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Marco Pio La Manna, Valentina Orlando, Paolo Li Donni, Guido Sireci, Paola Di Carlo, Antonio Cascio, Francesco Dieli, Nadia Caccamo
We used the Luminex Bead Array Multiplex Immunoassay to measure cytokines, chemokines and growth factors responses to the same antigens used for RD1-based Interferon γ Release Assay (IGRA) test. Seventy-nine individuals, 27 active TB, 32 latent infection subsets, 20 individuals derivative purified protein (PPD) negative (subjects that do not have any indurative cutaneous reaction after 72 hrs of intradermal injection of PPD) and with other pulmonary disease were retrospectively studied. Forty-eight analytes were evaluated by Luminex Assay in plasma obtained from whole blood stimulated cells...
2018: PloS One
Ryan Scott Kingsbury, Sophie Flotron, Shan Zhu, Douglas Call, Orlando Coronell
Ion exchange membranes (IEMs) are versatile materials relevant to a variety of water and waste treatment, energy production, and industrial separation processes. The defining characteristic of IEMs is their ability to selectively allow positive or negative ions to permeate, which is referred to as the permselectivity. Measured values of permselectivity that equal unity (corresponding to a perfectly-selective membrane) or exceed unity (theoretically impossible) have been reported for cation exchange membranes (CEMs)...
March 15, 2018: Environmental Science & Technology
Matti S Toivonen, Olimpia D Onelli, Gianni Jacucci, Ville Lovikka, Orlando J Rojas, Olli Ikkala, Silvia Vignolini
The understanding of the interaction between light and complex, random structures is the key for designing and tailoring the optical appearance and performance of many materials that surround us, ranging from everyday consumer products, such as those for personal care, paints, and paper, to light diffusers used in the LED-lamps and solar cells. Here, it is demonstrated that the light transport in membranes of pure cellulose nanofibrils (CNFs) can be controlled to achieve bright whiteness in structures only a few micrometers thick...
March 13, 2018: Advanced Materials
Sunil H Adwani, Cai Yuan, Leen Alsaleh, Julie Pepe, Khalid Abusaada
RATIONALE, AIMS, AND OBJECTIVES: Several studies have looked at patient-related variables influencing hospital length of stay (LOS) in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). However, there has been increasing recognition that physician-related factors also play a significant role. This study aims to evaluate differences in practice patterns between teaching and nonteaching services and their effect on LOS in a large community hospital. METHODS: A retrospective study of 354 patients admitted to Florida Hospital, Orlando, with AECOPD between January 2009 and December 2011...
March 13, 2018: Journal of Evaluation in Clinical Practice
Juliana Harumi Arita, Mário H Barros, Felipe Gustavo Ravagnani, Marcello Ziosi, Lívia Rentas Sanches, Fabíola Rosa Picosse, Tania Oliveira Lopes, Patrícia de Carvalho Aguiar, Carolina Habermann Macabelli, Marcos Chiaratti, José Luiz Pedroso, Catarina M Quinzi, Orlando Graziani Póvoas Barsottini, Claudia Cristina Ferreiro-Barros
AMP-activated protein kinase (AMPK) regulates many different metabolic pathways in eukaryote cells including mitochondria biogenesis and energy homeostasis. Here we identify a patient with hypotonia, weakness, delayed milestones and neurological impairment since birth harbouring a novel homozygous mutation in the AMPK catalytic α-subunit 1, encoded by the PRKAA1 gene. The homozygous mutation p.S487 L in isoform 1 present in the patient is in a cryptic residue for AMPK activity. In the present study, we performed the characterization of mitochondrial respiratory properties of the patient, in comparison to healthy controls, through the culture of skin fibroblasts in order to understand some of the cellular consequences of the PRKAA1 mutation...
March 8, 2018: Biochimica et Biophysica Acta
Orlando Contreras-López, Tomás C Moyano, Daniela C Soto, Rodrigo A Gutiérrez
The rapid increase in the availability of transcriptomics data generated by RNA sequencing represents both a challenge and an opportunity for biologists without bioinformatics training. The challenge is handling, integrating, and interpreting these data sets. The opportunity is to use this information to generate testable hypothesis to understand molecular mechanisms controlling gene expression and biological processes (Fig. 1). A successful strategy to generate tractable hypotheses from transcriptomics data has been to build undirected network graphs based on patterns of gene co-expression...
2018: Methods in Molecular Biology
Luisa Iacovelli, Rosamaria Orlando, Alessandro Rossi, Paola Spinsanti, Daniela Melchiorri, Ferdinando Nicoletti
In spite of the recent advancement in the molecular characterization of malignant gliomas and medulloblastomas, the treatment of primary brain tumors remains suboptimal. The use of small molecule inhibitors of intracellular signaling pathways, inhibitors of angiogenesis, and immunotherapic agents is limited by systemic adverse effects, limited brain penetration, and, in some cases, lack of efficacy. Thus, adjuvant chemo-therapy and radiotherapy still remain the gold standard in the treatment of grade-IV astrocytoma (glioblastoma multiforme) and medulloblastoma...
