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https://www.readbyqxmd.com/read/29786965/l-and-d-threo-ethylphenidate-concentrations-pharmacokinetics-and-pharmacodynamics-in-horses
#1
Heather K Knych, Dan S McKemie, Kelsey Seminoff, Petra Hartmann, Lynn Hovda, Dionne Benson
Ethylphenidate is a psychostimulant and analogue of the commonly prescribed compound, methylphenidate (Ritalin®). There are a limited number of studies describing the disposition and pharmacologic/toxicological effects of ethylphenidate in any species. The abuse potential in equine athletes along with the limited data available regarding administration in horses necessitates further study. The objectives of the current study were to describe drug concentrations, develop an analytical method that could be used to regulate its use and describe the pharmacodynamic effects of ethylphenidate in horses...
May 22, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29786932/bandgap-tunable-preparation-of-smooth-and-large-two-dimensional-antimonene
#2
Xin Wang, Junjie He, Benqing Zhou, Youming Zhang, Jiatao Wu, Rui Hu, Liwei Liu, Jun Song, Junle Qu
As a highly stable bandgap semiconductor, antimonene is an intriguing two-dimensional (2D) material in optoelectronics. However, its short layer distance and strong binding energy make it challenging to prepare high-quality large 2D antimonene; therefore, its predicted tunable bandgap has not been experimentally confirmed. In this work, we used a novel and simple approach to prepare smooth and large 2D antimonene with uniform layers through a pregrinding and subsequent sonication-assisted liquid-phase exfoliation process...
May 22, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29786885/automated-buildup-of-biomimetic-films-in-cell-culture-microplates-for-high-throughput-screening-of-cellular-behaviors
#3
Paul Machillot, Catarina Quintal, Fabien Dalonneau, Loic Hermant, Pauline Monnot, Kelsey Matthews, Vincent Fitzpatrick, Jie Liu, Isabelle Pignot-Paintrand, Catherine Picart
An automatic method is established for layer-by-layer (LbL) assembly of biomimetic coatings in cell culture microplates using a commercial liquid-handling robot. Highly homogeneous thin films are formed at the bottom of each microwell. The LbL film-coated microplates are compatible with common cellular assays, using microplate readers and automated microscopes. Cellular adhesion is screened on crosslinked and peptide-functionalized LbL films and stem cell differentiation in response to increasing doses of bone morphogenetic proteins (2, 4, 7, 9)...
May 22, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29786855/speciation-of-bio-available-iodine-in-abalone-haliotis-discus-hannai-by-high-performance-liquid-chromatography-hyphenated-with-inductively-coupled-plasma-mass-spectrometry-using-an-in-vitro-method
#4
Han Sol Doh, Hyun Jin Park
Abalone is one of the most valuable marine products found in East Asia because it is rich in nutritious substances including iodine. In this study, the in vitro dialyzability approach was used to assess the bio-available iodine species in abalone. Iodide, iodate, 3-iodo-L-tyrosine (MIT), and 3,5-diiodo-L-tyrosine (DIT) were separated by high-performance liquid chromatography hyphenated with inductively coupled plasma-mass spectrometry (HPLC-ICP-MS). To assure the consistency, reliability, and accuracy of the data, the method was validated...
May 22, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29786837/high-intensity-ultrasound-for-salmonella-enteritidis-inactivation-in-culture-and-liquid-whole-eggs
#5
Chayapa Techathuvanan, Doris Helen D'Souza
High intensity ultrasound (HIU) continues to be researched as a nonthermal inactivation technology of appeal to food manufacturers. The advantages of HIU include maintenance of product quality, freshness, product homogenization, along with simultaneous inactivation of pathogens. Besides, it is simple, relatively inexpensive, and easily adaptable to most processing environments. This study investigated the effect of HIU for Salmonella Enteritidis inactivation in culture and liquid whole eggs (LWEs) to decrease egg-associated outbreaks...
May 22, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29786736/phase-behaviour-and-applications-of-a-binary-liquid-mixture-of-methanol-and-a-thermotropic-liquid-crystal
#6
Luis A Serrano, Maximiliano J Fornerod, Ye Yang, Simon Gaisford, Francesco Stellacci, Stefan Guldin
Herein, we report on the phase behaviour of a binary liquid mixture composed of methanol (MeOH) and the thermotropic liquid crystal 4-cyano-4'-pentylbiphenyl (5CB). The corresponding phase diagram combines features of a conventional liquid-liquid mixture with characteristics that are particular to the nematic liquid crystal. We observe four arrangements as a function of composition and temperature, namely monophasic isotropic, monophasic nematic, biphasic isotropic-isotropic and biphasic isotropic-nematic, with an upper critical solution temperature of 24...
