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https://www.readbyqxmd.com/read/29241957/evaluation-of-adsorption-selectivity-of-immunoglobulins-m-a-and-g-and-purification-of-immunoglobulin-m-with-mixed-mode-resins
#1
Ying-Di Luo, Qi-Lei Zhang, Shan-Jing Yao, Dong-Qiang Lin
This study investigated adsorption selectivity of immunoglobulin M (IgM), immunoglobulin A (IgA) and immunoglobulin (IgG) on four mixed-mode resins with the functional ligands of 4-mercatoethyl-pyridine (MEP), 2-mercapto-1-methylimidazole (MMI), 5-aminobenzimidazole (ABI) and tryptophan-5-aminobenzimidazole (W-ABI), respectively. IgM purification processes with mixed-mode resins were also proposed. All resins showed typical pH-dependent adsorption, and high adsorption capacity was found at pH 5.0-8.0 with low adsorption capacity under acidic conditions...
December 9, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29237228/methotrexate-and-azathioprine-in-severe-atopic-dermatitis-a-5-year-follow-up-study-of-a-randomised-controlled-trial
#2
L A A Gerbens, S A S Hamann, M W D Brouwer, E Roekevisch, M M G Leeflang, Ph I Spuls
BACKGROUND: Systemic treatment is indicated for moderate-to-severe atopic dermatitis (AD), refractory to topical treatment. Long-term evidence, up to 5 years, of off-label prescribed methotrexate (MTX) and azathioprine (AZA) is lacking. OBJECTIVES: To investigate long-term effectiveness, safety and drug survival of MTX and AZA. METHODS: In an open-label follow up phase of a clinical trial patients were seen every 3 months for 5 years. MTX and AZA doses could be in- or decreased concurrent with daily clinical practice...
December 13, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29233117/elizabethkingia-miricola-as-an-opportunistic-oral-pathogen-associated-with-superinfectious-complications-in-humoral-immunodeficiency-a-case-report
#3
Przemysław Zdziarski, Mariola Paściak, Klaudia Rogala, Agnieszka Korzeniowska-Kowal, Andrzej Gamian
BACKGROUND: Elizabethkingia miricola is a rare Gram-negative bacterium found in water and clinical specimens. Typical culturing methods often misidentify Elizabethkingia spp. as Flavobacterium or Chryseobacterium. Although diagnosis is based on culturing samples taken from sterile sites, such as blood, a proper identification of this bacterium requires an expertise that goes beyond the capabilities of a typical clinical laboratory. CASE PRESENTATION: A 35-year-old woman diagnosed with common variable immunodeficiency was admitted to our center...
December 12, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29217879/iga-dominant-infection-related-glomerulonephritis-in-india-a-single-center-experience
#4
J Dhanapriya, T Balasubramaniyan, S P Maharajan, T Dineshkumar, R Sakthirajan, N Gopalakrishnan, M Nagarajan
IgA-dominant infection-related glomerulonephritis (IRGN) is a distinct morphologic variant of IRGN, characterized by dominant or codominant glomerular deposits of IgA, mostly in elderly and patients with diabetes. More cases are being reported in recent times due to increased awareness of the disease entity and increased rate of Staphylococcus infection. It usually presents as rapidly progressive renal failure with proteinuria, and treatment guidelines for this disease entity are not well defined. We report here 12 cases of IgA-dominant IRGN seen over a period of 5 years from a single center...
November 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29214527/assessment-of-the-diagnostic-value-of-specific-anti-toxocara-iga-in-slovakian-patients-suspected-to-have-toxocarosis
#5
Vojtech Boldiš, František Ondriska, Simona Lipková
Human toxocarosis is one of the most widespread and prevalent helminthic zoonosis in many countries, including Slovakia. The aim was to evaluate the usefulness of IgA anti-Toxocara antibody detection in the serodiagnosis of toxocarosis. The levels of specific IgA antibodies were determined by excretory-secretory (ES)-enzyme-linked immunosorbent assay (ELISA). The IgA seropositivity in IgG anti-Toxocara seropositive patients (n = 52) was 32.7% and found to be highest in the oldest age groups (P = 0.026)...
