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https://www.readbyqxmd.com/read/28236270/oxidative-and-carbonyl-stress-in-pregnant-women-with-obstructive-sleep-apnea
#1
Nazia Khan, Geralyn Lambert-Messerlian, Joao Filipe Monteiro, Julius Hodosy, Ľubomíra Tóthová, Peter Celec, Elizabeth Eklund, Patrizia Curran, Ghada Bourjeily
PURPOSE: Pregnant women are particularly susceptible to sleep-disordered breathing. Obstructive sleep apnea (OSA) in pregnancy is associated with poor pregnancy and fetal outcomes. Oxidative stress caused by intermittent hypoxemia and reoxygenation may impact pregnancy health. We hypothesize that pregnant women with OSA have a pronounced oxidative stress profile. METHODS: A case-control study was performed to study oxidative stress markers in the serum of pregnant women with or without OSA...
February 24, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28121644/peripartum-management-of-obstructive-sleep-apnea
#2
Jessica L Booth, Ashley M Tonidandel
The prevalence of obstructive sleep apnea is unknown during pregnancy, but the syndrome is likely underdiagnosed and rising in frequency along with the obesity epidemic. Obstructive sleep apnea is associated with adverse outcomes, including hypertensive disorders of pregnancy, gestational diabetes, preterm, and cesarean delivery. Obese pregnant women should be screened and referred to a sleep medicine specialist for evaluation. Continuous positive airway pressure is the treatment of choice with demonstrated safety and compliance in pregnancy...
January 24, 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28103130/serum-progesterone-levels-in-pregnant-women-with-obstructive-sleep-apnea-a-case-control-study
#3
Jennifer Lee, Elizabeth E Eklund, Geralyn Lambert-Messerlian, Glenn E Palomaki, Kristen Butterfield, Patrizia Curran, Ghada Bourjeily
BACKGROUND: Pregnancy is a risk factor for sleep disordered breathing, including obstructive sleep apnea (OSA). Progesterone, one of the key hormones in pregnancy, a known respiratory drive stimulant, increases ventilation and may protect against OSA. We aimed to examine the relationship between circulating progesterone and OSA, after accounting for body weight and gestational age. METHODS: A case control study was conducted of pregnant women with OSA and those at low risk for the disorder...
March 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28090638/late-gestational-intermittent-hypoxia-induces-metabolic-and-epigenetic-changes-in-male-adult-offspring-mice
#4
Abdelnaby Khalyfa, Rene Cortese, Zhuanhong Qiao, Honggang Ye, Riyue Bao, Jorge Andrade, David Gozal
Pregnancy, particularly late gestation, has been associated with a relatively high prevalence of obstructive sleep apnea (OSA). Intermittent hypoxia (IH), a hallmark of OSA, could impose significant long-term effects on somatic growth, energy homeostasis, and metabolic function in offspring. We hypothesized that IH during late pregnancy (LG-IH) may increase the propensity for metabolic dysregulation and obesity in adult offspring via epigenetic modifications. Time-pregnant female C57BL/6 mice were exposed to LG-IH or room air (LG-RA) during days 13-18 of gestation...
January 15, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28077252/incorporating-body-type-apple-vs-pear-in-stop-bang-questionnaire-improves-its-validity-to-detect-osa
#5
Lisa Sangkum, Ikrita Klair, Chok Limsuwat, Sabrina Bent, Leann Myers, Supat Thammasitboon
STUDY OBJECTIVE: The aim of this study is to evaluate whether adding the item of "apple body type" to the STOP-BANG questionnaire enhances diagnostic performance of the questionnaire for detecting obstructive sleep apnea (OSA). DESIGN: Cross-sectional study. SETTING: Sleep center setting. PATIENTS: Two hundred and eight subjects who were referred for an evaluation of possible OSA at Tulane Comprehensive Sleep Center...
January 8, 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28040612/association-of-obstructive-sleep-apnea-with-adverse-pregnancy-related-outcomes-in-military-hospitals
#6
Dennis L Spence, Rhonda C Allen, Monica A Lutgendorf, Virginia R Gary, John D Richard, Sara C Gonzalez
BACKGROUND: Obstructive sleep apnea (OSA) is associated with significant morbidity and mortality in non-obstetrical and obstetrical patients. OBJECTIVES: To estimate the prevalence of OSA and its relationship with pregnancy-related complications in a general obstetric population of Department of Defense beneficiaries receiving direct-care at military treatment facilities. STUDY DESIGN: A retrospective cohort study of all women (N=305,001) who gave birth at a military treatment facility from 2008 to 2014...
December 14, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27974870/hemodynamic-response-to-upper-airway-obstruction-in-hypertensive-and-normotensive-pregnant-women
#7
John Reid, Riley A Glew, Joe Mink, John Gjevre, Mark Fenton, Robert Skomro, Femi Olatunbosun
Background. Mild obstructive sleep apnea is common in pregnancy and may have an exacerbating role in gestational hypertension, although currently the interaction between these two diseases is uncertain. Methods. We analyzed 43 pregnant subjects, 28 with gestational hypertension (GH) and 15 with normal healthy pregnancy, by level I polysomnography. Additionally, diastolic and systolic blood pressure changes in response to obstructive respiratory events were measured by noninvasive beat-by-beat monitoring. We also assessed a subgroup (n = 27) of women with respiratory disturbance indexes <5, for blood pressure responses to very subtle obstructive respiratory disturbances ("airflow reductions")...
