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MRI-guided HIFU

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https://www.readbyqxmd.com/read/28633808/impact-of-mr-guided-boiling-histotripsy-in-distinct-murine-tumor-models
#1
Martijn Hoogenboom, Dylan C Eikelenboom, Renske J E van den Bijgaart, Arend Heerschap, Pieter Wesseling, Martijn H den Brok, Jurgen J Fütterer, Gosse J Adema
Interest in mechanical high intensity focused ultrasound (HIFU) ablation is rapidly growing. Boiling histotripsy (BH) is applied for mechanical fragmentation of soft tissue into submicron fragments with limited temperature increase using the shock wave and cavitation effects of HIFU. Research on BH has been largely limited to ex vivo experiments. As a consequence, the in vivo pathology after BH treatment and the relation to preexistent tissue characteristics are not well understood. This study reports on in vivo MR guided BH treatment, either with 100 or 200 pulses per focal spot, in three different subcutaneous mouse tumor models: a soft-tissue melanoma (B16OVA), a compact growing thymoma (EL4), and a highly vascularized neuroblastoma (9464D)...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28626862/acoustic-field-characterization-of-a-clinical-magnetic-resonance-guided-high-intensity-focused-ultrasound-system-inside-the-magnet-bore
#2
Satya V V N Kothapalli, Michael B Altman, Ari Partanen, Leighton Wan, H Michael Gach, William Straube, Dennis E Hallahan, Hong Chen
PURPOSE: With the expanding clinical application of magnetic resonance-guided high intensity focused ultrasound (MR-HIFU), acoustic field characterization of MR-HIFU systems is needed for facilitating regulatory approval and ensuring consistent and safe power output of HIFU transducers. However, the established acoustic field measurement techniques typically use equipment that cannot be used in a magnetic resonance imaging (MRI) suite, thus posing a challenge to the development and execution of HIFU acoustic field characterization techniques...
June 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28616725/the-role-of-t1-perfusion-based-classification-in-magnetic-resonance-guided-high-intensity-focused-ultrasound-ablation-of-uterine-fibroids
#3
Bilgin Keserci, Nguyen Minh Duc
OBJECTIVE: To comparatively evaluate the role of magnetic resonance (MR) T1 perfusion-based time-signal intensity (SI) curves of fibroid tissue and the myometrium in classification of fibroids for predicting treatment outcomes of high-intensity focused ultrasound (HIFU) treatment. METHODS: The fibroids of 74 women who underwent MR-HIFU treatment were classified into group A (time-SI curve of fibroid lower than that of the myometrium) and group B (time-SI curve of fibroid equal to or higher than that of the myometrium)...
June 14, 2017: European Radiology
https://www.readbyqxmd.com/read/28579687/therapeutic-ultrasound-and-prostate-cancer
#4
REVIEW
Karthik M Sundaram, Sam S Chang, David F Penson, Sandeep Arora
Therapeutic ultrasound approaches including high-intensity focused ultrasound (HIFU) are emerging as popular minimally invasive alternative treatments for localized, low-to-intermediate risk prostate cancer. FDA approval was recently granted for two ultrasound-guided HIFU devices. Clinical trials for devices using MRI guidance are ongoing. The current level of evidence for whole-gland ultrasound ablation suggests that its clinical efficacy and adverse event rates including erectile dysfunction and urinary incontinence are similar to current definitive therapies such as radical prostatectomy and external-beam radiotherapy...
June 2017: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/28540807/technical-aspects-of-osteoid-osteoma-ablation-in-children-using-mr-guided-high-intensity-focussed-ultrasound
#5
Pavel S Yarmolenko, Avinash Eranki, Ari Partanen, Haydar Celik, AeRang Kim, Matthew Oetgen, Viktoriya Beskin, Domiciano Santos, Janish Patel, Peter C W Kim, Karun Sharma
BACKGROUND: Osteoid osteoma (OO) is a painful bone tumour occurring in children and young adults. Magnetic resonance imaging-guided high intensity focussed ultrasound (MR-HIFU) allows non-invasive treatment without ionising radiation exposure, in contrast to the current standard of care treatment with radiofrequency ablation (RFA). This report describes technical aspects of MR-HIFU ablation in the first 8 paediatric OO patients treated in a safety and feasibility clinical trial (total enrolment of up to 12 patients)...
