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https://www.readbyqxmd.com/read/28102882/factors-associated-with-significant-mri-findings-in-medical-walk-in-patients-with-acute-headache
#1
Joris Budweg, Till Sprenger, Anthony De Vere-Tyndall, Anne Hagenkord, Christoph Stippich, Christoph T Berger
QUESTION: Acute headache is a main reason for emergency consultations and can be a symptom of dangerous neurological conditions. We hypothesised that in medical walk-in headache patients with low suspicion of intracranial bleeding significant findings in brain magnetic resonance imaging (MRI) are associated with clinical features. METHODS: Retrospective chart review on medical outpatient referrals for brain MRI (2010-2014) with the chief complaint "acute headache" (duration <4 weeks)...
January 19, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28102598/novel-findings-of-left-ventricular-non-compaction-cardiomyopathy-microform-cleft-lip-and-poor-vision-in-patient-with-smc1a-associated-cornelia-de-lange-syndrome
#2
Tara L Wenger, Penny Chow, Stephanie C Randle, Anna Rosen, Craig Birgfeld, Joanna Wrede, Patrick Javid, Darcy King, Vivian Manh, Anne V Hing, Erin Albers
Relatively few patients with Cornelia de Lange syndrome (CdLS) due to SMC1A mutation have been reported, limiting understanding of the full extent of the phenotype. Compared to children with classic NIPBL-associated CdLS, patients with SMC1A-associated CdLS have a milder physical phenotype with prominent intellectual disability, high rate of cleft palate and absence of limb reductions. We present a patient with SMC1A-associated CdLS who had typical features including developmental delay, seizure disorder, feeding difficulties, hirsutism, and cleft palate...
February 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28101047/acute-anterior-uveitis-in-a-patient-taking-fingolimod-fty720-for-multiple-sclerosis
#3
Heather Gwen Mack, Melissa Chih-Hui Tien, Owen Bruce White
Fingolimod is an oral sphingosine-1-phosphate (S1P) receptor modulator and the first oral therapy for relapsing-remitting multiple sclerosis. Its use has been complicated by a low rate of cystoid macular edema usually in the first 3 months after commencement of the medication. We report the case of a 34-year-old male with relapsing-remitting multiple sclerosis, who developed acute anterior uveitis on day 5 of fingolimod treatment. He responded to appropriate treatment and cessation of drug, but developed low-grade chronic anterior uveitis without cystoid macular edema...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28100481/safety-of-anterior-chamber-paracentesis-using-a-30-gauge-needle-integrated-with-a-specially-designed-disposable-pipette
#4
Koji Kitazawa, Chie Sotozono, Noriko Koizumi, Kenji Nagata, Tsutomu Inatomi, Hiroshi Sasaki, Shigeru Kinoshita
AIMS: To investigate the safety of anterior chamber (AC) paracentesis using a 30-gauge needle integrated with a specially designed disposable pipette. METHODS: In this retrospective observational case-series study, AC paracentesis was performed on 301 eyes of 301 patients between September 2009 and August 2016 at the Department of Ophthalmology, Kyoto Prefectural University of Medicine and the Baptist Eye Institute, Kyoto, Japan. AC paracentesis was performed with the patient placed in the supine position using a 30-gauge needle integrated with a disposable pipette with one hand, and the safety post procedure was then evaluated...
January 18, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28100383/-hiv-antibody-detection-results-in-patients-seeking-medical-care-in-peking-union-medical-college-hospital-2003-2014
#5
X J Song, Z F Qiu, W Cao, J Xie, Z J Zhang, S X Xu, T S Li
Objective: To better understand the infection status of HIV in the patients seeking medical care in Peking Union Medical College Hospital. Methods: The HIV detection data of the patients in the hospital from 2003-2014 were collected for a statistical analysis with software SPSS 19.0. Results: A total of 715 421 patients were screened, and 1 012 (0.14%) patients were HIV positive, and HIV infection were confirmed in 776 (0.11%) patients by Western Blot testing. The detection rate of HIV infection increased from 0...
