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https://www.readbyqxmd.com/read/29054477/-update-on-recommendations-for-screening-for-hydroxychloroquine-retinopathy
#1
A Couturier, A Giocanti-Aurégan, B Dupas, J-F Girmens, Y Le Mer, N Massamba, E Barreau, I Audo
INTRODUCTION: Recommendations for screening for chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy have recently been changed by the American Academy of Ophthalmology, taking into account new published data on toxicity prevalence, risk factors, location of onset in the retina and the efficacy of screening tests. METHODS: Literature review. RESULTS AND DISCUSSION: The risk of developing CQ or HCQ retinopathy depends on the daily dose and duration of treatment...
October 17, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29053603/clinical-and-genetic-evaluation-of-a-cohort-of-pediatric-patients-with-severe-inherited-retinal-dystrophies
#2
Valentina Di Iorio, Marianthi Karali, Raffaella Brunetti-Pierri, Mariaelena Filippelli, Giuseppina Di Fruscio, Mariateresa Pizzo, Margherita Mutarelli, Vincenzo Nigro, Francesco Testa, Sandro Banfi, Francesca Simonelli
We performed a clinical and genetic characterization of a pediatric cohort of patients with inherited retinal dystrophy (IRD) to identify the most suitable cases for gene therapy. The cohort comprised 43 patients, aged between 2 and 18 years, with severe isolated IRD at the time of presentation. The ophthalmological characterization also included assessment of the photoreceptor layer integrity in the macular region (ellipsoid zone (EZ) band). In parallel, we carried out a targeted, next-generation sequencing (NGS)-based analysis using a panel that covers over 150 genes with either an established or a candidate role in IRD pathogenesis...
October 20, 2017: Genes
https://www.readbyqxmd.com/read/29053399/new-pathogenic-variant-in-the-fgf10-gene-in-the-agenesis-of-lacrimal-and-salivary-gland-syndrome-ophthalmological-and-genetic-study
#3
Maria Jesus Rodrigo, Miriam Idoipe, Silvia Izquierdo, Maria Satue, Antonio Mateo, Antonio Sanchez, Elena Garcia-Martin, Luis Pablo
Aplasia/agenesis of lacrimal and salivary glands is a rare congenital defect that has been associated with disturbances in fibroblast growth factor 10 (FGF10). It can present with symptoms of congenital lacrimal obstruction, dry eye, and dry mouth. We report the ophthalmological and genetic study of a 19-year-old woman and her relatives suffering from this syndrome. A new probably pathogenic variant is described in the FGF10 gene.
October 20, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29053133/-ophthalmic-disorders-as-a-manifestation-of-parkinson-s-disease
#4
N B Chesnokova, T A Pavlenko, M V Ugrumov
Parkinson's disease is a severe neurodegenerative disease accompanied with the degeneration of dopaminergic neurons in the central and peripheral nervous system. The diagnosis of Parkinson's disease can still be made only on the stage of irreversible and nearly total degeneration of the nigrostriatum dopaminergic system and exhaustion of brain compensatory mechanisms that explains the low efficacy of therapy. Ophthalmic pathology is one of the nonmotor symptoms of Parkinson's disease. This can be explained firstly by the fact that eye is a 'peripheral part of brain' and secondly by the involvement of dopaminergic neurons (dopamine-producing cells) that are subject to the selective degeneration during Parkinson's disease in the regulation of visual function in the eye and brain...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29052094/severe-physical-complications-among-survivors-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis
#5
Cristina Olteanu, Neil H Shear, Hall F Chew, Rena Hashimoto, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Michael Ziv, Shachar Sade, Marc G Jeschke, Roni P Dodiuk-Gad
INTRODUCTION: Few studies have reported the physical complications among Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) survivors. OBJECTIVE: The aim of this study was to comprehensively characterize the physical complications among SJS/TEN survivors and to learn about patients' perspectives of surviving SJS/TEN. METHODS: SJS/TEN survivors older than 18 years of age were assessed by different methods: a medical interview; a questionnaire assessing patients' perspectives; thorough skin, oral mucous membrane, and ophthalmic examinations; and a retrospective assessment of medical records...
