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https://www.readbyqxmd.com/read/28350963/gd-dots-with-strong-ligand-water-interaction-for-ultrasensitive-magnetic-resonance-renography
#1
Xiao-Yu Zheng, Kai Zhao, Jinglong Tang, Xin-Yu Wang, Lin-Dong Li, Nai-Xiu Chen, Yan-Jie Wang, Shuo Shi, Xiaodong Zhang, Sivakumar Malaisamy, Ling-Dong Sun, Xiaoying Wang, Chunying Chen, Chun-Hua Yan
Magnetic resonance imaging (MRI) contrast agents (CAs) with both significantly enhanced relaxivity and minimal safety risk are of great importance for sensitive clinical diagnosis, which, however, have rarely been reported. Herein, we present a simple strategy to improve relaxivity by introducing surface ligands with strong interaction to water molecules. As a proof of concept, NaGdF4 nanoparticles (NPs) capped by polyacrylic acid (PAA) show superior relaxivity to those capped by polyethylenimine (PEI) and polyethylene glycol (PEG), which is attributed to the strong hydrogen bond capacity of PAA to water molecules as revealed by theoretical calculation...
March 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28350816/multi-channel-mri-segmentation-of-eye-structures-and-tumors-using-patient-specific-features
#2
Carlos Ciller, Sandro De Zanet, Konstantinos Kamnitsas, Philippe Maeder, Ben Glocker, Francis L Munier, Daniel Rueckert, Jean-Philippe Thiran, Meritxell Bach Cuadra, Raphael Sznitman
Retinoblastoma and uveal melanoma are fast spreading eye tumors usually diagnosed by using 2D Fundus Image Photography (Fundus) and 2D Ultrasound (US). Diagnosis and treatment planning of such diseases often require additional complementary imaging to confirm the tumor extend via 3D Magnetic Resonance Imaging (MRI). In this context, having automatic segmentations to estimate the size and the distribution of the pathological tissue would be advantageous towards tumor characterization. Until now, the alternative has been the manual delineation of eye structures, a rather time consuming and error-prone task, to be conducted in multiple MRI sequences simultaneously...
2017: PloS One
https://www.readbyqxmd.com/read/28350785/the-picture-study-diagnostic-accuracy-of-multiparametric-mri-in-men-requiring-a-repeat-prostate-biopsy
#3
Lucy A M Simmons, Abi Kanthabalan, Manit Arya, Tim Briggs, Dean Barratt, Susan C Charman, Alex Freeman, James Gelister, David Hawkes, Yipeng Hu, Charles Jameson, Neil McCartan, Caroline M Moore, Shonit Punwani, Navin Ramachandran, Jan van der Meulen, Mark Emberton, Hashim U Ahmed
BACKGROUND: Transrectal prostate biopsy has limited diagnostic accuracy. Prostate Imaging Compared to Transperineal Ultrasound-guided biopsy for significant prostate cancer Risk Evaluation (PICTURE) was a paired-cohort confirmatory study designed to assess diagnostic accuracy of multiparametric magnetic resonance imaging (mpMRI) in men requiring a repeat biopsy. METHODS: All underwent 3 T mpMRI and transperineal template prostate mapping biopsies (TTPM biopsies)...
March 28, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28347131/preclinical-in-vivo-cancer-straightway-to-patients
#4
Marion de Jong, Stephen Mather, Theodosia Maina
Detection of useful cellular targets has strongly stimulated personalized tumor-targeted imaging and therapy approaches, also involving synthesis and evaluation of nuclear imaging probes with potential for clinical applications. Reviews of preclinical and translational studies concerning such probes, including radiolabeled antibodies, nanobodies, affibodies, peptides, small molecule inhibitors, and nanoparticles, are presented in this issue. As most tracers described in these articles have been developed for the field of cancer imaging and radionuclide therapy, the current article on preclinical studies will focus on cancer research as well...
June 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28346854/breast-cancer-related-lymphedema-differentiating-fat-from-fluid-using-magnetic-resonance-imaging-segmentation
#5
Yuka Sen, Yi Qian, Louise Koelmeyer, Robert Borotkanics, Robyn Ricketts, Helen Mackie, Thomas C Lam, Kevin Ho Shon, Hiroo Suami, John Boyages
BACKGROUND: Lymphedema is an iatrogenic complication after breast cancer treatment in which lymph fluid in the affected limb progresses to fat deposition and fibrosis that are amenable to liposuction treatment. Magnetic resonance imaging (MRI) for lymphedema can differentiate fat tissue from fluid, but estimating relative volumes remains problematic. METHODS AND RESULTS: Patients underwent routine bilateral arm MRI both before and after liposuction for advanced lymphedema...
