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JOURNAL ARTICLE
Ewa Pius-Sadowska, Anna Niedźwiedź, Piotr Kulig, Bartłomiej Baumert, Anna Sobuś, Dorota Rogińska, Karolina Łuczkowska, Zofia Ulańczyk, Szymon Wnęk, Igor Karolak, Edyta Paczkowska, Katarzyna Kotfis, Miłosz Kawa, Iwona Stecewicz, Piotr Zawodny, Bogusław Machaliński
The exact pathophysiology of severe COVID-19 is not entirely elucidated, but it has been established that hyperinflammatory responses and cytokine storms play important roles. The aim of this study was to examine CMV status, select chemokines, and complement components in COVID-19, and how concentrations of given molecules differ over time at both molecular and proteomic levels. A total of 210 COVID-19 patients (50 ICU and 160 non-ICU patients) and 80 healthy controls were enrolled in this study. Concentrations of select chemokines (CXCL8, CXCL10, CCL2, CCL3, CCR1) and complement factors (C2, C9, CFD, C4BPA, C5AR1, CR1) were examined at mRNA and protein levels with regard to a COVID-19 course (ICU vs...
September 26, 2022: International Journal of Molecular Sciences
#22
JOURNAL ARTICLE
Jacek Kolcz, Elzbieta Karnas, Zbigniew Madeja, Ewa K Zuba-Surma
BACKGROUND: Fontan surgery with cardiopulmonary bypass (CPB) causes tremendous systemic stress and inflammatory responses, affecting postoperative organ function, morbidity, and mortality. Although this reaction triggers partially protective anti-inflammatory responses, it is harmful in patients with single ventricle congenital heart defects. Despite decades of research, an effective anti-inflammatory and stress defense strategy is lacking. This study investigated the influence of inhaled nitric oxide (NO) during CPB on early clinical results, including the duration of postoperative respiratory support as a primary outcome and a panel of laboratory analytes...
October 13, 2022: Journal of Intensive Care
#23
REVIEW
Maria Damps, Maksymilian Gajda, Ludwik Stołtny, Małgorzata Kowalska, Ewa Kucewicz-Czech
The debate about medical futility often involves intensive care units where life-support procedures are routinely applied. Futile therapy is part of end-of-life therapy. In the discussion about medical futility it is important to distinguish the effect of therapy from the benefit for the patient. The goal of treatment is not to maintain the function of an organ, body part or physiological activity, but to maintain health as a whole. Prolonging ineffective treatment violates the standard of good medical practice...
2022: Anaesthesiology Intensive Therapy
#24
JOURNAL ARTICLE
Piotr Buda, Ewa Strauss, Danuta Januszkiewicz-Lewandowska, Ewa Czerwinska, Kamila Ludwikowska, Leszek Szenborn, Ewelina Gowin, Magdalena Okarska-Napierała, Ernest Kuchar, Janusz Ksia Zyk
BACKGROUND: Macrophage activation syndrome (MAS) is a potentially life-threatening complication of various inflammatory disorders, including multisystem inflammatory syndrome in children (MIS-C). MIS-C refractory to treatment should raise suspicion of MAS, which can be fatal if a definitive diagnosis is delayed. Unfortunately, there is a lack of data on MAS in children with MIS-C. OBJECTIVE: Our study aims to analyze the risk factors for the development of MAS in MIS-C, its clinical course and response to treatment, and identify predictive factors for pediatric intensive care...
2022: Frontiers in Pediatrics
#25
JOURNAL ARTICLE
Brenden Osborne, Irina Oltean, Ewa Sucha, Nicholas Mitsakakis, Nick Barrowman, Shannon Bainbridge, Dina El Demellawy
INTRODUCTION: Villitis of unknown etiology (VUE) is associated with fetal growth restriction (FGR) and adverse short-term neonatal outcomes. No investigation to date has found which VUE features are driving the association with FGR diagnosis. METHODS: A retrospective cohort study of placenta pathology specimens (2013-2017) was conducted. Independent variables of interest were: VUE distribution (focal vs diffuse), location (basal vs non-basal), and grade (high vs low)...