December 6, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/29211757/distinct-fecal-and-oral-microbiota-composition-in-human-type-1-diabetes-an-observational-study
#6
Pieter F de Groot, Clara Belzer, Ömrüm Aydin, Evgeni Levin, Johannes H Levels, Steven Aalvink, Fransje Boot, Frits Holleman, Daniël H van Raalte, Torsten P Scheithauer, Suat Simsek, Frank G Schaap, Steven W M Olde Damink, Bart O Roep, Joost B Hoekstra, Willem M de Vos, Max Nieuwdorp
OBJECTIVE: Environmental factors driving the development of type 1 diabetes (T1D) are still largely unknown. Both animal and human studies have shown an association between altered fecal microbiota composition, impaired production of short-chain fatty acids (SCFA) and T1D onset. However, observational evidence on SCFA and fecal and oral microbiota in adults with longstanding T1D vs healthy controls (HC) is lacking. RESEARCH DESIGN AND METHODS: We included 53 T1D patients without complications or medication and 50 HC matched for age, sex and BMI...
2017: PloS One
https://www.readbyqxmd.com/read/29201234/efficacy-safety-and-influencing-factors-of-intra-calf-muscular-injection-of-bone-marrow-mononuclear-cells-in-the-treatment-of-type-2-diabetes-mellitus-induced-lower-extremity-vascular-disease
#7
Hui-Min Zhou, Fan Liu, Ai-Ge Yang, Yu-Qing Guo, Ya-Ru Zhou, Yong-Quan Gu, Bao-Yong Yan, Quan-Hai Li
The efficacy, safety and impact of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) associated with the intra-calf muscular injection of bone marrow mononuclear cells (BMMCs) in the treatment of type 2 diabetes mellitus (T2DM)-induced lower extremity vascular disease (LEVD) were evaluated. Patients with T2DM-LEVD were randomly divided into a control group and BMMCs group to assess the efficacy and safety of the treatment; serum VEGF and bFGF levels were detected. The BMMCs group was divided into superior genicular artery (SGA) and inferior genicular artery (IGA) subgroups as well as low-dose and high-dose subgroups for the comparison of efficacy indices...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29199436/-considerations-on-the-treatment-of-iga-nephropathy-on-the-basis-of-the-results-of-the-latest-studies-stop-igan-testing-nefigan
#8
Judit Nagy, Balázs Sági, Judit Máté, Tibor Vas, Tibor Kovács
IgA nephropathy is an immune-mediated chronic glomerulonephritis with a great variability in clinical presentation and outcome. The disease can progress to end-stage renal failure in 25% of patients. For this reason we should identify patients with potential to progress. Most important risk factors for progression are persistent proteinuria, hypertension, decreased renal function and some histological lesions. The actually suggested treatment is summarized in KDIGO Clinical Practice Guideline from 2012. They suggest to give firstly non-specific supportive treatment (especially renin-angiotensin system blocking agents)...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29184156/hiv-1-env-dna-prime-plus-gp120-and-gp70-v1v2-boosts-induce-high-level-of-v1v2-specific-igg-and-adcc-responses-and-low-level-of-env-specific-iga-response-implication-for-improving-rv144-vaccine-regimen
#9
Qian Wang, Yanyan Dai, Zhiwu Sun, Xiaojie Su, Yufeng Yu, Chen Hua, Wei Xu, Shibo Jiang, Lu Lu
No abstract text is available yet for this article.
November 29, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29168584/hemolysis-and-iga-antibodies-against-tissue-transglutaminase-when-are-antibody-test-results-no-longer-reliable
#10
Johannes Wolf, Norman Haendel, Johannes Remmler, Carl Elias Kutzner, Thorsten Kaiser, Thomas Mothes
BACKGROUND: Antibodies against tissue transglutaminase (TTG) of isotype IgA (IgA-aTTG) represent reliable diagnostic markers to confirm or exclude celiac disease (CD). Hemolysis (HL) is an important pre-analytical factor. HL can be quantified as HL index (HI) correlating with the concentration of free hemoglobin. TTG is abundant in erythrocytes and released upon HL. In immunoassays, the released TTG may interfere with binding of IgA-aTTG to the coated TTG. METHODS: We selected 17 HL-free sera from children with biopsy-confirmed CD: 7 with low-positive (1-5 multiples of upper limit of normal [×ULN]), 5 with intermediate (5-10 × ULN) and 5 with high IgA-aTTG (10-15 × ULN)...
