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https://www.readbyqxmd.com/read/29041913/detrimental-effects-of-specific-periodontopathic-bacterial-infection-on-tachyarrhythmia-compared-to-bradyarrhythmia
#1
Norio Aoyama, Jun-Ichi Suzuki, Naho Kobayashi, Tomoya Hanatani, Norihiko Ashigaki, Asuka Yoshida, Yuka Shiheido, Hiroki Sato, Hidetoshi Kumagai, Yuichi Ikeda, Hiroshi Akazawa, Issei Komuro, Masato Minabe, Yuichi Izumi, Mitsuaki Isobe
BACKGROUND: Tachyarrhythmia (TA) and bradyarrhythmia (BA) are cardiac rhythm disorders that result in the decline of quality of life. While patients with periodontitis are at a high risk of cardiovascular disease (CVD), little causal information between TA and BA has been provided to date. To assess the relationship, periodontal bacterial infection in patients with TA or BA was evaluated. METHODS: The subjects were patients with TA (n = 98) or BA (n = 40) who attended Tokyo Medical and Dental University hospital...
October 17, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29038457/bacteriome-genetic-structures-of-urban-deposits-are-indicative-of-their-origin-and-impacted-by-chemical-pollutants
#2
Romain Marti, Céline Bécouze-Lareure, Sébastien Ribun, Laurence Marjolet, Claire Bernardin Souibgui, Jean-Baptiste Aubin, Gislain Lipeme Kouyi, Laure Wiest, Didier Blaha, Benoit Cournoyer
Urban activities generate surface deposits over impervious surfaces that can represent ecological and health hazards. Bacteriome genetic structures of deposits washed off during rainfall events, over an urban industrial watershed, were inferred from 16 S rRNA gene (rrs) sequences generated by high throughput sequencing. Deposits were sampled over a 4 year-period from a detention basin (DB). Major shifts, matching key management practices, in the structure of these urban bacteriomes, were recorded. Correlation analyses of rrs similarities between samples and their respective concentrations in chemical pollutants, markers of human fecal contaminations (HF183) and antimicrobial resistances (integrons), were performed...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038128/microbial-composition-predicts-genital-tract-inflammation-and-persistent-bacterial-vaginosis-in-adolescent-south-african-women
#3
Katie Lennard, Smritee Dabee, Shaun L Barnabas, Enock Havyarimana, Anna Blakney, Shameem Z Jaumdally, Gerrit Botha, Nonhlanhla N Mkhize, Linda-Gail Bekker, David A Lewis, Glenda Gray, Nicola Mulder, Jo-Ann S Passmore, Heather B Jaspan
Young African females are at increased risk of HIV acquisition, and genital inflammation or the vaginal microbiome may contribute to this risk. We studied these factors in 168 HIV negative South African adolescent women aged 16-22 years. Unsupervised clustering of 16S rRNA gene sequences revealed three clusters (subtypes), one of which was strongly associated with genital inflammation. In a multivariate model, microbiome compositional subtype and hormonal contraception were significantly associated with genital inflammation...
October 16, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29035946/role-of-the-lung-microbiome-in-hiv-pathogenesis
#4
Meera K Shenoy, Susan V Lynch
PURPOSE OF REVIEW: The purpose of this review is to summarize recent findings on the lung microbiome in HIV-infected patients and associated pulmonary diseases, and the relationship of airway microbial communities to metabolic and immune signatures within this patient population. RECENT FINDINGS: The lung microbiome in HIV infection is a relatively new and rapidly developing field; early studies in the field produced inconclusive evidence as to whether HIV-infection changes the lower airway microbiome...
October 14, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29035085/lung-microbiota-is-related-to-smoking-status-and-to-development-of-ards-in-critically-ill-trauma-patients
#5
Ariane R Panzer, Susan V Lynch, Chaz Langelier, Jason D Christie, Kathryn McCauley, Mary Nelson, Christopher K Cheung, Neal L Benowitz, Mitchell J Cohen, Carolyn S Calfee
RATIONALE: Cigarette smoking is associated with increased risk of acute respiratory distress syndrome (ARDS) in patients following severe trauma; however, mechanisms underlying this association are unknown. OBJECTIVES: To determine whether cigarette smoking contributes to ARDS development following trauma by altering community composition of the lung microbiota Methods: We studied lung microbiota of mechanically ventilated patients admitted to the intensive care unit (ICU) following severe blunt trauma using 16S rRNA gene amplicon sequencing of endotracheal aspirate (ETA) samples obtained upon ICU admission (n=74) and at 48 hours post-admission (n=30)...
