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https://www.readbyqxmd.com/read/28646191/prednisolone-induces-apoptosis-in-corneal-epithelial-cells-through-the-intrinsic-pathway
#1
Jin Suk Ryu, Jung Hwa Ko, Mee Kum Kim, Won Ryang Wee, Joo Youn Oh
Glucocorticoid eye drops are one of the most widely used medications in ophthalmology. However, little is known about the effects of glucocorticoids on corneal epithelial cells that are directly exposed to topically-administered glucocorticoids. Here we investigated the effects of prednisolone, a synthetic glucocorticoid analogue frequently used in the clinic, on corneal epithelial cells. Results showed that prednisolone decreased survival of corneal epithelial cells by inhibiting proliferation and inducing apoptosis in a dose-dependent manner...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28644261/is-intravenous-thrombolysis-safe-and-effective-in-central-retinal-artery-occlusion-a-critically-appraised-topic
#2
Oana M Dumitrascu, Joanne F Shen, Madhavi Kurli, Maria I Aguilar, Lisa A Marks, Bart M Demaerschalk, Dean M Wingerchuk, Cumara B O'Carroll
BACKGROUND: Central retinal artery occlusion (CRAO) is a neurological and ophthalmologic emergency associated with poor visual recovery. There is a dilemma regarding the appropriate treatment, as formal guidelines are lacking. Despite being considered an ocular equivalent of cerebral infarction, the time window of intravenous (IV) thrombolysis administration for maximum efficacy and safety in CRAO remains uncertain. OBJECTIVE: To critically assess the current evidence regarding the safety and effectiveness of IV thrombolysis in the treatment of patients with CRAO...
July 2017: Neurologist
https://www.readbyqxmd.com/read/28644236/cyp1b1-cytopathy-uncommon-phenotype-of-a-homozygous-cyp1b1-deletion-as-internal-corneal-ulcer-of-von-hippel
#3
Valeria Oliva-Biénzobas, Alejandro Navas, Mirena C Astiazarán, Oscar Francisco Chacón-Camacho, Jose A Bermúdez-Magner, Mariana Takane, Enrique Graue-Hernández, Juan Carlos Zenteno
PURPOSE: To report a mutation of CYP1B1 in a newborn with a rare phenotype without the classic features of anterior segment dysgenesis or congenital glaucoma. METHODS: The newborn presented with diffuse corneal edema and bilaterally elevated intraocular pressure (IOP). Ophthalmological examination, ultrasound, and ultrasound biomicroscopy were performed; congenital infections were ruled out. Genetic analysis was performed. The patient underwent penetrating keratoplasty and goniotomy in a single surgical time...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28644103/prognostic-significance-of-intraoperative-change-in-the-fractional-anisotropy-and-the-volume-of-the-optic-chiasma-during-resection-of-suprasellar-tumors
#4
Hussam Metwali, Mario Giordano, Katja Kniese, Rudolf Fahlbusch
OBJECTIVE The aim of this study was to test the prognostic significance of intraoperative changes in the fractional anisotropy (FA) and the volume of the optic chiasma and their correlation with visual outcome. METHODS Twenty-eight sequential patients with suprasellar tumors presenting with chiasma compression syndrome were surgically treated under intraoperative MRI control between March 2014 and July 2016. The FA and the volume of the optic chiasma were measured immediately before and immediately after tumor resection...
June 23, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28643712/comparison-of-macular-pigment-optical-density-in-patients-with-dry-and-wet-age-related-macular-degeneration
#5
Ayhan Ozyurt, Nilufer Kocak, Pınar Akan, Ozlem Gursoy Calan, Taylan Ozturk, Mahmut Kaya, Eyup Karahan, Suleyman Kaynak
AIM: The aim of the study was to evaluate the macular pigment optical density (MPOD) levels in patients with wet age-related macular degeneration (AMD), dry AMD, and also in healthy controls. SETTINGS AND DESIGN: This study was conducted at Department of Ophthalmology, and the study design was a prospective study. PATIENTS AND METHODS: Forty-eight patients with wet AMD, 51 patients with dry AMD, and 50 controls were included in the study. All patients were naive to both previous lutein or zeaxanthin administration and any previous intravitreal injections...
June 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28643708/residency-evaluation-and-adherence-design-study-young-ophthalmologists-perception-of-their-residency-programs-clinical-and-surgical-skills
#6
Parikshit Gogate, Partha Biswas, Sundaram Natarajan, Dandapani Ramamurthy, Debashish Bhattacharya, Karl Golnik, Barun Kumar Nayak
BACKGROUND: Residency training is the basis of good clinical and surgical practice. PURPOSE: The aim is to know the demographics, training experience, and perception of young ophthalmologists to improve the present residency programs in India. SETTING: Young ophthalmologists trained in India. METHODS: A survey was conducted by the Academic and Research Committee of the All India Ophthalmology Society, in 2014-2016 of young ophthalmologists (those trained between 2002 and 2012, with 2-10 years' postresidency experience) to gauge teaching of clinical and surgical skills during the postgraduate residency program...
