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Ophthalmological

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https://www.readbyqxmd.com/read/28719506/zika-virus-associated-ocular-and-neurologic-disorders-the-emergence-of-new-evidence
#1
Fatih Şahiner, Ali Korhan Siğ, Ümit Savaşçi, Kemal Tekin, Fahrettin Akay
BACKGROUND: It has been approximately 70 years since the discovery of the Zika virus (ZIKV). It had been established that the virus causes mild infections, and is confined to Africa and Asia; however, major changes in the clinical and epidemiologic patterns of ZIKV infection have occurred in recent years. The virus has attracted intense interest because of the possible association of several autoimmune and neurodevelopmental disorders. METHODS: We present a summary of the articles that attempt to explain the ZIKV unknowns, and strengthen the association with some disorders that are thought to be related to ZIKV, by describing the discovery milestones from the initial identification of the virus to the present day...
July 13, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28719416/the-ophthalmology-surgical-competency-assessment-rubric-for-trabeculectomy
#2
Catherine M Green, Sarwat Salim, Deepak P Edward, Raghu C Mudumbai, Karl Golnik
PURPOSE: To produce an internationally valid tool to assess skill in performing trabeculectomy surgery. METHODS: A panel of 5 experts developed a tool for assessing trabeculectomy surgery by using a modified Dreyfus scale of skill acquisition and providing descriptors for each level of skill for each category. The tool was then reviewed by a panel of 10 international content experts for their constructive comments, which were incorporated into the final rubric tool...
July 17, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28717786/setting-priorities-for-diabetic-retinopathy-clinical-research-and-identifying-evidence-gaps
#3
Jimmy T Le, Susan Hutfless, Tianjing Li, Neil M Bressler, James Heyward, Ava K Bittner, Adam Glassman, Kay Dickersin
PURPOSE: Prioritizing comparative effectiveness research may contribute to obtaining answers that clinicians perceive they need and may minimize research that could be considered wasteful. Our objective was to identify evidence gaps and set priorities for new systematic reviews and randomized controlled trials for managing diabetic retinopathy (DR), including diabetic macular edema (DME). DESIGN: Cross-sectional study. PARTICIPANTS: Diabetic Retinopathy Clinical Research Network (DRCR...
March 2017: Ophthalmology retina
https://www.readbyqxmd.com/read/28717579/deep-learning-based-automated-segmentation-of-macular-edema-in-optical-coherence-tomography
#4
Cecilia S Lee, Ariel J Tyring, Nicolaas P Deruyter, Yue Wu, Ariel Rokem, Aaron Y Lee
Evaluation of clinical images is essential for diagnosis in many specialties. Therefore the development of computer vision algorithms to help analyze biomedical images will be important. In ophthalmology, optical coherence tomography (OCT) is critical for managing retinal conditions. We developed a convolutional neural network (CNN) that detects intraretinal fluid (IRF) on OCT in a manner indistinguishable from clinicians. Using 1,289 OCT images, the CNN segmented images with a 0.911 cross-validated Dice coefficient, compared with segmentations by experts...
July 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28717565/twenty-five-years-of-optical-coherence-tomography-the-paradigm-shift-in-sensitivity-and-speed-provided-by-fourier-domain-oct-invited
#5
Johannes F de Boer, Rainer Leitgeb, Maciej Wojtkowski
Optical coherence tomography (OCT) has become one of the most successful optical technologies implemented in medicine and clinical practice mostly due to the possibility of non-invasive and non-contact imaging by detecting back-scattered light. OCT has gone through a tremendous development over the past 25 years. From its initial inception in 1991 [Science254, 1178 (1991)] it has become an indispensable medical imaging technology in ophthalmology. Also in fields like cardiology and gastro-enterology the technology is envisioned to become a standard of care...
July 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28715851/paradigm-shifts-peregrinations-and-pixies-in-ophthalmology
#6
REVIEW
A O Minas Coroneo
Defending vision, our highest bandwidth sense, challenges human ingenuity. Replacing or repairing highly specialized but scarce tissue within constraints of transparency, tissue shape and alignment, tissue borders and pressure maintenance, presents special challenges. Many, mostly destructive surgical procedures, were developed prior to an understanding of underlying pathophysiology. For a number of conditions, both reconstructive and destructive procedures co-exist yet there are few guidelines as to the better approach...
July 17, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28715582/iris-freckles-a-potential-biomarker-for-chronic-sun-damage
#7
Christoph Schwab, Christoph Mayer, Iris Zalaudek, Regina Riedl, Markus Richtig, Werner Wackernagel, Rainer Hofmann-Wellenhof, Georg Richtig, Gerald Langmann, Lisa Tarmann, Andreas Wedrich, Erika Richtig
Purpose: To investigate the role of sunlight exposure in iris freckles formation. Methods: We prospectively examined volunteers attending a skin cancer screening program conducted by ophthalmologists and dermatologists. Frequency and topographical variability of iris freckles were noted and associated with behavioral and dermatologic characteristics indicating high sun exposure. Results: Six hundred thirty-two participants (n = 360; 57% female) were examined...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28715565/jama-ophthalmology
#8
(no author information available yet)
No abstract text is available yet for this article.