November 23, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29156562/biodegradable-chitosan-decreases-the-immune-response-to-trichinella-spiralis-in-mice
#11
Klaudia Brodaczewska, Natalia Wolaniuk, Katarzyna Lewandowska, Katarzyna Donskow-Łysoniewska, Maria Doligalska
The purpose of this study was to evaluate the potential of chitosan units released during natural degradation of the polymer to activate the immune system against T. spiralis infection. High molecular weight chitosan was injected intraperitoneally into C57BL/6 mice. Flow cytometry and cytokine concentration, measured by ELISA, were used to characterize peritoneal cell populations during T. spiralis infection. The strong chemo-attractive properties of chitosan caused considerable infiltration into the peritoneal cavity of CD11b⁺ cells, with reduced expression of MHC class II, CD80, CD86, Dectin-1 or CD23 receptors in comparison to T...
November 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29154122/broncho-vaxom-in-pediatric-recurrent-respiratory-tract-infections-a-systematic-review-and-meta-analysis
#12
REVIEW
Ju Yin, Baoping Xu, Xiantao Zeng, Kunling Shen
OBJECTIVES: Assess the efficacy and safety of Broncho-Vaxom in pediatric recurrent respiratory tract infections (RRTIs). METHODS: Published randomized controlled trials (RCTs) of Broncho-Vaxom for pediatric RRTI were searched using PubMed, Embase, Cochrane Library, CBM, CNKI, WanFang Data, and VIP databases up to January 2017. Risk of bias was evaluated in accordance to the guidelines of the Cochrane collaboration and the level of evidence was graded according to the GRADE...
November 16, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29149900/immunogenic-potential-of-a-salmonella-typhimurium-live-vaccine-for-pigs-against-monophasic-salmonella-typhimurium-dt-193
#13
Tobias Theuß, Elke Ueberham, Jörg Lehmann, Thomas Lindner, Sven Springer
BACKGROUND: Monophasic Salmonella Typhimurium (mSTM) strains account for up to 8.6% of all human Salmonellosis cases. They have an increasing prevalence during recent years and several human cases with hospitalisation were reported. These strains are often isolated from pigs and pork - one primary source of human infection. A Salmonella Typhimurium (STM) live vaccine has been proven successful in controlling of STM infections in pigs for many years. The aim of this study was to test the immunogenicity of the vaccine in weaners during oral challenge with a virulent mSTM strain and to examine the kinetics of STM-specific IgA, IgM and IgG antibodies induced by vaccination and infection...
November 17, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29129698/evaluation-of-different-parameters-of-humoral-and-cellular-immune-responses-in-hiv-serodiscordant-heterosexual-couples-humoral-response-potentially-implicated-in-modulating-transmission-rates
#14
María Julia Ruiz, Jimena Salido, Lorena Abusamra, Yanina Ghiglione, Cintia Cevallos, Gabriel Damilano, Ana María Rodriguez, César Trifone, Natalia Laufer, Luis D Giavedoni, Omar Sued, Horacio Salomón, María Magdalena Gherardi, Gabriela Turk
As the HIV/AIDS pandemic still progresses, understanding the mechanisms governing viral transmission as well as protection from HIV acquisition is fundamental. In this context, cohorts of HIV serodiscordant heterosexual couples (SDC) represent a unique tool. The present study was aimed to evaluate specific parameters of innate, cellular and humoral immune responses in SDC. Specifically, plasma levels of cytokines and chemokines, HIV-specific T-cell responses, gp120-specific IgG and IgA antibodies, and HIV-specific antibody-dependent cellular cytotoxicity (ADCC) activity were assessed in nine HIV-exposed seronegative individuals (ESN) and their corresponding HIV seropositive partners (HIV(+)-P), in eighteen chronically infected HIV subjects (C), nine chronically infected subjects known to be HIV transmitters (CT) and ten healthy HIV(-) donors (HD)...
November 3, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29126302/the-clinical-utility-of-measuring-igg-subclass-immunoglobulins-during-immunological-investigation-for-suspected-primary-antibody-deficiencies
#15
Antony R Parker, Markus Skold, David B Ramsden, J Gonzalo Ocejo-Vinyals, Marcos López-Hoyos, Stephen Harding
Measurement of IgG subclass concentrations is a standard laboratory test run as part of a panel to investigate the suspicion of antibody deficiency. The assessment is clinically important when total IgG is within the normal age-specific reference range. The measurement is useful for diagnosis of IgG subclass deficiency, to aid the diagnosis of specific antibody deficiency, as a supporting test for the diagnosis of common variable immunodeficiency, as well as for risk stratification of patients with low IgA...
