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https://www.readbyqxmd.com/read/28227000/missing-rri-interpolation-for-hrv-analysis-using-locally-weighted-partial-least-squares-regression
#1
Keisuke Kamata, Koichi Fujiwara, Toshiki Yamakawa, Manabu Kano, Keisuke Kamata, Koichi Fujiwara, Toshiki Yamakawa, Manabu Kano
The R-R interval (RRI) fluctuation in electrocardiogram (ECG) is called heart rate variability (HRV). Since HRV reflects autonomic nervous function, HRV-based health monitoring services, such as stress estimation, drowsy driving detection, and epileptic seizure prediction, have been proposed. In these HRV-based health monitoring services, precise R wave detection from ECG is required; however, R waves cannot always be detected due to ECG artifacts. Missing RRI data should be interpolated appropriately for HRV analysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222521/the-effects-of-lw-afc-on-the-hippocampus-transcriptome-in-senescence-accelerated-mouse-prone-8-strain-a-mouse-model-of-alzheimer-s-disease
#2
Jianhui Wang, Yang Liu, Xiaorui Cheng, Xiaorui Zhang, Feng Liu, Gang Liu, Shanyi Qiao, Ming Ni, Wenxia Zhou, Yongxiang Zhang, Fei Li
The senescence-accelerated mouse prone 8 (SAMP8) strain is considered a robust experimental model for developing preventative and therapeutic treatments for Alzheimer's disease (AD), a neurodegenerative disease which cannot be effectively prevented, halted, or cured. Our previous studies showed that LW-AFC, a new formula derived from the classical traditional Chinese medicinal prescription Liuwei Dihuang decoction, ameliorates cognitive deterioration in PrP-hAβPPswe/PS1ΔE9 transgenic mice and SAMP8 mice. This study aims to investigate the mechanism that mediates how LW-AFC improves cognitive deficit on the basis of the transcriptome...
February 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28215802/occurrence-of-halogenated-and-organophosphate-flame-retardants-in-sediment-and-fish-samples-from-three-european-river-basins
#3
Monica Giulivo, Ettore Capri, Eleni Kalogianni, Radmila Milacic, Bruno Majone, Federico Ferrari, Ethel Eljarrat, Damià Barceló
Classic (polybromodiphenyl ethers, PBDEs) and emerging halogenated flame retardants (HFRs) such as decabromodiphenyl ethane (DBDPE) and halogenated norbornenes, as well as organophosphate flame retardants (OPFRs) were analysed in 52 sediments and 27 fish samples from three European river basins, namely the Evrotas (Greece), the Adige (Italy) and the Sava (Slovenia, Croatia, Bosnia and Herzegovina and Serbia). This is the first time that FR levels have been reported in these three European river basins. The highest contamination was found in the Adige and Sava rivers, whereas lower values were obtained for the Evrotas...
February 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28203484/lw-afc-effects-on-n-glycan-profile-in-senescence-accelerated-mouse-prone-8-strain-a-mouse-model-of-alzheimer-s-disease
#4
Jianhui Wang, Xiaorui Cheng, Ju Zeng, Jiangbei Yuan, Zhongfu Wang, Wenxia Zhou, Yongxiang Zhang
Glycosylation is one of the most common eukaryotic post-translational modifications, and aberrant glycosylation has been linked to many diseases. However, glycosylation and glycome analysis is a significantly challenging task. Although several lines of evidence have indicated that protein glycosylation is defective in Alzheimer's disease (AD), only a few studies have focused on AD glycomics. The etiology of AD is unclear and there are no effective disease-modifying treatments for AD. In this study, we found that the object recognition memory, passive avoidance, and spatial learning and memory of senescence-accelerated mouse prone 8 (SAMP8) strain, an AD animal model, were deficient, and LW-AFC, which was prepared from the traditional Chinese medicine prescription Liuwei Dihuang decoction, showed beneficial effects on the deterioration of cognitive capability in SAMP8 mice...
