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https://www.readbyqxmd.com/read/29240298/diabetic-macular-edema-innovative-technologies-and-economic-impact-new-opportunities-for-the-lombardy-region-healthcare-system
#1
Emanuela Foglia, Lucrezia Ferrario, Francesco Bandello, Camilla Ferri, Innocente Figini, Michela Franzin, Gianpiera Gambaro, Ugo Introini, Massimo Medaglia, Giovanni Staurenghi, Patrizia Tadini, Andrea Fomiatti, Davide Croce
PURPOSE: Diabetic macular edema (DME) is a leading cause of vision loss and blindness. The aim of this study was to evaluate the economic benefits of introducing additional alternative technologies (Dexamethasone intravitreal implant - DEX - and Aflibercept injections), compared with the historical scenario of Ranibizumab intravitreal injections. METHODS: A 3-year budget impact model was developed, taking into consideration the perspective of the Lombardy Region Healthcare Service (LRHS)...
December 14, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29239906/nerve-growth-factor-changes-and-corneal-nerve-repair-after-keratoplasty
#2
Yueji Pan, Fang Liu, Xiaofeng Qi, Yuan Hu, Feihong Xu, Hui Jia
SIGNIFICANCE: Measured tear concentration of nerve growth factor is correlated with postoperative corneal reinnervation among patients who undergo keratoplasty. This may be a future therapeutic target for post-keratoplasty corneal nerve regeneration. PURPOSE: To determine the relationship between changes in the content of nerve growth factor (NGF) in tear fluid and corneal subepithelial nerve regeneration in patients after keratoplasty. METHODS: In this retrospective study, 30 eyes of 28 patients (15 males, 13 females; mean age 42...
December 13, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29239680/the-spots-system-an-ocular-scoring-system-optimized-for-use-in-modern-preclinical-drug-development-and-toxicology
#3
Joshua Seth Eaton, Paul E Miller, Ellison Bentley, Sara M Thomasy, Christopher J Murphy
PURPOSE: To present a semiquantitative ocular scoring system comprising elements and criteria that address many of the limitations associated with systems commonly used in preclinical studies, providing enhanced cross-species applicability and predictive value in modern ocular drug and device development. METHODS: Revisions to the ocular scoring systems of McDonald-Shadduck and Hackett-McDonald were conducted by board-certified veterinary ophthalmologists at Ocular Services On Demand (OSOD) over the execution of hundreds of in vivo preclinical ocular drug and device development studies and general toxicological investigations...
December 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29238687/status-of-otorhinolaryngology-as-specialty-of-choice-among-female-medical-graduates
#4
Sunil Garg, Rubeena Arora, Sunil Kumar, Gautam Bir Singh
Specialty choices among medical graduates have undergone changes over time. We aimed to analyze status of otorhinolaryngology as specialty of choice among female medical graduates and factors affecting it. A total of 123 female medical graduates were surveyed during their internship over a period of 1 year in a tertiary-care hospital. Each intern was assessed using a questionnaire at the end of otorhinolaryngology rotation. The survey included nine questions about future career choices with special focus on ENT as a choice for specialization...
December 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29238020/-prolonged-optic-disc-swelling-in-kawasaki-disease-a-case-report-and-literature-review
#5
Yusuke Tsumura, Hiroshi Masuda, Sachiko Nishina, Tohru Kobayashi, Hiroshi Ono, Hitoshi Kato, Jun Abe, Akira Ishiguro
  Kawasaki disease (KD), an acute childhood panvasculitis, presents a variety of ocular complications as well as conjunctival injection among the principal symptoms. However, most pediatricians are unfamiliar with the ophthalmological complications of KD. A 2-year-old girl was referred to us from the ophthalmology department due to injected bulbar conjunctivae and optic disc swelling. She had familial exudative vitreoretinopathy as an underlying disease and the ocular findings had been made by chance while the patient was receiving an eye examination...
2017: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29237924/glaucoma-in-patients-with-eyes-close-to-areas-affected-by-port-wine-stain-has-lateral-and-gender-predilection
#6
Yue Wu, Ru-Jing Yu, Di Chen, Li Xu, Mao Li, Li Zhu, Chun-Yu Guo, Wen-Yi Guo
BACKGROUND: The location of facial port-wine stain (PWS) may be helpful for predicting some associated anomalies; high glaucoma incidence is found in patients with eyes close to PWS-affected areas (V1, ophthalmic branch area of the trigeminal nerve). This study aimed to investigate the characteristics of glaucoma in V1-affected PWS. METHODS: A total of 569 patients with V1 area-affected PWS were reviewed in the study. The large series was based on the referral system between the Department of Plastic and Reconstructive Surgery and the Department of Ophthalmology...