January 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28099310/national-institutes-of-health-funding-to-departments-of-orthopaedic-surgery-at-u-s-medical-schools
#6
Jason Silvestre, Jaimo Ahn, L Scott Levin
BACKGROUND: The National Institutes of Health (NIH) is the largest supporter of biomedical research in the U.S., yet its contribution to orthopaedic research is poorly understood. In this study, we analyzed the portfolio of NIH funding to departments of orthopaedic surgery at U.S. medical schools. METHODS: The NIH RePORT (Research Portfolio Online Reporting Tools) database was queried for NIH grants awarded to departments of orthopaedic surgery in 2014. Funding totals were determined for award mechanisms and NIH institutes...
January 18, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28099282/risk-factors-for-acanthamoeba-keratitis-a-multistate-case-control-study-2008-2011
#7
Allison C Brown, Jonathan Ross, Daniel B Jones, Sarah A Collier, Tracy L Ayers, Robert M Hoekstra, Bryon Backensen, Sharon L Roy, Michael J Beach, Jonathan S Yoder
OBJECTIVE: To identify modifiable risk factors contributing to Acanthamoeba keratitis (AK) infection. METHODS: A case-control investigation was conducted. Case patients were soft contact lens wearers with laboratory-confirmed AK. Control were soft contact lens wearers ≥12 years of age, with no history of AK. Case patients were recruited from 14 ophthalmology referral centers and a clinical laboratory. Control were matched on state of residence and type of primary eye care provider (ophthalmologist or optometrist)...
January 17, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28099212/dysfunctional-tear-syndrome-dry-eye-disease-and-associated-tear-film-disorders-new-strategies-for-diagnosis-and-treatment
#8
Mark S Milner, Kenneth A Beckman, Jodi I Luchs, Quentin B Allen, Richard M Awdeh, John Berdahl, Thomas S Boland, Carlos Buznego, Joseph P Gira, Damien F Goldberg, David Goldman, Raj K Goyal, Mitchell A Jackson, James Katz, Terry Kim, Parag A Majmudar, Ranjan P Malhotra, Marguerite B McDonald, Rajesh K Rajpal, Tal Raviv, Sheri Rowen, Neda Shamie, Jonathan D Solomon, Karl Stonecipher, Shachar Tauber, William Trattler, Keith A Walter, George O Waring, Robert J Weinstock, William F Wiley, Elizabeth Yeu
Dysfunctional tear syndrome (DTS) is a common and complex condition affecting the ocular surface. The health and normal functioning of the ocular surface is dependent on a stable and sufficient tear film. Clinician awareness of conditions affecting the ocular surface has increased in recent years because of expanded research and the publication of diagnosis and treatment guidelines pertaining to disorders resulting in DTS, including the Delphi panel treatment recommendations for DTS (2006), the International Dry Eye Workshop (DEWS) (2007), the Meibomian Gland Dysfunction (MGD) Workshop (2011), and the updated Preferred Practice Pattern guidelines from the American Academy of Ophthalmology pertaining to dry eye and blepharitis (2013)...
