keyword
https://read.qxmd.com/read/30323928/contemporary-analysis-of-functional-immune-recovery-to-opportunistic-and-vaccine-preventable-infections-after-allogeneic-haemopoietic-stem-cell-transplantation
#21
JOURNAL ARTICLE
Harini D de Silva, Rosemary A Ffrench, Maya Korem, Eva Orlowski, David J Curtis, Andrew Spencer, Sharon Avery, Sushrut Patil, Catherine Orla Morrissey
Objectives: Infections are a major cause of mortality after allogeneic haemopoietic stem cell transplantation (alloHSCT), and immune recovery is necessary for prevention. Novel transplant procedures have changed the epidemiology of infections but contemporary data on functional immune recovery are limited. In this pilot study, we aimed to measure immune recovery in the current era of alloHSCT. Methods: Twenty, 13, 11, 9 and 9 alloHSCT recipients had blood collected at baseline (time of conditioning) and 3-, 6-, 9-, and 12-months post-alloHSCT, respectively...
2018: Clinical & Translational Immunology
https://read.qxmd.com/read/30269248/follow-up-and-outcome-of-symptomatic-partial-or-absolute-iga-deficiency-in-children
#22
JOURNAL ARTICLE
Viviana Moschese, Loredana Chini, Simona Graziani, Mayla Sgrulletti, Vera Gallo, Gigliola Di Matteo, Simona Ferrari, Silvia Di Cesare, Emilia Cirillo, Andrea Pession, Claudio Pignata, Fernando Specchia
Selective IgA deficiency is defined as absolute or partial when serum IgA level is < 7 mg/dl or 2 SD below normal for age, respectively. Few data are available on partial selective IgA deficiency, as probably most children with low serum IgA are seldom referred to a specialist clinic in common pediatric practice. The aim of our study was to better define the profile of both symptomatic forms and their clinical outcome in a pediatric immunology setting. Thus, clinical and immunological data from 103 symptomatic patients with selective IgA deficiency (53 absolute and 50 partial), 4-18 years of age, were collected at diagnosis and 80 patients (44 absolute and 36 partial) were monitored for a mean period of 5 years...
January 2019: European Journal of Pediatrics
https://read.qxmd.com/read/29925902/characterisation-of-immunoparesis-in-newly-diagnosed-myeloma-and-its-impact-on-progression-free-and-overall-survival-in-both-old-and-recent-myeloma-trials
#23
JOURNAL ARTICLE
Jennifer L J Heaney, John P Campbell, Gulnaz Iqbal, David Cairns, Alex Richter, J Anthony Child, Walter Gregory, Graham Jackson, Martin Kaiser, Roger Owen, Faith Davies, Gareth Morgan, Janet Dunn, Mark T Drayson
We measured immunosuppression at myeloma diagnosis and assessed the impact on survival in 5826 UK myeloma trial patients. Polyclonal immunoglobulin levels were below normal in 85% of patients and above normal in only 0.4% of cases for IgA, 0.2% for IgM and no cases for IgG. Immunoparesis had a greater impact in recent trials: median overall survival (OS) was up to 3 years longer for patients without immunoparesis compared to the old trials, less than 1 year longer. Median progression-free survival (PFS) was 39%, 36% and 57% longer for patients with normal IgG, IgA and IgM levels, respectively...
June 20, 2018: Leukemia
https://read.qxmd.com/read/29796630/identification-of-serum-glycoprotein-ligands-for-the-immunomodulatory-receptor-blood-dendritic-cell-antigen-2
#24
JOURNAL ARTICLE
Jong-Won Kim, James Budzak, Yu Liu, Sabine A F Jégouzo, Kurt Drickamer, Maureen E Taylor
Blood dendritic cell antigen 2 (BDCA-2) is a C-type lectin found on the surface of plasmacytoid dendritic cells. It functions as a glycan-binding receptor that downregulates the production of type I interferons and thus plays a role in oligosaccharide-mediated immunomodulation. The carbohydrate recognition domain in BDCA-2 binds selectively to galactose-terminated bi-antennary glycans. Because the plasmacytoid dendritic cells function in a plasma environment rich in glycoproteins, experiments have been undertaken to identify endogenous ligands for blood dendritic cell antigen 2...
