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https://www.readbyqxmd.com/read/28749035/comparison-between-target-mri-in-gantry-and-cognitive-target-transperineal-or-transrectal-guided-prostate-biopsies-for-pirads-3-5-mri-lesions
#1
A J Yaxley, J W Yaxley, I Thangasamy, E Ballard, M Pokorny
OBJECTIVE: To compare the detection rates of prostate cancer in men with PIRADS 3-5 abnormalities on 3T mpMRI using in-bore MRI guided biopsy (MRGB) compared to cognitively directed transperineal biopsy (cTP) and transrectal (cTRUS). METHODS: This is a retrospective single centre study of consecutive men attending the private practice clinic of an experienced urologist performing MRGB and an experienced urologist performing cTP and cTRUS biopsy techniques for PIRADS 3-5 lesions identified on 3T mpMRI...
July 27, 2017: BJU International
https://www.readbyqxmd.com/read/28748318/surgical-outcome-of-wide-wedge-resection-in-poor-risk-patients-with-clinical-n0-non-small-cell-lung-cancer
#2
Hiroaki Tsunezuka, Daishiro Kato, Satoru Okada, Tatsuo Furuya, Junichi Shimada, Masayoshi Inoue
OBJECTIVE: Sublobar resection is practically indicated in poor-risk patients compromised cardiopulmonary reserve or for small ground-glass opacity-dominant adenocarcinomas. The aim of this study was to clarify the surgical outcomes of wide wedge resection in poor-risk patients with clinical-N0 non-small cell lung cancers. METHODS: Sixty-two poor-risk patients, who underwent wedge resection for clinical-N0 lung cancer, were retrospectively reviewed. We defined the ratio of the maximum diameter of the consolidation to the maximum tumour diameter as the consolidation-to-tumour ratio using high-resolution computed tomography...
July 26, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28748128/diagnosis-of-upper-quadrant-lymphedema-secondary-to-cancer-clinical-practice-guideline-from-the-oncology-section-of-apta
#3
Kimberly Levenhagen, Claire Davies, Marisa Perdomo, Kathryn Ryans, Laura Gilchrist
INTRODUCTION: The Oncology Section of APTA developed a clinical practice guideline to aid the clinician in diagnosing secondary upper-quadrant cancer-related lymphedema. METHODS: Following a systematic review of published studies and a structured appraisal process, recommendations were written to guide the physical therapist and other health care clinicians in their diagnostic process. Overall, clinical practice recommendations were formulated on the basis of the evidence for each diagnostic method and were assigned a grade based on the strength of the evidence for different patient presentations and clinical utility...
July 2017: Rehabilitation Oncology
https://www.readbyqxmd.com/read/28748105/a-feasibility-study-of-the-mini-after-telephone-intervention-for-the-management-of-fear-of-recurrence-in-breast-cancer-survivors-a-mixed-methods-study-protocol
#4
Susanne Cruickshank, Emma Steel, Deborah Fenlon, Jo Armes, Karen Scanlon, Elspeth Banks, Gerald Humphris
BACKGROUND: Fear of recurrence (FoR) is a major concern for patients following treatment for primary breast cancer, affecting 60-99% of breast cancer survivors. Mini-AFTER is a brief intervention developed to address this fear, that breast care nurses are ideally placed to deliver. However, their interest in delivering such an intervention is unknown and crucial to its introduction. This study aims to assess the perceived feasibility of the Mini-AFTER telephone intervention for implementation by breast care nurses to manage moderate levels of fear of recurrence among breast cancer survivors...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28747931/is-the-national-guideline-clearinghouse-a-trustworthy-source-of-practice-guidelines-for-child-and-youth-anxiety-and-depression
#5
Stephanie Duda, Christine Fahim, Peter Szatmari, Kathryn Bennett
OBJECTIVE: Innovative strategies that facilitate the use of high quality practice guidelines (PG) are needed. Accordingly, repositories designed to simplify access to PGs have been proposed as a critical component of the network of linked interventions needed to drive increased PG implementation. The National Guideline Clearinghouse (NGC) is a free, international online repository. We investigated whether it is a trustworthy source of child and youth anxiety and depression PGs. METHOD: English language PGs published between January 2009 and February 2016 relevant to anxiety or depression in children and adolescents (≤ 18 years of age) were eligible...