June 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28643705/ophthalmology-postgraduate-training-in-india-stirring-up-a-hornet-s-nest
#7
EDITORIAL
Amod Gupta
No abstract text is available yet for this article.
June 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28643703/ophthalmology-residency-training-in-india-quo-vadis
#8
EDITORIAL
Santosh G Honavar
No abstract text is available yet for this article.
June 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28643231/demodex-blepharitis-treated-with-a-novel-dilute-povidone-iodine-and-dmso-system-a-case-report
#9
Jesse S Pelletier, Kara Capriotti, Kevin S Stewart, Joseph A Capriotti
INTRODUCTION: Povidone-iodine aqueous solution is an antiseptic commonly used in ophthalmology for treatment of the ocular surface. Dimethylsulfoxide (DMSO) is a well-known skin penetration enhancer that is scarcely utilized in ophthalmic drug formulations. We describe here a low-dose formulation of 0.25% PVP-I in a gel containing DMSO for the treatment of Demodex blepharitis. CASE REPORT: A 95-year-old female presented with chronic blepharitis involving both the anterior and posterior eyelid margins...
June 22, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28643176/a-promising-tool-in-retina-regeneration-current-perspectives-and-challenges-when-using-mesenchymal-progenitor-stem-cells-in-veterinary-and-human-ophthalmological-applications
#10
REVIEW
Anna Cislo-Pakuluk, Krzysztof Marycz
Visual impairment is a common ailment of the current world population, with more exposure to CCD screens and fluorescent lighting, approximately 285 billion people suffer from this deficiency and 13% of those are considered clinically blind. More common causes for visual impairment include age-related macular degeneration (AMD), glaucoma and diabetic retinopathy (Zhu et al. Molecular Medicine Reports, 2015; Kolb et al. 2007; Machalińska et al. Current Eye Research, 34(9),748-760, 2009) among a few. As cases of retinal and optic nerve diseases rise, it is vital to find a treatment, which has led to investigation of the therapeutic potential of various stem cells types (Bull et al...
June 22, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28641680/ophthalmological-evaluation-of-integrated-resistance-and-aerobic-training-during-70-day-bed-rest
#11
Giovanni Taibbi, Ronita L Cromwell, Susana B Zanello, Patrice O Yarbough, Robert J Ploutz-Snyder, Bernard F Godley, Gianmarco Vizzeri
INTRODUCTION: We evaluated ophthalmic changes in healthy individuals who underwent integrated resistance and aerobic training (iRAT) during 70-d 6° head-down tilt (HDT) bed rest (BR). METHODS: Participants were selected using NASA standard screening procedures. Standardized NASA BR conditions were implemented. Subjects were randomly assigned to the iRAT protocol or no exercise during HDTBR. Weekly ophthalmic examinations were performed in the sitting (pre/post-BR only) and HDT (BR only) positions...
July 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28641461/the-impact-of-data-errors-on-the-outcome-of-randomized-clinical-trials
#12
Marc Buyse, Pierre Squifflet, Elisabeth Coart, Emmanuel Quinaux, Cornelis Ja Punt, Everardo D Saad
Background/aims Considerable human and financial resources are typically spent to ensure that data collected for clinical trials are free from errors. We investigated the impact of random and systematic errors on the outcome of randomized clinical trials. Methods We used individual patient data relating to response endpoints of interest in two published randomized clinical trials, one in ophthalmology and one in oncology. These randomized clinical trials enrolled 1186 patients with age-related macular degeneration and 736 patients with metastatic colorectal cancer...
June 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28641290/long-term-follow-up-of-choroidal-neovascularization-due-to-angioid-streaks-with-pro-re-nata-intravitreal-anti-vegf-treatment
#13
Giovanni Giacomelli, Lucia Finocchio, Ilaria Biagini, Andrea Sodi, Vittoria Murro, Ugo Introini, Monica Varano, Francesco Bandello, Ugo Menchini
PURPOSE: To evaluate the long-term outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) drugs with a pro re nata (PRN) regimen for the treatment of choroidal neovascularization (CNV) secondary to angioid streaks (AS). METHODS: This is a retrospective, multicenter, noncomparative case series of consecutive AS eyes affected by treatment-naïve CNV. A complete ophthalmologic examination was performed every 30-45 days after the loading phase, including fluorescein angiography and/or optical coherence tomography...
