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JOURNAL ARTICLE
Xinyue Ming, Shirui Chen, Huijuan Li, Yun Wang, Le Zhou, Yuncheng Lv
This review presents a summary of recent progress in research on the N6-methyladenosine (m6A) modification and regulatory roles in hepatic lipid metabolism. As the most abundant internal modification of eukaryotic RNA, the m6A modification is a dynamic and reversible process of the m6A enzyme system, which includes writers, erasers, and readers. m6A methylation depressed lipid synthesis and facilitated lipolysis in liver. The depletion of m6A methyltransferase Mettl14/Mettl3 raised fatty acid synthase (FAS), stearoyl-CoA desaturase-1 (SCD1), acetyl-CoA carboxylase (ACC), and elongase of very long chain fatty acids 6 (ELOVL6) in rodent liver, causing increases in liver weight, triglyceride (TG) production, and content in hepatocytes...
April 18, 2024: DNA and Cell Biology
#2
JOURNAL ARTICLE
Akram Yazdani, Seyyed Ali Mozaffarpur, Pouyan Ebrahimi, Hoda Shirafkan, Hamed Mehdinejad
BACKGROUND: One of the common concerns of healthcare systems is the potential for re-admission of COVID-19 patients. In addition to adding costs to the healthcare system, re-admissions also endanger patient safety. Recognizing the factors that influence re-admission, can help provide appropriate and optimal health care. The aim of this study was to assess comorbidities that affect re-admission and survival in COVID-19 patients using a joint frailty model. METHODS: This historical cohort study was done using data of patients with COVID-19 who were re-hospitalized more than twice in a referral hospital in North of Iran...
2024: PloS One
#3
JOURNAL ARTICLE
Inmyung Song
Inadequate health literacy is a risk factor for poor health outcomes and health-related quality of life (HRQoL). So far, the impact of health literacy on HRQoL has been examined for only a few chronic conditions. In this contribution, the relationship between health literacy and HRQoL in Korean adults with chronic conditions is examined using data of the cross-sectional Korea Health Panel Survey from 2021. Health literacy was measured with the 16-item European Health Literacy Survey Questionnaire (HLS-EU-Q16) and HRQoL with the European Quality of Life-5 Dimensions (EQ-5D)...
2024: PloS One
#4
JOURNAL ARTICLE
Oscar Andrés Cruz Martínez, Ingrid García, Gloria Mercedes Puerto, Nelson J Alvis-Zakzuk, Martha Patricia López, Juan Carlos Moreno Cubides, Ángela María Sánchez Salazar, Julián Trujillo Trujillo, Claudia Marcela Castro-Osorio, Vivian Vanessa Rubio, Carlos Castañeda-Orjuela, Ernesto Montoro, Peter Nguhiu, Inés García Baena
OBJECTIVE: To estimate the baseline to measure one of the three indicators of the World Health Organization (WHO) End TB strategy (2015-2035), measure the costs incurred by patients affected by tuberculosis (TB) during a treatment episode and estimate the proportion of households facing catastrophic costs (CC) and associated risk factors, in Colombia, 2021. MATERIAL AND METHODS: A nationally representative cross-sectional survey was conducted among participants on TB treatment in Colombia, using telephone interviews due to the exceptional context of the COVID-19 pandemic...
2024: PloS One
#5
REVIEW
Jean-Laurent Casanova, John D MacMicking, Carl F Nathan
Infectious diseases continue to claim many lives. Prevention of morbidity and mortality from these diseases would benefit not just from new medicines and vaccines but also from a better understanding of what constitutes protective immunity. Among the major immune signals that mobilize host defense against infection is interferon- γ (IFN- γ ), a protein secreted by lymphocytes. Forty years ago, IFN- γ was identified as a macrophage-activating factor, and, in recent years, there has been a resurgent interest in IFN- γ biology and its role in human defense...
April 19, 2024: Science
#6
JOURNAL ARTICLE
Zurui Ao, Xiaomei Hu, Shengli Tao, Xie Hu, Guoquan Wang, Mingjia Li, Fang Wang, Litang Hu, Xiuyu Liang, Jingfeng Xiao, Asadilla Yusup, Wenhua Qi, Qinwei Ran, Jiayi Fang, Jinfeng Chang, Zhenzhong Zeng, Yongshuo Fu, Baolin Xue, Ping Wang, Kefei Zhao, Le Li, Wenkai Li, Yumei Li, Mi Jiang, Yuanhe Yang, Haihua Shen, Xia Zhao, Yue Shi, Bo Wu, Zhengbing Yan, Mengjia Wang, Yanjun Su, Tianyu Hu, Qin Ma, Hao Bai, Lijun Wang, Ziyan Yang, Yuhao Feng, Danhua Zhang, Erhan Huang, Jiamin Pan, Huiying Ye, Chen Yang, Yanwei Qin, Chenqi He, Yanpei Guo, Kai Cheng, Yu Ren, Haitao Yang, Chengyang Zheng, Jiangling Zhu, Shaopeng Wang, Chengjun Ji, Biao Zhu, Hongyan Liu, Zhiyao Tang, Zhiheng Wang, Shuqing Zhao, Yanhong Tang, Hanfa Xing, Qinghua Guo, Yu Liu, Jingyun Fang
China's massive wave of urbanization may be threatened by land subsidence. Using a spaceborne synthetic aperture radar interferometry technique, we provided a systematic assessment of land subsidence in all of China's major cities from 2015 to 2022. Of the examined urban lands, 45% are subsiding faster than 3 millimeters per year, and 16% are subsiding faster than 10 millimeters per year, affecting 29 and 7% of the urban population, respectively. The subsidence appears to be associated with a range of factors such as groundwater withdrawal and the weight of buildings...