April 24, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28437003/high-intensity-focused-ultrasound-for-the-treatment-of-adenomyosis-selection-criteria-efficacy-safety-and-fertility
#6
Lian Zhang, Fangwen Rao, Raymond Setzen
Adenomyosis is a disorder of uterus in which endometrial glands and stroma are present within the uterine musculature. The main clinical manifestations are dysmenorrhea and menorrhagia. Adenomyosis has a great impact on both the quality of life and fertility of women. The treatment of adenomyosis remains an immense challenge MATERIAL AND METHODS: Relevant articles were searched through MEDLINE, Pubmed between 2000 and March 2017. The search terms of adenomyosis, magnetic resonance imaging (MRI) features of adenomyosis, high intensity focused ultrasound (HIFU), Ultrasound-guided HIFU and MRgFUS were used...
April 24, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28412225/enhancing-tissue-permeability-with-mri-guided-preclinical-focused-ultrasound-system-in-rabbit-muscle-from-normal-tissue-to-vx2-tumor
#7
Yao Sun, Xiaobing Xiong, Darpan Pandya, Youngkyoo Jung, Akiva Mintz, Satoru Hayasaka, Thaddeus J Wadas, King C P Li
High Intensity Focused Ultrasound (HIFU) is an emerging noninvasive, nonionizing physical energy based modality to ablate solid tumors with high power, or increase local permeability in tissues/tumors in pulsed mode with relatively low power. Compared with traditional ablative HIFU, nondestructive pulsed HIFU (pHIFU) is present in the majority of novel applications recently developed for enhancing the delivery of drugs and genes. Previous studies have demonstrated the capability of pHIFU to change tissue local permeability for enhanced drug delivery in both mouse tumors and mouse muscle...
June 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28256923/ultrasound-guided-high-intensity-focused-ultrasound-combined-with-gonadotropin-releasing-hormone-analogue-gnrha-ablating-uterine-leiomyoma-with-homogeneous-hyperintensity-on-t2-weighted-mr-imaging
#8
Shenghua Yang, Fanjing Kong, Ruijie Hou, Fengmei Rong, Nana Ma, Shaoping Li, Jun Yang
OBJECTIVE: The study aimed to evaluate the safety and efficiency of ultrasound-guided high-intensity focused ultrasound (USgHIFU) combined with gonadotropin-releasing hormone analogue (GnRHa)-ablating symptomatic uterine leiomyoma with homogeneous hyperintensity on T2 weighted MRI prospectively. METHODS: A total of 34 patients with 42 symptomatic uterine leiomyomas with homogeneous hyperintensity on T2 weighted MRI were enrolled in our study. In the patient who had multiple uterine leiomyomas, only one dominant leiomyoma was treated...
May 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28255351/tracking-perfluorocarbon-nanoemulsion-delivery-by-19-f-mri-for-precise-high-intensity-focused-ultrasound-tumor-ablation
#9
Soo Hyun Shin, Eun-Joo Park, Changki Min, Sun Il Choi, Soyeon Jeon, Yun-Hee Kim, Daehong Kim
Perfluorocarbon nanoemulsions (PFCNEs) have recently been undergoing rigorous study to investigate their ability to improve the therapeutic efficacy of tumor ablation by high intensity focused ultrasound (HIFU). For precise control of PFCNE delivery and thermal ablation, their accumulation and distribution in a tumor should be quantitatively analyzed. Here, we used fluorine-19 ((19)F) magnetic resonance imaging (MRI) to quantitatively track PFCNE accumulation in a tumor, and analyzed how intra-tumoral PFCNE quantities affect the therapeutic efficacy of HIFU treatment...