March 8, 2018: Current Opinion in Pharmacology
Federica Marasca, Beatrice Bodega, Valerio Orlando
Cells and tissues are continuously exposed to a changing microenvironment, hence the necessity of a flexible modulation of gene expression that in complex organism have been achieved through specialized chromatin mechanisms. Chromatin-based cell memory enables cells to maintain their identity by fixing lineage specific transcriptional programs, ensuring their faithful transmission through cell division; in particular PcG-based memory system evolved to maintain the silenced state of developmental and cell cycle genes...
March 9, 2018: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
Evangelina V Cores, Sandra Vanotti, Mabel Osorio, Berenice Silva, Orlando Garcea, Daniel G Politis
INTRODUCTION: prospective memory is the ability to remember actions in the future or remember delayed intentions. OBJECTIVE: to study the relationship between prospective memory complaints with an objective measure of prospective memory and affective-emotional variables such as depression and anxiety. SUBJECTS AND MATERIALS: 51 patients with multiple sclerosis relapsing-remitting and 46 participants in the control group were evaluated with a prospective memory task called El Condor, a questionnaire on subjective complaints of prospective memory, a depression inventory and an anxiety inventory...
July 2017: Vertex: Revista Argentina de Psiquiatriá
Ray Coniglio, Constance McGraw, Mike Archuleta, Heather Bentler, Leigh Keiter, Julie Ramstetter, Elizabeth Reis, Cristi Romans, Rachael Schell, Kelli Ross, Rachel Smith, Jodi Townsend, Alessandro Orlando, Charles W Mains
Colorado requires Level III and IV trauma centers to conduct a formal performance improvement program (PI), but provides limited support for program development. Trauma program managers and coordinators in rural facilities rarely have experience in the development or management of a PI program. As a result, rural trauma centers often face challenges in evaluating trauma outcomes adequately. Through a multidisciplinary outreach program, our Trauma System worked with a group of rural trauma centers to identify and define seven specific PI filters based on key program elements of rural trauma centers...
March 2018: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
Wenxing Zhu, Lujiang Hao, Xinli Liu, Borrás-Hidalgo Orlando, Yuyu Zhang
Epothilones constitute a new class of microtubule-stabilizing anticancer agents with promising preclinical and clinical activity. However, its systemic application still causes some toxic side effects. To reduce these undesired effects, advanced drug delivery systems based on cell targeting carriers are needed currently. In this study, the high quality bacterial ghosts of the probiotic Escherichia coli Nissle 1917 (EcN) were prepared in a large scale and retained fully intact surface structures for specific attachment to mammalian cells...
March 9, 2018: Drug Development and Industrial Pharmacy
Antonino Malacrinò, Orlando Campolo, Raul F Medina, Vincenzo Palmeri
Microorganisms are acknowledged for their role in shaping insects' evolution, life history and ecology. Previous studies have shown that microbial communities harbored within insects vary through ontogenetic development and among insects feeding on different host-plant species. In this study, we characterized the bacterial microbiota of the highly polyphagous Mediterranean fruit fly, Ceratitis capitata (Diptera: Tephritidae), at different instars and when feeding on different host-plant species. Our results show that the bacterial microbiota hosted within the Mediterranean fruit fly differs among instars and host-plant species...
2018: PloS One
Willy A Flegel, Qing Chen, Lilian Castilho, Margaret A Keller, Ellen B Klapper, William J Lane, France Pirenne, Gary Stack, Maryse St-Louis, Christopher A Tormey, Dan A Waxman, Christof Weinstock, Silvano Wendel, Gregory A Denomme
No abstract text is available yet for this article.
February 14, 2018: Blood Transfusion, Trasfusione del Sangue
(no author information available yet)
Abstracts of the 2018 AANS/CNS Joint Section on Disorders of the Spine and Peripheral Nerves Annual Meeting.
March 2018: Neurosurgical Focus
Fernando Rizzello, Ignazio Olivieri, Alessandro Armuzzi, Fabio Ayala, Vincenzo Bettoli, Luca Bianchi, Luca Cimino, Antonio Costanzo, Antonio Cristaudo, Salvatore D'Angelo, Marco Daperno, Anna Chiara Fostini, Mauro Galeazzi, Michele Gilio, Paolo Gionchetti, Paolo Gisondi, Ennio Lubrano, Antonio Marchesoni, Annamaria Offidani, Ambrogio Orlando, Daniela Pugliese, Carlo Salvarani, Raffaele Scarpa, Maurizio Vecchi, Giampiero Girolomoni
INTRODUCTION: Immune-mediated inflammatory diseases (IMIDs) are chronic autoimmune conditions that share common pathophysiologic mechanisms. The optimal management of patients with IMIDs remains challenging because the coexistence of different conditions requires the intervention of several specialists. The aim of this study was to develop a series of statements defining overarching principles that guide the implementation of a multidisciplinary approach for the management of spondyloarthritis (SpA)-related IMIDs including SpA, psoriasis, psoriatic arthritis, Crohn's disease, ulcerative colitis and uveitis...
