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IgA gammopathy

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https://www.readbyqxmd.com/read/27745940/-macro-ast-and-myeloma-an-incidental-association
#1
C Lartigau-Roussin, M H Paclet, H Audin, B Toussaint, T Henni, L Raffray
INTRODUCTION: Macro-AST is recognized as a classical aetiology of isolated and persistent increase of serum aspartate aminotransferase (AST) levels. Macro-AST are high molecular weight complexes associating AST and a macromolecule, often an immunoglobulin. Although those macroenzymes of unknown pathogenesis are usually non-pathogenic, association with several diseases, including autoimmune diseases and liver diseases has been described. CASE REPORT: We report here the case of a 45-year-old patient with previously normal liver enzymes in whom an AST elevation and an IgA monoclonal gammopathy were discovered concomitantly...
October 13, 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/27707674/benefits-of-new-immunoglobulin-derived-biomarkers-for-the-diagnosis-and-follow-up-of-patients-with-dysglobulinemia
#2
Natalia Ermak, Thao Nguyen-Khoa, Marie-Alexandra Alyanakian
The diagnostics and follow-up of monoclonal gammopathies such as multiple myeloma require precise analysis of the monoclonal component as well as the other immunoglobulins isotypes, which might be limited by the sensitivity of standard laboratory methods. New serum biomarkers were developed for routine practice in the last decades, such as the free light chain assays and more recently the heavy/light chain assay<strike>s</strike>. Studies have shown that serum free light chain measurement was useful in the identification and follow-up of pauci or nonsecretory myeloma, free light-chain multiple myeloma and AL amyloidosis...
October 1, 2016: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/27580763/a-case-of-severe-chronic-inflammatory-demyelinating-polyradiculoneuropathy-with-monoclonal-gammopathy-of-undetermined-significance-with-alternating-immunoglobulin-class-to-igm-from-iga
#3
Shintaro Hayashi, Shun Nagamine, Kouki Makioka, Susumu Kusunoki, Koichi Okamoto
A 71-year-old woman with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) with IgA-λ monoclonal gammopathy of undetermined significance (MGUS) showed the acute development of tetraplegia, respiratory failure, and a marked fluctuation of the blood pressure. Intravenous (IV) high-dose steroid therapy (methylprednisolone: 1 g/day × 3 days), followed by oral prednisolone (PSL) (40 mg/day), and IV immunoglobulin (IVIg, 0.4 g/kg/day × 5 days) administrations resulted in the amelioration of these symptoms...
September 29, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27559509/erythema-elevatum-diutinum-in-association-with-iga-monoclonal-gammopathy-a-rare-case-report
#4
Guru Prasad Patnala, Anila P Sunandini, Rama Rayavarapu, Padmasri Somala Yandapalli
Erythema elevatum diutinum (EED) is a rare form of vasculitis characterized clinically by red-violet brown papules, plaques, and nodules mainly involving the extensor surfaces; histologically by leukocytoclastic vasculitis in early lesions, and fibrosis and cholesterolosis in late lesions. EED has been associated with many systemic disorders including infections, autoimmune disorders, and both benign and malignant hematological disorders. As it is a rare form of vasculitis and only 250 cases reported till date, we report a case of EED in association with IgA monoclonal gammopathy with partial response to dapsone treatment...
July 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27516004/complete-remission-of-skin-lesions-in-a-patient-with-subcorneal-pustular-dermatosis-sneddon-wilkinson-disease-treated-with-anti-myeloma-therapy-association-with-disappearance-of-m-protein
#5
P A von dem Borne, M F Jonkman, R van Doorn
Subcorneal pustular dermatosis (SPD) or Sneddon-Wilkinson disease is a rare pustular skin disease that follows a chronic relapsing course. A well-known association exists between SPD and IgA monoclonal gammopathy of undetermined significance (IgA MGUS), which exists in up to 40% of cases. SPD has also been observed in IgA myeloma patients. In SPD direct and indirect immunofluorescence studies do not reveal in vivo bound IgA to the epithelial cell surface, in contrast to IgA pemphigus that has similar clinico-pathological features...