February 2017: Aging and Disease
https://www.readbyqxmd.com/read/28198722/triad-viii-nationwide-multicenter-evaluation-to-determine-whether-patient-video-testimonials-can-safely-help-ensure-appropriate-critical-versus-end-of-life-care
#5
Ferdinando L Mirarchi, Timothy E Cooney, Arvind Venkat, David Wang, Thaddeus M Pope, Abra L Fant, Stanley A Terman, Kevin M Klauer, Monica Williams-Murphy, Michael A Gisondi, Brian Clemency, Ankur A Doshi, Mari Siegel, Mary S Kraemer, Kate Aberger, Stephanie Harman, Neera Ahuja, Jestin N Carlson, Melody L Milliron, Kristopher K Hart, Chelsey D Gilbertson, Jason W Wilson, Larissa Mueller, Lori Brown, Bradley D Gordon
OBJECTIVE: End-of-life interventions should be predicated on consensus understanding of patient wishes. Written documents are not always understood; adding a video testimonial/message (VM) might improve clarity. Goals of this study were to (1) determine baseline rates of consensus in assigning code status and resuscitation decisions in critically ill scenarios and (2) determine whether adding a VM increases consensus. METHODS: We randomly assigned 2 web-based survey links to 1366 faculty and resident physicians at institutions with graduate medical education programs in emergency medicine, family practice, and internal medicine...
February 14, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28196346/organochlorine-pesticides-ocps-and-polychlorinated-biphenyls-pcbs-in-human-breast-milk-and-associated-health-risks-to-nursing-infants-in-northern-tanzania
#6
M H B Müller, A Polder, O B Brynildsrud, M Karimi, E Lie, W B Manyilizu, R H Mdegela, F Mokiti, M Murtadha, H E Nonga, J U Skaare, J L Lyche
This is the first study to report organochlorines (OCs), including chlorinated pesticides (OCPs) and polychlorinated biphenyls (PCBs) in human milk from Tanzania. The main aims of this study were to assess the level of contamination and the possible health risks related to OC exposure in nursing infants from the Northern parts of Tanzania. Ninety-five healthy mother-infant couples attending Mount Meru Regional Referral Hospital (MMRRH), Arusha, Tanzania, were assessed for associations between maternal/infant characteristics, i...
February 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/28192994/cats-internal-exposure-to-selected-brominated-flame-retardants-and-organochlorines-correlated-to-house-dust-and-cat-food
#7
J Norrgran Engdahl, A Bignert, B Jones, I Athanassiadis, Å Bergman, J M Weiss
Pet cats may be used as a biomarker for assessing exposures to organohalogen compounds (OHCs) adsorbed to household dust in home environments. This study explores two exposure routes of OHCs, ingestion of OHCs (i) via house dust and (ii) via cat food. House dust from 17 Swedish homes and serum from the participating families' pet cats were collected, and cat food was purchased matching the diet reported. Paired samples of cat serum, house dust, and cat food were analyzed for brominated flame retardants/natural products (polybrominated diphenyl ethers (PBDEs), decabromobiphenyl (BB-209), decabromodiphenyl ethane (DBDPE), 2,4,6-tribromophenol (2,4,6-TBP), OH-PBDEs) and organochlorines (polychlorinated biphenyls (PCBs), 1,1-bis(4,4'-dichlorodiphenyl)-2,2,2-trichloroethane (4,4'-DDT), 1,1-bis(4,4'-dichlorodiphenyl)-2,2-dichloroethene (4,4'-DDE), hexachlorobenzene (HCB), pentachlorophenol (PCP))...
February 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28184017/an-update-of-the-hong-kong-epilepsy-guideline-consensus-statement-on-the-use-of-antiepileptic-drugs-in-hong-kong
#8
J Ky Fong, E Ly Chan, H Leung, I Chan, R Sk Chang, G Cy Fong, E Lw Fung, C Ht Lui, B Bh Fung, T L Poon, D Siu, H T Wong, E Yeung, A Wy Yung, C Xl Zhu
OBJECTIVE: New information about antiepileptic drugs has arisen since the publication of the Hong Kong Epilepsy Guideline in 2009. This article set out to fill the knowledge gap between 2007 and 2016 on the use of antiepileptic drugs in Hong Kong. PARTICIPANTS: Between May 2014 and April 2016, four consensus meetings were held in Hong Kong, where a group comprising 15 professionals (neurologists, paediatricians, neurosurgeons, radiologists, and clinical psychologists) from both public and private sectors aimed to review the best available evidence and update all practising physicians on a range of clinical issues including drug-related matters...