March 27, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28346776/proton-exchange-in-a-paramagnetic-chemical-exchange-saturation-transfer-agent-from-experimental-studies-and-ab-initio-metadynamics-simulation
#6
Rodolphe Pollet, Célia S Bonnet, Pascal Retailleau, Philippe Durand, Éva Tóth
The proton-exchange process between water and a carbamate has been studied experimentally and theoretically in a lanthanide-based paramagnetic chemical exchange saturation transfer agent endowed with potential multimodality detection capabilities (optical imaging, or T1 MRI for the Gd(III) analogue). In addition to an in-depth structural analysis by a combined approach (using X-ray crystallography, NMR, and molecular dynamics), our ab initio simulation in aqueous solution sheds light on the reaction mechanism for this proton exchange, which involves structural Grotthuss diffusion...
March 27, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28346737/easl-and-aasld-recommendations-for-the-diagnosis-of-hcc-to-the-test-of-daily-practice
#7
Christophe Aubé, Frederic Oberti, Julie Lonjon, Georges Pageaux, Olivier Seror, Giséle N'Kontchou, Agnes Rode, Sylvie Radenne, Christophe Cassinotto, Julien Vergniol, Ivan Bricault, Vincent Leroy, Maxime Ronot, Laurent Castera, Sophie Michalak, Maxime Esvan, Valérie Vilgrain
AIM: To evaluate the diagnostic performance of CT, MRI, and CEUS alone and in combination, for the diagnosis of HCC between 10 and 30 mm, in a large population of cirrhotic patients. PATIENTS AND METHODS: In a multicentre prospective trial, 442 patients have been enrolled. Within a month CEUS, CT and MRI were performed for all patients. A composite algorithm was defined to obtain the more accurate gold standard. RESULTS: 544 nodules in 381 patients have been retained for the performance analysis...
March 27, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28346223/early-rectal-cancer-a-choice-between-local-excision-and-transabdominal-resection-a-review-of-the-literature-and-current-guidelines
#8
Giuseppe Pappalardo, Massimo Chiaretti
INTRODUCTION: Indication for Local Excision (LE) or Trans Abdominal Resections with Total Mesorectal Excision (TAR) in Early Rectal Cancer (ERC) are still controversial. MATERIAL OF STUDY: We reviewed meta-analyses, scientific societies guidelines, randomized and controlled clinical trials from 1999 to 2016 for a total of 146,231 patients. We included in our analysis the accuracy of different tools of investigation, the reliability of the endoscopic biopsies and compared the results of the various LE and TAR...
March 27, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28346006/magnetic-resonance-imaging-susceptibility-artifacts-in-the-cervical-vertebrae-and-spinal-cord-related-to-monocortical-screw-polymethylmethacrylate-implants-in-canine-cadavers
#9
Brian G Jones, Geoffrey T Fosgate, Eric M Green, Amy M Habing, Bianca F Hettlich
OBJECTIVE To characterize and compare MRI susceptibility artifacts related to titanium and stainless steel monocortical screws in the cervical vertebrae and spinal cord of canine cadavers. SAMPLE 12 canine cadavers. PROCEDURES Cervical vertebrae (C4 and C5) were surgically stabilized with titanium or stainless steel monocortical screws and polymethylmethacrylate. Routine T1-weighted, T2-weighted, and short tau inversion recovery sequences were performed at 3.0 T. Magnetic susceptibility artifacts in 20 regions of interest (ROIs) across 4 contiguous vertebrae (C3 through C6) were scored by use of an established scoring system...