June 23, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28640147/human-photoreceptor-cone-density-measured-with-adaptive-optics-technology-rtx1-device-in-healthy-eyes-standardization-of-measurements
#14
Anna Zaleska-Żmijewska, Zbigniew M Wawrzyniak, Magdalena Ulińska, Jerzy Szaflik, Anna Dąbrowska, Jacek P Szaflik
The anatomic structures of the anterior segment of the eye enable correct reception of stimuli by the retina, which contains receptors that receive light impulses and transmit them to the visual cortex. The aim of this study was to assess the effect of the size of the sampling window in an adaptive optics (AO) flood-illumination retinal camera (rtx1) on cone density measurements in the eyes of healthy individuals and to investigate the differences in cone density and spacing in different quadrants of the retina...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28640004/ocular-lesions-in-congenital-toxoplasmosis-in-santa-isabel-do-iva%C3%A3-paran%C3%A3-brazil
#15
Ana Paula Sanders, Tatiane Dos Santos, Cleusa KimieKoike Felipe, Maria Lucia Estevão, Caroni Cícero, Fernanda Evangelista, Carlos Alexandre Manrique, Angélica Sayuri Mizutani, Ana Lucia Falavigna-Guilherme
We verified clinical and psychopedagogic aspects of congenital cases with ocular sequelae, 13 years after toxoplasmosis outbreak in Santa Isabel do Ivaí, and current seroprevalence of this zoonosis in pregnant women. Audiologic and ophthalmologic evaluations were performed in congenital cases, in addition to collection of clinical and psychopedagogic data. In pregnant women, current seroprevalence was observed. Among affected teenagers, 2/5 are behind in school grade, 4/5 reported learning difficulties, requiring psychopedagogic monitoring, as well as ocular complaints...
June 17, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28639719/understanding-indigenous-patient-attendance-a-qualitative-study
#16
Stephen Copeland, Josephine Muir, Angus Turner
OBJECTIVE: To better understand Indigenous patient non-attendance at medical specialty appointments by learning from the patients attending their scheduled outreach ophthalmology clinic appointment. DESIGN, SETTING AND PARTICIPANTS: A qualitative study using face-to-face, semi-structured interviews with 69 Indigenous Australian ophthalmology patients and 8 clinic workers at one urban and one rural Aboriginal Medical Service (AMS) over the period from April 2015 to November 2015...
June 22, 2017: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/28639449/-optic-properties-of-myopic-correction-by-orthokeratology-contact-lenses-a-case-report
#17
M Mýlková, F Pluháček
INTRODUCTION: Orthokeratology lenses present a special type of hard contact lenses, which is used especially for myopic correction. The lenses are applied during the night, when thanks to their special shape cause temporally (reversible) change of the cornea shape. During the day, there is not necessary to wear any other refractive correction. Due to the wearing regimen, there is, comparing to the classical contact lenses, higher risk of health complications. For their safe use, it is necessary to pay attention to the application of lenses of adequate parameters, follow up the care and hygiene precautions, regular controls and early treatment of possible problems...
2017: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/28639368/botulinum-toxin-state-of-the-art
#18
REVIEW
Joseph Jankovic
Botulinun neurotoxin (BoNT) has emerged as one of the most multipurpose therapeutic agents in modern medicine with more clinical applications than any other drug currently on the market. Initially developed in the treatment of strabismus and neurologic movement disorders, the use of botulinun neurotoxin has been expanding during the past 3 decades to include the treatment of a variety of ophthalmologic, gastrointestinal, urologic, orthopedic, dermatologic, dental, secretory, painful, cosmetic, and other conditions...
June 22, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28636408/pattern-visual-evoked-potential-pattern-electroretinogram-and-retinal-nerve-fiber-layer-thickness-in-patients-with-migraine-during-and-after-aura
#19
Amany Abd El-Fattah El-Shazly, Yousra Ahmed Farweez, Momen Mahmoud Hamdi, Noha Ezzat El-Sherbiny
PURPOSE: To study pattern visual evoked potential (PVEP), pattern electroretinogram (PERG), and retinal nerve fiber layer (RNFL) thickness in patients with migraine during and after aura. MATERIALS AND METHODS: We included 60 eyes of 60 patients with migraine (Group 1) and 30 healthy volunteers (30 eyes) as controls (Group 2). Group 1 was studied twice, during a visual aura (1-a) and in between attacks (1-b). All participants underwent full ophthalmological examination, PVEP, PERG, and optical coherence tomographyOCT imaging of the RNFL thickness for each patient...
June 21, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28633137/incidence-and-characteristics-of-congenital-cataract-surgery-in-france-from-2010-to-2012-the-episafe-program
#20
Vincent Daien, Annick Le Pape, Didier Heve, Max Villain, Dominique Bremond Gignac
INTRODUCTION: Prevention of visual impairment due to congenital cataract is an international priority as part of VISION 2020 - The Right to Sight, the joint initiative of the World Health Organization and the International Agency for the Prevention of Blindness. The present study is part of the Epidemiology and Safety (EPISAFE) collaborative program aiming at assessing the epidemiology and safety of interventions in ophthalmology. METHODS: All children who underwent cataract surgery before the age of 1 year in France between January 2010 and December 2012 were identified by using the Programme de Médicalisation des Systèmes d'Information...
June 20, 2017: Ophthalmic Research
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