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https://www.readbyqxmd.com/read/28409003/-collinsella-phocaeensis-sp-nov-clostridium-merdae-sp-nov-sutterella-massiliensis-sp-nov-sutturella-timonensis-sp-nov-enorma-phocaeensis-sp-nov-mailhella-massiliensis-gen-nov-sp-nov-mordavella-massiliensis-gen-nov-sp-nov-and-massiliprevotella-massiliensis-gen
#1
S Ndongo, F Cadoret, G Dubourg, J Delerce, P-E Fournier, D Raoult, J-C Lagier
Here we report of summary of the characteristics of 'Collinsella phocaeensis' strain Marseille-P3245(T) sp. nov., 'Clostridium merdae' strain Marseille-P2953(T), 'Sutterella massiliensis' strain Marseille-P2435(T) sp. nov., 'Sutturella timonensis' strain Marseille-P3282(T) sp. nov., 'Enorma phocaeensis' Marseille-P3242(T) sp. nov., 'Mailhella massiliensis' strain Marseille-P3199(T) gen. nov., sp. nov., 'Mordavella massiliensis' strain Marseille-P3246(T) sp. nov. and 'Massiliprevotella massiliensis' strain Marseille-P2439(T) sp...
May 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/28392784/structure-and-function-of-the-fecal-microbiota-in-diarrheic-neonatal-piglets
#2
Qiaoli Yang, Xiaoyu Huang, Shengguo Zhao, Wenyang Sun, Zunqiang Yan, Pengfei Wang, Shenggui Li, Wangzhou Huang, Shengwei Zhang, Lixia Liu, Shuangbao Gun
Diarrhea is a leading cause of increased mortality in neonatal and young piglets. Aberration of the gut microbiota is one important factor in the etiology of piglet diarrhea. However, information regarding the structure and function of the gut microbiome in diarrheic neonatal piglets is limited. To investigate the composition and functional potential of the fecal microbiota in neonatal piglets, we performed 16S rRNA gene sequencing on 20 fecal samples from diarrheic piglets and healthy controls, and metagenomics sequencing on a subset of six samples...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28382453/metabolic-adaptation-to-the-aqueous-leaf-extract-of-moringa-oleifera-lam-supplemented-diet-is-related-to-the-modulation-of-gut-microbiota-in-mice
#3
Xiaoyu Gao, Qiuhong Xie, Ling Liu, Ping Kong, Jun Sheng, Hongyu Xiang
The aqueous leaf extract of Moringa oleifera Lam. (LM-A) is reported to have many health beneficial bioactivities and no obvious toxicity, but have mild adverse effects. Little is known about the mechanism of these reported adverse effects. Notably, there has been no report about the influence of LM-A on intestinal microecology. In this study, animal experiments were performed to explore the relationships between metabolic adaptation to an LM-A-supplemented diet and gut microbiota changes. After 8-week feeding with normal chow diet, the body weight of mice entered a stable period, and one of the group received daily doses of 750-mg/kg body weight LM-A by gavage for 4 weeks (assigned as LM); the other group received the vehicle (assigned as NCD)...
April 5, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28349974/sex-related-alterations-of-gut-microbiota-composition-in-the-btbr-mouse-model-of-autism-spectrum-disorder
#4
Lorena Coretti, Claudia Cristiano, Ermanno Florio, Giovanni Scala, Adriano Lama, Simona Keller, Mariella Cuomo, Roberto Russo, Raffaela Pero, Orlando Paciello, Giuseppina Mattace Raso, Rosaria Meli, Sergio Cocozza, Antonio Calignano, Lorenzo Chiariotti, Francesca Lembo
Alterations of microbiota-gut-brain axis have been invoked in the pathogenesis of autism spectrum disorders (ASD). Mouse models could represent an excellent tool to understand how gut dysbiosis and related alterations may contribute to autistic phenotype. In this study we paralleled gut microbiota (GM) profiles, behavioral characteristics, intestinal integrity and immunological features of colon tissues in BTBR T + tf/J (BTBR) inbred mice, a well established animal model of ASD. Sex differences, up to date poorly investigated in animal models, were specifically addressed...