May 22, 2018: Soft Matter
https://www.readbyqxmd.com/read/29786727/rational-design-of-multi-functional-gold-nanoparticles-with-controlled-biomolecule-adsorption-a-multi-method-approach-for-in-depth-characterization
#7
Isaac Ojea-Jiménez, Robin Capomaccio, Inês Osório, Dora Mehn, Giacomo Ceccone, Rohanah Hussain, Giuliano Siligardi, Pascal Colpo, François Rossi, Douglas Gilliland, Luigi Calzolai
Multi-functionalized nanoparticles are of great interest in biotechnology and biomedicine, especially for diagnostic and therapeutic purposes. However, at the moment the characterization of complex, multi-functional nanoparticles is still challenging and this hampers the development of advanced nanomaterials for biological applications. In this work, we have designed a model system consisting of gold nanoparticles functionalized with two differentially-terminated poly(ethylene oxide) ligands, providing both "stealth" properties and protein-binding capabilities to the nanoparticles...
May 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29786608/microscopic-aspects-of-wetting-using-classical-density-functional-theory
#8
Peter Yatsyshin, Miguel A Duran-Olivencia, Serafim Kalliadasis
Wetting is a rather efficient mechanism for nucleation of a phase (typically liquid) on the interface
 between two other phases (typically solid and gas). In many experimentally
 accessible cases of wetting, the interplay between the substrate structure,
 and the fluid-fluid and fluid-substrate intermolecular interactions brings
 about an entire ``zoo" of possible fluid configurations, such as liquid
 films with a thickness of a few nanometers, liquid nanodrops and liquid
 bridges...
May 22, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29786565/modelling-non-alcoholic-fatty-liver-disease-in-human-hepatocyte-like-cells
#9
Marcus J Lyall, Jessy Cartier, John P Thomson, Kate Cameron, Jose Meseguer-Ripolles, Eoghan O'Duibhir, Dagmara Szkolnicka, Baltasar Lucendo Villarin, Yu Wang, Giovanny Rodriguez Blanco, Warwick B Dunn, Richard R Meehan, David C Hay, Amanda J Drake
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease in developed countries. An in vitro NAFLD model would permit mechanistic studies and enable high-throughput therapeutic screening. While hepatic cancer-derived cell lines are a convenient, renewable resource, their genomic, epigenomic and functional alterations mean their utility in NAFLD modelling is unclear. Additionally, the epigenetic mark 5-hydroxymethylcytosine (5hmC), a cell lineage identifier, is rapidly lost during cell culture, alongside expression of the Ten-eleven-translocation ( TET ) methylcytosine dioxygenase enzymes, restricting meaningful epigenetic analysis...
July 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29786486/one-year-retention-of-gadolinium-in-the-brain-comparison-of-gadodiamide-and-gadoterate-meglumine-in-a-rodent-model
#10
Philippe Robert, Stefanie Fingerhut, Cécile Factor, Véronique Vives, Justine Letien, Michael Sperling, Marlène Rasschaert, Robin Santus, Sébastien Ballet, Jean-Marc Idée, Claire Corot, Uwe Karst
Purpose To compare the long-term brain elimination kinetics and gadolinium species in healthy rats after repeated injections of the contrast agents gadodiamide (a linear contrast agent) or gadoterate (a macrocyclic contrast agent). Materials and Methods Nine-week-old rats received five doses of 2.4 mmol gadolinium per kilogram of body weight over 5 weeks and were followed for 12 months with T1-weighted MRI (n = 140 rats, corresponding to seven time points, two contrast agents, and 10 rats per group). Animals were sacrificed at 1 week, 1 month, and 2, 3, 4, 5, and 12 months after the last injection...