July 2017: Journal of the Canadian Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28747769/response-of-cotton-phenology-to-climate-change-on-the-north-china-plain-from-1981-to-2012
#6
Zhanbiao Wang, Jing Chen, Fangfang Xing, Yingchun Han, Fu Chen, Lifeng Zhang, Yabing Li, Cundong Li
To identify countermeasures for the impacts of climate change on crop production, exploring the changes in crop phenology and their relationship to climate change is required. This study was based on cotton phenology and climate data collected from 13 agro-meteorological experimental stations and 13 meteorological stations on the North China Plain from 1981 to 2012. Spatiotemporal trends in the cotton phenology data, lengths of the different growing phases, mean temperatures, and rainfall were analyzed. These results indicated that warming accelerated cotton growth, advanced cotton phenology, and shortened the growing period of cotton...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747254/simulation-of-elution-profiles-in-liquid-chromatography-ii-investigation-of-injection-volume-overload-under-gradient-elution-conditions-applied-to-second-dimension-separations-in-two-dimensional-liquid-chromatography
#7
Dwight R Stoll, Ray W Sajulga, Bryan N Voigt, Eli J Larson, Lena N Jeong, Sarah C Rutan
An important research direction in the continued development of two-dimensional liquid chromatography (2D-LC) is to improve the detection sensitivity of the method. This is especially important in applications where injection of large volumes of effluent from the first dimension ((1)D) column into the second dimension ((2)D) column leads to severe (2)D peak broadening and peak shape distortion. For example, this is common when coupling two reversed-phase columns and the organic solvent content of the (1)D mobile phase overwhelms the (2)D column with each injection of (1)D effluent, leading to low resolution in the second dimension...
July 12, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28746860/integrating-rna-sequencing-into-neuro-oncology-practice
#8
REVIEW
David S Rogawski, Nicholas A Vitanza, Angela C Gauthier, Vijay Ramaswamy, Carl Koschmann
Malignant tumors of the central nervous system (CNS) cause substantial morbidity and mortality, yet efforts to optimize chemo- and radiotherapy have largely failed to improve dismal prognoses. Over the past decade, RNA sequencing (RNA-seq) has emerged as a powerful tool to comprehensively characterize the transcriptome of CNS tumor cells in one high-throughput step, leading to improved understanding of CNS tumor biology and suggesting new routes for targeted therapies. RNA-seq has been instrumental in improving the diagnostic classification of brain tumors, characterizing oncogenic fusion genes, and shedding light on intratumor heterogeneity...
July 8, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28746497/revealing-an-hiv-diagnosis-for-children-and-adolescents-subsidy-for-the-practice-of-care
#9
Bruna Pase Zanon, Cristiane Cardoso de Paula, Stela Maris de Mello Padoin
Objective: To collectively build a guide for following-up on HIV diagnosis disclosure to children and adolescents in a specialized service. Method: Convergent-care research approach with observation triangulation, interview and groups, conducted from May to June 2015 with seven health professionals in a pediatric outpatient clinic for infectious diseases. Thematic content analysis was developed. Results: The discussion of understanding the disclosure, its triggers, actors involved, used strategies, and limits and possibilities listed by the professionals subsidized the construction of a guide to be applied in the stages: analyzing children's questions and curiosities; evaluating their cognitive ability; discussing the reasons to reveal; listing the professionals involved on follow-up process; including family; developing strategies for disclosure...