2016: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/27924661/sleep-disordered-breathing-in-pregnancy-the-maternal-and-fetal-implications
#8
Shanthi Carnelio, Adam Morton, H David McIntyre
Sleep disordered breathing (SDB) which includes obstructive sleep apnoea (OSA) and upper airway resistance syndrome (UARS), has emerged as a risk factor for adverse maternal-foetal outcomes in pregnancy. Physiological changes of pregnancy predispose a woman 'at risk' towards developing SDB. The increasing incidence of OSA in pregnancy closely correlates with the population trends of obesity. Common screening tools validated in non-pregnant subjects including Epworth Sleepiness Scale (ESS) and Berlin Questionnaire (BQ) are poor predictors of SDB in pregnancy...
February 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27648062/insomnia-during-pregnancy-diagnosis-and-rational-interventions
#9
REVIEW
Ali M Hashmi, Shashi K Bhatia, Subhash K Bhatia, Imran S Khawaja
UNLABELLED: Sleep disturbances are common in pregnancy. Insomnia is a frequent sleep disturbance experienced by pregnant women which can be primary or due to co-morbid conditions. The differential diagnosis of insomnia in pregnancy includes anxiety disorders, mood disorders, breathing related sleep disorders and restless legs syndrome. Early interventions to treat the sleep disturbance are recommended to avoid adverse pregnancy outcomes. Management strategies include improving sleep hygiene, behavioral therapies, and pharmacotherapy...
July 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27085867/sleepiness-and-sleep-disordered-breathing-during-pregnancy
#10
Maria Sarberg, Marie Bladh, Ann Josefsson, Eva Svanborg
PURPOSE: This study aimed to examine if there is a difference in the prevalence of obstructive sleep apnea (OSA) and sleepiness between pregnant and non-pregnant women. It also aimed to evaluate if obstetric outcomes were associated to sleep-disordered breathing among the pregnant women. METHODS: One hundred pregnant women (gestational weeks 24-34) and 80 age- and body mass index-matched non-pregnant women underwent whole-night respiratory recordings (airflow, snoring, respiratory movements, body position, pulse oximetry)...
December 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27059378/obstructive-sleep-apnea-and-the-risk-of-preterm-delivery
#11
Kunyalak Na-Rungsri, Somrat Lertmaharit, Vitool Lohsoonthorn, Surachart Totienchai, Nattapong Jaimchariyatam
OBJECTIVE: The aim of this study was to evaluate the risk of obstructive sleep apnea (OSA) to preterm delivery (PTD), using the Berlin Questionnaire (BQ). METHODS: This was a large, prospective cohort study among pregnant Thai women. The BQ was employed for symptom-based OSA screening during the second trimester, and PTD was recorded in 1345 pregnant women. Multivariate models were applied in controlling for potential confounders. RESULTS: The overall prevalence of the high risk of OSA was 10...
September 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/26872044/diagnosis-and-treatment-of-obstructive-sleep-apnea-during-pregnancy
#12
Hairil Rizal Abdullah, Mahesh Nagappa, Naveed Siddiqui, Frances Chung
PURPOSE OF REVIEW: This review aims to provide an update on recent advances in the diagnosis and treatment of obstructive sleep apnea (OSA) during pregnancy and its effect on maternal and fetal outcomes. RECENT FINDINGS: Current OSA screening tools may not perform well in this population. There are some pieces of evidence linking poorer maternal and neonatal outcome with pregnant patients having OSA. At present, there are inadequate data on which to base fetal or maternal parameters for treatment of OSA, and no evidence that treatment in the short-term impacts maternal or neonatal outcomes...
June 2016: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/26626235/evaluation-of-obstructive-sleep-apnea-symptoms-in-pregnant-women-with-chronic-disease
#13
Mevlüt Karaduman, Oktay Sarı, Umit Aydoğan, Yaşam Kemal Akpak, Altuğ Semiz, Necip Cihangir Yılanlıoğlu, Uğur Keskin
OBJECTIVE: Obstructive sleep apnea syndrome (OSAS) is a disease which is estimated to be undiagnosed to a large extent. Hence, the prevalence of OSAS in pregnant women is unknown. We aimed to evaluate the symptoms of obstructive sleep apnea in pregnant women with chronic diseases. METHODS: In the study, 97 pregnant women with chronic diseases and 160 healthy pregnant women were included. A form questioning socio-demographic characteristics and pregnancy characteristics, Epworth scale and the Berlin questionnaire to evaluate the risk of OSAS were applied to participants...
October 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26330987/sleep-quality-and-obstructive-sleep-apnea-in-pregnant-women
#14
Mahsa Ghajarzadeh, Fariba Askari, Mona Mohseni, Mehdi Mohammadifar, Behzad Memari
No abstract text is available yet for this article.