August 1, 2018: Glycobiology
https://read.qxmd.com/read/29779634/low-pretransplant-iga-level-is-associated-with-early-post-lung-transplant-seromucous-infection
#25
JOURNAL ARTICLE
Sudish C Murthy, Robin K Avery, Marie Budev, Sandeep Gupta, Gösta B Pettersson, Edward R Nowicki, Atul Mehta, Jeffrey T Chapman, Jeevanantham Rajeswaran, Eugene H Blackstone
OBJECTIVES: Infection is an important cause of morbidity and mortality after lung transplantation. Immunoglobulins are part of both seromucous (IgA) and serum (IgG) infection defense mechanisms. We therefore hypothesized that lower pretransplant IgA levels would be associated with more early post-lung transplant seromucous infections and greater mortality independent of IgG. METHODS: From January 2000 to July 2010, 538 patients undergoing primary lung transplantation had pretransplant IgA (n = 429) and IgG (n = 488) measured as a clinical routine...
August 2018: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/29383769/serum-intestinal-fatty-acid-binding-protein-in-the-noninvasive-diagnosis-of-celiac-disease
#26
JOURNAL ARTICLE
Irene B Oldenburger, Victorien M Wolters, Tineke Kardol-Hoefnagel, Roderick H J Houwen, Henny G Otten
Current diagnostic guidelines for celiac disease (CD) in pediatric patients require a duodenal biopsy if the IgA anti-tissue transglutaminase (tTG) is below 10x the upper limit of normal (ULN). Additional markers may enable a noninvasive diagnosis in this group. Serum intestinal-fatty acid-binding protein (I-FABP), a marker for intestinal epithelial damage, could be useful in this respect. A total of 95 children with a clinical suspicion of CD and tTG 1-10x ULN were investigated. All had a duodenal biopsy and analysis of serum I-FABP...
March 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/29285804/centrifugation-free-washing-a-novel-approach-for-removing-immunoglobulin-a-from-stored-red-blood-cells
#27
JOURNAL ARTICLE
Eszter Vörös, Nathaniel Z Piety, Briony C Strachan, Madeleine Lu, Sergey S Shevkoplyas
Washed red blood cells (RBCs) are indicated for immunoglobulin A (IgA) deficient recipients. Centrifugation-based cell processors commonly used by hospital blood banks cannot consistently reduce IgA below the recommended levels, hence double washing is frequently required. Here, we describe a prototype of a simple, portable, disposable system capable of washing stored RBCs without centrifugation, while reducing IgA below 0.05 mg/dL in a single run. Samples from RBC units (n = 8, leukoreduced, 4-6 weeks storage duration) were diluted with normal saline to a hematocrit of 10%, and then washed using either the prototype washing system, or via conventional centrifugation...
August 2018: American Journal of Hematology
https://read.qxmd.com/read/29235061/differential-expression-of-immune-factor-between-patients-with-chronic-prostatitis-chronic-pelvic-pain-syndrome-and-the-healthy-volunteers
#28
JOURNAL ARTICLE
Chen Ye, Guang'an Xiao, Jian Xu, Shengfei Qin, Yuhua Luo, Guanghua Chen, H Henry Lai, Tie Zhou
PURPOSE: Immune mechanisms have been hypothesized to contribute to the development of CP/CPPS. In this study, we investigated the differential expression of immune factors between patients with CP/CPPS and healthy volunteers. METHODS: This study was registered in Australian New Zealand Clinical Trials Registry. Healthy volunteers and patients with CP/CPPS were enrolled in this study. The inclusion criteria for patients were below: (1) aged 18-45 years old; (2) prostatitis-related syndrome longer than 3 months; (3) normal routine urine culture and negative bacterial culture in prostatic fluid...
