keyword
https://read.qxmd.com/read/35065184/treadmill-training-attenuate-stz-induced-cognitive-dysfunction-in-type-2-diabetic-rats-via-modulating-grb10-igf-r-signaling
#1
JOURNAL ARTICLE
Ying Zhang, Dandan Chen, Meng Zhang, Jing Bian, Shuaiwei Qian, Xianjuan Kou
Type 2 diabetes is a major factor contributing to cognitive decline and Alzheimer's disease (AD). Treadmill running is considered to be a critical approach for mice and rats to lower blood sugar and improve learning and memory capacity. The growth factor receptor-bound protein 10 (Grb10) has been proposed to inhibit insulin signaling and defective brain insulin signaling resulted in the cognitive deficits in patients with AD. However, the positive roles of treadmill training on diabetic- related impaired cognitive function and their molecular mechanisms remain unclear...
April 2022: Brain Research Bulletin
https://read.qxmd.com/read/31040784/apelin-13-suppresses-neuroinflammation-against-cognitive-deficit-in-a-streptozotocin-induced-rat-model-of-alzheimer-s-disease-through-activation-of-bdnf-trkb-signaling-pathway
#2
JOURNAL ARTICLE
Huaiqing Luo, Yang Xiang, Xiangping Qu, Huijun Liu, Chi Liu, Guangyi Li, Li Han, Xiaoqun Qin
Alzheimer's disease (AD), a progressive neurodegenerative disease characterized by impairments of cognitive function as a result of synaptic deficits and neuronal loss, is associated with inflammation. Apelin-13, a predominant neuropeptide with inhibiting effect on inflammation, has beneficial effects on cognition memory and neuronal damage. However, whether apelin-13 can protect neurons to ameliorate cognitive deficits in AD by inhibiting the inflammatory response remains largely unknown. To test this hypothesis, rats were intracerebroventricularly (ICV) injected with streptozotocin (3 mg/kg) alone or in combination with apelin-13 (2 μg)...
2019: Frontiers in Pharmacology
https://read.qxmd.com/read/28077315/inhibition-of-inos-alleviates-cognitive-deficits-and-depression-in-diabetic-mice-through-downregulating-the-no-sgc-cgmp-pkg-signal-pathway
#3
JOURNAL ARTICLE
Xiao Yan Zhou, Fang Zhang, Chang Jiang Ying, Jing Chen, Ling Chen, Jing Dong, Yue Shi, Mang Tang, Xiao Tong Hu, Zhi Hua Pan, Na Na Xu, Kui Yang Zheng, Ren Xian Tang, Yuan Jian Song
Diabetes mellitus often results in a number of complications involving impaired brain function, including cognitive deficits and depression. However, the potential mechanisms for diabetes-related cognitive deficits and depression are not fully understood. Neurons in the hippocampal, cortical and amygdala functional regions are more susceptible to damage during hyperglycemia. Neuroprotection in the brain can rescue cognitive deficits and depression induced by hyperglycemia. This study investigated the potential mechanisms underlying diabetes-related congnitive deficits and depression, determined whether the inflammatory factor inducible nitric oxide synthase (iNOS) and the nitric oxide (NO)/soluble guanylyl cyclases (sGC)/cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG) pathway, play key roles in cognitive deficits and depression associated...
March 30, 2017: Behavioural Brain Research
https://read.qxmd.com/read/21278785/evodiamine-improves-congnitive-abilities-in-samp8-and-app-swe-ps1-%C3%AE-e9-transgenic-mouse-models-of-alzheimer-s-disease
#4
JOURNAL ARTICLE
Shu-min Yuan, Kai Gao, Dong-mei Wang, Xiong-zhi Quan, Jiang-ning Liu, Chun-mei Ma, Chuan Qin, Lian-feng Zhang
AIM: To investigate the effect of evodiamine (a quinolone alkaloid from the fruit of Evodia rutaecarpa) on the progression of Alzheimer's disease in SAMP8 and APP(swe)/PS1(ΔE9) transgenic mouse models. METHODS: The mice at age of 5 months were randomized into the model group, two evodiamine (50 mg·kg(-1)·d(-1) and 100 mg·kg(-1)·d(-1)) groups and an Aricept (2 mg·kg(-1)·d(-1)) group. The littermates of no-transgenic mice and senescence accelerated mouse/resistance 1 mice (SAMR1) were used as controls...
March 2011: Acta Pharmacologica Sinica
https://read.qxmd.com/read/8796153/cortical-visual-dysfunction-in-children-a-clinical-study
#5
JOURNAL ARTICLE
G Dutton, J Ballantyne, G Boyd, M Bradnam, R Day, D McCulloch, R Mackie, S Phillips, K Saunders
Damage to the cerebral cortex was responsible for impairment in vision in 90 of 130 consecutive children referred to the Vision Assessment Clinic in Glasgow. Cortical blindness was seen in 16 children. Only 2 were mobile, but both showed evidence of navigational blind-sight. Cortical visual impairment, in which it was possible to estimate visual acuity but generalised severe brain damage precluded estimation of cognitive visual function, was observed in 9 children. Complex disorders of cognitive vision were seen in 20 children...
1996: Eye
https://read.qxmd.com/read/2068960/neuropsychological-outcome-after-traumatic-temporal-lobe-damage
#6
JOURNAL ARTICLE
R Formisano, B Schmidhuber-Eiler, L Saltuari, E Cigany, G Birbamer, F Gerstenbrand
The most frequent sequelae after severe brain injury include changes in personality traits, disturbances of emotional behaviour and impairment of cognitive functions. In particular, emotional changes and/or verbal and non verbal dysfunctions were found in patients with bilateral or unilateral temporal lobe lesions. The aim of our study is to correlate the localization of the brain damage after severe brain injury, in particular of the temporal lobe, with the cognitive impairment and the emotional and behavioural changes resulting from these lesions...
1991: Acta Neurochirurgica
https://read.qxmd.com/read/686973/the-dose-response-ratio-in-electroconvulsive-therapy-a-preliminary-study
#7
JOURNAL ARTICLE
T R Price, T B Mackenzie, G J Tucker, C Culver
To investigate pretreatment patient variables that might correlate with dose-response characteristics of electroconvulsive therapy (ECT) and treatment outcomes, 14 patients were assessed on a daily basis, before and during treatment, using self-report affective scales, three simple paper-and-pencil tests of cognitive function,and finger-tapping speed. From these data, dose-response ratios and treatment outcome measures were derived. The dose-response ratio of ECT was found to correlate with age--the younger the patient, the more favorable the ratio...
September 1978: Archives of General Psychiatry
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