March 7, 2018: Advances in Therapy
Bhupesh Panwar, Suzanne E Judd, Virginia G Wadley, Nancy S Jenny, Virginia J Howard, Monika M Safford, Orlando M Gutiérrez
Importance: Higher circulating fibroblast growth factor 23 (FGF23) concentrations are associated with cardiovascular disease events linked to heart failure, but associations of FGF23 with coronary heart disease (CHD) have been less consistent. Objective: To determine the association of plasma FGF23 concentrations with incident CHD and whether this association differs by race, sex, or chronic kidney disease status. Design, Setting, and Participants: We examined the association of FGF23 concentrations with incident CHD risk within the Reasons for Geographic and Racial Differences in Stroke study, a prospective cohort of black and white adults 45 years and older enrolled between January 2003 and October 2007 with follow-up through December 31, 2011...
March 7, 2018: JAMA Cardiology
Graciela M Dias, Adeline Bidault, Patrick Le Chevalier, Gwenaëlle Choquet, Clio Der Sarkissian, Ludovic Orlando, Claudine Medigue, Valerie Barbe, Sophie Mangenot, Cristiane C Thompson, Fabiano L Thompson, Annick Jacq, Vianney Pichereau, Christine Paillard
The Brown Ring Disease (BRD) caused high mortality rates since 1986 in the Manila clam Venerupis philippinarum introduced and cultured in Western Europe from the 1970s. The causative agent of BRD is a Gram-Negative bacterium, Vibrio tapetis , which is also pathogenic to fish. Here we report the first assembly of the complete genome of V. tapetis CECT4600T , together with the genome sequences of 16 additional strains isolated across a broad host and geographic range. Our extensive genome dataset allowed us to describe the pathogen pan- and core genomes and to identify putative virulence factors...
2018: Frontiers in Microbiology
Hyeonseok Jin, Upasana Roy, Gwangrog Lee, Orlando D Schärer, Yunje Cho
DNA interstrand cross-links (ICLs) block the progress of the replication and transcription machineries and can weaken chromosomal stability, resulting in various diseases. FANCD2/FANCI-associated nuclease (FAN1) is a conserved structure-specific nuclease that unhooks DNA ICLs independently of the Fanconi anemia pathway. Recent structural studies have proposed two different mechanistic features for ICL unhooking by human FAN1: a specific basic pocket that recognizes the terminal phosphate of a 1-nt 5' flap or FAN1 dimerization...
March 7, 2018: Journal of Biological Chemistry
Carlos Edmundo Rodrigues Fontes, Marino Jose Mardegam, Orlando Ribeiro Prado-Filho, Marcos Victor Ferreira
BACKGROUND: Obtaining effective hemostasis either in the traumatic or surgical lesions of parenchymal viscera, especially the liver, has always been a challenge. AIM: Comparative study between the use of different hemostatic sponges in hepatic wound and their capacity of integration to cells in a short period. METHODS: Fifteen Wistar rats were divided into three groups. Through laparotomy a standardized wound in hepatic right lobe was made...
March 1, 2018: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
Florian J Alberto, Frédéric Boyer, Pablo Orozco-terWengel, Ian Streeter, Bertrand Servin, Pierre de Villemereuil, Badr Benjelloun, Pablo Librado, Filippo Biscarini, Licia Colli, Mario Barbato, Wahid Zamani, Adriana Alberti, Stefan Engelen, Alessandra Stella, Stéphane Joost, Paolo Ajmone-Marsan, Riccardo Negrini, Ludovic Orlando, Hamid Reza Rezaei, Saeid Naderi, Laura Clarke, Paul Flicek, Patrick Wincker, Eric Coissac, James Kijas, Gwenola Tosser-Klopp, Abdelkader Chikhi, Michael W Bruford, Pierre Taberlet, François Pompanon
The evolutionary basis of domestication has been a longstanding question and its genetic architecture is becoming more tractable as more domestic species become genome-enabled. Before becoming established worldwide, sheep and goats were domesticated in the fertile crescent 10,500 years before present (YBP) where their wild relatives remain. Here we sequence the genomes of wild Asiatic mouflon and Bezoar ibex in the sheep and goat domestication center and compare their genomes with that of domestics from local, traditional, and improved breeds...
March 6, 2018: Nature Communications
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