2015: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/26330183/high-risk-for-obstructive-sleep-apnea-and-other-sleep-disorders-among-overweight-and-obese-pregnant-women
#15
COMPARATIVE STUDY
Jayne R Rice, Gloria T Larrabure-Torrealva, Miguel Angel Luque Fernandez, Mirtha Grande, Vicky Motta, Yasmin V Barrios, Sixto Sanchez, Bizu Gelaye, Michelle A Williams
BACKGROUND: Obstructive sleep apnea (OSA), a common and serious disorder in which breathing repeatedly stops during sleep, is associated with excess weight and obesity. Little is known about the co-occurrence of OSA among pregnant women from low and middle-income countries. METHODS: We examined the extent to which maternal pre-pregnancy overweight or obesity status are associated with high risk for OSA, poor sleep quality, and excessive daytime sleepiness in 1032 pregnant women in Lima, Peru...
2015: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/26241261/obstructive-sleep-apnea-in-pregnancy-assessment-of-current-screening-tools
#16
COMPARATIVE STUDY
Ellen M Lockhart, Arbi Ben Abdallah, Methodius G Tuuli, Barbara L Leighton
OBJECTIVE: To estimate the predictive ability of current obstructive sleep apnea (OSA) screening tools and the individual questions in these tools at identifying pregnant women who have OSA. METHODS: A total of 293 third-trimester patients were enrolled between 2010 and 2012, and 248 patients had sleep monitor results. Recruited participants completed a questionnaire consisting of six OSA screening tools and overnight portable sleep monitoring. Predictive ability of the screening tools for OSA compared with results of the diagnosis from overnight sleep monitoring was estimated using the area under receiver operating characteristic curves...
July 2015: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/25957617/sleep-disorders-in-pregnancy-and-their-association-with-pregnancy-outcomes-a-prospective-observational-study
#17
S K Sharma, A Nehra, S Sinha, M Soneja, K Sunesh, V Sreenivas, D Vedita
PURPOSE: Sleep disturbances such as insomnia, nocturnal awakenings, restless legs syndrome, habitual snoring, and excessive daytime sleepiness are frequent during pregnancy, and these have been linked to adverse maternal and fetal outcomes. METHODS: A prospective observational study was performed in high-risk Indian pregnant women. We used modified Berlin questionnaire (MBQ), Pittsburgh sleep quality index (PSQI), International Restless Legs Syndrome Study Group 2011 criteria, and Epworth sleepiness scale to diagnose various sleep disorders, such as symptomatic OSA, poor sleep quality and insomnia, RLS, and excessive daytime sleepiness, respectively, in successive trimesters of pregnancy...
March 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/25566940/central-sleep-apnea-in-pregnant-women-with-sleep-disordered-breathing
#18
Ghada Bourjeily, Katherine M Sharkey, Jeffrey Mazer, Robin Moore, Susan Martin, Richard Millman
PURPOSE: Physiologic changes in the cardiac, respiratory, and renal systems in pregnancy likely impact ventilatory control. Though obstructive sleep apnea and snoring are common in the pregnant population, the predisposition to central respiratory events during sleep and the prevalence of such events is less well studied. The aim of this study was to assess the presence of central apneas during sleep in pregnant women and non-pregnant controls suspected of sleep disordered breathing. METHODS: Twenty-five pregnant women referred for polysomnography for sleep disordered breathing were compared with non-pregnant controls matched for age, body mass index, gender, and apnea hypopnea index (AHI)...
September 2015: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/25406273/screening-of-obstructive-sleep-apnea-during-pregnancy-differences-in-predictive-values-of-questionnaires-across-trimesters
#19
Visasiri Tantrakul, Piyaporn Sirijanchune, Panyu Panburana, Janejira Pengjam, Worakot Suwansathit, Viboon Boonsarngsuk, Christian Guilleminault
STUDY OBJECTIVES: Evaluation of Berlin and Stop-Bang questionnaires in detecting obstructive sleep apnea (OSA) across trimesters of pregnancy. METHODS: Pregnant women from a high-risk pregnancy clinic were recruited to complete sleep evaluations including Berlin and Stop-Bang Questionnaires. Overnight testing with Watch-PAT200 for diagnosis of OSA (cutoff point of apnea-hypopnea index ≥5 events/h) was performed. RESULTS: Seventy-two singleton pregnant women participated in the study...
February 15, 2015: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/25382105/obstructive-sleep-apnea-and-the-risk-of-perinatal-outcomes-a-meta-analysis-of-cohort-studies
#20
Ting Xu, Yuan Feng, Hui Peng, Dongying Guo, Taoping Li
Inconsistent information exists in the relationship between obstructive sleep apnea (OSA) and perinatal outcomes. This study was intended to investigate whether OSA in pregnant women has a potential to elevate the incidence of the maternal and neonatal outcomes by performing a meta-analysis of all available cohort studies. Five cohort studies including 977 participants were eligible for inclusion. The association between OSA and the risk of perinatal outcomes was expressed as relative risks (RR), with 95% confidence interval (CI)...
2014: Scientific Reports
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