May 17, 2018: Radiology
https://www.readbyqxmd.com/read/29786441/x-ray-photoelectron-spectroscopy-studies-of-nanoparticles-dispersed-in-static-liquid
#11
Luan Nguyen, Paul Pengcheng Tao, Huimin Liu, Mohamed Al-Hada, Matteo Amati, Hikmet Sezen, Luca Gregoratti, Yu Tang, Stephen D House, Franklin Feng Tao
For nanoparticles active for chemical and energy transformations in liquid environment, chemistries of surface or near-surface regions of these catalyst nanoparticles in liquid are crucial for fundamentally understanding their catalytic performances at a molecular level. Compared to catalysis at a solid-gas interface, there is very limited information on surface of these catalyst nanoparticles under working condition or during catalysis. Photoelectron spectroscopy is a surface-sensitive technique; however, it is challenging to study the surfaces of catalyst nanoparticles dispersed in liquid due to the short inelastic mean free path of photoelectrons travelling in liquid...
May 22, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29786431/ultrasonic-assisted-spin-coating-improved-junction-by-enhanced-permeation-of-coating-material-within-nanostructures
#12
Jong-Won Yun, Farman Ullah, Se-Jeong Jang, Do Hui Kim, Tri Khoa Nguyen, Ki Yeon Ryu, Shinuk Cho, Joon I Jang, Dooyong Lee, Sungkyun Park, Yong Soo Kim
Over the last decades, the spin coating (SC) technique has been widely used to prepare thin films of various materials in liquid phase on arbitrary substrates. The technique simply relies on centrifugal force to spread a coating solution radially outwards over the substrate. This mechanism works fairly well for solutions with low surface tension to form thin films of reasonable junctions on smooth substrates. Here, we present a modified SC technique, namely ultrasonic-assisted spin-coating (UASC), to form thin films of coating solution having high surface tension on rough substrates with excellent junctions...
May 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29786425/comprehensive-study-of-the-evolution-of-gas-liquid-partitioning-of-acetaldehyde-during-wine-alcoholic-fermentation
#13
Evelyne Aguera, Yannick Sire, Jean-Roch Mouret, Jean-Marie Sablayrolles, Vincent Farines
Determining the gas-liquid partitioning (K_i) of acetaldehyde during alcoholic fermentation is an important step in the optimization of fermentation control with the aim of minimizing the accumulation of this compound responsible for the undesired attributes of green apples and fresh cut grass in wines. In this work, the effect of the main fermentation parameters on the K_i of acetaldehyde was assessed. K_i values were found to be dependent on the temperature and composition of the medium. A non-linear correlation between the evolution of the K_i and fermentation progress was observed, attributed to the strong retention effect of ethanol at low concentrations and it was demonstrated that the partitioning of this specific molecule was not influenced by the CO2 production rate...
May 22, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29786170/immunopeptidomic-profiling-of-hla-a2-positive-triple-negative-breast-cancer-identifies-potential-immunotherapy-target-antigens
#14
Nicola Ternette, Marloes J M Olde Nordkamp, Julius Muller, Amanda P Anderson, Annalisa Nicastri, Adrian V S Hill, Benedikt M Kessler, Demin Li
The recent development in immune checkpoint inhibitors and chimeric antigen receptor (CAR) T-cells in the treatment of cancer has not only demonstrated the potency of utilising T-cell reactivity for cancer therapy, but has also highlighted the need for developing new approaches to discover targets suitable for such novel therapeutics. Here we analysed the immunopeptidomes of 6 HLA-A2-positive triple negative breast cancer (TNBC) samples by nano-ultra performance liquid chromatography tandem mass spectrometry (nUPLC-MS2 )...
May 22, 2018: Proteomics
https://www.readbyqxmd.com/read/29785903/high-intensity-light-pulses-to-reduce-microbial-load-in-fresh-cheese
#15
Valentina Lacivita, Amalia Conte, James G Lyng, Cristina Arroyo, Vittorio A Zambrini, Matteo A Del Nobile
The present study focused on the utilisation of High Intensity Light Pulses (HILP) treatment to preserve mozzarella cheese. First, the susceptibility of Pseudomonas fluorescens and Enterobacteriaceae to HILP (fluences from 0·39 to 28·0 J/cm2) in a transparent liquid was evaluated (in-vitro tests). Afterwards, the effects on inoculated mozzarella cheese were also assessed. Then untreated (Control) and HILP treated samples were packaged and stored at 10 °C for 2 weeks. Enterobacteriaceae, Pseudomonas spp. and pH were monitored during storage...