August 30, 2022: Placenta
#26
JOURNAL ARTICLE
Justyna Miśkiewicz-Bujna, Izabella Miśkiewicz-Migoń, Zofia Szmit, Dawid Przystupski, Monika Rosa, Anna Król, Krzysztof Kałwak, Marek Ussowicz, Ewa Gorczyńska
Introduction: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a treatment method for a wide range of malignant and non-malignant diseases. Infants constitute a distinct patient group, especially due to their organ immaturity and differences in drug metabolism. The present paper aims to analyse the short- and long-term outcomes after allo-HSCT in infants. Material and methods: In the study period, 67 patients under 12 months of age underwent allo-HSCT...
2022: Frontiers in Pediatrics
#27
JOURNAL ARTICLE
Patrycja Leśnik, Lidia Łysenko, Mariusz G Fleszar, Paulina Fortuna, Ewa Woźnica-Niesobska, Magdalena Mierzchała-Pasierb, Jarosław Janc
BACKGROUND Acute kidney injury (AKI) is one of the most common organ failures. An early diagnosis of AKI using specific biomarkers is essential for effective treatment. This study determined the serum concentrations of selected amino acids and amines using targeted liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) in patients with AKI during sepsis and septic shock treated in the Intensive Care Unit (ICU). MATERIAL AND METHODS A sample of 41 patients was divided into 2 groups: (1) patients with sepsis and septic shock along required continuous renal replacement therapy (CRRT) due to AKI (n=13), and (2) patients with sepsis and septic shock but without AKI (n=28)...
September 7, 2022: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
#28
MULTICENTER STUDY
Darko Antic, Natasa Milic, Thomas Chatzikonstantinou, Lydia Scarfò, Vladimir Otasevic, Nina Rajovic, David Allsup, Alejandro Alonso Cabrero, Martin Andres, Monica Baile Gonzales, Antonella Capasso, Rosa Collado, Raul Cordoba, Carolina Cuéllar-García, Juan Gonzalo Correa, Lorenzo De Paoli, Maria Rosaria De Paolis, Giovanni Del Poeta, Maria Dimou, Michael Doubek, Maria Efstathopoulou, Shaimaa El-Ashwah, Alicia Enrico, Blanca Espinet, Lucia Farina, Angela Ferrari, Myriam Foglietta, Alberto Lopez-Garcia, José A García-Marco, Rocío García-Serra, Massimo Gentile, Eva Gimeno, Maria Gomes da Silva, Odit Gutwein, Yervand K Hakobyan, Yair Herishanu, José Ángel Hernández-Rivas, Tobias Herold, Gilad Itchaki, Ozren Jaksic, Ann Janssens, Olga B Kalashnikova, Elżbieta Kalicińska, Arnon P Kater, Sabina Kersting, Maya Koren-Michowitz, Jorge Labrador, Deepesh Lad, Luca Laurenti, Alberto Fresa, Mark-David Levin, Carlota Mayor Bastida, Lara Malerba, Roberto Marasca, Monia Marchetti, Juan Marquet, Biljana Mihaljevic, Ivana Milosevic, Fatima Mirás, Marta Morawska, Marina Motta, Talha Munir, Roberta Murru, Raquel Nunes, Jacopo Olivieri, Miguel Arturo Pavlovsky, Inga Piskunova, Viola Maria Popov, Francesca Maria Quaglia, Giulia Quaresmini, Gianluigi Reda, Gian Matteo Rigolin, Amit Shrestha, Martin Šimkovič, Svetlana Smirnova, Martin Špaček, Paolo Sportoletti, Oana Stanca, Niki Stavroyianni, Doreen Te Raa, Kristina Tomic, Sanne Tonino, Livio Trentin, Ellen Van Der Spek, Michel van Gelder, Marzia Varettoni, Andrea Visentin, Candida Vitale, Vojin Vukovic, Ewa Wasik-Szczepanek, Tomasz Wróbel, Lucrecia Yáñez San Segundo, Mohamed Yassin, Marta Coscia, Alessandro Rambaldi, Emili Montserrat, Robin Foà, Antonio Cuneo, Marc Carrier, Paolo Ghia, Kostas Stamatopoulos
BACKGROUND: Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to COVID-19 related poor outcomes, including thrombosis and death, due to the advanced age, the presence of comorbidities, and the disease and treatment-related immune deficiency. The aim of this study was to assess the risk of thrombosis and bleeding in patients with CLL affected by severe COVID-19. METHODS: This is a retrospective multicenter study conducted by ERIC, the European Research Initiative on CLL, including patients from 79 centers across 22 countries...
