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Allergy&immunology

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https://www.readbyqxmd.com/read/29653235/factors-correlated-with-repeated-aspirin-dosing-during-aspirin-desensitization
#1
Charles F Schuler, James L Baldwin, Alan P Baptist
BACKGROUND: Aspirin desensitization is an appropriate procedure for many patients with aspirin-exacerbated respiratory disease (AERD). Patients can require aspirin re-dosing, which prolongs the desensitization process. The frequency of this is not widely reported, nor is it known which patients will require multiple re-dosing. OBJECTIVE: To determine the frequency of and factors associated with repeat aspirin re-dosing during desensitization. METHODS: Charts of aspirin desensitization procedures from 2011-2016 at the University of Michigan Allergy/Immunology Clinic were reviewed...
April 10, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29651973/the-clinical-and-immunological-features-of-patients-with-primary-antibody-deficiencies
#2
Gholamreza Azizi, Yasser Bagheri, Marzieh Tavakol, Forough Askarimoghaddam, Kiyoomars Poorrostami, Hosein Rafiemanesh, Reza Yazdani, Fatemeh Kiaee, Sima Habibi, Kosar Abouhamzeh, Hamed Mohammadi, Mostafa Qorbani, Hassan Abolhassani, Asghar Aghamohammadi
BACKGROUND: Primary antibody deficiency (PAD) comprises a range of diseases from early to late terminal B cells defects and is associated with the various clinical complications. METHODS: A total of 461 patients (311 males and 150 females) with PADs enrolled in the retrospective cohort study and for all patients' demographic information, clinical records and laboratory data were collected to investigate clinical complications. RESULTS: The most prevalent first presentations of immunodeficiency were respiratory tract infections in 63...
April 12, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29629957/how-to-actively-treat-food-allergy
#3
Valentina Pecora, Maurizio Mennini, Veronica Calandrelli, Giampiero Patriarca, Rocco Valluzzi, Vincenzo Fierro
PURPOSE OF REVIEW: In the last years, food allergy treatment is moving away from food avoidance to interventional treatments. We review here the recent developments on immunotherapy with food allergens. RECENT FINDINGS: Oral immunotherapy remains the best studied form of food immunotherapy. In 2017, further evidence has been added to its efficacy. Its mechanisms of action are under scrutiny. To reduce its side effects, studies have been dedicated to the simultaneous use of biologics, in particular omalizumab...
April 6, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29629055/accuracy-of-immunoblotting-assay-for-detection-of-specific-ige-compared-with-immunocap-in-allergic-patients
#4
Raheleh Shokouhi Shoormasti, Mohammad Reza Fazlollahi, Anoshirvan Kazemnejad, Masoud Movahedi, Behnoosh Tayebi, Zahra Yazdanyar, Zakieh Azadi, Zahra Pourpak, Mostafa Moin
Background and aim: Standardized techniques help us to better diagnosis and follow up of allergic diseases. In this study, we determined the sensitivity, accuracy, and specificity of an Immunoblotting test compared to ImmunoCAP as the reference in vitro test for detection of specific IgE in allergic patients. Methods: In this cross-sectional study, specific IgE level was determined in patients with allergic symptoms who referred to the Immunology, Asthma and Allergy Research Institute, Tehran, Iran from 2010-2016, by two techniques...
February 2018: Electronic Physician
https://www.readbyqxmd.com/read/29625844/who-iuis-allergen-nomenclature-providing-a-common-language
#5
Anna Pomés, Janet M Davies, Gabriele Gadermaier, Christiane Hilger, Thomas Holzhauser, Jonas Lidholm, Andreas L Lopata, Geoffrey A Mueller, Andreas Nandy, Christian Radauer, Sanny K Chan, Uta Jappe, Jörg Kleine-Tebbe, Wayne R Thomas, Martin D Chapman, Marianne van Hage, Ronald van Ree, Stefan Vieths, Monika Raulf, Richard E Goodman
A systematic nomenclature for allergens originated in the early 1980s, when few protein allergens had been described. A group of scientists led by Dr. David G. Marsh developed a nomenclature based on the Linnaean taxonomy, and further established the World Health Organization/International Union of Immunological Societies (WHO/IUIS) Allergen Nomenclature Sub-Committee in 1986. Its stated aim was to standardize the names given to the antigens (allergens) that caused IgE-mediated allergies in humans. The Sub-Committee first published a revised list of allergen names in 1986, which continued to grow with rare publications until 1994...
April 3, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29623581/clinical-presentation-of-cashew-nut-allergy-in-a-paediatric-cohort-attending-an-allergy-clinic-in-the-west-of-ireland
#6
Miranda Crealey, Salma Alamin, Vincent Tormey, Edina Moylett
BACKGROUND: Cashew nut (CN) allergy appears to be increasing. Reactions are variable and may include anaphylaxis. AIM: To describe the clinical features of CN allergy in a group of children attending an allergy clinic with suspected peanut allergy and confirmed sensitisation to CN. METHODS: Patients were identified retrospectively by reviewing the Immunology Database at University Hospital Galway over a 5-year period, Oct. 2010 to Sept. 2015...
