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https://www.readbyqxmd.com/read/28239621/assay-to-evaluate-bal-fluid-regulation-of-fibroblast-%C3%AE-sma-expression
#1
Jennifer L Larson-Casey, A Brent Carter
: Because transforming growth factor-β (TGF-β1) induces differentiation of fibroblasts to myofibroblasts, we developed a protocol to evaluate alveolar macrophage-derived TGF-β1 regulation of lung fibroblast differentiation (Larson-Casey et al., 2016). The protocol allows evaluating the ability of mouse bronchoalveolar lavage (BAL) fluid to alter fibroblast differentiation. Fibroblast differentiation was measured by the expression of α-smooth muscle actin (α-SMA). BACKGROUND: Alveolar macrophages play an integral role in pulmonary fibrosis development by increasing the expression of TGF-β1 (He et al...
November 20, 2016: Bio-protocol
https://www.readbyqxmd.com/read/28239445/maintenance-of-genome-stability-by-fanconi-anemia-proteins
#2
REVIEW
Anna Palovcak, Wenjun Liu, Fenghua Yuan, Yanbin Zhang
Persistent dysregulation of the DNA damage response and repair in cells causes genomic instability. The resulting genetic changes permit alterations in growth and proliferation observed in virtually all cancers. However, an unstable genome can serve as a double-edged sword by providing survival advantages in the ability to evade checkpoint signaling, but also creating vulnerabilities through dependency on alternative genomic maintenance factors. The Fanconi anemia pathway comprises an intricate network of DNA damage signaling and repair that are critical for protection against genomic instability...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28239378/enterococcus-durans-ep1-a-promising-anti-inflammatory-probiotic-able-to-stimulate-siga-and-to-increase-faecalibacterium-prausnitzii-abundance
#3
Paula Carasi, Silvia María Racedo, Claudine Jacquot, Anne Marie Elie, María de Los Ángeles Serradell, María C Urdaci
Enterococcus species, principally Enterococcus faecium are used as probiotics since a long time with preference in animal applications but safety considerations were updated and also new uses as probiotics can be envisaged. Fifteen Enterococcus strains isolated from different foods were identified and analyzed for virulence factors and antibiotic resistance. Three Enterococcus durans strains were selected to study their immunomodulatory properties on PBMC and Caco2 cells. Two strains presented a profile toward a mild inflammatory Th1 response considering TNF-α/IL-10 and IL-1β/IL-10 cytokines ratios...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28239178/prevalence-and-characteristics-of-exercise-induced-bronchoconstriction-in-high-school-and-college-athletes-at-2-240-m-altitude
#4
Martín Becerril-Ángeles, Mario H Vargas, Leonardo Hernández-Pérez, Nancy Judith Rivera-Istepan, Rebeca Ivonne Pérez-Hidalgo, Ana Gabriela Ortega-González, Severino Rubio-Domínguez, María Cristina Rodríguez-Gutiérrez, Radamés Gaxiola-Cortés, Rodrigo Dosal-Ulloa, Laura Graciela Gochicoa-Rangel
BACKGROUND: Athletes practicing strenuous physical activities may develop exercise-induced bronchoconstriction (EIB). We aimed to determine the prevalence and features of this condition in Mexico City (altitude, 2,240 m). METHODS: In the present study, 208 high school and college athletes performed a standardized EIB test on a treadmill. RESULTS: Responses to exercise had large between-subject variability in all physiological parameters (forced expiratory volume in one second [FEV1], heart rate, blood oxygen saturation level [SpO2], blood pressure), with nearly similar proportions of subjects in whom FEV1 increased or decreased...
January 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28239176/the-role-of-nramp1-slc11a1-gene-variant-d543n-1730g-a-in-the-genetic-susceptibility-to-develop-rheumatoid-arthritis-in-the-mexican-mestizo-population
#5
Perla Niño-Moreno, Edgar Turrubiartes-Martínez, Brenda Oceguera-Maldonado, Nubia Baltazar-Benítez, Cindy Negrete-González, Brenda Oliva-Ramírez, Lourdes Baranda, Roberto González-Amaro
BACKGROUND: Rheumatoid arthritis is a chronic inflammatory disease whose cause has not been fully elucidated. However, genetic factors seem to have an important role in its pathogenesis. OBJECTIVE: We analyzed the possible association between rheumatoid arthritis and variants of the SLC11A1 gene, which encodes for NRAMP1, a protein involved in the activation of phagocytes and synthesis of proinflammatory cytokines. METHODS: In a case-control study in a Mexican Mestizo population, blood samples from 188 patients with rheumatoid arthritis and 133 healthy individuals were obtained to determine the frequency of SLC11A1 gene variants INT4 (469+14G/C or rs3731865), D543N (1730G/A or rs17235409) and 3'UTR (1729+55del4 or rs17235416) by polymerase chain reaction and restriction fragment length polymorphism...