April 19, 2024: Science
#7
JOURNAL ARTICLE
S Marjolein van Cappellen, Hanneke E Creemers, Larissa Hoogsteder, Joan van Horn, Jessica J Asscher
BACKGROUND: Juvenile antisocial behavior can have long-lasting and devastating effects for juveniles themselves, victims, and society. Evidence-based treatment is vital. Forensic Outpatient Systemic Therapy (Forensische Ambulante Systeem Therapie; FAST) is a promising treatment for juveniles showing severe antisocial behavior including aggression, (domestic) violence, and delinquent behavior. FAST has a flexible intensity and length, addresses individual and systemic risk and protective factors, and is responsive to the abilities of the client (system), intervention characteristics all considered crucial for effective treatment...
2024: PloS One
#8
JOURNAL ARTICLE
Dan Xie, Meng Wang, Weiya Zhang
The Great Wall Villages (GWVs) are linked to the Great Wall in history, culture, and ecology. The cultural landscape resilience of Great Wall Villages (CLRGWVs) is distinctly significant. However, it is influenced by urbanization, pollution, and a lack of awareness of cultural landscape protection. Therefore, conservation and development practices still lack scientific strategies and guidance. This study proposes a new assessment system to quantify CLRGWVs, an analysis of the main influencing factors of resilience, and optimization paths to maintain sustainable development...
2024: PloS One
#9
JOURNAL ARTICLE
Na Li, Shanxiu Jin, Jingran Wu, Hongjuan Ji, Cheng Du, Bona Liu
BACKGROUND: To examine the trends in morbidity and mortality among ovarian cancer patients with liver metastases, and investigate the impact of different treatments on both overall survival (OS) and cancer-specific survival (CSS). METHODS: 2,925 ovarian cancer patients with liver metastases from Surveillance, Epidemiology, and End Results 2010-2019 were included. The primary endpoint was considered as OS and CSS. We conducted trend analysis of the incidence, OS and CSS rates of liver metastases in ovarian cancer...
2024: PloS One
#10
JOURNAL ARTICLE
Nalda Debsikréo, Birwé Léon Mankréo, Azoukalné Moukénet, Merwa Ouangkake, Nathan Mara, Ali Mahamat Moussa, Ndèye Coumba Toure-Kane, Françoise Lunel-Fabiani
INTRODUCTION: Infection by hepatitis B virus (HBV) is a major issue in public health. The prevalence of HBV in Chad is 12.4%, all age groups considered. Here, we aimed to determine the prevalence of HBV and its associated factors among university students in N'Djamena, the country's capital. METHODS: A cross-sectional survey of students at either the University of N'djamena or Emi Koussi University was conducted from 3 to 23 July 2021. All participating students provided signed, informed consent and were included in the study consecutively...
2024: PloS One
#11
JOURNAL ARTICLE
Kayleigh Dewhurst, Karin Spenser, Dean Fido
Public perception of regulated sexual behavior is a crucial factor in considering policy, particularly when UK sexual consent laws could criminalize the many young people who are increasingly engaging in underage sex. In contrast, other countries have progressively implemented consent age-spans to respect sexual autonomy while simultaneously protecting young people from sexual exploitation. This study investigated UK perceptions of consensual underage sex between similar-aged adolescents, with predominant focus on age-spans, as an adaptive alternative to dropping consent age...
April 18, 2024: Journal of Sex Research
#12
JOURNAL ARTICLE
Bruno Oliveira de Veras, Rianne Ferreira Felix, Geovanna Maria de Medeiros Moura, Daniela Maria do Amaral Ferraz Navarro, Júlio César Ribeiro de Oliveira Farias de Aguiar, Almir Gonçalves Wanderley, Márcia Vanusa da Silva, Maria Tereza Dos Santos Correia
This work aimed to investigate the chemical composition, antioxidant capacity, antibacterial activity, and intestinal and gastric protective effects, in addition to the acute toxicity of the essential oil of E. stictopetala (EOEs). ( E )-caryophyllene (18.01%), β-pinene (8.84%), and ( E )-nerolidol (8.24%), were the components found in higher content in the essential oil. The EOEs showed antioxidant capacity with IC50 values ranging from 220.28 to 283.67 μg/mL, in addition to presenting antibacterial activity against Escherichia coli , Enterobacter aerogenes , Vibrio cholerae , Salmonella enterica, and Listeria monocytogenes ...