April 5, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29610415/psychiatric-and-medical-conditions-in-transition-aged-individuals-with-asd
#7
Meghan N Davignon, Yinge Qian, Maria Massolo, Lisa A Croen
BACKGROUND AND OBJECTIVES: Children with autism spectrum disorder (ASD) have a variety of medical and psychiatric conditions and an increased use of health care services. There is limited information about the prevalence of psychiatric and medical conditions in adolescents and young adults with ASD. Our objective was to describe the frequency of medical and psychiatric conditions in a large population of diverse, insured transition-aged individuals with ASD. METHODS: Participants included Kaiser Permanente Northern California members who were enrolled from 2013 to 2015 and who were 14 to 25 years old...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29603410/low-dose-oral-immunotherapy-for-children-with-anaphylactic-peanut-allergy-in-japan
#8
Ken-Ichi Nagakura, Noriyuki Yanagida, Sakura Sato, Makoto Nishino, Tomoyuki Asaumi, Kiyotake Ogura, Motohiro Ebisawa
BACKGROUND: Oral immunotherapy (OIT) is a promising treatment for persons with allergy; however, it can also cause adverse allergic reactions. In this study, we investigated the efficacy of low-dose OIT for anaphylactic peanut allergy. METHODS: Twenty-four children (median age, 9.6 years) with anaphylaxis to peanuts were hospitalized for 5 days and then gradually fed increasing amounts of peanut powder up to 133 mg/day. One year later, they underwent an oral food challenge after 2 weeks of peanut avoidance...
March 30, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29601356/current-opinion-in-allergy-and-clinical-immunology-a-change-in-leadership
#9
Stephanie Fairbairn
No abstract text is available yet for this article.
March 29, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29601091/-to-screen-or-not-to-screen-comparing-the-health-and-economic-benefits-of-early-peanut-introduction-strategies-in-five-countries
#10
Marcus Shaker, David Stukus, Edmond S Chan, David M Fleischer, Jonathan M Spergel, Matthew Greenhawt
BACKGROUND: Early peanut introduction (EPI) in the first year of life is associated with reduced risk of developing peanut allergy in children with either severe eczema and/or egg allergy. However, EPI recommendations differ among countries with formal guidelines. METHODS: Using simulation and Markov modeling over a 20-year horizon to attempt to explore optimal EPI strategies applied to the US population, we compared high-risk infant specific IgE peanut screening (US/Canadian) with the Australiasian Society for Clinical Immunology and Allergy (Australia/New Zealand) (ASCIA) and the United Kingdom Department of Health (UKDOH) published EPI approaches...
March 30, 2018: Allergy
https://www.readbyqxmd.com/read/29578652/non-celiac-gluten-sensitivity-how-its-gut-immune-activation-and-potential-dietary-management-differ-from-celiac-disease
#11
REVIEW
Vera Rotondi Aufiero, Alessio Fasano, Giuseppe Mazzarella
Non-celiac gluten sensitivity (NCGS) is a clinical entity triggered by the ingestion of gluten-containing grains leading to intestinal and/or extraintestinal symptoms that resolve once the gluten-containing foodstuff is eliminated from the diet and it is diagnosed when celiac disease (CD) and wheat allergy (WA) have been ruled out. The limited knowledge about the pathophysiology of NCGS and the lack of validated biomarkers are still major limitations for clinical studies, making it difficult to differentiate NCGS from other gluten-related disorders (GRD)...
March 26, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29545800/dietary-fiber-pectin-directly-blocks-toll-like-receptor-2-1-and-prevents-doxorubicin-induced-ileitis
#12
Neha M Sahasrabudhe, Martin Beukema, Lingmin Tian, Berit Troost, Jan Scholte, Erik Bruininx, Geert Bruggeman, Marco van den Berg, Anton Scheurink, Henk A Schols, Marijke M Faas, Paul de Vos
Dietary carbohydrate fibers are known to prevent immunological diseases common in Western countries such as allergy and asthma but the underlying mechanisms are largely unknown. Until now beneficial effects of dietary fibers are mainly attributed to fermentation products of the fibers such as anti-inflammatory short-chain fatty acids (SCFAs). Here, we found and present a new mechanism by which dietary fibers can be anti-inflammatory: a commonly consumed fiber, pectin, blocks innate immune receptors. We show that pectin binds and inhibits, toll-like receptor 2 (TLR2) and specifically inhibits the proinflammatory TLR2-TLR1 pathway while the tolerogenic TLR2-TLR6 pathway remains unaltered...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29542892/lipid-transfer-protein-sensitization-in-an-apple-allergic-patient-a-case-report-from-northern-europe
#13
A Gülsen, U Jappe
We describe a case of a woman who developed three separate episodes of urticaria and ana-phylaxis during exercise after consuming an apple, with immunological evidence that nonspecific lipid transfer proteins (LTP) may have been responsible for these reactions. LTP sensitivity can cause life-threatening allergies and anaphylaxis. Although LTP sensitization is common in Mediterranean countries, the frequency of knowledge and diagnoses is increasing in Europe. Despite the geographic differences, LTP allergy should be kept on sight when facing severe anaphylaxis after consuming LTP-included food...