August 12, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27264923/scleredema-associated-iga-myeloma-with-myelofibrosis-in-a-young-adult-a-case-report
#6
Seema Rao, Rakhee Kar, Hara Prasad Pati, Renu Saxena
Scleredema of Buschke is a rare fibromucinous connective tissue disorder of unknown etiology. It is often associated with a benign monoclonal gammopathy and rarely with myelomatosis. We report a case of scleredema-associated IgA myeloma with myelofibrosis in a 24-year-old male patient. Scleredema generally affects young adults and onset of associated monoclonal gammopathy is at a younger age than when not associated with scleredema. However, presentation at a much younger age (24 years in our case) is very unusual...
December 5, 2008: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/27263458/iga-lambda-oligoclonal-gammopathy-in-multiple-myeloma
#7
İbrahim Tek, Dilsa Mızrak, Güngör Utkan, Selami Koçak Toprak, Hüseyin Tutkak, Abdullah Büyükçelik, Bulent Yalçın, Hakan Akbulut, Fikri İçli
No abstract text is available yet for this article.
June 5, 2010: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/27161311/diagnosis-risk-stratification-and-management-of-monoclonal-gammopathy-of-undetermined-significance-and-smoldering-multiple-myeloma
#8
REVIEW
N W C J van de Donk, T Mutis, P J Poddighe, H M Lokhorst, S Zweegman
Monoclonal gammopathy of undetermined significance (MGUS) is one of the most common premalignant disorders. IgG and IgA MGUS are precursor conditions of multiple myeloma (MM), whereas light-chain MGUS is a precursor condition of light-chain MM. Smoldering MM (SMM) is a precursor condition with higher tumor burden and higher risk of progression to symptomatic MM compared to MGUS. Assessment of the risk of progression of patients with asymptomatic monoclonal gammopathies is based on various factors including clonal burden, as well as biological characteristics, such as cytogenetic abnormalities and light-chain production...
May 2016: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/27013181/prognostic-impact-of-serum-heavy-light-chain-pairs-in-patients-with-monoclonal-gammopathy-of-undetermined-significance-and-smoldering-myeloma-long-term-results-from-a-single-institution
#9
Laura Magnano, Carlos Fernández de Larrea, Montserrat Elena, María Teresa Cibeira, Natalia Tovar, Juan I Aróstegui, Fabiola Pedrosa, Laura Rosiñol, Xavier Filella, Jordi Yagüe, Joan Bladé
BACKGROUND: Asymptomatic monoclonal gammopathies, such as monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM), are clinical conditions that usually precede symptomatic multiple myeloma. Therefore, risk stratification is crucial owing to the heterogeneous progression rate among these patients. In previous years, suppression of the uninvolved chain of specific heavy/light chain (HLC) pairs in serum has been identified as a new risk factor in MGUS. The aim of the present study was to investigate the prognostic effect of involved and uninvolved HLC pairs and HLC ratios on progression in a series of patients with MGUS and SMM...
June 2016: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/26972092/-renal-involvement-during-type%C3%A2-1-cryoglobulinemia
#10
Mohamad Zaidan, Florent Plasse, Marion Rabant, Vincent Javaugue, Bertrand Knebelmann, Marie-Alexandra Alyanakian, Dominique Joly, Dominique Nochy, Frank Bridoux
Cryoglobulins are circulating immunoglobulins that precipitate with cold temperature and dissolve with rewarming. Type 1 cryoglobulinemia is composed of a single monoclonal immunoglobulin and is associated with renal involvement in up to 40% of cases. Type 1 cryoglobulinemia is related to an underlying B-cell haematological malignancy in 60% of patients. In the remaining cases, in the absence of criteria for malignancy, the diagnosis of monoclonal gammopathy of renal significance should be established. The clinical and biological setting and histological features of type 1 cryoglobulinemia are globally similar to those of mixed cryoglobulinemia...
April 2016: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/26909911/expression-and-significance-of-mir-21-in-multiple-myeloma-patients
#11
J H Wang, W W Zhou, B X Liu, D L Man, Z D Yang, F R Liu, H Shang
The aim of the present study is to examine the expression level of peripheral mir-21 in multiple myeloma (MM) patients and to determine its clinical significance. MM patients (30), monoclonal gammopathy of undetermined significance (MGUS) patients (14), and normal controls (20) were recruited to determine the serum level of β2-MG, IgA and IgM, IgG, λ, κ, TP, ALB, Hb, LDH, and Ca(2+). Gene expression of mir-21 was quantified by SYBR green real-time fluorescent quantitative PCR. We found that the expression level of serum mir-21 in the MM group was significantly higher than the MGUS group and the NC group (P < 0...