August 26, 2022: Journal of Hematology & Oncology
#29
JOURNAL ARTICLE
Ing-Marie Larsson, Michael Hultström, Miklos Lipcsey, Robert Frithiof, Sten Rubertsson, Ewa Wallin
OBJECTIVES: This study aimed to describe the burden of illness and impact on health and working situation among former intensive care patients treated for COVID-19. METHODS: A prospective cohort study was performed at one intensive care unit of a university hospital in Sweden during the first wave of COVID-19 in spring 2020. The burden of illness in health status, cognitive, physical, and psychological outcomes, and working situation were assessed at four and 12 months after discharge from intensive care, using nine validated instruments...
August 15, 2022: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
#30
JOURNAL ARTICLE
Patrycja Leśnik, Lidia Łysenko, Małgorzata Krzystek-Korpacka, Ewa Woźnica-Niesobska, Magdalena Mierzchała-Pasierb, Jarosław Janc
Sepsis is a life-threatening organ dysfunction caused by the dysregulation of the host's response to an infection, where the dominant mechanism is tissue hypoperfusion. Currently, the marker used to define tissue disorders is lactate levels, which may be elevated in other disease states as well. Renin is an essential hormone for the proper functioning of the renin-angiotensin-aldosterone (RASS) system. It is secreted in the glomerular apparatus in response to hypoperfusion. This study aimed to assess the usefulness of renin as a marker of tissue hypoperfusion in patients with sepsis and septic shock...
August 15, 2022: International Journal of Molecular Sciences
#31
JOURNAL ARTICLE
Urszula Tokarczyk, Krzysztof Kaliszewski, Anna Kopszak, Łukasz Nowak, Karolina Sutkowska-Stępień, Maciej Sroczyński, Monika Sępek, Agata Dudek, Dorota Diakowska, Małgorzata Trocha, Damian Gajecki, Jakub Gawryś, Tomasz Matys, Justyna Maciejiczek, Valeriia Kozub, Roman Szalast, Marcin Madziarski, Anna Zubkiewicz-Zarębska, Krzysztof Letachowicz, Katarzyna Kiliś-Pstrusińska, Agnieszka Matera-Witkiewicz, Michał Pomorski, Marcin Protasiewicz, Janusz Sokołowski, Barbara Adamik, Krzysztof Kujawa, Adrian Doroszko, Katarzyna Madziarska, Ewa Anita Jankowska
Deviations in laboratory tests assessing liver function in patients with COVID-19 are frequently observed. Their importance and pathogenesis are still debated. In our retrospective study, we analyzed liver-related parameters: aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), total bilirubin (TBIL), albumin, comorbidities and other selected potential risk factors in patients admitted with SARS-CoV-2 infection to assess their prognostic value for intensive care unit admission, mechanical ventilation necessity and mortality...
August 1, 2022: Journal of Clinical Medicine
#32
JOURNAL ARTICLE
Justyna D Kowalska, Martyna Lara, Maria Hlebowicz, Elżbieta Mularska, Elżbieta Jabłonowska, Ewa Siwak, Alicja Wandałowicz, Magdalena Witak-Jędra, Anita Olczak, Monika Bociąga-Jasik, Magdalena Suchacz, Justyna Stempkowska-Rejek, Piotr Wasilewski, Miłosz Parczewski
PURPOSE: Immunocompromised patients are postulated to be at elevated risk of unfavorable outcomes of COVID-19. The exact effect of HIV infection on the course of COVID-19 remains to be elucidated. The aim of the study was to describe the epidemiological and clinical aspects of SARS-CoV-2 infection in HIV-infected individuals. METHODS: The HIV-positive patients who were diagnosed with SARS-CoV-2 infection were identified through thirteen specialist HIV clinics routinely following them due to HIV treatment...