October 19, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29051539/ophthalmological-symptoms-in-children-with-intracranial-cysts
#6
Anna Gotz Wieckowska, Lidia Glowka, Agata Brazert, Marta Pawlak
The purpose of this study was to perform an ophthalmological assessment in children with intracranial cysts and to assess the correlation between the occurrence of cysts and visual disorders. The documentation of 46 children with intracranial cysts, monitored by the Children's Outpatient Ophthalmology Clinic, Poznan, Poland was analysed. The best corrected visual acuity (BCVA), the alignment of the eyes, visual evoked potentials (VEP), comprehensive eye examination were performed in all patients. Additional ophthalmological tests were conducted to eliminate other causes of decreased visual acuity...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29050284/mutational-analysis-of-a-chinese-family-with-oculocutaneous-albinism-type-2
#7
Xiong Wang, Yaowu Zhu, Na Shen, Jing Peng, Chunyu Wang, Haiyi Liu, Yanjun Lu
Oculocutaneous albinism (OCA) is an autosomal recessive disorder characterized by hypopigmentation of the skin, hair, and eyes accompanied with ophthalmologic abnormalities. Molecular genetic test can confirm the diagnosis of the four subtypes of OCA (OCA1-4). Herein, we report a Chinese family with two patients affected by OCA. Mutations of TYR, OCA2, TYRP1, and SLC45A2 were examined by using PCR-sequencing. Large deletions or duplications of TYR and OCA2 were examined by Multiplex Ligation-dependent Probe Amplification (MLPA) assay...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050188/-sturge-weber-syndrome-in-port-wine-stain-patients-a-retrospective-study-on-the-clinical-features-and-screening-strategy
#8
Y Wu, R J Yu, X X Lin, W Y Guo
Objective: To investigate the clinical characteristics of Sturge-Weber syndrome (SWS) in the patients with Port-wine stain (PWS). Methods: A total of 279 PWS patients, 164 males, 115 females with a median age of first visit 17.00 (4.75, 56.00) months. Most of the PWS patients were referred to the Ophthalmology Department for screening eye problems when the cutaneous angiomas involved the ophthalmic division of the trigeminal nerve distribution. The intraocular pressure (IOP), cup to disk ratio (C/D), corneal condition and other essential measurements were examined to screen glaucoma or choroidal hemangioma...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29050187/-cytokine-analysis-of-aqueous-humor-in-aids-patients
#9
W J Kong, C G Guo, L Y Xie, W B Wei, H W Dong, C Chen, K F Du
Objective: To explore the Cytokine of aqueous humor in AIDS patients with different eye diseases. Methods: A case-control study including 38 patients who was diagnosed as acquired immunodeficiency syndrome(AIDS) at Infectious Center and Department of Ophthalmology in Beijing You'an Hospital, Capital Medical University. And 16 cases of 38 patients were cytomegalovirus retinitis (CMVR), 14 cases were HIV-related retinal disease, and 8 cases presented as normal. A series of tests were performed including vision acuity check, intraocular pressure, fundus photography, blood cell count of CD4+ T lymphocyte and the content of cytokines in aqueous humor by Luminex 200(TM) liquid chip analyzer...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29049681/jama-ophthalmology
#10
(no author information available yet)
No abstract text is available yet for this article.
October 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29049512/time-requirements-for-electronic-health-record-use-in-an-academic-ophthalmology-center
#11
Sarah Read-Brown, Michelle R Hribar, Leah G Reznick, Lorinna H Lombardi, Mansi Parikh, Winston D Chamberlain, Steven T Bailey, Jessica B Wallace, Thomas R Yackel, Michael F Chiang
Importance: Electronic health record (EHR) systems have transformed the practice of medicine. However, physicians have raised concerns that EHR time requirements have negatively affected their productivity. Meanwhile, evolving approaches toward physician reimbursement will require additional documentation to measure quality and cost of care. To date, little quantitative analysis has rigorously studied these topics. Objective: To examine ophthalmologist time requirements for EHR use...
October 12, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29047838/convolution-and-fourier-transform-based-reconstructors-for-pyramid-wavefront-sensor
#12
Iuliia Shatokhina, Ronny Ramlau
In this paper, we present two novel algorithms for wavefront reconstruction from pyramid-type wavefront sensor data. An overview of the current state-of-the-art in the application of pyramid-type wavefront sensors shows that the novel algorithms can be applied in various scientific fields such as astronomy, ophthalmology, and microscopy. Assuming a computationally very challenging setting corresponding to the extreme adaptive optics (XAO) on the European Extremely Large Telescope, we present the results of the performed end-to-end simulations and compare the achieved AO correction quality (in terms of the long-exposure Strehl ratio) to other methods, such as matrix-vector multiplication and preprocessed cumulative reconstructor with domain decomposition...
August 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047302/a-self-assembled-clavanin-a-coated-amniotic-membrane-scaffold-for-the-prevention-of-biofilm-formation-by-ocular-surface-fungal-pathogens
#13
Santi M Mandal, Jahangir Khan, Denial Mahata, Suman Saha, Jayangshu Sengupta, Osmar N Silva, Subhayan Das, Mahitosh Mandal, Octavio L Franco
Amniotic membrane (AM) is frequently used in ophthalmologic surgery for rapid ocular surface reconstruction. Sometimes it may create a major problem with associated infections after biofilm formation over the membrane. To overcome this problem, AM was coated with the antimicrobial peptide clavanin A. The antifungal activity of clavanin A in the native and self-assembled form was determined against the common ocular surface pathogens Candida albicans, Aspergillus fumigatus, Alternaria sp. and Fusarium sp. Biofilm formation over the coated surface was significantly reduced in comparison with the uncoated membrane...
