keyword
https://read.qxmd.com/read/38505057/postoperative-atrial-fibrillation-poaf-after-cardiac-surgery-clinical-practice-review
#21
REVIEW
Orlando R Suero, Ahmed K Ali, Lauren R Barron, Matthew W Segar, Marc R Moon, Subhasis Chatterjee
Postoperative atrial fibrillation (POAF) after cardiac surgery is associated with elevated morbidity and mortality. Although current prediction models have limited efficacy, several perioperative interventions can reduce patients' risk of POAF. These begin with preoperative medications, including beta-blockers and amiodarone. Moreover, patients should be screened for preexisting atrial fibrillation (AF) so that concomitant surgical ablation and left atrial appendage occlusion can be performed in appropriate candidates...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38501309/solid-wood-modification-toward-anisotropic-elastic-and-insulative-foam-like-materials
#22
JOURNAL ARTICLE
Xuetong Shi, Ran Bi, Zhangmin Wan, Feng Jiang, Orlando J Rojas
The methods used to date to produce compressible wood foam by top-down approaches generally involve the removal of lignin and hemicelluloses. Herein, we introduce a route to convert solid wood into a super elastic and insulative foam-like material. The process uses sequential oxidation and reduction with partial removal of lignin but high hemicellulose retention (process yield of 72.8%), revealing fibril nanostructures from the wood's cell walls. The elasticity of the material is shown to result from a lamellar structure, which provides reversible shape recovery along the transverse direction at compression strains of up to 60% with no significant axial deformation...
March 19, 2024: ACS Nano
https://read.qxmd.com/read/38500596/xpa-tumor-variant-leads-to-defects-in-ner-that-sensitize-cells-to-cisplatin
#23
JOURNAL ARTICLE
Alexandra M Blee, Kaitlyn S Gallagher, Hyun-Suk Kim, Mihyun Kim, Suhas S Kharat, Christina R Troll, Areetha D'Souza, Jiyoung Park, P Drew Neufer, Orlando D Schärer, Walter J Chazin
Nucleotide excision repair (NER) reduces efficacy of treatment with platinum (Pt)-based chemotherapy by removing Pt lesions from DNA. Previous study has identified that missense mutation or loss of the NER genes Excision Repair Cross Complementation Group 1 and 2 ( ERCC1 and ERCC2 ) leads to improved patient outcomes after treatment with Pt-based chemotherapies. Although most NER gene alterations found in patient tumors are missense mutations, the impact of mutations in the remaining nearly 20 NER genes is unknown...
March 2024: NAR cancer
https://read.qxmd.com/read/38499536/accurate-and-rapid-antibiotic-susceptibility-testing-using-a-machine-learning-assisted-nanomotion-technology-platform
#24
JOURNAL ARTICLE
Alexander Sturm, Grzegorz Jóźwiak, Marta Pla Verge, Laura Munch, Gino Cathomen, Anthony Vocat, Amanda Luraschi-Eggemann, Clara Orlando, Katja Fromm, Eric Delarze, Michał Świątkowski, Grzegorz Wielgoszewski, Roxana M Totu, María García-Castillo, Alexandre Delfino, Florian Tagini, Sandor Kasas, Cornelia Lass-Flörl, Ronald Gstir, Rafael Cantón, Gilbert Greub, Danuta Cichocka
Antimicrobial resistance (AMR) is a major public health threat, reducing treatment options for infected patients. AMR is promoted by a lack of access to rapid antibiotic susceptibility tests (ASTs). Accelerated ASTs can identify effective antibiotics for treatment in a timely and informed manner. We describe a rapid growth-independent phenotypic AST that uses a nanomotion technology platform to measure bacterial vibrations. Machine learning techniques are applied to analyze a large dataset encompassing 2762 individual nanomotion recordings from 1180 spiked positive blood culture samples covering 364 Escherichia coli and Klebsiella pneumoniae isolates exposed to cephalosporins and fluoroquinolones...
March 18, 2024: Nature Communications
https://read.qxmd.com/read/38494756/fermentation-of-whey-derived-matrices-by-kluyveromyces-marxianus-alcoholic-beverage-development-from-whey-and-fruit-juice-mixes
#25
JOURNAL ARTICLE
Gabriel A Gómez, Facundo Cuffia, Orlando G Nagel, Rafael L Althaus, Roberto J Ceruti
This research paper addresses the hypotheses that Kluyveromyces marxianus can be cultured with good alcohol production on different whey-derived matrices, and that the fermented product can be used in order to develop alcoholic beverages with acceptable sensory characteristics by mixtures with yeast-fermented fruit-based matrices. Growth and fermentative characteristics of Kluyveromyces marxianus LFIQK1 in different whey-derived matrices were explored by culturing (24 h, 30°C) on reconstituted whey, demineralized whey, heat-treated whey and milk permeate media...