January 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28239025/the-role-of-single-nucleotide-variants-of-the-energy-metabolism-linked-genes-sirt3-ppargc1a-and-apoe-in-amyotrophic-lateral-sclerosis-risk
#6
Diego Albani, Elisabetta Pupillo, Elisa Bianchi, Armando Chierchia, Rosalba Martines, Gianluigi Forloni, Ettore Beghi
Amyotrophic lateral sclerosis (ALS) is a multifactorial disease, possibly with contributions from genetics and lifestyle. We examined variants in genes relevant to energy metabolism and physical activity in a case-control association study, with the aim of assessing genetics and physical activity as contributors to ALS risk. A well-characterized sample of Italian ALS patients (101) and controls (101) from the EURALS Consortium underwent a questionnaire interview on demographic, physical and other lifestyle habits, and venipuncture for DNA extraction...
February 24, 2017: Genes & Genetic Systems
https://www.readbyqxmd.com/read/28238951/oral-administration-of-the-nitroxide-radical-tempol-exhibits-immunomodulatory-and-therapeutic-properties-in-multiple-sclerosis-models
#7
Sarah Neil, Jaebong Huh, Victoria Baronas, Xinhui Li, Henry F McFarland, Murali Cherukuri, James B Mitchell, Jacqueline A Quandt
Therapies with both immunomodulatory and neuroprotective properties are thought to have the greatest promise in reducing the severity and progression of multiple sclerosis (MS). Several reactive oxygen (ROS) and reactive nitrogen species (RNS) are implicated in inflammatory-mediated damage to the central nervous system (CNS) in MS and its animal model, experimental autoimmune encephalomyelitis (EAE). TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) is a stable nitroxide radical with potent antioxidant activity...
February 23, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28238930/the-acute-exposure-of-tetrachloro-p-benzoquinone-a-k-a-chloranil-triggers-inflammation-and-neurological-dysfunction-via-toll-like-receptor-4-signaling-the-protective-role-of-melatonin-preconditioning
#8
Juanli Fu, Xiaomin Xia, Zixuan Liu, Yawen Wang, Yuxin Wang, Qiong Shi, Xiufang Song, Erqun Song, Yang Song
This study is aimed to investigate the inflammation and neurological dysfunction induced by tetrachloro-p-benzoquinone (TCBQ) through Toll-like receptor 4 (TLR4) signaling. We also investigated the protective role of melatonin as an antioxidant and anti-inflammatory agent. In vitro model was established by rat pheochromocytoma PC12 cells, meanwhile, TLR4 wild-type (C57BL/6) and knockout mice (C57BL/10ScNJ TLR4(-/-)) were used as in vivo model. In vitro study showed TCBQ exposure enhanced the expression of TLR4, myeloid differentiation factor 88 (MyD88) at both transcriptional and post-transcriptional levels...
February 23, 2017: Toxicology
https://www.readbyqxmd.com/read/28238791/selol-an-organic-selenium-donor-prevents-lipopolysaccharide-induced-oxidative-stress-and-inflammatory-reaction-in-the-rat-brain
#9
Agnieszka Dominiak, Anna Wilkaniec, Henryk Jęśko, Grzegorz A Czapski, Anna M Lenkiewicz, Eliza Kurek, Piotr Wroczyński, Agata Adamczyk
Neuroinflammation and oxidative stress are key intertwined pathological factors in many neurological, particularly neurodegenerative diseases, such as Alzheimer's and Parkinson's disorders as well as autism. The present study was conducted to evaluate the protective effects of Selol, an organic selenium donor, against lipopolysaccharide (LPS)-mediated inflammation in rat brain. The results demonstrated that the peripheral administration of LPS in a dose of 100 μg/kg b.w. evoked typical pathological reaction known as systemic inflammatory response...
February 23, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28238747/role-of-c-ebp-homologous-protein-chop-and-endoplasmic-reticulum-in-asthma-exacerbation-by-regulating-the-il-4-stat6-tfec-il-4r%C3%AE-positive-feedback-loop-in-m2-macrophages
#10
Yi Wang, Jianghui Zhu, Lei Zhang, Zhijun Zhang, Long He, Yong Mou, Yanhan Deng, Yong Cao, Ping Yang, Yunchao Su, Jianping Zhao, Shu Zhang, Qilin Yu, Jifa Hu, Zhishui Chen, Qin Ning, Xudong Xiang, Yongjian Xu, Cong-Yi Wang, Weining Xiong
BACKGROUND: C/EBP homologous protein (CHOP), a marker of endoplasmic reticulum (ER) stress, exhibits aberrant expression patterns during the development of asthma. However, its exact role in asthma pathogenesis is not fully understood. OBJECTIVES: We aimed to determine the function and mechanism of CHOP in the pathogenesis of allergic asthma in patients and animals. METHODS: Studies were conducted in asthmatic patients and CHOP(-/-) mice to dissect the role of CHOP and ER stress in asthma pathogenesis...