July 27, 2022: Infection
#33
JOURNAL ARTICLE
Daniel Chober, Bogusz Aksak-Wąs, Katarzyna Bobrek-Lesiakowska, Anna Budny-Finster, Ewa Hołda, Joanna Mieżyńska-Kurtycz, Grzegorz Jamro, Miłosz Parczewski
INTRODUCTION: Acute lung injury is associated with dysfunctional immune response to SARS-CoV-2. This leads to CRS, which require immunomodulatory treatments aiming to limit the excessive production of cytokines. The literature so far indicates the effectiveness of tocilizumab in patients with COVID-19-associated pneumonia, but there is no clear evidence of its effectiveness in patients with at least 50% lung involvement; therefore, we aimed to bridge this gap in knowledge. MATERIALS AND METHODS: Longitudinal data for 4287 patients with confirmed COVID-19 infection were collected between 1st March 2020 and 16th of January 2022...
April 20, 2022: Journal of Clinical Medicine
#34
Kamil Buczkowski, Irena Ożóg-Zabolska, Jacek Gulczyński, Ewa Iżycka-Świeszewska
Hypoxic hepatitis is a rare complication of type 1 diabetes with unknown prevalence in Pediatrics. We present a case report of an 11-year-old boy admitted to the ER in the spring of 2020 (the beginning of the COVID19 pandemic in Poland) due to nausea, abdominal pain, and weight loss. A diagnosis of type 1 diabetes accompanied by severe ketoacidosis (pH 6.9, blood glucose 632mg/dl, ketone bodies in urine - 150mg/dl) was made. The hyperglycemia, ketoacidosis, and water-electrolyte disturbances were treated in the Pediatric Intensive Care Unit...
2022: Autopsy & Case Reports
#35
JOURNAL ARTICLE
Krzysztof Kaliszewski, Dorota Diakowska, Łukasz Nowak, Urszula Tokarczyk, Maciej Sroczyński, Monika Sępek, Agata Dudek, Karolina Sutkowska-Stępień, Katarzyna Kiliś-Pstrusińska, Agnieszka Matera-Witkiewicz, Michał Pomorski, Marcin Protasiewicz, Janusz Sokołowski, Barbara Adamik, Krzysztof Kujawa, Adrian Doroszko, Katarzyna Madziarska, Ewa Anita Jankowska
Gastrointestinal manifestations may accompany the respiratory symptoms of COVID-19. Abdominal pain (AP) without nausea and vomiting is one of the most common. To date, its role and prognostic value in patients with COVID-19 is still debated. Therefore, we performed a retrospective analysis of 2184 individuals admitted to hospital due to COVID-19. We divided the patients into four groups according to presented symptoms: dyspnea, n = 871 (39.9%); AP, n = 97 (4.4%); AP with dyspnea together, n = 50 (2.3%); and patients without dyspnea and AP, n = 1166 (53...
March 25, 2022: Journal of Clinical Medicine
#36
MULTICENTER STUDY
Ewa Trejnowska, Dominik Drobiński, Piotr Knapik, Marta Wajda-Pokrontka, Konstanty Szułdrzyński, Jakub Staromłyński, Wojciech Nowak, Maciej Urlik, Marek Ochman, Waldemar Goździk, Wojciech Serednicki, Jakub Śmiechowicz, Jakub Brączkowski, Wojciech Bąkowski, Anna Kwinta, Michał O Zembala, Piotr Suwalski
BACKGROUND: In Poland, the clinical characteristics and outcomes of patients with COVID-19 requiring extracorporeal membrane oxygenation (ECMO) remain unknown. This study aimed to answer these unknowns by analyzing data collected from high-volume ECMO centers willing to participate in this project. METHODS: This retrospective, multicenter cohort study was completed between March 1, 2020, and May 31, 2021 (15 months). Data from all patients treated with ECMO for COVID-19 were analyzed...