January 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28098730/novel-classification-system-for-combined-hamartoma-of-the-retina-and-retinal-pigment-epithelium
#9
Vaidehi S Dedania, Cem Ozgonul, David N Zacks, Cagri G Besirli
PURPOSE: To develop an anatomical classification scheme for combined hamartoma of the retina and retinal pigment epithelium (RPE) and specify recommendations for follow-up interval. METHODS: Retrospective review of patients with combined hamartoma of the retina and RPE examined during a 7-year period (2008-2015). The clinical presentation, fundus examination, and optical coherence tomography were analyzed. RESULTS: Lesions were classified based on location, fundus features, and optical coherence tomography findings...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28098725/how-vitreomacular-interface-modifies-the-efficacy-of-anti-vegf-therapy-for-myopic-choroidal-neovascularization
#10
Pierluigi Iacono, Maurizio Battaglia Parodi, Lorenzo Iuliano, Francesco Bandello
PURPOSE: To evaluate the efficacy of intravitreal ranibizumab in the treatment of myopic choroidal neovascularization (mCNV) complicated by vitreoretinal interface alterations. METHODS: Thirty-two patients affected by mCNV and concurrent vitreoretinal interface disorders, including macular epiretinal membrane (18 patients), lamellar macular hole (4 patients), full-thickness macular hole (1 patient), broad/focal vitreomacular traction (3 patients), broad/focal vitreomacular adhesion (4 patients), and myopic foveoschisis (2 patients), were enrolled in a prospective study...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28097453/seven-cases-of-localized-invasive-sino-orbital-aspergillosis
#11
Hideaki Kawakami, Kiyofumi Mochizuki, Kyoko Ishida, Kiyofumi Ohkusu
PURPOSE: To describe the clinical manifestations and prognoses in 7 patients with invasive sino-orbital aspergillosis (ISOA). METHODS: This was a retrospective study of consecutive patients who were diagnosed as having ISOA at the Gifu University Hospital and Gifu Municipal Hospital between January 1993 and December 2015. Data were collected on demographics, initial manifestations, examination findings, treatments, clinical course, and outcomes. RESULTS: The median age of the 7 patients with ISOA was 68 years; 5 of them had diabetes...
January 17, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28097083/recurrent-squamous-cell-carcinoma-of-the-eyelid-presenting-as-trigeminal-neuralgia
#12
Nicole Spitzer, Naazli Shaikh, Leah Strickland, Son Ho
This paper describes two patients with squamous cell carcinoma (SCC) of the periocular and periorbital skin who presented with trigeminal neuralgia. Both patients had previous cutaneous SCC of the scalp treated successfully with surgical resection but later presented with neuro-ophthalmic findings suggesting perineural invasion (PNI) of SCC. PNI of SCC in the periocular skin or orbit can lead to devastating effects if malignant cells seed into the orbit and adjacent cranial nerves as our two patients developed an orbital apex syndrome...
December 16, 2016: Curēus
https://www.readbyqxmd.com/read/28096311/the-comparison-of-health-status-between-male-and-female-medical-radiation-workers-in-china
#13
Hui Wang, Qianshu Chen, Guochao Liu, Youjia Tian, Fengmei Zhang, Jianying Qu, David Lim, Zhihui Feng
To assess the health statue of chronically exposed Chinese medical radiation workers. A cross-sectional study of 530 medical radiation workers in a city of China was conducted to document the health status and the monitored annually absorbed doses. Long-term and low-dose radiation exposure can affect a number of health indicators in the individuals, which covered the cardiovascular system, hematologic system, ophthalmology, liver and kidney's functions, chromosome aberration and micronucleus. The differences in the health status between male and female individuals were associated with job types and exposed years of service...
January 16, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28095138/leber-congenital-amaurosis-from-darkness-to-light-an-ode-to-irene-maumenee
#14
Razek Georges Coussa, Irma Lopez Solache, Robert K Koenekoop
This article is dedicated to Irene Hussels-Maumenee, Professor of Human Genetics and Ophthalmology, Johns Hopkins' Wilmer Eye Institute, Ocular Genetics Fellowship director in 1994-1995. Leber congenital amaurosis (LCA) has almost come full circle, from a profound and molecularly uncharacterized form of congenital retinal blindness to one in which a large number of causative genes and disease pathways are known, and the world's first human retinal disease to be treated by gene therapy. Dr. Maumenee's insights, efforts, and leadership have contributed significantly to this remarkable scientific journey...
January 17, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28095086/retinal-findings-and-a-novel-tinf2-mutation-in-revesz-syndrome-clinical-and-molecular-correlations-with-pediatric-retinal-vasculopathies
#15
Mrinali P Gupta, Katherine E Talcott, David Y Kim, Suneet Agarwal, Shizuo Mukai
BACKGROUND: Revesz syndrome is a telomere disorder in the dyskeratosis congenita (DKC) spectrum characterized by exudative retinopathy, bone marrow failure, neuroradiographic abnormalities, and integumentary findings. MATERIALS/METHODS: We report the ophthalmologic findings, documented by examinations under anesthesia with clinical photography and fluorescein angiography, as well as the systemic manifestations and genetic and molecular testing, in identical twins with Revesz syndrome, and compare and contrast these features to those of other pediatric retinal vasculopathies...
