Changshan Wan, Tao Ji, Liwei Wang, Qiuyan Wu, Qiuyu Chen, Yali Wang, Yaqian Li, Fengming He, Wentian Liu, Weilong Zhong, Bangmao Wang
Many immune-mediated diseases have the common genetic basis, as an autoimmune disorder, celiac disease (CeD) primarily affects the small intestine, and is caused by the ingestion of gluten in genetically susceptible individuals. As for ulcerative colitis (UC), which most likely involves a complex interplay between some components of the commensal microbiota and other environmental factors in its origin. These two autoimmune diseases share a specific target organ, the bowel. The etiology and immunopathogenesis of both conditions characterized by chronic intestinal inflammation, ulcerative colitis and celiac disease, are not completely understood...
April 13, 2024: International Immunopharmacology