December 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29236278/head-and-neck-surgical-reconstruction-in-operation-iraqi-freedom-and-operation-enduring-freedom-afghanistan-a-systematic-review
#7
Samantha J Mikals, Joshua M Jabaut, Art A Ambrosio
Historically, head and neck injuries constituted 16 to 20% of all nonfatal combat injuries. However, advances in body and vehicle armor in the context of the use of ambushes and improvised explosive devices by enemy combatants have resulted in fewer fatalities from head and neck wounds, and thus the incidence of nonfatal head and neck injuries has risen to as high as 52%. Despite this increase, data regarding specific injury distributions, surgical cases, and approaches to repair are lacking in the current literature...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29236169/current-treatment-of-central-retinal-artery-occlusion-a-national-survey
#8
Teddy S Youn, Patrick Lavin, Morgan Patrylo, Joseph Schindler, Howard Kirshner, David M Greer, Matthew Schrag
BACKGROUND: Central retinal artery occlusion (CRAO) is an ophthalmological emergency, the retinal analog of a stroke. To date there is no consensus or national guidelines on how this disorder should be managed. As academic neurologists and ophthalmologists treat CRAO frequently, we set out to understand how these clinicians approach patients with CRAO with a national survey. METHODS: We identified university-associated teaching hospitals offering vascular neurology, neuro-ophthalmology and/or retina fellowships in the US and asked the directors of the programs to respond to questions in an open response format to profile the acute management of CRAO at their institution...
December 13, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29234870/-good-practice-procedures-for-acquisition-and-preparation-of-cryopreserved-human-amniotic-membranes-from-donor-placentas
#9
REVIEW
H Thomasen, J Schroeter, T Reinhard, B Seitz, K-P Steuhl, D Meller
Within the framework of obtaining a valid authorization for tissue preparation of cryopreserved human amniotic membranes at the Paul Ehrlich Institute, pursuant to § 21a paragraph 1 of the German Medicines Act (AMG), parts of the existing good practice procedures for acquisition of cryopreserved human amniotic membranes from donor placentas were reviewed and supplemented by new knowledge. The present good practice procedures were formulated in cooperation with members of the section for tissue transplantation and biotechnology of the German Ophthalmological Society...
December 12, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29234226/patterns-of-ophthalmic-emergencies-presenting-to-a-referral-hospital-in-medina-city-saudi-arabia
#10
Omar M Alabbasi, Maan Al-Barry, Raghad F Albasri, Haitham F Khashim, Mohammad M Aloufi, Mohammed F Abdulaal, Dareen W Alsaidalany, Adel S Alahmadi, Hanan Habeeb, Waseem A Aalam
Background: Data are required on ophthalmic cases that present to the emergency eye clinics in Madinah, Saudi Arabia for proper allocation of healthcare resources. Objectives: To determine the frequency and various diagnoses of patients presenting to the A&E at Ohud Hospital, Madinah, Saudi Arabia. Methods: Data was collected prospectively for all patients who presented to the A&E ophthalmology clinic from June 2014 to September 2014. The data was analyzed and presented using frequency of incidence and percentages...
October 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29234224/chiasmal-syndrome-clinical-characteristics-in-patients-attending-an-ophthalmological-center
#11
Aline Astorga-Carballo, Juan Carlos Serna-Ojeda, Mayra Fabiola Camargo-Suarez
Purpose: To present the clinical characteristics of a group of patients with the diagnosis of chiasmal syndrome who attended a large ophthalmological institute. Methods: Retrospective, observational clinical study with the review of medical records of patients with a diagnosis of chiasmal syndrome. The following variables were assessed: demographic characteristics, chief complaint upon presentation, best-corrected visual acuity (BCVA), presence or absence of diplopia, pupillary responses, optic nerve head morphology, etiology, and results from the ancillary tests including Ishihara test, Goldmann visual field (GVF) perimetry and neuroimaging...
October 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29234223/retinal-nerve-fiber-layer-thickness-in-children-with-%C3%AE-thalassemia-major
#12
Feyzahan Uzun, Emine Esra Karaca, Gönül Yıldız Yerlikaya, Hüseyin Fındık, Mehmet Akın
Purpose: To measure the retinal nerve fiber layer thickness (RNFLT) in children with β-thalassemia major and to compare with healthy controls. Methods: A total of 47 patients with β-thalassemia major and 51 healthy controls were included. Each subject underwent a standard ophthalmological examination. RNFLT measurements were performed using optical coherence tomography. Results: Mean age of the patient group and healthy controls were 13...
October 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29233702/endoscopic-endonasal-repair-with-polyethylene-implants-in-medial-orbital-wall-fractures-a-prospective-study-on-25-cases
#13
Giacomo Colletti, Alberto Maria Saibene, Lorenzo Giannini, Margherita Dessy, Carlotta Pipolo, Fabiana Allevi, Paolo Lozza, Giovanni Felisati, Federico Biglioli
The aim of the study was to assess the mid-term effectiveness and safety of an original technique consisting of reconstructing fractures of the medial wall of the orbit with porous polyethylene implants with an exclusive transnasal approach. Twenty-five patients were treated. Each patient underwent a pre-operative ophthalmologic evaluation and a CT scan. The surgery started with an anteroposterior ethmoidectomy of the fractured side; all the fractured bone fragments were removed and all usual landmarks of healthy bony margins were identified...