April 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28345573/clinical-correlation-of-imaging-findings-in-congenital-cranial-dysinnervation-disorders-involving-abducens-nerve
#10
Chanchal Gupta, Pradeep Sharma, Rohit Saxena, Ajay Garg, Sanjay Sharma
PURPOSE: High-resolution magnetic resonance imaging (MRI) of intracranial parts of sixth nerve and seventh nerve and the extraocular muscles (EOMs) in orbit to correlate the clinical characteristics in patients with two special forms of strabismus in congenital cranial dysinnervation disorders which are Duane's retraction syndrome (DRS) and Mobius syndrome. MATERIALS AND METHODS: Morphological analysis by 3T MRI of orbit (using surface coils) and brain (using 32 channel head coil) was performed on 6 patients with clinical DRS (1 bilateral), 2 cases with Mobius syndrome, and 1 case with congenital sixth nerve palsy...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28345546/high-resolution-3t-magnetic-resonance-imaging-of-the-triangular-fibrocartilage-complex-in-chinese-wrists-correlation-with-cross-sectional-anatomy
#11
Hui-Li Zhan, Wen-Ting Li, Rong-Jie Bai, Nai-Li Wang, Zhan-Hua Qian, Wei Ye, Yu-Ming Yin
BACKGROUND: The injury of the triangular fibrocartilage complex (TFCC) is a common cause of ulnar-sided wrist pain. The aim of this study was to investigate if the high-resolution 3T magnetic resonance imaging (MRI) could demonstrate the detailed complex anatomy of TFCC in Chinese. METHODS: Fourteen Chinese cadaveric wrists (from four men and three women; age range at death from 30 to 60 years; mean age at 46 years) and forty healthy Chinese wrists (from 20 healthy volunteers, male/female: 10/10; age range from 21 to 53 years with a mean age of 32 years) in Beijing Jishuitan Hospital from March 2014 to March 2016 were included in this study...
April 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28345524/conventional-mri-features-for-predicting-the-clinical-outcome-of-patients-with-invasive-placenta
#12
Ting Chen, Xiao Quan Xu, Hai Bin Shi, Zheng Qiang Yang, Xin Zhou, Yi Pan
PURPOSE: We aimed to evaluate whether morphologic magnetic resonance imaging (MRI) features could help to predict the maternal outcome after uterine artery embolization (UAE)-assisted cesarean section (CS) in patients with invasive placenta previa. METHODS: We retrospectively reviewed the MRI data of 40 pregnant women who have undergone UAE-assisted cesarean section due to suspected high risk of massive hemorrhage caused by invasive placenta previa. Patients were divided into two groups based on the maternal outcome (good-outcome group: minor hemorrhage and uterus preserved; poor-outcome group: significant hemorrhage or emergency hysterectomy)...
March 27, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28345516/a-case-of-bilateral-megaducts-diagnostic-and-treatment-methods
#13
L Vatin, J M Foletti, C Collet, A Varoquaux, C Chossegros
INTRODUCTION: The pathology of the saliva glands comprises both tumoral and obstructive disorders. The latter include lithiasis, stenosis and megaduct. In this paper, we describe a clinical case of bilateral megaduct, a rare pathology, using sialo-MRI imaging and a conservative diagnostic-cum-therapeutic technique, sialendoscopy with dilation followed by catheterization. CLINICAL CASE: Our female patient presented oversized parotids with an unsightly deformation of the face (parotid ducts visible beneath the skin) and itchy cheeks, from which she had suffered for several years...
February 17, 2017: J Stomatol Oral Maxillofac Surg
https://www.readbyqxmd.com/read/28345405/thickness-distribution-of-glenohumeral-joint-cartilage
#14
Christoph Schleich, Bernd Bittersohl, Gerald Antoch, Rüdiger Krauspe, Christoph Zilkens, Jörn Kircher
High-resolution 3-dimensional cartilage-specific magnetic resonance imaging (MRI) was performed at 3 T to test the following hypotheses: (1) there is a nonuniform cartilage thickness distribution both on the proximal humerus and on the glenoid surface and (2) the glenohumeral joint as a combined system is congruent with the level of the joint cartilage surface without substantial radial mismatch. Inclusion of 38 volunteers (19 females, mean age 24.34 ± 2.22 years; range 21-29 years) in a prospective study...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28345195/diagnosing-neonatal-transphyseal-fractures-of-the-distal-humerus
#15
Matthew Kay, Carly Simpkins, Peter Shipman, Colin Whitewood
A traumatic birth can cause significant upper limb injury; the presenting features are non-specific and the differential diagnosis long. Transphyseal fractures of the distal humerus are a rare but clinically important birth injury. This injury has typical radiographic findings, which due to the un-ossified nature of the distal humeral epiphysis can easily be misinterpreted. This article presents the radiographic appearance correlated with arthrography, ultrasound and MRI obtained from four cases of neonatal transphyseal fracture of the distal humerus...
