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Allergy&immunology

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https://www.readbyqxmd.com/read/29451619/increase-of-10-in-the-rate-of-adverse-drug-reactions-for-each-drug-administered-in-hospitalized-patients
#1
Marisa Rosimeire Ribeiro, Antonio Abílio Motta, Luiz Augusto Marcondes-Fonseca, Jorge Kalil-Filho, Pedro Giavina-Bianchi
OBJECTIVE: To assess the risk factors, incidence and severity of adverse drug reactions in in-patients. METHODS: This prospective study evaluated 472 patients treated at a teaching hospital in Brazil between 2010 and 2013 by five medical specialties: Internal Medicine, General Surgery, Geriatrics, Neurology, and Clinical Immunology and Allergy. The following variables were assessed: patient age, gender, comorbidities, family history of hypersensitivity, personal and family history of atopy, number of prescribed drugs before and during hospitalization, hospital diagnoses, days of hospitalization...
2018: Clinics
https://www.readbyqxmd.com/read/29434271/adherence-and-quality-of-life-in-adults-and-children-during-3-years-of-slit-treatment-with-grazax-a-real-life-study
#2
Hampus Kiotseridis, Peter Arvidsson, Vibeke Backer, Vagn Braendholt, Alf Tunsäter
Respiratory allergic disease represents a global health problem, 30% of the population suffers from allergic rhinoconjunctivitis and 20% suffer from asthma. Allergy immunotherapy induce immunological tolerance and thereby modify the response to allergens and sublingual immunotherapy (SLIT) offers the possibility of home administration of allergen therapy, but adherence is more uncertain. The aim of the study was to investigate the adherence with GRAZAX in adults and children ≥ 5 years during three consecutive years of treatment...
February 12, 2018: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/29428698/mast-cells-basophils-and-eosinophils-from-allergy-to-cancer
#3
REVIEW
A Rigoni, M P Colombo, C Pucillo
Basophils, eosinophils and mast cells were first recognized by Paul Ehrlich in the late 19th century. These cells have common, but non-redundant roles, in the pathogenesis of allergic diseases and in the protection against parasites. Nevertheless, in virtue of their shared-adeptness to produce a huge variety of immunological mediators and express membrane-bound receptors, they are able to interact with immune and non-immune components of the tissue microenvironment, contributing to the regulation of tissue homeostasis and immune response while participating to further deregulation of tissues transforming into neoplasia...
February 7, 2018: Seminars in Immunology
https://www.readbyqxmd.com/read/29423275/a-roadmap-towards-personalized-immunology
#4
Sylvie Delhalle, Sebastian F N Bode, Rudi Balling, Markus Ollert, Feng Q He
Big data generation and computational processing will enable medicine to evolve from a "one-size-fits-all" approach to precise patient stratification and treatment. Significant achievements using "Omics" data have been made especially in personalized oncology. However, immune cells relative to tumor cells show a much higher degree of complexity in heterogeneity, dynamics, memory-capability, plasticity and "social" interactions. There is still a long way ahead on translating our capability to identify potentially targetable personalized biomarkers into effective personalized therapy in immune-centralized diseases...
2018: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/29411702/practical-guidelines-for-perioperative-hypersensitivity-reactions
#5
REVIEW
J J Laguna, J Archilla, I Doña, M Corominas, G Gastaminza, C Mayorga, P Berjes-Gimeno, P Tornero, S Martin, A Planas, E Moreno, M J Torres
Perioperative hypersensitivity reactions constitute a first-line problem for anesthesiologists and allergists, so it is advisable that hospitals have a consensus protocol for the diagnosis and management of these reactions. However, this kind of protocols is not present in many hospitals, leading to problems in treatment, the communication of incidents and subsequent etiological diagnosis. In this document we present a systematic review of the available scientific evidence and provide general guidelines for the management of acute episodes and for referral of patients with perioperative hypersensitivity reactions to Allergy Units...
February 7, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29410333/impact-of-pollution-on-allergy-immunology
#6
EDITORIAL
David B Peden
No abstract text is available yet for this article.
February 1, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29410031/intraperitoneal-administration-of-aluminium-based-adjuvants-produces-severe-transient-systemic-adverse-events-in-mice
#7
Sandra N Freiberger, Deborah S Leuthard, Agathe Duda, Emmanuel Contassot, Michaela Thallmair, Thomas M Kündig, Pål Johansen
Vaccines typically come with adjuvants that trigger the innate immune system in order to prepare best possible inflammatory conditions as to allow the adaptive immune system to become activated, generally for the induction of antibodies. The oldest approved and most abundant immunological adjuvants are salts of aluminium, which are also frequently used in animal models of immunisation and allergy desensitization. In rodents, the intraperitoneal administration of aluminium adjuvants is commonly performed and considered safe...