2017: Theranostics
https://www.readbyqxmd.com/read/28210800/preservation-of-the-endometrial-enhancement-after-magnetic-resonance-imaging-guided-high-intensity-focused-ultrasound-ablation-of-submucosal-uterine-fibroids
#10
Young-Sun Kim, Tae-Joong Kim, Hyo Keun Lim, Hyunchul Rhim, Sin-Ho Jung, Joong Hyun Ahn, Jeong-Won Lee, Byoung-Gie Kim
OBJECTIVE: To evaluate the integrity of endometrial enhancement after magnetic resonance imaging-guided high-intensity focused ultrasound (MR-HIFU) ablation of submucosal uterine fibroids based on contrast-enhanced MRI findings, and to identify the risk factors for endometrial impairment. METHODS: In total, 117 submucosal fibroids (diameter: 5.9 ± 3.0 cm) in 101 women (age: 43.6 ± 4.4 years) treated with MR-HIFU ablation were retrospectively analysed...
February 16, 2017: European Radiology
https://www.readbyqxmd.com/read/28119893/expulsion-of-fibroids-to-the-endometrial-cavity-after-magnetic-resonance-imaging-guided-high-intensity-focused-ultrasound-surgery-mrgfus-treatment-of-intramural-uterine-fibroids
#11
Jae-Hyeok Jeong, Gil Pyo Hong, Yu-Ri Kim, Da Gyo Hong, Jae-Eun Ha, Jung In Yeom, Eun-Jeong Kim, Hyung-Il Kim, Kyu-Sup Lee
OBJECTIVES: This report seeks to introduce some cases of the patients who received magnetic resonance imaging (MRI)-guided high intensity focused ultrasound (HIFU) surgery (MRgFUS)-based intramural uterine fibroids treatment where the post-MRgFUS intramural uterine fibroids decreased in its volume and protruded towards the endometrial cavity to be expelled by hysteroscopy. METHODS: Of the 157 patients who had received MRgFUS treatment in the Obstetrics and Gynecology of the Hospital from March, 2015 to February, 2016; this study examined 6 of the cases where, after high intensity focused ultrasound treatment, intramural uterine fibroids protruded towards the endometrial cavity to be removed by hysteroscopic myomectomy...
December 2016: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/28109895/pilot-study-of-the-mirabilis-system-prototype-for-rapid-noninvasive-uterine-myoma-treatment-using-an-ultrasound-guided-volumetric-shell-ablation-technique
#12
Jessica E Parsons, Michael P H Lau, Patrick J Martin, Joel J Islas Lagos, Juan M Aguilar Aguirre, José G Garza Leal
STUDY OBJECTIVE: The primary objective of this pilot study was to evaluate the safety and acute tissue ablation efficacy of a transabdominal high-intensity focused ultrasound (HIFU) prototype device that uses ultrasound imaging guidance for rapid noninvasive ablation of uterine myomas. The secondary objective was to assess preliminary myoma-related symptom improvement and myoma volume reduction at 3 to 6 months post-treatment in subsets of patients. DESIGN: Multicenter prospective single-arm pilot study (Canadian Task Force classification II-2)...