October 16, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29034108/intestinal-microbiota-changes-in-mice-lacking-pituitary-adenylate-cyclase-activating-polypeptide-pacap-bifidobacteria-make-the-difference
#6
Markus M Heimesaat, Gernot Reifenberger, Viktoria Vicena, Anita Illes, Gabriella Horvath, Andrea Tamas, Balazs D Fulop, Stefan Bereswill, Dora Reglodi
Pituitary adenylate cyclase activating polypetide (PACAP) constitutes a neuropeptide that is widely distributed in the host exerting essential cytoprotective properties, whereas PACAP(-/-) mice display increased susceptibility to distinct immunopathological conditions. The orchestrated interplay between the gut microbiota and the host is pivotal in immune homeostasis and resistance to disease. Potential pertubations of the intestinal microbiota in PACAP(-/-) mice, however, have not been addressed so far. For the first time, we performed a comprehensive survey of the intestinal microbiota composition in PACAP(-/-) and wildtype (WT) mice starting 2 weeks postpartum until 18 months of age applying quantitative culture-independent techniques...
September 2017: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/29031240/colonization-of-oropharynx-and-lower-respiratory-tract-in-critical-patients-risk-of-ventilator-associated-pneumonia
#7
Ivany Machado de Carvalho Baptista, Frederico Canato Martinho, Gustavo Giacomelli Nascimento, Carlos Eduardo da Rocha Santos, Renata Falchete do Prado, Marcia Carneiro Valera
OBJECTIVE: To investigate the microbial diversity existing in oral cavity and respiratory tract samples (from mini-bronchoalveolar lavage (BAL), endotracheal aspirate, and orotracheal tube) of patients on mechanical ventilation by using the checkerboard DNA-DNA hybridisation. Also, the study aimed to evaluate whether the microbial profile in the oral cavity is found in respiratory tract samples, at different periods of mechanical ventilation time (12h, 48h, 96h) in attempt to identification of relationship between VAP (ventilator-associated pneumonia) and bacterial species studied...
October 2, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29029398/dietary-zno-nanoparticles-alters-intestinal-microbiota-and-inflammation-response-in-weaned-piglets
#8
Tian Xia, Wenqing Lai, Miaomiao Han, Meng Han, Xi Ma, Liying Zhang
The present study was carried out to determine whether low dose of zinc oxide nanoparticles (Nano-ZnO) could serve as a potential substitute of pharmacological dose of traditional ZnO in weaned piglets. 180 crossbred weaning piglets were randomly assigned to 3 treatments. Experimental animals were fed basal diet supplemented with 0 mg Zn/kg (Control), 600 mg Zn/kg (Nano-ZnO) and 2000 mg Zn/kg (ZnO) for 14 days. On day 14 after weaning, the piglets fed Nano-ZnO did not differ from those fed traditional ZnO in growth performance and jejunal morphology, while Nano-ZnO treatment could significantly alleviate the incidence of diarrhea (P < 0...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29026700/relationship-between-the-remaining-dentin-thickness-and-coronal-pulp-status-of-decayed-primary-molars
#9
Roula Berbari, Hussein Fayyad-Kazan, Mohamad Ezzedine, Mohammad Fayyad-Kazan, Daniel Bandon, Elia Sfeir
AIMS AND OBJECTIVES: The aim of this study was to assess the correlation between the remaining dentin thickness (RDT) in deep decayed primary molars and the inflammatory status and bacterial composition of the corresponding coronal pulp. We hypothesized that RDT could be used as a reference for clinicians in assigning the indication for pulpotomy. MATERIALS AND METHODS: Pulpotomies were conducted on the cameral pulp of 48 primary molars. Microorganisms, such as Lactobacillus sp...
September 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29026604/transglucosidase-improves-the-bowel-movements-in-type-2-diabetes-mellitus-patients-a-preliminary-randomized-double-blind-placebo-controlled-study
#10
Akihiro Shimozato, Makoto Sasaki, Naotaka Ogasawara, Yasushi Funaki, Masahide Ebi, Chiho Goto, Satoshi Koikeda, Takashi Joh, Kunio Kasugai
BACKGROUND: Recent studies have highlighted the relationship between gut microbiota and bowel movements. OBJECTIVE: We aimed to evaluate transglucosidase treatment efficacy for bowel movements in patients with type 2 diabetes mellitus and to clarify the relationship between bowel movements, dietary habits, gut microbiota and fecal short-chain fatty acids. METHODS: In this randomized double-blind, placebo-controlled study, 66 patients received placebo or transglucosidase (300 or 900 mg/day) orally, for 12 weeks...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29023524/polymorphism-il-1rn-rs419598-reduces-the-susceptibility-to-generalized-periodontitis-in-a-population-of-european-descent
#11
Francisco Mesa, Esperanza Lanza, Llenalia García, Rafael Marfil-Alvarez, Antonio Magan-Fernandez
Interleukin (IL) 1-ra is a potent endogenous competitive inhibitor of IL-α and β and has an anti-inflammatory role. Study objectives were: 1) to assess the associations of IL-1RN genetic single nucleotide polymorphism (SNP) (rs419598) with generalized chronic periodontitis (GCP), generalized aggressive periodontitis (GAgP), and absence of periodontitis and 2) to assess its association with the load of five periodontopathogenic bacteria and periodontal clinical variables. A cross-sectional analytic study was conducted in 123 patients with GCP, 60 patients with GAgP, and 20 controls...