March 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28275689/distinct-microbiome-neuroimmune-signatures-correlate-with%C3%A2-functional-abdominal-pain-in-children-with-autism-spectrum-disorder
#5
Ruth Ann Luna, Numan Oezguen, Miriam Balderas, Alamelu Venkatachalam, Jessica K Runge, James Versalovic, Jeremy Veenstra-VanderWeele, George M Anderson, Tor Savidge, Kent C Williams
BACKGROUND & AIMS: Emerging data on the gut microbiome in autism spectrum disorder (ASD) suggest that altered host-microbe interactions may contribute to disease symptoms. Although gut microbial communities in children with ASD are reported to differ from individuals with neurotypical development, it is not known whether these bacteria induce pathogenic neuroimmune signals. METHODS: Because commensal clostridia interactions with the intestinal mucosa can regulate disease-associated cytokine and serotonergic pathways in animal models, we evaluated whether microbiome-neuroimmune profiles (from rectal biopsy specimens and blood) differed in ASD children with functional gastrointestinal disorders (ASD-FGID, n = 14) compared with neurotypical (NT) children with FGID (NT-FGID, n = 15) and without abdominal pain (NT, n = 6)...
March 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28249783/diet-driven-microbiota-dysbiosis-is-associated-with-vagal-remodeling-and-obesity
#6
Tanusree Sen, Carolina R Cawthon, Benjamin Thomas Ihde, Andras Hajnal, Patricia M DiLorenzo, Claire B de La Serre, Krzysztof Czaja
Obesity is one of the major health issues in the United States. Consumption of diets rich in energy, notably from fats and sugars (high-fat/high-sugar diet: HF/HSD) is linked to the development of obesity and a popular dietary approach for weight loss is to reduce fat intake. Obesity research traditionally uses low and high fat diets and there has been limited investigation of the potential detrimental effects of a low-fat/high-sugar diet (LF/HSD) on body fat accumulation and health. Therefore, in the present study, we investigated the effects of HF/HSD and LF/HSD on microbiota composition, gut inflammation, gut-brain vagal communication and body fat accumulation...
May 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28219687/structural-modulation-of-gut-microbiota-during-alleviation-of-antibiotic-associated-diarrhea-with-herbal-formula
#7
Weijie Lv, Cui Liu, Chunxin Ye, Jiaqi Sun, Xiaowen Tan, Chao Zhang, Qian Qu, Dayou Shi, Shining Guo
The gut microbiome is hypothesized to play a critical role in gastrointestinal diseases, including antibiotic-associated diarrhea (AAD). To determine whether the traditional Chinese herbal formula of Shen Ling Bai Zhu San (SLBZS) modulates the composition of the gut microbiome during AAD treatment, an AAD diarrhea model was prepared in rats by gastric gavage with lincomycin for 7 successive days, followed by administration of SLBZS for one week. At all time points after the SLBZS treatment, the diarrhea rates were significantly or at least numerically lower than that of the untreated model group...
February 21, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28197578/chemical-characterization-of-the-glycated-myofibrillar-proteins-from-grass-carp-ctenopharyngodon-idella-and-their-impacts-on-the-human-gut-microbiota-in-vitro-fermentation
#8
Kaining Han, Ye Yao, Shiyuan Dong, Sun Jin, Hang Xiao, Haohao Wu, Mingyong Zeng
In this study, the chemical characterization of glycoconjugates of myofibrillar proteins from grass carp conjugated with glucose via Maillard reaction for up to 24 h of dry-heating was investigated, and their impacts on the microbial community in vitro human fecal fermentation were firstly evaluated by high-throughput sequencing technologies. The glycation greatly increased the furosine levels in glycoconjugates, which reached the maximum level (2.87 ± 0.08 mg per 100 mg protein) for 9 h of heating, and resulted in the structural changes of myofibrillar proteins based on the sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Fourier transform infrared spectroscopy (FTIR) analysis...
February 15, 2017: Food & Function
https://www.readbyqxmd.com/read/28178201/rett-syndrome-a-focus-on-gut-microbiota
#9
Elisa Borghi, Francesca Borgo, Marco Severgnini, Miriam Nella Savini, Maria Cristina Casiraghi, Aglaia Vignoli
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder affecting 1 in 10,000 live female births. Changes in microbiota composition, as observed in other neurological disorders such as autism spectrum disorders, may account for several symptoms typically associated with RTT. We studied the relationship between disease phenotypes and microbiome by analyzing diet, gut microbiota, and short-chain fatty acid (SCFA) production. We enrolled eight RTT patients and 10 age- and sex-matched healthy women, all without dietary restrictions...