March 2018: International Urology and Nephrology
https://read.qxmd.com/read/29216227/immunoparesis-in-newly-diagnosed-multiple-myeloma-patients-effects-on-overall-survival-and-progression-free-survival-in-the-danish-population
#29
JOURNAL ARTICLE
Rasmus Sørrig, Tobias W Klausen, Morten Salomo, Annette J Vangsted, Ulf Christian Frølund, Kristian T Andersen, Anja Klostergaard, Carsten Helleberg, Robert S Pedersen, Per T Pedersen, Sissel Helm-Petersen, Elena Manuela Teodorescu, Birgitte Preiss, Niels Abildgaard, Peter Gimsing
Immunoparesis (hypogammaglobulinemia) is associated to an unfavorable prognosis in newly diagnosed Multiple myeloma (MM) patients. However, this finding has not been validated in an unselected population-based cohort. We analyzed 2558 newly diagnosed MM patients in the Danish Multiple Myeloma Registry representing the entire MM population in Denmark from 2005-2013. Two-thousand two hundred and fifty three patients (90%) presented with reduction below lower normal levels of at least one uninvolved immunoglobulin...
2017: PloS One
https://read.qxmd.com/read/29128760/vitamin-d-deficiency-in-children-with-recurrent-respiratory-infections-with-or-without-immunoglobulin-deficiency
#30
JOURNAL ARTICLE
Nel Dąbrowska-Leonik, Ewa Bernatowska, Małgorzata Pac, Wiktor Filipiuk, Jan Mulawka, Barbara Pietrucha, Edyta Heropolitańska-Pliszka, Katarzyna Bernat-Sitarz, Beata Wolska-Kuśnierz, Bożena Mikołuć
PURPOSE: The objective of this study was to evaluate thevitamin D concentration in patients with recurrent respiratory infections with or without immunoglobulin G, A or M (IgG, IgA, IgM) deficiency, and to find a correlation between the vitamin D concentration and the response to hepatitis B vaccination. MATERIALS AND METHOD: The study involved 730 patients with recurrent respiratory infections. The concentration of 25-hydroxyvitamin D (25(OH)D), immunoglobulins G, A and M, anti-HBs was determined...
March 2018: Advances in Medical Sciences
https://read.qxmd.com/read/28928736/selective-igm-deficiency-an-underestimated-primary-immunodeficiency
#31
REVIEW
Sudhir Gupta, Ankmalika Gupta
Although selective IgM deficiency (SIGMD) was described almost five decades ago, it was largely ignored as a primary immunodeficiency. SIGMD is defined as serum IgM levels below two SD of mean with normal serum IgG and IgA. It appears to be more common than originally realized. SIGMD is observed in both children and adults. Patients with SIGMD may be asymptomatic; however, approximately 80% of patients with SIGMD present with infections with bacteria, viruses, fungi, and protozoa. There is an increased frequency of allergic and autoimmune diseases in SIGMD...
2017: Frontiers in Immunology
https://read.qxmd.com/read/28782118/undetectable-negative-tissue-transglutaminase-iga-antibodies-predict-mucosal-healing-in-treated-coeliac-disease-patients
#32
JOURNAL ARTICLE
H Fang, K S King, J J Larson, M R Snyder, T T Wu, M J Gandhi, J A Murray
BACKGROUND: Tissue transglutaminase (tTG) immunoglobulin A (IgA) testing is a sensitive adjunct to the diagnosis of coeliac disease. The threshold for positivity was developed for diagnosis, with negative results reported as below the reference value (<4 U/mL). AIM: To investigate if an undetectable (tTG IgA<1.2 U/mL) is more predictive of healing compared to patients with negative but detectable serology (1.2-3.9 U/mL). METHODS: We performed a retrospective study of 402 treated coeliac disease patients seen at the Mayo Clinic with negative tTG IgA values drawn within 1 month of duodenal biopsy between January 2009 and December 2015...