March 18, 2024: Journal of Dairy Research
https://read.qxmd.com/read/38491228/molecularly-defined-sinonasal-malignancies-an-overview-with-focus-on-the-current-who-classification-and-recently-described-provisional-entities
#26
JOURNAL ARTICLE
Alena Skálová, Abbas Agaimy, Martina Bradova, Vincent Vander Poorten, Ehab Hanna, Orlando Guntinas-Lichius, Alessandro Franchi, Henrik Hellquist, Roderick H W Simpson, Fernando Lopéz, Sandra Nuyts, Carlos Chiesa-Estomba, Sweet Ping Ng, Akihiro Homma, Yong Teng, Ilmo Leivo, Alfio Ferlito
Classification of tumors of the head and neck has evolved in recent decades including a widespread application of molecular testing in tumors of the sinonasal tract, salivary glands, and soft tissues with a predilection for the head and neck. The availability of new molecular techniques has allowed for the definition of multiple novel tumor types unique to head and neck sites. Moreover, an expanding spectrum of immunohistochemical markers specific to genetic alterations facilitates rapid identification of diagnostic molecular abnormalities...
March 16, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38490985/biobased-and-biodegradable-films-exhibiting-circularly-polarized-room-temperature-phosphorescence
#27
JOURNAL ARTICLE
Mengnan Cao, Yiran Ren, Yue Wu, Jingjie Shen, Shujun Li, Zhen-Qiang Yu, Shouxin Liu, Jian Li, Orlando J Rojas, Zhijun Chen
There is interest in developing sustainable materials displaying circularly polarized room-temperature phosphorescence, which have been scarcely reported. Here, we introduce biobased thin films exhibiting circularly polarized luminescence with simultaneous room-temperature phosphorescence. For this purpose, phosphorescence-active lignosulfonate biomolecules are co-assembled with cellulose nanocrystals in a chiral construct. The lignosulfonate is shown to capture the chirality generated by cellulose nanocrystals within the films, emitting circularly polarized phosphorescence with a 0...
March 15, 2024: Nature Communications
https://read.qxmd.com/read/38490026/electroextraction-of-methylene-blue-from-aqueous-environmental-samples-using-paper-points-coupled-with-hollow-fiber-membranes
#28
JOURNAL ARTICLE
Ricardo Mathias Orlando, Miloš Dvořák, Pavel Kubáň
This article introduces a novel approach by coupling paper points with hollow fiber membrane for electroextraction (PP-HF-EE). The method was innovatively applied to extract methylene blue (MB) from large water volumes (up to 580 mL). A comprehensive study of six key parameters - organic filter, acceptor and donor phase composition, extraction time, applied voltage, and sample volume - was conducted using conventional flatbed scanning and digital image analysis. Our results revealed that extraction performance was primarily influenced by time, with low voltages (50 V) and low-conductivity organic filters (1-decanol) yielding comparable results to higher settings (300 V or 1-pentanol)...
March 5, 2024: Talanta
https://read.qxmd.com/read/38488274/breast-ultrasound-an-opportunity-to-detect-unsuspected-pleural-and-pulmonary-abnormalities
#29
JOURNAL ARTICLE
Antonio Corvino, Luigi Basile, Andrea Boccatonda, Carlo Varelli, Domenico Tafuri, Giulio Cocco, Orlando Catalano
PURPOSE: While scanning women for breast US, is possible to observe changes in the appearance of the pleural line or in the most superficial portion of the lung. The objective of this single-center, prospective study was to determine the prevalence of a variety of pleural and pulmonary US findings during routine breast US. METHODS: In this study, there were 200 women undergoing standard breast US examination. The presence of pleural and pulmonary abnormalities in these cases was recorded...
March 15, 2024: Journal of Clinical Ultrasound: JCU
https://read.qxmd.com/read/38488103/liquid-templated-graphene-aerogel-electromagnetic-traps
#30
JOURNAL ARTICLE
Seyyed Alireza Hashemi, Ahmadreza Ghaffarkhah, Farhad Ahmadijokani, Hatef Yousefian, Sameer E Mhatre, Anna Sinelshchikova, Gabriel Banvillet, Milad Kamkar, Orlando J Rojas, Stefan Wuttke, Mohammad Arjmand
For decades, the inherently reflective nature of metallic electromagnetic (EM) shields and their induced secondary EM pollution have posed significant challenges for sensitive electronics. While numerous efforts have been made to develop superior EM shielding systems, the issue of reflection dominancy in metallic substrates remains unresolved. Herein, we addressed this long-lasting obstacle by pairing metallic shields with ultra-lightweight (density of 3.12-3.40 mg cm-3 ) elastic anti-reflection aerogels, altering their shielding mechanism from dominant reflection (reflectance >0...