March 2, 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29524535/advances-in-the-approach-to-the-patient-with-food-allergy
#14
Amy M Scurlock, Stacie M Jones
Advances in food allergy diagnosis, management, prevention and therapeutic interventions have been significant over the past two decades. Evidence based national and international guidelines have streamlined food allergy diagnosis and management, while paradigm shifting work in primary prevention of peanut allergy has resulted in significant modifications in the approach to early food introduction in infants and toddlers. Innovative investigation of food allergy epidemiology, systems biology, impact, and management has provided important insights...
March 7, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29524260/patch-testing-in-gastrointestinal-diseases-a-systematic-review-of-the-patch-test-and-atopy-patch-test
#15
LETTER
S Gayam, Z Zinn, M Chelliah, J Teng
No abstract text is available yet for this article.
March 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29519764/identifying-the-factors-and-root-causes-associated-with-the-unintentional-usage-of-an-adrenaline-auto-injector-in-japanese-children-and-their-caregivers
#16
Kemal Sasaki, Tomoko Nakagawa, Shiro Sugiura, Motohiro Ebisawa, Komei Ito
BACKGROUND: The unintentional usage of adrenaline auto-injectors may cause injury to caregivers or patients. To prevent such incidents, we assessed the causative factors of these incidents. METHODS: The Anaphylaxis Working Group of the Japanese Society of Pediatric Allergy and Clinical Immunology requested that society members register cases in which adrenaline auto-injectors were unintentionally used. One hundred cases were reported from June 2015 to March 2016...
March 5, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29516263/the-impact-of-baked-egg-and-baked-milk-diets-on-ige-and-non-ige-mediated-allergy
#17
REVIEW
Julia Upton, Anna Nowak-Wegrzyn
Baked milk (BM) and baked egg (BE) diets are increasingly used in the management of milk and egg allergy, rather than avoidance. Children with tolerance versus reactivity to BM and BE may have smaller skin prick test and lower specific IgE, and BM-tolerant children have less basophil reactivity and more peripheral T regulatory cells. However, most milk- and egg-allergic children tolerate BM and BE and an individual's reactivity is unpredictable. Non-reactivity is due to conformational changes in the allergens...
March 8, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29515571/nanoparticles-for-the-induction-of-antigen-specific-immunological-tolerance
#18
REVIEW
Takashi Kei Kishimoto, Roberto A Maldonado
Antigen-specific immune tolerance has been a long-standing goal for immunotherapy for the treatment of autoimmune diseases and allergies and for the prevention of allograft rejection and anti-drug antibodies directed against biologic therapies. Nanoparticles have emerged as powerful tools to initiate and modulate immune responses due to their inherent capacity to target antigen-presenting cells (APCs) and deliver coordinated signals that can elicit an antigen-specific immune response. A wide range of strategies have been described to create tolerogenic nanoparticles (tNPs) that fall into three broad categories...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29512854/contribution-of-repeated-infections-in-asthma-persistence-from-preschool-to-school-age-design-and-characteristics-of-the-predicta-cohort
#19
Paraskevi Xepapadaki, Claus Bachert, Susetta Finotto, Tuomas Jartti, George N Konstantinou, Alexander Kiefer, Marek Kowalski, Anna Lewandowska-Polak, Heikki Lukkarinen, Eirini Roumpedaki, Anna Sobanska, Ina Sintobin, Tytti Vuorinen, Nan Zhang, Theodor Zimmermann, Nikolaos G Papadopoulos
BACKGROUND: The PreDicta cohort was designed to prospectively evaluate wheeze/asthma persistence in preschoolers in association to viral/microbial exposures and immunological responses. We present the cohort design, demographic/disease characteristics and evaluate unsupervised and predefined phenotypic subgroups at inclusion. METHODS: PreDicta is a 2-year prospective study conducted in five European regions, including children 4-6 years with a diagnosis of asthma as cases and healthy age-matched controls...
March 7, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29507553/the-diagnosis-and-management-of-food-allergies-position-paper-of-the-food-allergy-section-the-polish-society-of-allergology
#20
Zbigniew Bartuzi, Maciej Kaczmarski, Mieczysława Czerwionka-Szaflarska, Teresa Małaczyńska, Aneta Krogulska
The paper concerns the current position of the Polish Society of Allergology Food Allergy Section on the diagnosis and management of food allergies. The aim of this position is to provide evidence-based recommendations on the diagnosis and management of patients with allergic hypersensitivity to foods. This position statement includes a systematic review of studies in three areas, namely, the epidemiology, diagnosis and management of food allergies. While taking into account the specific Polish setting, in this publication we also used the current European Academy of Allergy and Clinical Immunology (EAACI) position paper and other current position statements, including those of the United States National Institute of Allergy and Infectious Diseases (NIAID)...
October 2017: Postȩpy Dermatologii i Alergologii
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