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Ruijie He, Xishan Huang, Yanjun Zhang, Liangdeng Wu, Hui Nie, Dexiong Zhou, Buming Liu, Shengping Deng, Ruiyun Yang, Shuai Huang, Zhijie Nong, Jun Li, Yan Huang
A pair of enantiomers and a pair of 2,3-dihydro-1H-indene epimers, rac-indidene A (rac-1), indidenes B and C (2, 3); four new coumarin glucosides (4-7); and four known coumarin glucosides (8-11) were isolated from the bark of Streblus indicus (Bur.) Corner. The structures of 1-11 were defined by physical data analyses, including MS, NMR, and single-crystal X-ray diffraction. The absolute configurations of the 2,3-dihydro-1H-indene derivatives were defined via experimental and calculated ECD data. rac-Indidene A and indidenes B and C showed inhibitory activity against A549 and MCF-7 tumor cells with IC50 values in the range of 2...
October 5, 2016: Journal of Natural Products
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