May 2018: Journal of Dairy Research
https://www.readbyqxmd.com/read/29785755/energy-resolved-mass-spectrometry-of-chlorogenic-acids-and-its-application-to-isomer-quantification-by-direct-infusion-tandem-mass-spectrometry
#16
Javier Hernandez, Anja Müller, Rakesh Jaiswal, Juan Z Davalos, Nikolai Kuhnert
INTRODUCTION: With the advent of high-perfomance liquid chromatography (HPLC)-tandem mass spectrometry (MS) using ion trap mass analysers it is possible to acquire unambigious structural information in particular with respect to aspects of regiochemistry and stereochemistry of organic compounds present in complex mixtures such as coffee extracts. However, HPLC-MS methods are resource extensive, laborious and lacking user friendliness. OBJECTIVE: To introduce a simple parameter - the energy threshhold for fragmentation - determined using energy resolved MS and demonstrate its value for the complete structural characterisation and even relative quantification of individual isomeric chlrogenic acids in direct infusion experiments...
May 21, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29785728/ultrafast-capillary-electrophoresis-method-for-the-simultaneous-determination-of-ammonium-and-diphenhydramine-in-pharmaceutical-samples
#17
Brenda M C Costa, Mariana C Marra, Thiago C Oliveira, Rodrigo A A Munoz, Alex D Batista, Claudimir L do Lago, Eduardo M Richter
Ammonium and diphenhydramine are active ingredients commonly found in the same pharmaceutical preparations. We report for the first time a sub-minute method for the simultaneous determination of ammonium and diphenhydramine. The method is based on capillary electrophoresis with capacitively coupled contactless conductivity detection. Both analytes can be quantified in a single run (∼80 injections h-1 ) using 30 mmol L-1 2-(N-morpholino)ethanesulfonic acid and 15 mmol L-1 lithium hydroxide (pH = 6.0) as a background electrolyte...
May 22, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29785715/current-advances-in-screening-for-bioactive-components-from-medicinal-plants-by-affinity-ultrafiltration-mass-spectrometry
#18
Guilin Chen, Bill X Huang, Mingquan Guo
INTRODUCTION: Medicinal plants have played an important role in maintaining human health for thousands of years. However, the interactions between the active components in medicinal plants and some certain biological targets during a disease are still unclear in most cases. OBJECTIVE: To conduct the high-throughput screening for small active molecules that can interact with biological targets, which is of great theoretical significance and practical value. METHODOLOGY: The ultrafiltration mass spectrometry (UF-LC/MS) is a powerful bio-analytical method by combining affinity ultrafiltration and liquid chromatography-mass spectrometry (LC/MS), which could rapidly screen and identify small active molecules that bind to biological targets of interest at the same time...
May 21, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29785657/novel-non-invasive-early-detection-of-lung-cancer-using-liquid-immunobiopsy-metabolic-activity-profiles
#19
Yochai Adir, Shoval Tirman, Shirley Abramovitch, Cynthia Botbol, Aviv Lutaty, Tali Scheinmann, Eyal Davidovits, Irit Arbel, Giora Davidovits, Sonia Schneer, Michal Shteinberg, Hagit Peretz Soroka, Ruven Tirosh, Fernando Patolsky
Lung cancer is the leading cause of cancer death worldwide. Survival is largely dependent on the stage of diagnosis: the localized disease has a 5-year survival greater than 55%, whereas, for spread tumors, this rate is only 4%. Therefore, the early detection of lung cancer is key for improving prognosis. In this study, we present an innovative, non-invasive, cancer detection approach based on measurements of the metabolic activity profiles of immune system cells. For each Liquid ImmunoBiopsy test, a 384 multi-well plate is loaded with freshly separated PBMCs, and each well contains 1 of the 16 selected stimulants in several increasing concentrations...
May 21, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29785645/concurrent-coupling-of-realistic-and-ideal-models-of-liquids-and-solids-in-hamiltonian-adaptive-resolution-simulations
#20
Maziar Heidari, Robinson Cortes-Huerto, Kurt Kremer, Raffaello Potestio
To understand the properties of a complex system it is often illuminating to perform a comparison with a simpler, even idealised one. A prototypical application of this approach is the calculation of free energies and chemical potentials in liquids, which can be decomposed in the sum of ideal and excess contributions. In the same spirit, in computer simulations it is possible to extract useful information on a given system making use of setups where two models, an accurate one and a simpler one, are concurrently employed and directly coupled...
May 23, 2018: European Physical Journal. E, Soft Matter
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