March 15, 2024: Nanoscale
https://read.qxmd.com/read/38483010/multiphase-under-liquid-biofabrication-with-living-soft-matter-a-route-to-customize-functional-architectures-with-microbial-nanocellulose
#31
JOURNAL ARTICLE
Yi Lu, Yeedo Chun, Xuetong Shi, Dong Wang, Farhad Ahmadijokani, Orlando J Rojas
The growth of aerobic microbes at air-water interfaces typically leads to biofilm formation. Herein, we introduce a fermentative alternative that relies on oil-water interfaces to support bacterial activity and aerotaxis. The process uses under-liquid biofabrication by structuring bacterial nanocellulose (BNC) to achieve tailorable architectures. We first evaluate cellulose productivity in static conditions using sets of oil homologues, classified in order of polarity. The oils are shown for their ability to sustain bacterial growth and BNC production according to air transfer and solubilization, both of which impact the physiochemical properties of the produced biofilms...
March 14, 2024: Advanced Materials
https://read.qxmd.com/read/38481832/editorial-education-in-public-health-2022
#32
EDITORIAL
Stefano Orlando, Enamul Kabir, Andrew Harver, Jie Hu
No abstract text is available yet for this article.
2024: Frontiers in Public Health
https://read.qxmd.com/read/38479034/hereditary-motor-and-sensory-neuropathy-okinawa-type-mimicking-proximal-myopathy
#33
Vinícius Lopes Braga, João Vitor Gerdulli Tamanini, Sofia Monaco Gama, Pedro Henrique Almeida Fraiman, Thiago Yoshinaga Tonholo Silva, Denizart Santos-Neto, Orlando Graziani Povoas Barsottini, José Luiz Pedroso
Hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P), or, Okinawa type, is a rare neuromuscular disorder characterized by proximal dominant neurogenic atrophy and distal sensory alterations with an autosomal dominant inheritance pattern. We present a case of a Brazilian woman of Okinawan ancestry, with symmetrical proximal weakness, fasciculations, absent patellar reflexes and positive familial history for the same symptoms. These findings led to genetic testing, which identified a variant in the TFG gene (c...
February 28, 2024: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38477803/efficiency-of-mixed-and-rigid-occlusal-stabilization-splints-randomized-clinical-trial
#34
JOURNAL ARTICLE
Layza Rossatto Oppitz, Ana Carolina Mastriani Arantes, Roberto Ramos Garanhani, Carlos Alberto Costa, Cristiano Miranda de Araujo, Orlando Motohiro Tanaka, Patricia Kern di Scala Andreis, Claudia Schappo, Sérgio Aparecido Ignácio, Aline Cristina Batista Rodrigues Johann, Rodrigo Nunes Rached, Elisa Souza Camargo
Occlusal stabilization splints are the most common treatment for controlling the deleterious effects of sleep bruxism. This study aimed to evaluate the effectiveness of a low-cost, mixed occlusal splint (MOS) compared to that of a rigid splint. A randomized clinical trial was performed on 43 adults of both sexes with possible sleep bruxism and satisfactory dental conditions. They were divided into rigid occlusal splint (ROS) (n = 23) and MOS (n = 20) groups. Masticatory muscle and temporomandibular joint (TMJ) pain intensity (visual analog scale), quality of life (WHOQOL-BREF), indentations in the oral mucosa, anxiety, and depression (HADS), number of days of splint use, and splint wear were evaluated...
2024: Brazilian Oral Research
https://read.qxmd.com/read/38476736/infective-endocarditis-due-to-citrobacter-koseri-following-testicular-trauma-case-report-and-literature-review
#35
Julian Orlando Casallas-Barrera, Claudia Marcela Poveda-Henao, Karen Andrea Mantilla-Viviescas, Edwin Silva-Monsalve
Infective endocarditis (IE) is a condition with low prevalence but high mortality rates within intensive care units. Microbiologically, most cases are attributed to Gram-positive cocci, while Gram-negative bacilli are less commonly involved. This case report describes a patient with IE caused by Citrobacter koseri (C. koseri) with secondary bacteremia due to blunt testicular trauma and epididymitis. We conducted a review of the literature to assess the clinical and associated risk factors of this underreported condition...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38473355/cost-effectiveness-of-treatment-optimisation-with-biomarkers-for-immunotherapy-in-solid-tumours-a-systematic-review
#36
REVIEW
Sara Mucherino, Valentina Lorenzoni, Isotta Triulzi, Marzia Del Re, Valentina Orlando, Annalisa Capuano, Romano Danesi, Giuseppe Turchetti, Enrica Menditto
This study investigated the health economic evaluations of predictive biomarker testing in solid tumours treated with immune checkpoint inhibitors (ICIs). Searching PubMed, EMBASE, and Web of Science from June 2010 to February 2022, 58 relevant articles were reviewed out of the 730 screened. The focus was predominantly on non-small cell lung cancer (NSCLC) (65%) and other solid tumours (40%). Among the NSCLC studies, 21 out of 35 demonstrated cost-effectiveness, notably for pembrolizumab as first-line treatment when preceded by PD-L1 assessment, cost-effective at a threshold of $100,000/QALY compared to the standard of care...