July 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28715155/asteroid-hyalosis-masquerading-as-vitreous-hemorrhage-on-point-of-care-sonography
#9
Penelope C Lema, Daniel Mantuani, Arun Nagdev, Srikar Adhikari
Point-of-care ocular sonography is frequently used in the emergency department to evaluate patients with vision disorders. We describe a case series of 3 patients who ultimately had a diagnosis of asteroid hyalosis, a lesser-known condition that on point-of-care sonography may be mistaken for vitreous hemorrhage. Asteroid hyalosis is considered a benign degenerative condition. In contrast, vitreous hemorrhage may be an ocular emergency that warrants an urgent ophthalmologic consultation if there is an underlying retinal tear or detachment...
July 17, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28713835/rapid-detection-of-the-mt3243a%C3%A2-%C3%A2-g-mutation-using-urine-sediment-in-elderly-chinese-type-2-diabetic-patients
#10
Yinan Zhang, Xiujuan Du, Xinqian Geng, Chen Chu, Huijuan Lu, Yixie Shen, Ruihua Chen, Pingyan Fang, Yanmei Feng, Xiaojie Zhang, Yan Chen, Yanping Zhou, Congrong Wang, Weiping Jia
OBJECTIVE: In this study, we aimed to identify mt3243A > G mutation carriers in a group of Chinese elderly type 2 diabetic patients by a rapid and noninvasive diagnostic system. METHODS: DNA was extracted from blood, saliva, and urine sediment samples. The mutation screening and quantitation of heteroplasmy were performed by high-resolution melting (HRM) curve and pyrosequencing, respectively. Patients with mt3243A > G mutation underwent a detailed audiometric, ophthalmologic, neurological, and cardiac examination...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28712656/treatments-for-ocular-adnexal-lymphoma-a-report-by-the-american-academy-of-ophthalmology
#11
Michael T Yen, Jurij R Bilyk, Edward J Wladis, Elizabeth A Bradley, Louise A Mawn
PURPOSE: To review the literature to determine the efficacy of available treatments for ocular adnexal lymphoma (OAL) and to evaluate the outcomes and complications of treatments in patients older than 13 years. METHODS: A literature search was conducted last in March 2017 in the PubMed and Cochrane Library databases for English-language original research investigations that evaluated treatment outcomes for OAL. The searches identified 307 unique citations, and 27 studies were selected according to the criteria outlined for this assessment...
July 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28712175/corneal-complications-and-visual-impairment-in-vernal-keratoconjunctivitis-patients
#12
Abdus Salam Arif, Bushra Aaqil, Afsheen Siddiqui, Zainab Nazneen, Umer Farooq
BACKGROUND: Vernal kerato-conjunctivitis (VKC) is an infrequent but serious form of allergic conjunctivitis common in warm and humid areas where air is rich in allergens. It affects both eyes asymmetrically. Although VKC is a self-limiting disease but visions affecting corneal complications influence the quality of life in school children. The aim of this study was to list the corneal complications due to this condition and to find out the extent of visual impairment among VKC patients...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28712034/recurrence-of-acute-lymphoblastic-leukemia-manifesting-as-serous-retinal-detachments-and-optic-disc-swelling
#13
Ozge Yabas Kiziloglu, Mert Mestanoglu, Ozgun Melike Totuk Gedar, Cafer Adiguzel, Okan Toygar
PURPOSE: The aim of this case report is to describe a patient with acute lymphoblastic leukemia (ALL) who developed bilateral serous retinal detachments and unilateral optic disc swelling. METHODS: A 23-year-old woman with ALL presented to the ophthalmology clinic with bilateral subacute visual loss. RESULTS: Ophthalmologic examination revealed bilateral serous retinal detachments and unilateral optic disc swelling. Magnetic resonance imaging for differential diagnosis was inconclusive; however, cerebrospinal fluid sampling demonstrated leukemic involvement of the central nervous system...
July 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28711766/a-tool-for-automated-diabetic-retinopathy-pre-screening-based-on-retinal-image-computer-analysis
#14
Manuel E Gegundez-Arias, Diego Marin, Beatriz Ponte, Fatima Alvarez, Javier Garrido, Carlos Ortega, Manuel J Vasallo, Jose M Bravo
AIM: This paper presents a methodology and first results of an automatic detection system of first signs of Diabetic Retinopathy (DR) in fundus images, developed for the Health Ministry of the Andalusian Regional Government (Spain). MATERIAL AND METHODS: The system detects the presence of microaneurysms and haemorrhages in retinography by means of techniques of digital image processing and supervised classification. Evaluation was conducted on 1058 images of 529 diabetic patients at risk of presenting evidence of DR (an image of each eye is provided)...