February 2, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29408543/precision-medicine-in-cow-milk-allergy-proteomics-perspectives-from-allergens-to-patients
#8
Enza D' Auria, Chiara Mameli, Cristian Piras, Lucia Cococcioni, Andrea Urbani, Gian Vincenzo Zuccotti, Paola Roncada
Cow's milk allergy (CMA) is one of the most common food allergies, especially during childhood. CMA is an immunological mediated adverse reaction to one or more cow's milk proteins, which are normally harmless to a non-allergic individual, as the result of a failure of oral tolerance. To make a correct diagnosis of CMA and a proper treatment are critical in clinical practice. Application of proteomics along with new bio-informatics tools in the field of food allergy is one of the hot topics presented in recent years...
February 3, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29408409/characterization-of-a-hybrid-protein-designed-with-segments-of-allergens-from-blomia-tropicalis-and-dermatophagoides-pteronyssinus
#9
Dalgys Martínez, Jose Fernando Cantillo, Helber Herazo, Judith Wortmann, Walter Keller, Luis Caraballo, Leonardo Puerta L
BACKGROUND: Sensitization to allergens of the house dust mites Dermatophagoides pteronyssinnus and Blomia tropicalis is an important risk factor for asthma and allergic diseases. Allergen-specific immunotherapy is currently based on natural allergen extracts, however, in the last years recombinant allergens with different modifications have shown promising immunological properties that may be advantageously applied for developing novel allergy vaccines. METHODS: A hybrid molecule (MAVAC-BD-2) containing epitopes of B...
February 3, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29407420/changes-in-emergency-department-concordance-with-guidelines-for-the-management-of-stinging-insect-induced-anaphylaxis-1999-2001-versus-2013-2015
#10
Sunday Clark, Krislyn M Boggs, Diana S Balekian, Kohei Hasegawa, Phuong Vo, Brian H Rowe, Carlos A Camargo
BACKGROUND: Changes in emergency department (ED) concordance with guidelines for the management of stinging insect-induced anaphylaxis (SIIA) are not known. OBJECTIVE: We describe temporal changes in ED concordance with guidelines for the management of SIIAs. METHODS: We analyzed data from two multicenter retrospective studies of patients with stinging insect-related acute allergic reactions seen in one of 14 North American EDs during two time periods: 1999-2001 and 2013-2015...
January 30, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29406838/real-world-characteristics-and-treatment-patterns-in-patients-with-urticaria-initiating-omalizumab-in-the-united-states
#11
Xuehua Ke, Abhishek Kavati, Debra Wertz, Qing Huang, Liya Wang, Vincent J Willey, Judith J Stephenson, Benjamin Ortiz, Brandee Paknis, Jonathan A Bernstein, Lisa A Beck
BACKGROUND: Omalizumab is indicated for the management of chronic idiopathic urticaria (CIU) in patients aged 12 years or older with persistent hives that are not adequately controlled by H1 antihistamines. While its safety and efficacy in CIU patients have been evaluated in multiple clinical trials, real-world use of omalizaumab in CIU has not been well characterized. OBJECTIVE: To assess demographics, clinical characteristics, and treatment patterns of CIU patients who initiated omalizumab to better understand the usage of this agent in CIU management in the real world...
December 19, 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29397373/the-journal-of-allergy-and-clinical-immunology-in%C3%A2-practice-2017-year-in-review
#12
REVIEW
Michael Schatz, Scott H Sicherer, Robert S Zeiger
An impressive number of clinically impactful studies and reviews were published in The Journal of Allergy and Clinical Immunology: In Practice in 2017. As a service to our readers, the editors provide this Year in Review article to highlight and contextualize the advances published over the past year. We include information from articles on asthma, allergic rhinitis, rhinosinusitis, immunotherapy, atopic dermatitis, contact dermatitis, food allergy, anaphylaxis, drug hypersensitivity, urticarial/angioedema, eosinophilic disorders, and immunodeficiency...
January 31, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29397372/conducting-an-integrative-health-interview
#13
Maureen George, Melissa Avila, Thomas Speranger, Heidi K Bailey, William S Silvers
Complementary medicine incorporates the use of non-evidence-based complementary modalities into conventional (Western) medicine. Alternative medicines are approaches that are used in place of conventional medicine. Integrative medicine is the synthesis of conventional medical treatments with "evidence-based" complementary medical practices. When complementary approaches are incorporated into mainstream health care, it is called integrative health (IH). Among children and adults, IH is common despite not all therapies being safe and/or effective...
January 31, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29393671/importance-of-maternal-diet-in-the-training-of-the-infant-s-immune-system-during-gestation-and-lactation
#14
P V Jeurink, K Knipping, F Wiens, K Barańska, B Stahl, J Garssen, B Krolak-Olejnik
Latest forecasts predict that half of the European population will be allergic within the coming 15 years, with food allergies contributing substantially to the total burden; preventive measures are urgently needed. Unfortunately, all attempted alimentary strategies for primary prevention of allergic diseases through allergen avoidance so far have failed. This also holds true for the prevention of food allergies in breastfed infants by the common practice of excluding certain foods with allergenic potential from the maternal diet...