February 29, 2024: Cancers
https://read.qxmd.com/read/38473058/linking-acrosome-size-and-genetic-divergence-in-an-inter-oceanic-mussel-from-the-pacific-and-atlantic-coasts-a-case-of-incipient-speciation
#37
JOURNAL ARTICLE
Carolina Briones, José J Nuñez, Montse Pérez, Orlando Garrido, Bernardita Campos, Karina Godoy, Ricardo Hartley, Pablo A Oyarzún, Ricardo Guiñez
In recent years, advances in analyses of the sperm morphology and genetics of Perumytilus purpuratus have allowed to two evolutionary scenarios for this mussel to be suggested: (1) the scenario of cryptic species and (2) the scenario of incipient or in progress speciation. For a better understanding of the evolutionary history of P. purpuratus , we performed extensive sampling along a latitudinal gradient of ca. 7180 km of coastline-from the Southern Pacific Ocean to the Atlantic Ocean-and we delved deeper into the sperm morphology of P...
February 21, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38472028/inhibitory-action-of-antibiotics-on-kluyveromyces-marxianus
#38
JOURNAL ARTICLE
Rafael Lisandro Althaus, Orlando Guillermo Nagel, Dafna Eluk
A bioassay containing Kluyveromyces marxianus in microtiter plates was used to determine the inhibitory action of 28 antibiotics (aminoglycosides, beta-lactams, macrolides, quinolones, tetracyclines and sulfonamides) against this yeast in whey. For this purpose, the dose-response curve for each antibiotic was constructed using 16 replicates of 12 different concentrations of the antibiotic. The plates were incubated at 40°C until the negative samples exhibited their indicator (5-7h). Subsequently, the absorbances of the yeast cells in each plate were measured by the turbidimetric method (λ=600nm) and the logistic regression model was applied...
March 11, 2024: Revista Argentina de Microbiología
https://read.qxmd.com/read/38470178/specific-cellular-microenvironments-for-spatiotemporal-regulation-of-star-and-steroid-synthesis
#39
REVIEW
Ana Fernanda Castillo, Cecilia Poderoso, Paula Mariana Maloberti, Fabiana Cornejo Maciel, María Mercedes Mori Sequeiros Garcia, Ulises Daniel Orlando, Pablo Mele, Yanina Benzo, Melina Andrea Dattilo, Jesica Prada, Luciano Quevedo, Matías Belluno, Cristina Paz, Ernesto Jorge Podesta
For many years, research in the field of steroid synthesis has aimed to understand the regulation of the rate-limiting step of steroid synthesis, i.e., the transport of cholesterol from the outer to the inner mitochondrial membrane, and identify the protein involved in the conversion of cholesterol into pregnenolone. The extraordinary work by B Clark, J Wells, S R King, and D M Stocco eventually identified this protein and named it steroidogenic acute regulatory protein (StAR). The group's finding was also one of the milestones in understanding the mechanism of non-vesicular lipid transport between organelles...
March 1, 2024: Journal of Endocrinology
https://read.qxmd.com/read/38465241/equine-herpesvirus-4-infected-domestic-horses-associated-with-sintashta-spoke-wheeled-chariots-around-4-000-years-ago
#40
JOURNAL ARTICLE
Ophélie Lebrasseur, Kuldeep Dilip More, Ludovic Orlando
Equine viral outbreaks have disrupted the socio-economic life of past human societies up until the late 19th century and continue to be of major concern to the horse industry today. With a seroprevalence of 60-80 per cent, equine herpesvirus 4 (EHV-4) is the most common horse pathogen on the planet. Yet, its evolutionary history remains understudied. Here, we screen the sequenced data of 264 archaeological horse remains to detect the presence of EHV-4. We recover the first ancient EHV-4 genome with 4...
2024: Virus Evolution
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