April 18, 2024: Natural Product Research
#13
JOURNAL ARTICLE
Dana Lassri, Ateret Gewirtz-Meydan
BACKGROUND: Childhood sexual abuse (CSA) is a significant risk factor with consistently demonstrated negative implications for satisfaction with adult romantic relationships. Yet, research on risk and protective factors in this context is scarce, particularly among well-functioning adults. OBJECTIVE: Addressing this gap, the present study focused on the potential mediating and moderating roles of mentalizing or reflective functioning, i.e., the capacity to understand oneself and others in terms of intentional mental states...
April 18, 2024: Psychological Trauma: Theory, Research, Practice and Policy
#14
JOURNAL ARTICLE
Sibel Nayman, Isabelle Florence Schricker, Iris Reinhard, Janina Kim Dreer, Annika Sophie Richter, Christine Kuehner
Premenstrual dysphoric disorder (PMDD) is characterized by a cyclical symptom course. Previous research provides limited findings on possible menstrual-cycle-related psychological and psychoendocrinological processes in PMDD. By using ambulatory assessment (AA), we aimed to compare mood and cortisol cyclicity in individuals with PMDD and healthy controls (HC), and to assess effects of habitual and momentary repetitive negative thinking (RNT) and present moment awareness (PMA) on mood and cortisol across the cycle in both groups...
April 18, 2024: J Psychopathol Clin Sci
#15
JOURNAL ARTICLE
Hongjuan Fu, Jianbo He, Cong Li, Chang Hui
Theaflavin-3,3'-digallate (TFDG) in black tea has a strong antioxidant capacity. However, its effect on diabetic liver and kidney injury and the underlying mechanisms remain unclear. In the present study, our findings indicated that TFDG administration effectively lowers the fasting blood glucose and serum lipid concentrations and enhances the functionality and cellular architecture of the liver and kidney in rats with diabetes. The data also showed that TFDG mitigates oxidative harm in the liver and kidney of rats afflicted with diabetes...
April 18, 2024: Journal of Agricultural and Food Chemistry
#16
JOURNAL ARTICLE
Annie Chen, Wei-Min Chu, Norman Peng
Online consultation services have the potential to reduce the workload of healthcare staff, provide timely care to patients, and improve doctor-patient relationships. The COVID-19 pandemic has accelerated the development of these services and platforms, but it remains to be seen whether the general public will continue to use them after the pandemic is under control. This research proposes a framework to examine the factors contributing to UK adults' continued usage of online healthcare consultation services after COVID-19 restrictions have been lifted...
April 18, 2024: Health Marketing Quarterly
#17
JOURNAL ARTICLE
S S Dunaevskaya, E Yu Sergeeva, N M Titova, Yu A Fefelova, V V Deulina
We present modern data on the role of superoxide dismutase (SOD) in antioxidant protection and gene regulation in acute pancreatitis. Antioxidant enzymes are essential in pathogenesis of numerous diseases. SOD is one of the key enzymes of antioxidant system. In this review, we analyzed activity of this enzyme depending on various factors, mechanisms and role in physiological and pathological processes, in particular, acute pancreatitis. SOD is significantly less active in patients with severe acute pancreatitis accompanied by renal failure, severe circulatory disorders and high mortality...
2024: Khirurgiia
#18
JOURNAL ARTICLE
Niccolo' Tesi, Sven van der Lee, Marc Hulsman, Natasja M van Schoor, Martijn Huisman, Yolande Pijnenburg, Wiesje M van der Flier, Marcel Reinders, Henne Holstege
BACKGROUND: Alzheimer's disease (AD) prevalence increases with age, yet a small fraction of the population reaches ages > 100 years without cognitive decline. We studied the genetic factors associated with such resilience against AD. METHODS: Genome-wide association studies identified 86 single nucleotide polymorphisms (SNPs) associated with AD risk. We estimated SNP frequency in 2281 AD cases, 3165 age-matched controls, and 346 cognitively healthy centenarians...
April 18, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#19
JOURNAL ARTICLE
Olivia Creutz, Tijs Bolz, Menno Baumann
Child-to-Parent Violence -The Blind Spot in Research on Family Violence? A Systematic Review Child-to-parent violence (CPV) is a phenomenon that has received little attention in the German scientific community. With this paper, the authors present the international state of research in the context of a systematic review. By means of a search a dataset of 317 scientific publications for the period 2012-2022 was identified at August 2022. After applying the inclusion and exclusion criteria, 14 studies were finally defined and analyzed in detail...
March 2024: Praxis der Kinderpsychologie und Kinderpsychiatrie
#20
JOURNAL ARTICLE
Ahmad Y Alqassim
Vector-borne diseases exert immense health burdens worldwide. Malaria alone causes over 200 million cases and 600,000 deaths annually. Transmission involves complex drivers requiring examination beyond entomological factors. A systematic literature search across databases identified relevant studies on vector-borne disease determinants published in the last two decades, with priority given to rigorous designs like longitudinal analyses, reviews, and meta-analyses from diverse epidemic regions, allowing narrative synthesis of key determinants, relationships, and gaps...
April 18, 2024: Journal of Vector Borne Diseases
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