October 2017: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/28624578/accuracy-in-diagnosis-of-celiac-disease-without-biopsies-in%C3%A2-clinical-practice
#33
MULTICENTER STUDY
Katharina Julia Werkstetter, Ilma Rita Korponay-Szabó, Alina Popp, Vincenzo Villanacci, Marianna Salemme, Gabriele Heilig, Søren Thue Lillevang, Maria Luisa Mearin, Carmen Ribes-Koninckx, Adrian Thomas, Riccardo Troncone, Birgit Filipiak, Markku Mäki, Judit Gyimesi, Mehri Najafi, Jernej Dolinšek, Stine Dydensborg Sander, Renata Auricchio, Alexandra Papadopoulou, Andreas Vécsei, Peter Szitanyi, Ester Donat, Rafaella Nenna, Philippe Alliet, Francesca Penagini, Hélène Garnier-Lengliné, Gemma Castillejo, Kalle Kurppa, Raanan Shamir, Almuthe Christine Hauer, Françoise Smets, Susana Corujeira, Myriam van Winckel, Stefan Buderus, Sonny Chong, Steffen Husby, Sibylle Koletzko
BACKGROUND & AIMS: The guidelines of the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition allow for diagnosis of celiac disease without biopsies in children with symptoms and levels of immunoglobulin A against tissue-transglutaminase (TGA-IgA) 10-fold or more the upper limit of normal (ULN), confirmed by detection of endomysium antibodies (EMA) and positivity for HLA-DQ2/DQ8. We performed a large, international prospective study to validate this approach. METHODS: We collected data from consecutive pediatric patients (18 years or younger) on a gluten-containing diet who tested positive for TGA-IgA from November 2011 through May 2014, seen at 33 pediatric gastroenterology units in 21 countries...
October 2017: Gastroenterology
https://read.qxmd.com/read/28461188/validation-of-antibody-based-strategies-for-diagnosis-of-pediatric-celiac-disease-without-biopsy
#34
MULTICENTER STUDY
Johannes Wolf, David Petroff, Thomas Richter, Marcus K H Auth, Holm H Uhlig, Martin W Laass, Peter Lauenstein, Andreas Krahl, Norman Händel, Jan de Laffolie, Almuthe C Hauer, Thomas Kehler, Gunter Flemming, Frank Schmidt, Astor Rodrigues, Dirk Hasenclever, Thomas Mothes
BACKGROUND & AIMS: A diagnosis of celiac disease is made based on clinical, genetic, serologic, and duodenal morphology features. Recent pediatric guidelines, based largely on retrospective data, propose omitting biopsy analysis for patients with concentrations of IgA against tissue transglutaminase (IgA-TTG) >10-fold the upper limit of normal (ULN) and if further criteria are met. A retrospective study concluded that measurements of IgA-TTG and total IgA, or IgA-TTG and IgG against deamidated gliadin (IgG-DGL) could identify patients with and without celiac disease...
August 2017: Gastroenterology
https://read.qxmd.com/read/28337541/tyrosine-kinase-inhibitor-therapy-induced-changes-in-humoral-immunity-in-patients-with-chronic-myeloid-leukemia
#35
JOURNAL ARTICLE
Hanna L M Rajala, Mohamed El Missiry, Anniina Ruusila, Perttu Koskenvesa, Tim H Brümmendorf, Bjorn T Gjertsen, Jeroen Janssen, Kourosh Lotfi, Berit Markevärn, Ulla Olsson-Strömberg, Leif Stenke, Jesper Stentoft, Johan Richter, Henrik Hjorth-Hansen, Anna Kreutzman, Satu Mustjoki
PURPOSE: Tyrosine kinase inhibitors (TKIs) have well-characterized immunomodulatory effects on T and NK cells, but the effects on the humoral immunity are less well known. In this project, we studied TKI-induced changes in B cell-mediated immunity. METHODS: We collected peripheral blood (PB) and bone marrow (BM) samples from chronic myeloid leukemia (CML) patients before and during first-line imatinib (n = 20), dasatinib (n = 16), nilotinib (n = 8), and bosutinib (n = 12) treatment...