April 7, 2022: Critical Care: the Official Journal of the Critical Care Forum
#37
JOURNAL ARTICLE
Patrycja Zalas-Więcek, Małgorzata Prażyńska, Łukasz Pojnar, Anna Pałka, Dorota Żabicka, Monika Orczykowska-Kotyna, Aleksandra Polak, Barbara Możejko-Pastewka, Ewa Anna Głowacka, Izabela Pieniążek, Małgorzata Pawlik, Maciej Grys, Monika Bogiel
Purpose: Infections caused by resistant Gram-negative bacteria are becoming increasingly common and now pose a serious public health threat worldwide, because they are difficult to treat due to few treatment options and they are associated with high morbidity and mortality. The combination of ceftazidime with the beta-lactamase inhibitor avibactam - seems to be the right choice in this situation. The aim of the study was to evaluate the activity of ceftazidime/avibactam and other commonly used antibiotics against Enterobacterales and Pseudomonas aeruginosa strains isolated within last years in Poland...
2022: Infection and Drug Resistance
#38
JOURNAL ARTICLE
Marcin Protasiewicz, Konrad Reszka, Wojciech Kosowski, Barbara Adamik, Wojciech Bombala, Adrian Doroszko, Damian Gajecki, Jakub Gawryś, Maciej Guziński, Maria Jedrzejczyk, Krzysztof Kaliszewski, Katarzyna Kilis-Pstrusinska, Bogusława Konopska, Agnieszka Kopec, Krzysztof Kujawa, Anna Langner, Anna Larysz, Weronika Lis, Lilla Pawlik-Sobecka, Joanna Gorka-Dynysiewicz, Marta Rosiek-Biegus, Agnieszka Matera-Witkiewicz, Tomasz Matys, Michał Pomorski, Mateusz Sokolski, Janusz Sokołowski, Anna Tomasiewicz-Zapolska, Katarzyna Madziarska, Ewa A Jankowska
The coronavirus disease 2019 (COVID-19) shows high incidence of thromboembolic events in humans. In the present study, we aimed to evaluate if anticoagulation prior to COVID-19 infection may impact clinical profile, as well as mortality rate among patients hospitalized with COVID-19. The study was based on retrospective analysis of medical records of patients with laboratory confirmed SARS-CoV-2 infection. After propensity score matching (PSM), a group of 236 patients receiving any anticoagulant treatment prior to COVID-19 infection (AT group) was compared to 236 patients without previous anticoagulation (no AT group)...
January 12, 2022: Journal of Clinical Medicine
#39
JOURNAL ARTICLE
Ewa Sobieszczuk, Łukasz Napiórkowski, Piotr Szczudlik, Anna Kostera-Pruszczyk
INTRODUCTION: Myasthenia gravis (MG) is a rare autoimmune disorder of neuromuscular junction. MG healthcare burden has not been studied in Poland before. METHODS: Data were drawn from the National Health Fund database; MG patient was defined as a person who received at least once medical service with ICD-10 code MG (G70) and at least two reimbursed prescriptions for pyridostigmine bromide or ambenonium chloride in two consecutive years. We have analyzed treatment: immunosuppression, intravenous immunoglobulins (IVIg), plasma exchange (PE), the number and length of hospitalizations (LOS), intensive care unit (ICU) care, and deaths between 2013 and 2018...
April 2022: Acta Neurologica Scandinavica
#40
JOURNAL ARTICLE
Barbara Zych, Witold Błaż, Ewa Dmoch-Gajzlerska, Katarzyna Kanadys, Anna Lewandowska, Małgorzata Nagórska
The experience of hospitalization of a newborn in the Neonatal Intensive Care Unit (NICU) may become distressing both for the baby and parent. The study aimed to assess the degree of parental stress and coping strategies in parents giving KMC to their babies hospitalized in NICU compared to the control group parents not giving KMC. The prospective observational study enrolled a cohort of 337 parents of premature babies hospitalized in NICU in 2016 in Eastern Poland. The Parental Stressor Scale: Neonatal Intensive Care Unit, Coping Inventory for Stressful Situations were used...
December 2, 2021: International Journal of Environmental Research and Public Health
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