2017: PloS One
https://www.readbyqxmd.com/read/28993327/in-vitro-activity-of-pexiganan-and-10-comparator-antimicrobials-against-502-anaerobic-isolates-recovered-from-skin-and-skin-structure-infections-sssi
#12
Ellie J C Goldstein, Diane M Citron, Kerin L Tyrrell, Eliza S Leoncio
Pexiganan, a cationic peptide, exhibited a broad range of anti-anaerobic antimicrobial activity. MIC90s were as follows: B. fragilis, 16 μg/ml; other Bacteroidesfragilis group spp., 4 μg/ml; Prevotella and Fusobacterium spp., 32 μg/ml; and Porphyromonas spp., 64 μg/ml; P. acnes, 4 μg/ml; E. lenta and P. anaerobius, 32 μg/ml; other Gram-positive rods and cocci, 4 μg/ml; Clostridium perfringens, 128 μg/ml; and other clostridia, 256 μg/ml. Pexiganan cream shows potential as adjunctive therapy for SSSIs involving anaerobes...
October 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28989139/prevalence-of-periodontal-destruction-and-putative-periodontal-pathogens-in-the-same-lebanese-family
#13
Zoubeida Al Yahfoufi
AIM: Periodontal diseases are associated with microorganisms rich in Gram-negative species. Several studies have indicated the presence of few a periodontopathic microorganisms in the same family. A parent with severe adult periodontitis, who is infected with bacteria associated with periodontal disease, may function as a source of infection. Their children may be at a greater risk to become colonized with bacteria. The purpose of this investigation was (1) to explore the presence of three bacteria, such as Porphyromonas gingivalis (PG), Prevotella intermedia (PI), and Aggregatibacter actinomycetemcomitans (AA) in the same Lebanese family and (2) to study the clinical destruction in the same family and their relations as members of this family due to the presence of PG...
October 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28988196/the-oral-microbiota-in-colorectal-cancer-is-distinctive-and-predictive
#14
Burkhardt Flemer, Ryan D Warren, Maurice P Barrett, Katryna Cisek, Anubhav Das, Ian B Jeffery, Eimear Hurley, Micheal O'Riordain, Fergus Shanahan, Paul W O'Toole
BACKGROUND AND AIMS: Microbiota alterations are linked with colorectal cancer (CRC) and notably higher abundance of putative oral bacteria on colonic tumours. However, it is not known if colonic mucosa-associated taxa are indeed orally derived, if such cases are a distinct subset of patients or if the oral microbiome is generally suitable for screening for CRC. METHODS: We profiled the microbiota in oral swabs, colonic mucosae and stool from individuals with CRC (99 subjects), colorectal polyps (32) or controls (103)...
October 7, 2017: Gut
https://www.readbyqxmd.com/read/28987726/inhibition-of-malodorous-gas-formation-by-oral-bacteria-with-cetylpyridinium-and-zinc-chloride
#15
Jeong Hyun Kang, Dae Jeong Kim, Bong Kyu Choi, Ji Woon Park
OBJECTIVE: The antimicrobial efficacy of zinc- (ZnCl2) and cetylpyridinium-chloride (CPC) and their inhibition capacity on volatile sulfur compound (VSC) production by oral bacterial strains were investigated. DESIGN: Minimum inhibitory concentrations (MIC) and growth curves were determined for ZnCl2, CPC, and CPC with ZnCl2 solutions against eight oral microorganisms (Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, Prevotella intermedia, Treponema denticola, Tannerella forsythia, Staphylococcus aureus and Streptococcus mutans) known to be involved in the pathophysiology of both halitosis and periodontal disease...