July 20, 2017: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/28746271/facial-assessment-and-injection-guide-for-botulinum-toxin-and-injectable-hyaluronic-acid-fillers-focus-on-the-upper-face
#10
Maurício de Maio, Arthur Swift, Massimo Signorini, Steven Fagien
Techniques for the administration of injectable fillers and neuromodulators for facial aesthetic rejuvenation and enhancement continue to evolve. As the number of physicians with limited experience in providing aesthetic treatments expands, the need for guidance and training from more experienced injectors has become apparent. The use of a slow, careful, and methodical injection technique is imperative in all treatment settings and for all facial areas. Constant attention to local anatomy, particularly arteries, veins, and nerve bundles, is critical for minimizing complications...
August 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28746073/medicine-as-a-community-of-practice-implications-for-medical-education
#11
Richard L Cruess, Sylvia R Cruess, Yvonne Steinert
The presence of a variety of independent learning theories makes it difficult for medical educators to construct a comprehensive theoretical framework for medical education, resulting in numerous and often unrelated curricular, instructional, and assessment practices. Linked with an understanding of identity formation, the concept of communities of practice could provide such a framework, emphasizing the social nature of learning. Individuals wish to join the community, moving from legitimate peripheral to full participation, acquiring the identity of community members and accepting the community's norms...
July 25, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28745847/transient-global-amnesia-emergency-department-evaluation-and-management-digest
#12
Jeremy Samuel Faust, Andreea Nemes, Milana Zaurova
Transient global amnesia is a clinically distinct syndrome characterized by the acute inability to form new memories. It can last up to 24 hours. The diagnosis is dependent on eliminating other more serious etiologies including toxic ingestions, acute strokes, complex partial seizures, and central nervous system infections. Transient global amnesia confers no known long-term risks; however, when abnormal signs or symptoms are present, they take precedence and guide the formulation of a differential diagnosis and investigation...
August 22, 2016: Emergency Medicine Practice
https://www.readbyqxmd.com/read/28745842/toxic-alcohol-ingestion-prompt-recognition-and-management-in-the-emergency-department-digest
#13
Gillian A Beauchamp, Matthew Valento, Jeremy Kim
Identifying patients with potential toxic alcohol exposure and initiating appropriate management is critical to avoid significant patient morbidity. Sources of toxic alcohol exposure include ethylene glycol, methanol, diethylene glycol, propylene glycol, and isopropanol. Treatment considerations include the antidotes fomepizole and ethanol, and hemodialysis for removal of the parent compound and its toxic metabolites. Additional interventions include adjunctive therapies that may improve acidosis and enhance clearance of the toxic alcohol or metabolites...
September 22, 2016: Emergency Medicine Practice
https://www.readbyqxmd.com/read/28745635/a-practical-guide-on-coupling-a-scanning-mobility-sizer-and-inductively-coupled-plasma-mass-spectrometer-smps-icpms
#14
Mohamed Tarik, Debora Foppiano, Adrian Hess, Christian Ludwig
A large variety of analytical methods are available to characterize particles in aerosols and suspensions. The choice of the appropriate technique depends on the properties to be determined. In many fields information about particle size and chemical composition are of great importance. While in aerosol techniques particle size distributions of gas-borne particles are determined online, their elemental composition is commonly analyzed offline after an appropriate sampling and preparation procedure. To obtain both types of information online and simultaneously, a hyphenated setup was recently developed, including a Scanning Mobility Particle Sizer (SMPS) and an Inductively Coupled Plasma Mass Spectrometer (ICPMS)...
July 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28745570/soft-tissue-tumor-immunohistochemistry-update-illustrative-examples-of-diagnostic-pearls-to-avoid-pitfalls
#15
Shi Wei, Evita Henderson-Jackson, Xiaohua Qian, Marilyn M Bui
CONTEXT: - Current 2013 World Health Organization classification of tumors of soft tissue arranges these tumors into 12 groups according to their histogenesis. Tumor behavior is classified as benign, intermediate (locally aggressive), intermediate (rarely metastasizing), and malignant. In our practice, a general approach to reaching a definitive diagnosis of soft tissue tumors is to first evaluate clinicoradiologic, histomorphologic, and cytomorphologic features of the tumor to generate some pertinent differential diagnoses...