May 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28069193/safety-of-ultrasound-guided-high-intensity-focused-ultrasound-ablation-for-diffuse-adenomyosis-a-retrospective-cohort-study
#13
Yujie Feng, Liang Hu, Wenzhi Chen, Rong Zhang, Xi Wang, Jinyun Chen
OBJECTIVES: To evaluate the safety of ultrasound-guided high-intensity focused ultrasound (HIFU) ablation for patients with diffuse adenomyosis. METHODS: This was a retrospective cohort study. The data was collected from 417 symptomatic adenomyosis patients who underwent ultrasound-guided HIFU between January 2012 and December 2015 at 1st Affiliated Hospital of Chongqing Medical University, Chongqing, China. Among them were 260 patients with diffuse adenomyosis (Group D) and 157 patients with focal adenomyosis (Group F)...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28067975/assessment-of-acute-thermal-damage-volumes-in-muscle-using-magnetization-prepared-3d-t2-weighted-imaging-following-mri-guided-high-intensity-focused-ultrasound-therapy
#14
Robert M Staruch, Joris Nofiele, Jamie Walker, Chenchen Bing, Ananth J Madhuranthakam, April Bailey, Young-Sun Kim, Avneesh Chhabra, Dennis Burns, Rajiv Chopra
PURPOSE: To evaluate magnetization-prepared 3D T2 -weighted magnetic resonance imaging (MRI) measurements of acute tissue changes produced during ablative MR high-intensity focused ultrasound (MR-HIFU) exposures. MATERIALS AND METHODS: A clinical MR-HIFU system (3T) was used to generate thermal lesions (n = 24) in the skeletal muscles of three pigs. T1 -weighted, 2D T2 -weighted, and magnetization-prepared 3D T2 -weighted sequences were acquired before and after therapy to evaluate tissue changes following ablation...
January 9, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27799004/comparing-high-intensity-focal-ultrasound-hemiablation-to-robotic-radical-prostatectomy-in-the-management-of-unilateral-prostate-cancer-a-matched-pair-analysis
#15
Simone Albisinni, Fouad Aoun, Simon Bellucci, Ibrahim Biaou, Ksenija Limani, Eric Hawaux, Alexandre Peltier, Roland van Velthoven
INTRODUCTION: Although still experimental, focal treatment is being increasingly implemented in the management of prostate cancer (PCa). Aim of the current study was to compare functional and oncologic outcomes of high-intensity focal ultrasound (HIFU) hemiablation of the prostate to robot-assisted laparoscopic prostatectomy (RALP) in the management of unilateral PCa. MATERIALS: Fifty-five men with unilateral, clinically localized PCa underwent HIFU hemiablation of the affected prostatic lobe between 2007 and 2015...
January 2017: Journal of Endourology
https://www.readbyqxmd.com/read/27774787/template-free-synthesis-of-hollow-porous-organosilica-fe3o4-hybrid-nanocapsules-toward-magnetic-resonance-imaging-guided-high-intensity-focused-ultrasound-therapy
#16
Ming Ma, Fei Yan, Minghua Yao, Zijun Wei, Dongliang Zhou, Heliang Yao, Hairong Zheng, Hangrong Chen, Jianlin Shi
Entirely differing from the common templating-based multistep strategy for fabricating multifunctional hollow mesoporous silica nanoparticles (HMSN), a facile and template-free synthetic strategy has been established to construct a unique hollow/mesoporous organosilica nanocapsule (OSNC) concurrently encapsulating both isopentyl acetate (PeA) liquid and superparamagnetic iron oxides inside (denoted as PeA@OSNC). This novel material exhibits ultrasmall and uniform particle size (∼82 nm), high surface area (∼534 m(2)·g(-1)), and excellent colloidal stability in aqueous solution...
November 9, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27686583/high-intensity-focused-ultrasound-hyperthermia-for-enhanced-macromolecular-delivery
#17
Nick Frazier, Allison Payne, Joshua de Bever, Christopher Dillon, Apoorva Panda, Nithya Subrahmanyam, Hamidreza Ghandehari
Mild hyperthermia has been used in combination with polymer therapeutics to further increase delivery to solid tumors and enhance efficacy. An attractive method for generating heat is through non-invasive high intensity focused ultrasound (HIFU). HIFU is often used for ablative therapies and must be adapted to produce uniform mild hyperthermia in a solid tumor. In this work a magnetic resonance imaging guided HIFU (MRgHIFU) controlled feedback system was developed to produce a spatially uniform 43°C heating pattern in a subcutaneous mouse tumor...
November 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
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