2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26894382/smoldering-multiple-myeloma-emerging-concepts-and-therapeutics
#12
REVIEW
Srinath Sundararajan, Abhijeet Kumar, Neha Korde, Amit Agarwal
Smoldering multiple myeloma (SMM) is a pre-malignant condition with an inherent risk for progression to multiple myeloma (MM). The 2014 IMWG guidelines define smoldering multiple myeloma as a monoclonal gammopathy disorder with serum monoclonal protein (IgG or IgA) ≥30 g/L or urinary monoclonal protein ≥500 mg per 24 h and/or clonal bone marrow plasma cells 10-60 % without any myeloma-defining events or amyloidosis. The risk for progression of SMM to MM vary based on clinical, laboratory, imaging, and molecular characteristics...
April 2016: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/26838245/the-immunotyping-distribution-of-serum-monoclonal-paraprotein-and-environmental-impact-on-multiple-myeloma-mm-and-monoclonal-gammopathy-of-uncertain-significance-mgus-in-taiwan-a-medical-center-based-experience
#13
Chih-Chun Chang, Ming-Jang Su, Shu-Jene Lee, Yu-Hui Tsai, Lin-Yin Kuo, I-Hsin Lin, Hui-Ling Huang, Tzung-Hai Yen, Fang-Yeh Chu
BACKGROUND: Whether ambient exposure to environmental pollutants leads to hematopoietic malignancies such as multiple myeloma (MM) remains to be ascertained. Therefore, we aimed to investigate the immunotyping distribution of serum monoclonal paraprotein and the environmental influence on MM and monoclonal gammopathy of uncertain significance (MGUS) in the Taiwanese population. MATERIALS AND METHODS: Serum protein electrophoresis with immunosubtraction by the capillary zone electrophoresis method was performed as primary screening for MM and MGUS...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/26677889/should-routine-laboratories-stop-doing-screening-serum-protein-electrophoresis-and-replace-it-with-screening-immune-fixation-electrophoresis-no-quick-fixes-counterpoint
#14
Joel D Smith, Geoffrey Raines, Hans G Schneider
Monoclonal gammopathies are characterised by the production of a monoclonal immunoglobulin or free light chains by an abnormal plasma cell or B-cell clone and may indicate malignancy or a precursor (MGUS). There is currently no consensus on the initial test or combination of tests to be performed in suspected monoclonal gammopathies but serum protein electrophoresis and urine protein electrophoresis are commonly requested as initial investigations. If abnormal, immunofixation electrophoresis is then performed to confirm the presence of paraprotein and to determine its heavy and light chain type...
June 1, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/26663802/poems-syndrome-with-igg-%C3%AE-iga-%C3%AE%C2%BA-biclonal-gammopathy-and-abnormal-serum-free-light-chain-ratio-a-case-report
#15
Ji Yeon Ham, Jang Soo Suh, Won-Kil Lee, Kyung Eun Song
BACKGROUND: POEMS syndrome is a rare paraneoplastic disorder with atypical plasma cell proliferation. Cases of POEMS syndrome presented with either biclonal gammopathy or an abnormal serum free light chain ratio are considered uncommon. The present authors encountered a case of POEMS syndrome with IgG-λ/IgA-κ biclonal gammopathy with dominant κ free light chain and abnormal serum free light chain ratio. CASE: A 56-year-old man with a history of Castleman disease was suspected with POEMS syndrome and admitted for further evaluation for B-cell proliferative disease to rule out multiple myeloma...
2015: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/26638898/bimodal-immunoglobulin-a-gammopathy-in-a-cat-with-feline-myeloma-related-disorders
#16
Masaya Igase, Takako Shimokawa Miyama, Satoshi Kambayashi, Yumiko Shimoyama, Hiroko Hiraoka, Yumi Hirata, Miki Iwata, Kenji Baba, Takuya Mizuno, Masaru Okuda
A 10-year-old female spayed mixed breed cat with a subcutaneous mass on the right hind limb was revealed with bimodal monoclonal gammopathy composed of IgA by immunoelectrophoresis and immunofixation. Approximately 1 month after referral, the cat died due to renal failure. Postmortem immunohistopathologic evaluation of the subcutaneous mass revealed neoplastic cell proliferation of plasma cells and giant myeloma cells. Neoplastic cells were also present in the liver and spleen. These results led to the diagnosis of a rare case of feline myeloma-related disorders with extramedullary plasmacytoma infiltrating in multiple locations...