February 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28176851/comparative-study-of-the-gut-microbiome-potentially-related-to-milk-protein-in-murrah-buffaloes-bubalus-bubalis-and-chinese-holstein-cattle
#10
Jiachao Zhang, Chuanbiao Xu, Dongxue Huo, Qisong Hu, Qiannan Peng
Previous studies suggested a close relationship between ruminant gut microbes and the mammary gland. In this study, shotgun metagenomic sequencing was used to reveal the differences in the intestinal microbiome potentially related to milk components in Murrah buffaloes and Chinese Holstein cattle. A PCoA based on the weighted Unifrac distances showed an apparent clustering pattern in the structure of intestinal microbiota between buffalo and cattle. We could attribute the structural difference to the genera of Sutterella, Coprococcus and Dorea...
February 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28035686/interaction-between-atypical-antipsychotics-and-the-gut-microbiome-in-a-bipolar-disease-cohort
#11
Stephanie A Flowers, Simon J Evans, Kristen M Ward, Melvin G McInnis, Vicki L Ellingrod
OBJECTIVES: The atypical antipsychotic (AAP) class is often associated with metabolic disease, but the mechanistic underpinnings of this risk are not understood. Due to reports linking gut bacteria function to metabolic disease, we hypothesize that AAP treatment in adults results in gut dysbiosis potentiating metabolic criteria. This report describes recent findings linking AAP treatment with differences in gut microbiota communities in a human cohort with bipolar disorder (BD). METHODS: In a cross-sectional design, we obtained 16S ribosomal sequences from 117 BD patients (49 AAP treated, 68 non-AAP treated)...
March 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/27956653/environmental-enteric-dysfunction-and-the-fecal-microbiota-in-malawian-children
#12
M Isabel Ordiz, Kevin Stephenson, Sophia Agapova, Kristine M Wylie, Ken Maleta, John Martin, Indi Trehan, Phillip I Tarr, Mark J Manary
Environmental enteric dysfunction (EED) is often measured with a dual sugar absorption test and implicated as a causative factor in childhood stunting. Disturbances in the gut microbiota are hypothesized to be a mechanism by which EED is exacerbated, although this supposition lacks support. We performed 16S ribosomal RNA gene sequencing of fecal samples from 81 rural Malawian children with varying degrees of EED to determine which bacterial taxa were associated with EED. At the phyla level, Proteobacteria abundance is reduced with severe EED...
February 8, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27882443/gut-microbiota-and-autism-key-concepts-and-findings
#13
Helen T Ding, Ying Taur, John T Walkup
There is an emerging body of evidence linking the intestinal microbiota with autism spectrum disorders (ASD). Studies have demonstrated differences in the composition of gut bacteria between children with ASD and controls. Certain intestinal bacteria have been observed in abundance and may be involved in the pathogenesis of ASD; including members of the Clostridium and Sutterella genus. Evidence from animal models suggest that certain microbial shifts in the gut may produce changes consistent with the clinical picture of autism, with proposed mechanisms including toxin production, aberrations in fermentation processes/products, and immunological and metabolic abnormalities...
November 24, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27856622/in-vitro-fermentation-of-b-gos-impact-on-faecal-bacterial-populations-and-metabolic-activity-in-autistic-and-non-autistic-children
#14
Roberta Grimaldi, Drinalda Cela, Jonathan R Swann, Jelena Vulevic, Glenn R Gibson, George Tzortzis, Adele Costabile
Children with autism spectrum disorders (ASD) often suffer gastrointestinal problems consistent with imbalances in the gut microbial population. Treatment with antibiotics or pro/prebiotics has been postulated to regulate microbiota and improve gut symptoms, but there is a lack of evidence for such approaches, especially for prebiotics. This study assessed the influence of a prebiotic galactooligosaccharide (B-GOS) on gut microbial ecology and metabolic function using faecal samples from autistic and non-autistic children in an in vitro gut model system...
February 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/27833600/mucosal-prevalence-and-interactions-with-the-epithelium-indicate-commensalism-of-sutterella-spp
#15
Kaisa Hiippala, Veera Kainulainen, Marko Kalliomäki, Perttu Arkkila, Reetta Satokari
Sutterella species have been frequently associated with human diseases, such as autism, Down syndrome, and inflammatory bowel disease (IBD), but the impact of these bacteria on health still remains unclear. Especially the interactions of Sutterella spp. with the host are largely unknown, despite of the species being highly prevalent. In this study, we addressed the interaction of three known species of Sutterella with the intestinal epithelium and examined their adhesion properties, the effect on intestinal barrier function and the pro-inflammatory capacity in vitro...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27744637/bacteriological-analysis-of-saliva-from-partially-or-fully-engorged-female-adult-rhipicephalus-microplus-by-next-generation-sequencing
#16
Liangliang Xiang, Błażej Poźniak, Tian-Yin Cheng
Tick-borne diseases are a major epidemiological problem worldwide. The aim of this study was to investigate the bacterial composition of saliva obtained from engorged adult Rhipicephalus microplus females. Saliva samples collected from partially or fully engorged adult female ticks were analysed using an ultra-high-throughput Illumina HiSeq 2500 sequencing system. To elucidate the possible routes of bacterial transmission, the bacterial flora from whole ticks were also investigated. Proteobacteria, Firmicutes, and Actinobacteria were the predominant phyla in all samples, and Acinetobacter, Rickettsia, Escherichia and Coxiella were the major genera...