February 23, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28238722/hormetic-modulation-of-hepatic-insulin-sensitivity-by-advanced-glycation-end-products
#11
Nelly T Fabre, Karina Thieme, Karolline S Silva, Sérgio Catanozi, Ana Mercedes Cavaleiro, Danilo A C Pinto, Maristela M Okamoto, Mychel Raony P T Morais, Bárbara Falquetto, Telma M Zorn, Ubiratan F Machado, Marisa Passarelli, Maria Lúcia Correa-Giannella
Because of the paucity of information regarding metabolic effects of advanced glycation end products (AGEs) on liver, we evaluated effects of AGEs chronic administration in (1) insulin sensitivity; (2) hepatic expression of genes involved in AGEs, glucose and fat metabolism, oxidative stress and inflammation and; (3) hepatic morphology and glycogen content. Rats received intraperitoneally albumin modified (AlbAGE) or not by advanced glycation for 12 weeks. AlbAGE induced whole-body insulin resistance concomitantly with increased hepatic insulin sensitivity, evidenced by activation of AKT, inactivation of GSK3, increased hepatic glycogen content, and decreased expression of gluconeogenesis genes...
February 23, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28238669/ellagic-acid-exerts-protective-effect-in-intrastriatal-6-hydroxydopamine-rat-model-of-parkinson-s-disease-possible-involvement-of-er%C3%AE-nrf2-ho-1-signaling
#12
Tourandokht Baluchnejadmojarad, Nafiseh Rabiee, Sedigheh Zabihnejad, Mehrdad Roghani
Parkinson's disease (PD) is a prevalent movement disorder in the elderly with progressive loss of mesencephalic dopaminergic neurons and incapacitating motor and non-motor complications. Ellagic acid is a natural phenolic compound with potent antioxidant and anti-inflammatory properties. In this study, we investigated its possible neuroprotective effect in 6-hydroxydopamine (6-OHDA) rat model of PD. Intrastriatal 6-OHDA-lesioned rats were pretreated with ellagic acid at a dose of 50 mg/kg/day for 1 week. Results showed that ellagic acid attenuates apomorphine-induced rotational bias and lowers the latency to initiate and the total time in the narrow beam task and this beneficial effect was partially abrogated following intracerebroventricular microinjection of estrogen receptor β (ERβ) antagonist...
February 23, 2017: Brain Research
https://www.readbyqxmd.com/read/28238452/comparison-of-ultraviolet-a-light-protection-standards-in-the-united-states-and-european-union-through-in%C3%A2-vitro-measurements-of-commercially-available-sunscreens
#13
Steven Q Wang, Haoming Xu, Joseph W Stanfield, Uli Osterwalder, Bernd Herzog
BACKGROUND: The importance of adequate ultraviolet A light (UVA) protection has become apparent in recent years. The United States and Europe have different standards for assessing UVA protection in sunscreen products. OBJECTIVE: We sought to measure the in vitro critical wavelength (CW) and UVA protection factor (PF) of commercially available US sunscreen products and see if they meet standards set by the United States and the European Union. METHODS: Twenty sunscreen products with sun protection factors ranging from 15 to 100+ were analyzed...
February 23, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28238276/the-predictive-value-of-an-adjusted-copd-assessment-test-score-on-the-risk-of-respiratory-related-hospitalizations-in-severe-copd-patients
#14
Joanne M Sloots, Christopher A Barton, Julie Buckman, Katherine L Bassett, Job van der Palen, Peter A Frith, Tanja W Effing
We evaluated whether a chronic obstructive pulmonary disease (COPD) assessment test (CAT) with adjusted weights for the CAT items could better predict future respiratory-related hospitalizations than the original CAT. Two focus groups (respiratory nurses and physicians) generated two adjusted CAT algorithms. Two multivariate logistic regression models for infrequent (≤1/year) versus frequent (>1/year) future respiratory-related hospitalizations were defined: one with the adjusted CAT score that correlated best with future hospitalizations and one with the original CAT score...
February 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28238046/toxicity-of-chromium-vi-to-two-mussels-and-an-amphipod-in-water-only-exposures-with-or-without-a-co-stressor-of-elevated-temperature-zinc-or-nitrate
#15
Ning Wang, James L Kunz, Christopher D Ivey, Christopher G Ingersoll, M Christopher Barnhart, Elizabeth A Glidewell
The objectives of the present study were to develop methods for propagating western pearlshell (Margaritifera falcata) for laboratory toxicity testing and evaluate acute and chronic toxicity of chromium VI [Cr(VI)] to the pearlshell and a commonly tested mussel (fatmucket, Lampsilis siliquoidea at 20 °C or in association with a co-stressor of elevated temperature (27 °C), zinc (50 µg Zn/L), or nitrate (35 mg NO3/L). A commonly tested invertebrate (amphipod, Hyalella azteca) also was tested in chronic exposures...
