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https://read.qxmd.com/read/37997293/methylene-c-sp3-h-arylation%C3%A2-enables-the-stereoselective-synthesis-and-structure-revision-of-indidene-natural-products
#1
JOURNAL ARTICLE
Anton Kudashev, Stefania Vergura, Marco Zuccarello, Thomas Bürgi, Olivier Baudoin
The divergent synthesis of two indane polyketides of the indidene family, namely (±)-indidene A (11 steps, 1.7%) and (+)-indidene C (13 steps, 1.3%), is reported. The synthesis of the trans-configured common indane intermediate was enabled by Pd0-catalyzed methylene C(sp3)-H arylation, which was performed in both racemic and enantioselective (e.r. >99:1) modes. Further elaboration of this common intermediate by Ni-catalyzed dehydrogenative coupling allowed the rapid installation of the aroyl moiety of (±)-indidene A...
November 23, 2023: Angewandte Chemie
https://read.qxmd.com/read/27704822/structural-characterization-and-assessment-of-the-cytotoxicity-of-2-3-dihydro-1h-indene-derivatives-and-coumarin-glucosides-from-the-bark-of-streblus-indicus
#2
JOURNAL ARTICLE
Ruijie He, Xishan Huang, Yanjun Zhang, Liangdeng Wu, Hui Nie, Dexiong Zhou, Buming Liu, Shengping Deng, Ruiyun Yang, Shuai Huang, Zhijie Nong, Jun Li, Yan Huang
A pair of enantiomers and a pair of 2,3-dihydro-1H-indene epimers, rac-indidene A (rac-1), indidenes B and C (2, 3); four new coumarin glucosides (4-7); and four known coumarin glucosides (8-11) were isolated from the bark of Streblus indicus (Bur.) Corner. The structures of 1-11 were defined by physical data analyses, including MS, NMR, and single-crystal X-ray diffraction. The absolute configurations of the 2,3-dihydro-1H-indene derivatives were defined via experimental and calculated ECD data. rac-Indidene A and indidenes B and C showed inhibitory activity against A549 and MCF-7 tumor cells with IC50 values in the range of 2...
October 28, 2016: Journal of Natural Products
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