September 28, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28983469/population-genomic-insights-into-variation-in-prevotella-intermedia-and-prevotella-nigrescens-isolates-and-its-association-with-periodontal-disease
#16
Yifei Zhang, Min Zhen, Yalin Zhan, Yeqing Song, Qian Zhang, Jinfeng Wang
High-throughput sequencing has helped to reveal the close relationship between Prevotella and periodontal disease, but the roles of subspecies diversity and genomic variation within this genus in periodontal diseases still need to be investigated. We performed a comparative genome analysis of 48 Prevotella intermedia and Prevotella nigrescens isolates that from the same cohort of subjects to identify the main drivers of their pathogenicity and adaptation to different environments. The comparisons were done between two species and between disease and health based on pooled sequences...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28976454/the-gut-and-its-microbiome-as-related-to-central-nervous-system-functioning-and-psychological-well-being-introduction-to-the-special-issue-of-psychosomatic-medicine
#17
Emeran A Mayer, Elaine Y Hsiao
Accumulating evidence indicates bidirectional associations between the brain and the gut microbiome with both top-down and bottom-up processes. This article describes new developments in brain-gut interactions as an introduction to a special issue of Psychosomatic Medicine, based on a joint symposium of the American Psychosomatic Society and the American Gastroenterological Association. Literature review articles indicate that several psychiatric disorders are associated with altered gut microbiota, whereas evidence linking functional gastrointestinal disorders and dysbiosis has not been firmly established...
October 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28970732/ketogenic-diet-poses-a-significant-effect-on-imbalanced-gut-microbiota-in-infants-with-refractory-epilepsy
#18
Gan Xie, Qian Zhou, Chuang-Zhao Qiu, Wen-Kui Dai, He-Ping Wang, Yin-Hu Li, Jian-Xiang Liao, Xin-Guo Lu, Su-Fang Lin, Jing-Hua Ye, Zhuo-Ya Ma, Wen-Jian Wang
AIM: To investigate whether patients with refractory epilepsy and healthy infants differ in gut microbiota (GM), and how ketogenic diet (KD) alters GM. METHODS: A total of 14 epileptic and 30 healthy infants were recruited and seizure frequencies were recorded. Stool samples were collected for 16S rDNA sequencing using the Illumina Miseq platform. The composition of GM in each sample was analyzed with MOTHUR, and inter-group comparison was conducted by R software...
September 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28968427/evolution-in-fecal-bacterial-viral-composition-in-infants-of-two-central-african-countries-gabon-and-republic-of-the-congo-during-their-first-month-of-life
#19
Lionel Brazier, Eric Elguero, Claudine Kombila Koumavor, Nicolas Renaud, Franck Prugnolle, Frédéric Thomas, Simon Ategbo, Moyen Engoba, Obengui, Eric M Leroy, Patrick Durand, François Renaud, Pierre Becquart
Few studies have analyzed the gut microbiota of child in unindustrialized countries, but none during the first month of life. Stool samples were collected from healthy newborns in hospitals of Gabon (n = 6) and Republic of the Congo (n = 9) at different time points during the first month of life: meconium, day 2 (D02), day 7 (D07) and day 28 (D28). In addition, one fecal sample was collected from each mother after delivery. Metagenomic sequencing was performed to determine the bacterial communities, and multiplex real-time PCR was used to detect the presence of seven enteric viruses (rotavirus a, adenovirus, norovirus I and II, sapovirus, astrovirus, enterovirus) in these samples...
2017: PloS One
https://www.readbyqxmd.com/read/28966614/detection-of-increased-plasma-interleukin-6-levels-and-prevalence-of-prevotella-copri-and-bacteroides-vulgatus-in-the-feces-of-type-2-diabetes-patients
#20
Aline Zazeri Leite, Nathália de Campos Rodrigues, Marina Ignácio Gonzaga, João Carlos Cicogna Paiolo, Carolina Arantes de Souza, Nadine Aparecida Vicentini Stefanutto, Wellington Pine Omori, Daniel Guariz Pinheiro, João Luiz Brisotti, Euclides Matheucci Junior, Vânia Sammartino Mariano, Gislane Lelis Vilela de Oliveira
Intestinal dysbiosis and metabolic endotoxemia have been associated with metabolic disorders, such as obesity, insulin resistance, and type 2 diabetes (T2D). The main goal of the present study was to evaluate the intestinal dysbiosis in Brazilian T2D patients and correlate these data with inflammatory cytokines and lipopolysaccharides (LPS) plasma concentrations. This study was approved by the Ethics Committees from Barretos Cancer Hospital and all individuals signed the informed consent form. Stool samples were required for DNA extraction, and the V3/V4 regions of bacterial 16S were sequenced using an Illumina platform...
2017: Frontiers in Immunology
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