January 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/27681875/neuropeptide-y-overexpressing-female-and-male-mice-show-divergent-metabolic-but-not-gut-microbial-responses-to-prenatal-metformin-exposure
#17
Henriikka Salomäki-Myftari, Laura H Vähätalo, Liisa Ailanen, Sami Pietilä, Asta Laiho, Arno Hänninen, Juha-Pekka Pursiheimo, Eveliina Munukka, Anniina Rintala, Eriika Savontaus, Ullamari Pesonen, Markku Koulu
BACKGROUND: Prenatal metformin exposure has been shown to improve the metabolic outcome in the offspring of high fat diet fed dams. However, if this is evident also in a genetic model of obesity and whether gut microbiota has a role, is not known. METHODS: The metabolic effects of prenatal metformin exposure were investigated in a genetic model of obesity, mice overexpressing neuropeptide Y in the sympathetic nervous system and in brain noradrenergic neurons (OE-NPYDβH)...
2016: PloS One
https://www.readbyqxmd.com/read/27611781/urinary-microbiota-associated-with-preterm-birth-results-from-the-conditions-affecting-neurocognitive-development-and-learning-in-early-childhood-candle-study
#18
Nicholas J Ollberding, Eszter Völgyi, Maurizio Macaluso, Ranjit Kumar, Casey Morrow, Frances A Tylavsky, Chandrika J Piyathilake
Preterm birth (PTB) is the leading cause of infant morbidity and mortality. Genitourinary infection is implicated in the initiation of spontaneous PTB; however, examination of the urinary microbiota in relation to preterm delivery using next-generation sequencing technologies is lacking. In a case-control study nested within the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) study, we examined associations between the urinary microbiota and PTB. A total of 49 cases (delivery < 37 weeks gestation) and 48 controls (delivery ≥ 37 weeks gestation) balanced on health insurance type were included in the present analysis...
2016: PloS One
https://www.readbyqxmd.com/read/27569192/consumption-of-a-high-fat-diet-alters-the-seminal-fluid-and-gut-microbiomes-in-male-mice
#19
Angela B Javurek, William G Spollen, Sarah A Johnson, Nathan J Bivens, Karen H Bromert, Scott A Givan, Cheryl S Rosenfeld
Our prior work showed that a novel microbiome resides in the seminal vesicles of wild-type and oestrogen receptor α (Esr1) knock-out mice and is impacted by the presence of functional Esr1 genes. The seminal fluid microbiome (SFM) may influence the health and reproductive status of the male, along with that of his partner and offspring. A high-fat diet (HFD) alters metabolites and other factors within seminal fluid and might affect the SFM. Adult (~15 weeks old) male mice were placed for 4 weeks on a control or high-fat diet and seminal fluid and fecal samples were collected, bacterial DNA isolated and subjected to 16s rRNA sequencing...
August 29, 2016: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/27352007/alterations-of-the-human-gut-microbiome-in-multiple-sclerosis
#20
Sushrut Jangi, Roopali Gandhi, Laura M Cox, Ning Li, Felipe von Glehn, Raymond Yan, Bonny Patel, Maria Antonietta Mazzola, Shirong Liu, Bonnie L Glanz, Sandra Cook, Stephanie Tankou, Fiona Stuart, Kirsy Melo, Parham Nejad, Kathleen Smith, Begüm D Topçuolu, James Holden, Pia Kivisäkk, Tanuja Chitnis, Philip L De Jager, Francisco J Quintana, Georg K Gerber, Lynn Bry, Howard L Weiner
The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis (MS, n=60) and healthy controls (n=43). Microbiome alterations in MS include increases in Methanobrevibacter and Akkermansia and decreases in Butyricimonas, and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes...
June 28, 2016: Nature Communications
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