May 3, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/26484033/fibrillary-glomerulonephritis-combined-with-chronic-inflammatory-demyelinating-polyneuropathy
#17
Woo Kyung Sung, Jin Uk Jeong, Ki Tae Bang, Jong Ho Shin, Ji Hyung Yoo, Nak Min Kim, Jun Hyung Park, Joo Heon Kim
A 58-yr-old man presented with leg edema and subacute weakness of his bilateral lower extremities. Urinary and serum immunoelectrophoresis revealed the presence of lambda-type Bence Jones proteins. He was ultimately diagnosed with monoclonal gammopathy of undetermined significance (MGUS). A renal biopsy specimen showed fibrillary glomerulonephritis (FGN), which was randomly arranged as 12-20 m nonbranching fibrils in the basement membranes. Immunofluorescence studies were negative for immunoglobulin (Ig)G, IgM, IgA, C3, and kappa light chains in the capillary walls and mesangial areas...
June 2015: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/26365596/the-spectrum-of-neutrophilic-dermatoses-associated-with-monoclonal-gammopathy-association-with-iga-isotype-and-inflammatory-profile
#18
REVIEW
Raphael Szalat, Gentiane Monsel, Wilfried Le Goff, Maxime Battistella, Djaouida Bengouffa, Marie-Helene Schlageter, Jean-David Bouaziz, Bertrand Arnulf, Marguerite Vignon, Philippe Lesnik, Anne Saussine, Marion Malphettes, Anne Lazareth, Marie-Dominique Vignon-Pennamen, Martine Bagot, Jean-Claude Brouet, Jean-Paul Fermand, Michel Rybojad, Bouchra Asli
BACKGROUND: Neutrophilic dermatoses refer to a group of cutaneous inflammatory disorders characterized by neutrophilic infiltration of the skin. Neutrophilic dermatoses have been reported in association with various conditions including autoimmune diseases, inflammatory bowel diseases, and neoplasia. In the later condition, myeloproliferative disorders and monoclonal gammopathy (monoclonal immunoglobulin [MIg]) are the most frequent. Only few data are available in case of neutrophilic dermatoses associated with MIg regarding the pathophysiology and the clinical outcome...
November 2015: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/26314987/factors-associated-with-an-increased-risk-of-vertebral-fracture-in-monoclonal-gammopathies-of-undetermined-significance
#19
J M Piot, M Royer, A Schmidt-Tanguy, E Hoppé, M Gardembas, T Bourrée, M Hunault, S François, F Boyer, N Ifrah, G Renier, A Chevailler, M Audran, D Chappard, H Libouban, G Mabilleau, E Legrand, B Bouvard
Monoclonal gammopathies of undetermined significance (MGUS) have been shown to be associated with an increased risk of fractures. This study describes prospectively the bone status of MGUS patients and determines the factors associated with vertebral fracture. We included prospectively 201 patients with MGUS, incidentally discovered, and with no known history of osteoporosis: mean age 66.6±12.5 years, 48.3% women, 51.7% immunoglobulin G (IgG), 33.3% IgM and 10.4% IgA. Light chain was kappa in 64.2% patients...
August 28, 2015: Blood Cancer Journal
https://www.readbyqxmd.com/read/26299085/lymphoplasmacytic-lymphoma-with-iga-paraproteinemia
#20
Jing Guan, Fang Fang, Zonghong Shao
BACKGROUND: Lymphoplasmacytic lymphoma is a type of B-cell Non-Hodgkin's lymphoma. The monoclonal immunoglobulin of IgA type is rarely seen in the clinical practice. METHODS: We report a patient with anemia, thrombocytopenia, hepatomegaly, and splenomegaly. Serum immuno-electrophoresis, bone marrow morphology, and flow cytometry assays were used for the diagnosis of this patient. RESULTS: The monoclonal gammopathy was detected in the serum protein electrophoresis...
2015: Clinical Laboratory
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