February 25, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28237999/the-poly-%C3%AE-d-glutamic-acid-capsule-surrogate-of-bacillus-anthracis-capsule-induces-interferon-gamma-production-in-nk-cells-through-interactions-with-macrophages
#16
Hae-Ri Lee, Jun Ho Jeon, Gi-Eun Rhie
The poly-γ-D-glutamic acid (PGA) capsule, a major virulence factor of Bacillus anthracis, provides protection of the Bacillus from phagocytosis and allows its unimpeded growth in the host. We investigated crosstalk between murine NK cells and macrophages stimulated with PGA capsule of Bacillus licheniformis, a surrogate of B. anthracis capsule. PGA induced interferon-gamma (IFN-γ) production from NK cells cultured with macrophages. This effect was dependent on macrophage-derived IL-12 and cell-cell contact interaction with macrophages through NK cell receptor NKG2D and its ligand RAE-1...
February 24, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28237874/interleukin-37-suppresses-the-inflammatory-response-to-protect-cardiac-function-in-old-endotoxemic-mice
#17
Jilin Li, Yufeng Zhai, Lihua Ao, Haipeng Hui, David A Fullerton, Charles A Dinarello, Xianzhong Meng
Myocardial inflammatory responses to endotoxemia are enhanced in old mice, which results in worse cardiac dysfunction. Anti-inflammatory cytokine interleukin (IL)-37 has a broad effect on innate immunoresponses. We hypothesized that IL-37 suppresses myocardial inflammatory responses to protect cardiac function during endotoxemia in old mice. Old (20-24month) wild-type (WT), and IL-37 transgenic (IL-37tg) mice were treated with lipopolysaccharide (LPS, 0.5mg/kg, iv) or normal saline (0.1ml/mouse, iv). Six hours later, left ventricle (LV) function was assessed using a pressure-volume microcatheter...
February 23, 2017: Cytokine
https://www.readbyqxmd.com/read/28237772/factors-related-to-shunt-survival-in-paediatric-hydrocephalus-could-failure-be-avoided
#18
Sara Iglesias, Bienvenido Ros, Álvaro Martín, Antonio Carrasco, Miguel Segura, Angela Ros, Francisca Rius, Miguel Ángel Arráez
BACKGROUND: Improved shunt survival and a better understanding of factors related to failure in paediatric hydrocephalus still pose a challenge for neurosurgeons, in order to avoid morbidity and mortality, as well as the economic impact of repeated revision surgeries. For these reasons, an analysis is performed on the factors related to the first shunt failure in the long-term follow-up of a series in a single centre. METHODS: A retrospective review was conducted on 166 hydrocephalic paediatric patients shunted for the first time between 2000 and 2014...
February 22, 2017: Neurocirugía
https://www.readbyqxmd.com/read/28237391/retraction-notice-to-s-allyl-cysteine-protects-against-6-hydroxydopamine-induced-neurotoxicity-in-the-rat-striatum-involvement-of-nrf2-transcription-factor-activation-and-modulation-of-signaling-kinase-cascades-frb-53-5-2012-1024-1040
#19
Julio César Tobón-Velasco, Genaro Vázquez-Victorio, Marina Macías-Silva, Elvis Cuevas, Syed F Ali, Perla D Maldonado, María Eva González-Trujano, Antonio Cuadrado, José Pedraza-Chaverrí, Abel Santamaría
No abstract text is available yet for this article.
March 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28237325/the-effect-of-lysophosphatidic-acid-together-with-interferon-tau-on-the-global-transcriptomic-profile-in-bovine-endometrial-cells
#20
Dorota Boruszewska, Ilona Kowalczyk-Zieba, Emilia Sinderewicz, Katarzyna Grycmacher, Joanna Staszkiewicz, Izabela Woclawek-Potocka
In cows, lysophosphatidic acid (LPA), which acts in an auto/paracrine manner, serves as a luteotropic factor during early pregnancy by stimulating progesterone and prostaglandin E2 secretion, thus protecting the bovine corpus luteum and early embryo development. Our hypothesis was that LPA exerted some local effects on the bovine endometrium prior to early embryo-maternal interactions and that interferon tau (IFNτ), the pregnancy recognition signal, modulated this action. In the present study, we applied an in vitro model involving whole-transcriptomic profiling to examine the effects of LPA on gene expression in bovine endometrial cells...
April 1, 2017: Theriogenology
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