July 8, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28710686/-ophthalmological-assessment-in-the-severely-handicapped-persons-act-and-in-blindness-statement-of-the-professional-association-of-ophthalmologists-germany-the-german-ophthalmological-society-processed-by-the-joint-commission-on-law-status-january-2017
#15
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
July 14, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28709965/sensorimotor-outcomes-in-children-with-prenatal-exposure-to-methadone
#16
Sylvia H Yoo, Lauren M Jansson, Hee-Jung Park
PURPOSE: To report the presentation and characteristics of strabismus in children with prenatal methadone exposure. METHODS: The medical records children with prenatal methadone exposure were retrospectively reviewed. Those who were evaluated by pediatric ophthalmology were included. Information on the timing and types of prenatal exposure by trimester of pregnancy was then collected from the patients' mothers' charts. The children's perinatal histories and ophthalmologic findings were collected from their pediatric clinic charts and ophthalmology clinic charts, respectively...
July 11, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28709412/study-protocol-safety-and-efficacy-of-propranolol-0-2-eye-drops-in-newborns-with-a-precocious-stage-of-retinopathy-of-prematurity-drop-rop-0-2-a-multicenter-open-label-single-arm-phase-ii-trial
#17
Luca Filippi, Giacomo Cavallaro, Elettra Berti, Letizia Padrini, Gabriella Araimo, Giulia Regiroli, Valentina Bozzetti, Chiara De Angelis, Paolo Tagliabue, Barbara Tomasini, Giuseppe Buonocore, Massimo Agosti, Angela Bossi, Gaetano Chirico, Salvatore Aversa, Roberta Pasqualetti, Pina Fortunato, Silvia Osnaghi, Barbara Cavallotti, Maurizio Vanni, Giulia Borsari, Simone Donati, Giuseppe Nascimbeni, Giancarlo la Marca, Giulia Forni, Silvano Milani, Ivan Cortinovis, Paola Bagnoli, Massimo Dal Monte, Anna Maria Calvani, Alessandra Pugi, Eduardo Villamor, Gianpaolo Donzelli, Fabio Mosca
BACKGROUND: Retinopathy of prematurity (ROP) still represents one of the leading causes of visual impairment in childhood. Systemic propranolol has proven to be effective in reducing ROP progression in preterm newborns, although safety was not sufficiently guaranteed. On the contrary, topical treatment with propranolol eye micro-drops at a concentration of 0.1% had an optimal safety profile in preterm newborns with ROP, but was not sufficiently effective in reducing the disease progression if administered at an advanced stage (during stage 2)...
July 14, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28709401/signal-transducer-and-activator-of-transcription-3-stat3-promoter-methylation-and-expression-in-pituitary-adenoma
#18
Indre Valiulyte, Giedrius Steponaitis, Daina Skiriute, Arimantas Tamasauskas, Paulina Vaitkiene
BACKGROUND: Pituitary adenoma (PA) is a benign brain tumor that can cause neurological, endocrinological and ophthalmological aberrations. Till now there is a need to identify factors that can influence the tumor invasiveness and recurrence. The aim of this study was to evaluate the associations between the signal transducer and activator of transcription 3 (STAT3) promoter methylation, mRNA expression and the invasiveness or recurrence of PAs and patient clinical characteristics. METHODS: Study participants comprised of 102 subjects with a diagnosis of PA: 54 functioning and 48 non-functioning, 58 invasive and 30 non-invasive PAs and 14 relapses...
July 14, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28708816/determination-of-the-minimal-clinically-important-difference-of-the-university-of-north-carolina-dry-eye-management-scale
#19
Christopher J Hwang, Reeves Ellis, Richard M Davis, Sue Tolleson-Rinehart
PURPOSE: To establish an initial estimation of the MCID of the University of North Carolina Dry Eye Management Scale (UNC DEMS) and assess its association with patient perceptions of symptom change. METHODS: Thirty-three patients (33.3% men, 67.7% women, mean age 60.5 yrs) with previous DEMS scores were recruited from a UNC ophthalmology clinic in spring 2014. We used anchor-based methods, categorizing important symptom change, to compare the change in the DEMS scores across visits to patient assessments of change; linear regression coefficients estimated the MCID...
July 13, 2017: Cornea
https://www.readbyqxmd.com/read/28708221/rapid-response-to-dexamethasone-intravitreal-implant-in-diabetic-macular-edema
#20
Giuseppe Lo Giudice, Antonio Avarello, Gianluca Campana, Alessandro Galan
PURPOSE: To evaluate the early effects of dexamethasone (DEX) intravitreal implants in patients with diabetic macular edema (DME). METHODS: This was a prospective, single-arm, interventional clinical series. Eighteen patients (18 eyes) with chronic/recalcitrant or naive DME were included. Patients underwent single DEX intravitreal implant. Clinical assessments, including ophthalmologic examination, central retinal thickness (CRT) measurement by spectral-domain optical coherence tomography (SD-OCT) scan, best-corrected visual acuity (BCVA), and intraocular pressure (IOP) were carried out at baseline, 1-3 hours, and then 3, 7, and 30 days after treatment...
July 1, 2017: European Journal of Ophthalmology
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