January 17, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28094585/relationship-between-plasma-homocysteine-level-and-glaucomatous-retinal-nerve-fiber-layer-defect
#16
Jae Yeun Lee, Joon Mo Kim, In Tae Kim, Chung Kwon Yoo, Yu Sam Won, Jung Hoon Kim, Hyun Seok Kwon, Ki Ho Park
AIMS: To investigate the association between plasma homocysteine levels and glaucomatous retinal nerve fiber layer (RNFL) defect in South Korean population. MATERIALS AND METHODS: This retrospective cross-sectional study included subjects who underwent screening at Kangbuk Samsung Hospital Health Screening Center between August 2012 and July 2013. Subjects underwent physical examination and provided samples for laboratory analysis of homocysteine. Subjects were divided equally into four quartiles (Qs) based on plasma homocysteine level...
January 17, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28094480/anesthetic-complications-during-general-anesthesia-without-intravenous-access-in-pediatric-ophthalmologic-clinic-assessment-of-5216-cases
#17
Chun W Hung, Lauren Licina, David H Abramson, Vittoria Arslan-Carlon
BACKGROUNDː General anesthesia utilizing inhalational agents without intravenous (IV) access for minor procedures is controversial1. Eliminating IV access increases efficiency and patient satisfaction; however, the ability to introduce rapid acting medications into the circulation during an unanticipated emergency becomes challenging. The objective of this study was to examine complication risk following pediatric ophthalmologic examinations under anesthesia (EUA) without IV placement. METHODSː A retrospective review of consecutive pediatric patients who underwent EUA for retinoblastoma management was performed from 2004 to 2014...
January 17, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28094301/the-occurrence-rate-of-acute-onset-postoperative-endophthalmitis-after-cataract-surgery-in-chinese-small-and-medium-scale-departments-of-ophthalmology
#18
Yanan Zhu, Xinyi Chen, Peiqing Chen, Jianjun Wu, Huixia Hua, Ke Yao
Endophthalmitis can be a devastating complication after cataract surgery. Therefore, this study sought to better understand the occurrence rate of acute-onset postoperative endophthalmitis after cataract surgery in Chinese small and medium-scale departments of ophthalmology, as well as identify its risk factors and assess the treatment options. This investigation revealed 52 postoperative endophthalmitis cases in 46,185 operations at 30 hospitals from 2011 to 2013, at an occurrence rate of 0.11%. A small cataract surgery volume of less than 500 cases per year (OR 2...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28094062/-optic-disc-granuloma-secondary-to-sarcoidosis
#19
L Qu-Knafo, A Auregan-Giocanti
We report a case of optic disc granuloma due to sarcoidosis. A 64-year-old, caucasian female with a history of pulmonary sarcoidosis presented with a vision loss on her left eye. The ophthalmologic examination revealed a discrete optic disc infiltrate compatible with the diagnosis of optic disc granuloma. Fluorescein angiography showed diffusion and impregnation of the granuloma without vascularitis. The optical coherence tomography demonstrated a homogenous and isoreflective lesion at the optic disc. The patient recovered her visual acuity after systemic corticosteroid treatment...
January 13, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28094044/diagnosis-and-treatment-of-acute-retinal-necrosis-a-report-by-the-american-academy-of-ophthalmology
#20
Scott D Schoenberger, Stephen J Kim, Jennifer E Thorne, Prithvi Mruthyunjaya, Steven Yeh, Sophie J Bakri, Justis P Ehlers
PURPOSE: To evaluate the available evidence in peer-reviewed publications about the diagnosis and treatment of acute retinal necrosis (ARN). METHODS: Literature searches of the PubMed and Cochrane Library databases were last conducted on July 27, 2016. The searches identified 216 unique citations, and 49 articles of possible clinical relevance were reviewed in full text. Of these 49 articles, 27 were deemed sufficiently relevant or of interest, and they were rated according to strength of evidence...
January 13, 2017: Ophthalmology
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