November 8, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/29109718/siga-tgf-%C3%AE-1-il-10-and-tnf%C3%AE-in-colostrum-are-associated-with-infant-group-b-streptococcus-colonization
#16
Kirsty Le Doare, Katie Bellis, Amadou Faal, Jessica Birt, Daniel Munblit, Holly Humphries, Stephen Taylor, Fiona Warburton, Paul T Heath, Beate Kampmann, Andrew Gorringe
Background: Group B Streptococcus (GBS) is a major cause of mortality and morbidity in infants and is associated with transmission from a colonized mother at birth and via infected breastmilk. Although maternal/infant colonization with GBS is common, the majority of infants exposed to GBS remain unaffected. The association between breastmilk immune factors and infant colonization and disease prevention has not been elucidated. Objectives: We have investigated the association between SIgA and cytokines in breastmilk and infant GBS colonization and clearance...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29106627/bi-nucleation-of-podocytes-is-uniformly-accompanied-by-foot-processes-widening-in-renal-disease
#17
Johanna Mühldorfer, Eva Pfister, Maike Büttner-Herold, Monika Klewer, Kerstin Amann, Christoph Daniel
Background: Podocytes are terminally differentiated glomerular cells expressing a highly complex architecture and lacking the ability to proliferate. However, during renal injury or stress these cells can re-enter into the cell cycle but fail to divide. As a consequence, bi- and multi-nucleated podocytes can be identified in renal biopsies from patients with various kidney diseases. It is still unclear whether the occurrence of such cells is dependent on or correlates with renal damage and if bi- or multi-nucleation results in ultrastructural alterations such as e...
July 2, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29101397/gut-dysbiosis-and-impairment-of-immune-system-homeostasis-in-perinatally-exposed-mice-to-bisphenol-a-precede-obese-phenotype-development
#18
Yann Malaisé, Sandrine Menard, Christel Cartier, Eric Gaultier, Frédéric Lasserre, Corinne Lencina, Cherryl Harkat, Nancy Geoffre, Laïla Lakhal, Isabelle Castan, Maïwenn Olier, Eric Houdeau, Laurence Guzylack-Piriou
Epidemiology evidenced the Bisphenol A (BPA), a chemical found in daily consumer products, as an environmental contributor to obesity and type II diabetes (T2D) in Humans. However, the BPA-mediated effects supporting these metabolic disorders are still unknown. Knowing that obesity and T2D are associated with low-grade inflammation and gut dysbiosis, we performed a longitudinal study in mice to determine the sequential adverse effects of BPA on immune system and intestinal microbiota that could contribute to the development of metabolic disorders...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29094324/a-caucasian-american-patient-with-celiac-disease-diagnosed-in-japan-and-successfully-treated-with-a-gluten-free-diet
#19
Haruka Wada, Mari Hayashida, Taro Sato, Shintaro Minowa, Osamu Ikezaki, Tatsuya Mitsui, Miki Miura, Yoshihiko Ohmori, Daisuke Saito, Akihito Sakuraba, Hideo Kamiichi, Kengo Tokunaga, Makoto Mochizuki, Junji Shibahara, Hideaki Mori, Tadakazu Hisamatsu
We report the case of a 33-year-old Caucasian American man diagnosed with celiac disease in Japan. He presented to a community hospital because of chronic watery diarrhea and weight loss for 6 months. The laboratory data showed low serum albumin and serum cholesterol. A colonoscopy was normal. He was referred to our hospital for further work-up. Serum tissue transglutaminase immunoglobulin A (IgA) and endomysial antibody were positive. The HLA type was DQ2. Esophagogastroduodenoscopy (EGD) revealed nodular and mosaic-patterned mucosa from the bulb to the second part of the duodenum...
November 1, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29093399/the-renoprotective-effects-of-docosahexaenoic-acid-as-an-add-on-therapy-in-patients-receiving-eicosapentaenoic-acid-as-treatment-for-iga-nephropathy-a-pilot-uncontrolled-trial
#20
Takahito Moriyama, Saeko Kumon, Takahiro Kamiyama, Kazunori Karasawa, Keiko Uchida, Kosaku Nitta
Objective Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have been reported to have beneficial effects in patients with IgA nephropathy (IgAN). Although DHA and EPA have different mechanisms of action, no study to date has assessed their individual actions in patients with IgAN. This study therefore analyzed the effects administering DHA in addition to EPA for the treatment of IgAN. Methods Twenty-one IgAN patients who were being treated with EPA (1,800 mg/day) were switched to EPA (1,860 mg/day) and DHA (1,500 mg/day)...
November 1, 2017: Internal Medicine
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