March 27, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28345171/spatio-angular-consistent-construction-of-neonatal-diffusion-mri-atlases
#16
Behrouz Saghafi, Jaeil Kim, Geng Chen, Feng Shi, Weili Lin, Pew-Thian Yap, Dinggang Shen
Atlases constructed using diffusion-weighted imaging are important tools for studying human brain development. Atlas construction is in general a two-step process involving spatial registration and fusion of individual images. The focus of most studies so far has been on improving the accuracy of registration while image fusion is commonly performed using simple averaging, often resulting in fuzzy atlases. In this article, we propose a patch-based method for diffusion-weighted (DW) atlas construction. Unlike other atlases that are based on the diffusion tensor model, our atlas is model-free and generated directly from the diffusion-weighted images...
March 27, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28345164/comparing-functional-mri-protocols-for-small-iron-rich-basal-ganglia-nuclei-such-as-the-subthalamic-nucleus-at-7-t-and-3-t
#17
Gilles de Hollander, Max C Keuken, Wietske van der Zwaag, Birte U Forstmann, Robert Trampel
The basal ganglia (BG) form a network of subcortical nuclei. Functional magnetic resonance imaging (fMRI) in the BG could provide insight in its functioning and the underlying mechanisms of Deep Brain Stimulation (DBS). However, fMRI of the BG with high specificity is challenging, because the nuclei are small and variable in their anatomical location. High resolution fMRI at field strengths of 7 Tesla (T) could help resolve these challenges to some extent. A set of MR protocols was developed for functional imaging of the BG nuclei at 3 T and 7 T...
March 27, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28344811/the-role-of-imaging-in-the-diagnosis-of-primary-prostate-cancer
#18
Hugh Harvey, Nandita M deSouza
Ultrasound and magnetic resonance imaging (MRI) are key imaging modalities in prostate cancer diagnosis. MRI offers a range of intrinsic contrast mechanisms (T2, diffusion-weighted imaging (DWI), MR spectroscopy (MRS)) and extrinsic contrast-generating options based on tumour vascular state following injection of weakly paramagnetic agents such as gadolinium. Together these parameters are referred to as multiparametric (mp)MRI and are used for detecting and guiding biopsy and staging prostate cancer. Although sensitivity of mpMRI is <75% for disease detection, specificity is >90% and a standardised reporting system together with MR-guided targeted biopsy is the optimal diagnostic pathway...
December 2016: Journal of Clinical Urology
https://www.readbyqxmd.com/read/28344687/disseminated-pancreatic-neuroendocrine-neoplasm-nen-with-an-uncommon-localisation-in-the-central-nervous-system-a-case-report
#19
Joanna Białkowska, Agnieszka Kolasińska-Ćwikła, Dorota Mroczkowska, Mariusz Sowa, Łukasz Grabarczyk, Wojciech Maksymowicz, Andrzej Cichocki, Jarosław B Ćwikła
BACKGROUND: Neuroendocrine neoplasms (NEN) are rare neoplasms that originate from neuroendocrine cells and are characterized by the potential of hormonal activity. Approximately 70% of these tumours are located in the gastrointestinal system (GI), followed by the bronchi, endocrine glands-like C cells of the thyroid (medullary carcinoma), the parasympathetic and sympathetic system (paragangliomas, pheochromocytoma) and other very rare locations. The prevalence of cerebral metastases in neuroendocrine tumours is estimated by various authors to be approximately 1...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28344685/focal-biliary-system-obstruction-and-atypical-liver-mass-intrabiliary-ruptured-cyst-hydatid-case-report
#20
Esra Ummuhan Mermi, Nurdan Fidan, Muammer Murat
BACKGROUND: Hydatid disease can involve any part of the body, but the liver is the most frequently affected organ. Intrabiliary rupture is one of the most serious complications of a hepatic hydatid cyst. Radiological findings, especially magnetic resonance imaging and magnetic resonance cholangiopancreatography (MRI/MRCP), are helpful in the diagnosis of hydatid disease. CASE REPORT: We present a 48-year-old female patient with complaints of abdominal pain and jaundice...
2017: Polish Journal of Radiology
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