note-combination-of-multiple-epid-imager-layers-improves-image-quality-and-tracking-performance-of-low-contrast-to-noise-objects
#17
Stephen Sf Yip, Joerg Rottmann, Haijian Chen, Daniel Morf, Rony Füglistaller, Josh Star-Lack, George Zentai, Ross Berbeco
PURPOSE: We hypothesized that combining multiple amorphous silicon flat panel layers increases photon detection efficiency in an electronic portal imaging device (EPID), improving image quality and tracking accuracy of low contrast targets during radiotherapy METHODS: The prototype imager evaluated in this study contained 4 individually programmable layers each with a copper converter layer, Gd2 O2 S scintillator and active-matrix flat panel imager (AMFPI). The imager was placed on a Varian TrueBeam linac and a Las Vegas phantom programmed with sinusoidal motion (peak-to-peak amplitude=20mm, Period=3...
June 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28636751/using-experimentation-to-understand-the-10-year-snowshoe-hare-cycle-in-the-boreal-forest-of-north-america
#18
C J Krebs, R Boonstra, S Boutin
Population cycles have long fascinated ecologists from the time of Charles Elton in the 1920s. The discovery of large population fluctuations in undisturbed ecosystems challenged the idea that pristine nature was in a state of balance. The 10-year cycle of snowshoe hares (Lepus americanus Erxleben) across the boreal forests of Canada and Alaska is a classic cycle, recognized by fur traders for more than 300 years. Since the 1930s ecologists have investigated the mechanisms that might cause these cycles. Proposed causal mechanisms have varied from sunspots to food supplies, parasites, diseases, predation, and social behaviour...
June 21, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28636616/temnothorax-rugatulus-ant-colonies-consistently-vary-in-nest-structure-across-time-and-context
#19
Nicholas DiRienzo, Anna Dornhaus
A host of animals build architectural constructions. Such constructions frequently vary with environmental and individual/colony conditions, and their architecture directly influences behavior and fitness. The nests of ant colonies drive and enable many of their collective behaviors, and as such are part of their 'extended phenotype'. Since ant colonies have been recently shown to differ in behavior and life history strategy, we ask whether colonies differ in another trait: the architecture of the constructions they create...
2017: PloS One
https://www.readbyqxmd.com/read/28636532/a-novel-pan-nox-inhibitor-apx-115-protects-kidney-injury-in-streptozotocin-induced-diabetic-mice-possible-role-of-peroxisomal-and-mitochondrial-biogenesis
#20
Guideock Kwon, Md Jamal Uddin, Gayoung Lee, Songling Jiang, Ahreum Cho, Jung Hwa Lee, Sae Rom Lee, Yun Soo Bae, Sung Hwan Moon, Soo Jin Lee, Dae Ryong Cha, Hunjoo Ha
NADPH oxidase (Nox)-derived reactive oxygen species (ROS) are increasingly recognized as a key factor in inflammation and extracellular matrix accumulation in diabetic kidney disease. APX-115 (3-phenyl-1-(pyridin-2-yl)-4-propyl-1-5-hydroxypyrazol HCl) is a novel orally active pan-Nox inhibitor. The objective of this study was to compare the protective effect of APX-115 with a renin-angiotensin system inhibitor (losartan), the standard treatment against kidney injury in diabetic patients, on streptozotocin (STZ)-induced diabetic kidney injury...
June 16, 2017: Oncotarget
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