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Central centrifugal cicatrical

J P Sundberg, D Taylor, G Lorch, J Miller, K A Silva, B A Sundberg, D Roopenian, L Sperling, D Ong, L E King, H Everts
A number of C57BL/6 (B6) substrains are commonly used by scientists for basic biomedical research. One of several B6 strain-specific background diseases is focal alopecia that may resolve or progress to severe, ulcerative dermatitis. Clinical and progressive histologic changes of skin disease commonly observed in C57BL/6J and preliminary studies in other closely related substrains are presented. Lesions develop due to a primary follicular dystrophy with rupture of severely affected follicles leading to formation of secondary foreign body granulomas (trichogranulomas) in affected B6 substrains of mice...
March 2011: Veterinary Pathology
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