February 2, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29387518/effect-of-administrating-polysaccharide-from-black-currant-ribes-nigrum-l-on-atopic-dermatitis-in-nc-nga-mice
#15
Hiroshi Ashigai, Yuta Komano, Guanying Wang, Yasuji Kawachi, Kazuko Sunaga, Reiko Yamamoto, Ryoji Takata, Mika Miyake, Takaaki Yanai
Atopic dermatitis (AD) is a chronic inflammatory skin disease that causes dry skin and functional disruption of the skin barrier. AD is often accompanied by allergic inflammation. AD patient suffer from heavy itching, and their quality of life is severely affected. Some pharmaceuticals for AD have some side effects such as skin atrophy. So it is necessary to develop mild solutions such as food ingredients without side effects. There are various causes of AD. It is especially induced by immunological imbalances such as IFN-γ reduction...
2018: Bioscience of Microbiota, Food and Health
https://www.readbyqxmd.com/read/29384667/effects-of-simulated-smog-atmospheres-in-rodent-models-of-metabolic-and-immunologic-dysfunction
#16
Marie McGee Hargrove, Samantha J Snow, Robert W Luebke, Charles E Wood, Jonathan Krug, Q Todd Krantz, Charly King, Carey Copeland, Shaun D McCullough, Kymberly M Gowdy, Urmila Kodavanti, M Ian Gilmour, Stephen Gavett
Air pollution is a diverse and dynamic mixture of gaseous and particulate matter, limiting our understanding of associated adverse health outcomes. The biological effects of two simulated smog atmospheres (SA) with different compositions but similar air quality health indexes were compared in a non-obese diabetic rat model (Goto-Kakizaki, GK) and three mouse immune models (house dust mite (HDM) allergy, antibody response to heat-killed pneumococcus, and resistance to influenza A infection). In GK rats, both SA-PM (high particulate matter) and SA-O3 (high ozone) decreased cholesterol levels immediately after a 4-hour exposure, whereas only SA-O3 increased airflow limitation...
January 31, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29384106/recommendations-for-the-use-of-molecular-diagnostics-in-the-diagnosis-of-allergic-dis-eases
#17
REVIEW
D Villalta, E Tonutti, N Bizzaro, I Brusca, V Sargentini, R Asero, M B Bilo, G Manzotti, F Murzilli, L Cecchi, A Musarra
The Study Group on Allergology of the Italian Society of Clinical Pathology and Laboratory Medicine (SIPMeL) and the Associazione Italiana degli Allergologi e Immunologi Territoriali e Ospedalieri (AAIITO) developed the present recommendations on the diagnosis of allergic diseases based on the use of molecular allergenic components, whose purpose is to provide the pathologists and the clinicians with information and algorithms enabling a proper use of this second-level diagnostics. Molecular diagnostics allows definition of the exact sensitization profile of the allergic patient...
November 27, 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29379542/clinical-and-immunological-effects-of-vitamin-d-supplementation-during-the-pollen-season-in-children-with-allergic-rhinitis
#18
Joanna Jerzyńska, Włodzimierz Stelmach, Błażej Rychlik, Paweł Majak, Daniela Podlecka, Katarzyna Woicka-Kolejwa, Iwona Stelmach
Introduction: Vitamin D deficiency has been proposed as a potential contributing factor in patients with allergic diseases. We compared the clinical and immunological effects of vitamin D supplementation to placebo during the pollen season in children with allergic rhinitis. Material and methods: Thirty-eight children aged 5-12, sensitive to grass pollen, participated in a prospective, randomized, double-blind, placebo-controlled trial. Children received either vitamin D 1000 IU daily supplementation or placebo...
January 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29369411/safety-and-efficacy-of-epicutaneous-immunotherapy-for-food-allergy
#19
REVIEW
Julie Wang, Hugh A Sampson
Food allergy is increasingly common in children, affecting about 4-8%. The mainstays of management remain allergen avoidance and emergency preparedness to treat allergic reactions with emergency medications. Unfortunately, these approaches are unsatisfactory for many patients and their families as the restrictions, constant vigilance and unpredictable severity of allergic reactions negatively impact quality of life. In recent decades, there has been significant interest in developing treatments for food allergy that lead to desensitization in order to increase thresholds for triggering allergic reactions and decrease the risk of reacting to allergen-contaminated food products...
January 25, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29368358/birth-order-and-pediatric-allergic-disease-a-nationwide-longitudinal-survey
#20
Tomonobu Kikkawa, Takashi Yorifuji, Yosuke Fujii, Masato Yashiro, Ayumi Okada, Masanori Ikeda, Hiroyuki Doi, Hirokazu Tsukahara
BACKGROUND: Environmental factors seem to be related to the incidence of allergic disease. Children with a later birth order are often exposed to environments where pathogens and endotoxins can be found, and thus have a higher risk of developing infectious diseases. Therefore, birth order is regarded as an indicator that reflects postnatal environment. However, longitudinal studies are limited on this subject. This study sought to elucidate the relationships between birth order and allergic disease...
January 25, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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