August 2017: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/28078662/low-immunoglobulin-e-flags-two-distinct-types-of-immune-dysregulation
#36
JOURNAL ARTICLE
M Elkuch, V Greiff, C T Berger, M Bouchenaki, T Daikeler, A Bircher, A A Navarini, I Heijnen, M Recher
During the last two decades, hyper-immunoglobulin (Ig)E syndromes have been characterized clinically and molecularly in patients with genetically determined primary immunodeficiencies. However, the detection of low IgE levels, defined here as below detection limit in the routine clinical immunology laboratory, has received little attention. We analysed the association of serum IgA, IgM and IgG levels (including IgG subclasses) with low, normal or high serum IgE levels in patients evaluated in a single-centre out-patient immunodeficiency and allergy clinic...
March 2017: Clinical and Experimental Immunology
https://read.qxmd.com/read/27836054/clinical-phenotypes-of-hyper-igm-syndromes
#37
REVIEW
M Teresa de la Morena
The primary immunodeficiency (PID) diseases comprise a heterogeneous group of inherited disorders of immune function. Technical advancements in whole-genome, whole-exome, and RNA-sequencing have seen the explosion of genetic discoveries in the field of PIDs. The present review aims to focus on a group of immunodeficiency disorders associated with elevated levels of IgM (hyper IgM; HIGM) and provides a clinical differential diagnosis. Most patients present for evaluation of immunodeficiency due to recurrent infections, and laboratory studies show either a clear isolated elevation of serum immunoglobulin M (IgM) with low or absent IgG, IgA, and IgE...
November 2016: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/27393102/effect-of-partial-splenic-embolization-on-the-immune-function-of-cirrhosis-patients-with-hypersplenism
#38
JOURNAL ARTICLE
Gui-Yun Jin, Chuan-Zhu Lv, Deng Tang, Shao-Wen Cheng, Chao-Qian Li
OBJECTIVE: To discover the effect of partial splenic embolization on the immune function of cirrhotic patients with hypersplenism. METHODS: Patients involved in the study were enrolled and divided into three groups, including control group, experimental group, and complication group. Numbers of CD3(+), CD4(+) and CD8(+) T cells and CD4(+)CD25(+)CDl27(low/-) Treg cells in the peripheral blood of patients before surgery, 1 month, 6 months, 1 year, and 2 years after surgery were analyzed by fluorescence active cell sorting (FACS)...
July 2016: Asian Pacific Journal of Tropical Medicine
https://read.qxmd.com/read/26779698/detection-of-specific-immunoglobulin-e-antibodies-toward-common-airborne-allergens-peanut-wheat-and-latex-in-solvent-detergent-treated-pooled-plasma
#39
JOURNAL ARTICLE
Torunn O Apelseth, Venny L Kvalheim, Einar K Kristoffersen
BACKGROUND: Allergic transfusion reactions (ATRs) present with a broad range of symptoms probably caused by mediators released from mast cells and basophil granulocytes upon activation. Passive immunoglobulin (Ig)E sensitization may yield clinical symptoms and positive allergy tests. Unexpected findings of IgE antibodies in pooled solvent/detergent (S/D)-treated plasma (Octaplas, Octapharma) during routine analysis initiated an investigation of serum proteins. STUDY DESIGN AND METHODS: Consecutive batches of S/D-plasma transfused during September 2014 through March 2015 were investigated for IgE, IgG, IgA IgM, C3, C4, haptoglobin, anti-nuclear antibodies (ANAs), and red blood cell (RBC) antibodies...
May 2016: Transfusion
https://read.qxmd.com/read/25876637/-effects-of-astragalus-polysaccharide-on-intestinal-immune-function-of-rats-with-severe-scald-injury
#40
JOURNAL ARTICLE
Cuilan Huang, Jianhua Zhan, Jinhua Luo
OBJECTIVE: To observe the effects of astragalus polysaccharide (AP) on the intestinal mucosal morphology, level of secretory IgA (s-IgA) in intestinal mucus, and distribution of T lymphocyte subsets in Peyer's patch in rats with severe scald injury. METHODS: One hundred and thirty SD rats were divided into sham injury group (SI, sham injured, n = 10), scald group (S, n = 30), low dosage group (LD, n = 30), moderate dosage group (MD, n = 30), and high dosage group (HD, n = 30) according to the random number table...
February 2015: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
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