August 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28745008/-you-cannot-collect-data-using-your-own-resources-and-put-it-on-open-access-perspectives-from-africa-about-public-health-data-sharing
#16
Evelyn Anane-Sarpong, Tenzin Wangmo, Claire Leonie Ward, Osman Sankoh, Marcel Tanner, Bernice Simone Elger
Data-sharing is a desired default in the field of public health and a source of much ethical deliberation. Sharing data potentially contributes the largest, most efficient source of scientific data, but is fraught with contextual challenges which make stakeholders, particularly those in under-resourced contexts hesitant or slow to share. Relatively little empirical research has engaged stakeholders in discussing the issue. This study sought to explore relevant experiences, contextual, and subjective explanations around the topic to provide a rich and detailed presentation of what it means to different stakeholders and contexts to share data and how that can guide practice and ethical guidance...
July 25, 2017: Developing World Bioethics
https://www.readbyqxmd.com/read/28745003/an-evolutionary-perspective-on-the-systems-of-adaptive-immunity
#17
Viktor Müller, Rob J de Boer, Sebastian Bonhoeffer, Eörs Szathmáry
We propose an evolutionary perspective to classify and characterize the diverse systems of adaptive immunity that have been discovered across all major domains of life. We put forward a new function-based classification according to the way information is acquired by the immune systems: Darwinian immunity (currently known from, but not necessarily limited to, vertebrates) relies on the Darwinian process of clonal selection to 'learn' by cumulative trial-and-error feedback; Lamarckian immunity uses templated targeting (guided adaptation) to internalize heritable information on potential threats; finally, shotgun immunity operates through somatic mechanisms of variable targeting without feedback...
July 26, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28744966/social-media-and-organ-donation-ethically-navigating-the-next-frontier
#18
Macey L Henderson, Kristel A Clayville, Jonathan S Fisher, Kristin K Kuntz, Harvey Mysel, Tanjala S Purnell, Randolph L Schaffer, Laurence A Sherman, Elizabeth P Willock, Elisa J Gordon
As the organ shortage continues to grow, the creation of social media communities by transplant centers and the public is rapidly expanding to increase the number of living donors. Social media communities are arranged in myriad ways, and without standardization, raising concerns about potential recipients' and potential donors' autonomy and quality of care. Social media communities magnify and modify extant ethical issues in deceased and living donation related to privacy, confidentiality, professionalism, and informed consent, and increase the potential for undue influence and coercion for potential living donors and transplant candidates...
July 25, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28744073/gadolinium-based-contrast-agents-in-current-practice-risks-of-accumulation-and-toxicity-in-patients-with-normal-renal-function
#19
Anju Ranga, Yatish Agarwal, Kanika J Garg
Despite being decked as the most prized compounds in the nugget box of contrast agents for clinical radiologists, and carrying an indisputable tag of safety of the US Food and Drug Administration for close to three decades, all may not be seemingly well with the family of gadolinium compounds. If the first signs of violations of primum non nocere in relation to gadolinium-based contrast agents (GBCAs) appeared in the millennium year with the first published report of skin fibrosis in patients with compromised renal function, the causal relationship between the development of nephrogenic systemic fibrosis (NSF) and GBCAs, first proposed by two European groups in 2006, further precluded their use in renocompromised patients...
April 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28742719/pediatric-gastroenterologists-approach-to-venous-thromboembolism-prophylaxis-in-pediatric-inflammatory-bowel-disease
#20
Kimberley Ann Chien, Hoda T Hammad, Linda Gerber, Sujit Sheth, Robbyn Sockolow, Nicole Elena Kucine
The risk of venous thromboembolism (VTE) is significantly increased in inflammatory bowel disease (IBD) patients. For the adult population, prophylaxis guidelines exist to help guide physicians in their management of high-risk IBD patients. While it is known that children with IBD also experience increased rates of VTE, there is no clear consensus on how best to prevent these unwanted complications. We sought to better understand practicing pediatric gastroenterologists' awareness of this issue and practices surrounding prevention of VTE in their pediatric patients...
July 22, 2017: Journal of Pediatric Gastroenterology and Nutrition
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