November 21, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29233535/history-of-the-american-journal-of-ophthalmology-a-100th-anniversary-update
#14
EDITORIAL
Michael W Stewart, Sarah L Duncan Powers, Richard K Parrish
No abstract text is available yet for this article.
December 9, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29233084/a-model-for-meta-analysis-of-correlated-binary-outcomes-the-case-of-split-body-interventions
#15
Orestis Efthimiou, Dimitris Mavridis, Adriani Nikolakopoulou, Gerta Rücker, Sven Trelle, Matthias Egger, Georgia Salanti
In several areas of clinical research, it is common for trials to assign different sites of the participants' bodies to different interventions. For example, a randomized controlled trial comparing surgical techniques for correcting myopia may randomize each eye of a participant to a different operation. Under such bilateral ('split-body') interventions, the observations from each participant are correlated. It is challenging to account for these correlations at the meta-analysis level, especially when the outcome is rare...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29232989/impact-of-cataract-on-health-related-quality-of-life-in-a-longitudinal-japanese-chronic-obstructive-pulmonary-cohort
#16
Hidehiro Irie, Shotaro Chubachi, Minako Sato, Mamoru Sasaki, Naofumi Kameyama, Takashi Inoue, Yoshitaka Oyamada, Hidetoshi Nakamura, Koichiro Asano, Tomoko Betsuyaku
Cigarette smoking increases the risk of developing both cataract and chronic obstructive pulmonary disease (COPD). The prevalence of cataract and the clinical characteristics of COPD patients with cataract were retrospectively investigated in a 2-year observational COPD cohort. We analyzed 395 patients with complete data on ophthalmologic evaluation (319 subjects with COPD and 76 subjects at risk of COPD). There was no difference in the prevalence of cataract between COPD patients and those at risk (47.0% vs...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29232345/factors-associated-with-lack-of-vision-improvement-in-children-with-cortical-visual-impairment
#17
Swati Handa, Seyed E Saffari, Mark Borchert
BACKGROUND: Improvement in vision has been noted in children with cortical visual impairment (CVI), resulting from disparate types of brain injury. The purpose of our study was to determine the risk factors associated with poor recovery of vision in this group of patients. METHODS: Case records of children who were born before 2010 with at least 4 follow-up visits for CVI were reviewed for underlying etiologies of CVI, visual acuity (VA), and associated neurological and ophthalmological disorders...
December 8, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29232337/retinal-telangiectasia-in-patients-with-pathologic-myopia-a-case-series
#18
Boya Lei, Ruiping Gu, Chen Jiang, Gezhi Xu
PURPOSE: To describe the characteristics of retinal telangiectasia in eyes with pathologic myopia. METHODS: The study included 10 patients (18 eyes) who were diagnosed with pathologic myopia combined with retinal telangiectasia. The patients visited our retinal clinic every 3 months. Nine eyes underwent vitrectomy for vision-threatening complications after diagnosis. All eyes underwent comprehensive ophthalmologic examinations including multimodal retinal imaging at presentation and at each follow-up...
December 8, 2017: Retina
https://www.readbyqxmd.com/read/29230414/analysis-of-the-ocular-refractive-state-in-fighting-bulls-astigmatism-prevalence
#19
Juan M Bueno, Matteo Lo Sapio, J Manuel Sanes, Juan Seva
The purpose of this study was to describe the ocular refractive state (ORS) of fighting bulls. The study consisted of 90 ophthalmological healthy animals (85 in post-mortem and 5 in living conditions, resp.). The ORS of the eyes (2 per animal) was determined using streak retinoscopy. In vivo animals were assessed at a fighting bull farm facility. Post-mortem measurements were carried out at a local arena. The ORS along the horizontal meridian ranged between -1.00 and +2.50 diopters (D), with a mean of +0.66 ± 0...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29230267/presenting-signs-of-retinoblastoma-at-a-tertiary-level-teaching-hospital-in-ethiopia
#20
Jemal Zeberga Shifa, Alemayehu Mekonnen Gezmu
Introduction: Retinoblastoma is a primary malignant intraocular neoplasm that arise from immature retinoblasts with in developing retina. The commonest presenting sign in developing country is proptosis which is the late presenting sign. We report presenting signs of retinoblastoma in Ethiopian children seen at a tertiary level teaching hospitals in Ethiopia. Methods: Prospective case series study was done on children who presented with retinoblastoma between May 1, 2005 and September 1, 2006...
2017: Pan African Medical Journal
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