October 19, 2017: Biofouling
https://www.readbyqxmd.com/read/29046981/ophthalmologic-disease-in-hiv-infection-recent-changes-in-pathophysiology-and-treatment
#14
REVIEW
Michael W Stewart
PURPOSE OF REVIEW: Ophthalmologic conditions were among the earliest described findings in patients with the acquired immunodeficiency syndrome (AIDS). The purpose of this review is to highlight recent changes in the pathophysiology and management of ophthalmologic conditions in patients infected with the human immunodeficiency virus (HIV). RECENT FINDINGS: The introduction of highly active antiretroviral therapy (HAART) in 1996 changed ophthalmologic findings from predominantly acute infectious diseases to chronic, slowly progressive, debilitating conditions...
October 19, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29044680/effects-of-three-blood-derived-products-on-equine-corneal-cells-an-in-vitro-study
#15
J O Rushton, E Kammergruber, A Tichy, M Egerbacher, B Nell, S Gabner
BACKGROUND: Despite advances in therapy of corneal ulcerative diseases in horses, a vast number of cases require surgical intervention, due to poor response to treatment. Topical application of serum has been used for many years, based on its anti-collagenolytic properties and the presence of growth factors promoting corneal wound healing. However, although other blood derived products i.e. platelet rich plasma (PRP), plasma rich in growth factors (PRGF) have been widely used in equine orthopaedics and in human ophthalmology, no reports of the effects of these blood derived products exist in equine ophthalmology...
October 16, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29044060/interocular-symmetry-of-retinal-nerve-fiber-layer-and-optic-nerve-head-parameters-measured-by-cirrus-high-definition-optical-coherence-tomography-in-a-normal-pediatric-population
#16
Neelam Pawar, Devendra Maheshwari, Meenakshi Ravindran, Renagappa Ramakrishnan
PURPOSE: To determine interocular differences in the retinal nerve fiber layer (RNFL) and optic nerve head (ONH) parameters in a pediatric population using Cirrus high-definition optical coherence tomography (HD-OCT). METHODS: Seventy normal Indian children aged 5-17 years presenting to the Pediatric Clinic were included in this observational cross-sectional study. All subjects underwent a comprehensive ophthalmologic examination and an evaluation of the RNFL and ONH by Cirrus HD-OCT...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29043533/corneal-cross-linking-has-no-effect-on-matrix-metalloproteinase-9-and-13-levels-during-fungal-keratitis-on-the-early-stage
#17
Ayse Kalkanci, Kamil Bilgihan, Huseyin Baran Ozdemir, Atiye Seda Yar Saglam, Funda Karakurt, Merve Erdogan
The aim of our study was to investigate matrix metalloproteinases, MMP-9 and MMP-13 levels, in the rabbit model of Fusarium and Candida keratitis treated by corneal cross-linking (PACK-CXL). Rabbit corneas were inoculated with fungal inoculum for keratitis. Each group divided into four subgroups, including un-treated group, PACK-CXL group, voriconazole group and PACK-CXL plus voriconazole group. PACK-CXL was applied with 0.25% riboflavin in accelerated Dresden protocol, and 0.1% voriconazole drops were administered...
October 17, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29043440/-boston-keratoprosthesis-73%C3%A2-eyes-from-germany-an-overview-of-experiences-from-two-centers
#18
F Schaub, I Neuhann, P Enders, B O Bachmann, B Koller, T Neuhann, C Cursiefen
BACKGROUND: The Boston Keratoprosthesis (B-KPro) is a therapeutic option for corneal replacement for visual rehabilitation in eyes with poor a prognosis for penetrating keratoplasty (high-risk eyes). Since 2009, this approach has been used in the MVZ Prof. Neuhann, Munich, and since 2013 also at the Department of Ophthalmology, University of Cologne. An overview of results from the first 73 eyes in these departments is presented. METHODS: All recipient eyes of both centers which received a B-KPro type I (BI-KPro) between November 2009 and March 2017 were included...
October 17, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29042759/early-and-intermediate-age-related-macular-degeneration-update-and-clinical-review
#19
REVIEW
Alfredo García-Layana, Francisco Cabrera-López, José García-Arumí, Lluís Arias-Barquet, José M Ruiz-Moreno
Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in developed countries. With the aging of population, AMD will become globally an increasingly important and prevalent disease worldwide. It is a complex disease whose etiology is associated with both genetic and environmental risk factors. An extensive decline in the quality of life and progressive need of daily living assistance resulting from AMD among those most severely affected highlights the essential role of preventive strategies, particularly advising patients to quit smoking...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29040009/ocular-involvement-in-patients-with-fungemia-in-an-urban-tertiary-care-center
#20
Kenneth W Price, Edmund Tsui, Irene Barbazetto, Lisa Park
PURPOSE: To illustrate the rate of endogenous endophthalmitis associated with fungemia and evaluate the importance of screening in a public city hospital. METHODS: A retrospective review was performed on all inpatient ophthalmology consults for fungemia from 2010 to 2015. Clinical histories, ocular examinations, and microbial cultures were reviewed. RESULTS: Of 95 patients (mean age 51.6 years, 75% male) with fungemia, 9/95 (9.5%) demonstrated intraocular involvement...
October 17, 2017: Ocular Immunology and Inflammation
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