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MRI-guided HIFU

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https://www.readbyqxmd.com/read/28069193/safety-of-ultrasound-guided-high-intensity-focused-ultrasound-ablation-for-diffuse-adenomyosis-a-retrospective-cohort-study
#1
Yujie Feng, Liang Hu, Wenzhi Chen, Rong Zhang, Xi Wang, Jinyun Chen
OBJECTIVES: To evaluate the safety of ultrasound-guided high-intensity focused ultrasound (HIFU) ablation for patients with diffuse adenomyosis. METHODS: This was a retrospective cohort study. The data was collected from 417 symptomatic adenomyosis patients who underwent ultrasound-guided HIFU between January 2012 and December 2015 at 1st Affiliated Hospital of Chongqing Medical University, Chongqing, China. Among them were 260 patients with diffuse adenomyosis (Group D) and 157 patients with focal adenomyosis (Group F)...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28067975/assessment-of-acute-thermal-damage-volumes-in-muscle-using-magnetization-prepared-3d-t2-weighted-imaging-following-mri-guided-high-intensity-focused-ultrasound-therapy
#2
Robert M Staruch, Joris Nofiele, Jamie Walker, Chenchen Bing, Ananth J Madhuranthakam, April Bailey, Young-Sun Kim, Avneesh Chhabra, Dennis Burns, Rajiv Chopra
PURPOSE: To evaluate magnetization-prepared 3D T2 -weighted magnetic resonance imaging (MRI) measurements of acute tissue changes produced during ablative MR high-intensity focused ultrasound (MR-HIFU) exposures. MATERIALS AND METHODS: A clinical MR-HIFU system (3T) was used to generate thermal lesions (n = 24) in the skeletal muscles of three pigs. T1 -weighted, 2D T2 -weighted, and magnetization-prepared 3D T2 -weighted sequences were acquired before and after therapy to evaluate tissue changes following ablation...
January 9, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27799004/comparing-high-intensity-focal-ultrasound-hemiablation-to-robotic-radical-prostatectomy-in-the-management-of-unilateral-prostate-cancer-a-matched-pair-analysis
#3
Simone Albisinni, Fouad Aoun, Simon Bellucci, Ibrahim Biaou, Ksenija Limani, Eric Hawaux, Alexandre Peltier, Roland van Velthoven
INTRODUCTION: Although still experimental, focal treatment is being increasingly implemented in the management of prostate cancer (PCa). Aim of the current study was to compare functional and oncologic outcomes of high-intensity focal ultrasound (HIFU) hemiablation of the prostate to robot-assisted laparoscopic prostatectomy (RALP) in the management of unilateral PCa. MATERIALS: Fifty-five men with unilateral, clinically localized PCa underwent HIFU hemiablation of the affected prostatic lobe between 2007 and 2015...
January 2017: Journal of Endourology
https://www.readbyqxmd.com/read/27774787/template-free-synthesis-of-hollow-porous-organosilica-fe3o4-hybrid-nanocapsules-toward-magnetic-resonance-imaging-guided-high-intensity-focused-ultrasound-therapy
#4
Ming Ma, Fei Yan, Minghua Yao, Zijun Wei, Dongliang Zhou, Heliang Yao, Hairong Zheng, Hangrong Chen, Jianlin Shi
Entirely differing from the common templating-based multistep strategy for fabricating multifunctional hollow mesoporous silica nanoparticles (HMSN), a facile and template-free synthetic strategy has been established to construct a unique hollow/mesoporous organosilica nanocapsule (OSNC) concurrently encapsulating both isopentyl acetate (PeA) liquid and superparamagnetic iron oxides inside (denoted as PeA@OSNC). This novel material exhibits ultrasmall and uniform particle size (∼82 nm), high surface area (∼534 m(2)·g(-1)), and excellent colloidal stability in aqueous solution...
November 9, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27686583/high-intensity-focused-ultrasound-hyperthermia-for-enhanced-macromolecular-delivery
#5
Nick Frazier, Allison Payne, Joshua de Bever, Christopher Dillon, Apoorva Panda, Nithya Subrahmanyam, Hamidreza Ghandehari
Mild hyperthermia has been used in combination with polymer therapeutics to further increase delivery to solid tumors and enhance efficacy. An attractive method for generating heat is through non-invasive high intensity focused ultrasound (HIFU). HIFU is often used for ablative therapies and must be adapted to produce uniform mild hyperthermia in a solid tumor. In this work a magnetic resonance imaging guided HIFU (MRgHIFU) controlled feedback system was developed to produce a spatially uniform 43°C heating pattern in a subcutaneous mouse tumor...
November 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
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