February 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28167042/effects-of-tungsten-on-uptake-transport-and-subcellular-distribution-of-molybdenum-in-oilseed-rape-at-two-different-molybdenum-levels
#9
Shiyu Qin, Xuecheng Sun, Chengxiao Hu, Qiling Tan, Xiaohu Zhao, Shoujun Xu
Due to the similarities of molybdenum (Mo) with tungsten (W) in the physical structure and chemical properties, studies involving the two elements have mainly examined their competitive relationships. The objectives of this study were to assess the effects of equimolar W on Mo accumulation, transport and subcellular distribution in oilseed rape at two Mo levels with four treatments: Mo1 (1μmol/L Mo, Low Mo), Mo1+W1 (1μmol/L Mo+1μmol/LW, Low Mo with Low W), Mo200 (200μmol/L Mo, High Mo) and Mo200+W200 (200μmol/L Mo+200μmol/L Mo, High Mo with high W)...
March 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28149995/trophic-transfer-of-hexabromocyclododecane-in-the-terrestrial-and-aquatic-food-webs-from-an-e-waste-dismantling-region-in-east-china
#10
Chaofei Zhu, Pu Wang, Yingming Li, Zhaojing Chen, Honghua Li, Patrick Ssebugere, Qinghua Zhang, Guibin Jiang
Trophic transfer of hexabromocyclododecane (HBCD) was investigated in both the terrestrial and aquatic food webs from an e-waste dismantling region in East China. The mean Σ3HBCD concentrations in the terrestrial species varied from 0.91 (0.16-1.85) ng g(-1) lipid weight (lw) in dragonflies (Pantala flavescens) to 40.3 (22.1-51.1) ng g(-1) lw in rats (Rattus norvegicus). The isomeric profile indicated that α-HBCD presented a decreasing trend along the trophic level (TL) (from 97.2% to 16.3% of Σ3HBCDs), while γ-HBCD showed a reverse trend (from 2...
February 2, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28149563/association-between-postoperative-bulla-neogenesis-at-the-staple-line-and-resected-lung-weight-for-primary-spontaneous-pneumothorax-a-retrospective-study-using-the-inverse-probability-of-treatment-weighted-method-in-patients-grouped-according-to-age
#11
Kenji Tsuboshima, Machiko Nagata, Teppei Wakahara, Yasumi Matoba, Yoshimasa Maniwa
BACKGROUND: Bullectomy using autosutures is the standard procedure in patients with primary spontaneous pneumothorax (PSP). However, postoperative bulla neogenesis (POBN) along the staple line is relatively common and promotes PSP recurrence. We have previously reported the relationship between POBN and resected lung weight (LW). However, recently published data indicate that young patients with PSP have a high postoperative recurrence rate. Therefore, we evaluated the relationship between POBN and LW in PSP patients, subdivided according to age...
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28139300/identification-of-a-novel-12-bp-insertion-deletion-indel-of-ips-related-oct4-gene-and-its-association-with-reproductive-traits-in-male-piglets
#12
Fa Ren, Shuai Yu, Rui Chen, Xiaoyan Lv, Chuanying Pan
As a key factor of cellular reprogramming, Oct4 is one of vital transcription factors for induced pluripotent stem cells (iPSCs). Loss of its function or deletion causes apoptosis in primordial germ cells (PGCs), which affect reproductive traits in mammals. In this study, a novel 12-bp insertion/deletion (indel) polymorphism (NC_010449:g.2759-2760insGGTTTTTGTCTA) within the Oct4 gene was identified in 442 pigs of Large White (LW) and Landrace (LD) breeds, showing three genotypes designated as II, ID, and DD...
January 23, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28127058/overcoming-the-loss-of-blue-sensitivity-through-opsin-duplication-in-the-largest-animal-group-beetles
#13
Camilla R Sharkey, M Stanley Fujimoto, Nathan P Lord, Seunggwan Shin, Duane D McKenna, Anton Suvorov, Gavin J Martin, Seth M Bybee
Opsin proteins are fundamental components of animal vision whose structure largely determines the sensitivity of visual pigments to different wavelengths of light. Surprisingly little is known about opsin evolution in beetles, even though they are the most species rich animal group on Earth and exhibit considerable variation in visual system sensitivities. We reveal the patterns of opsin evolution across 62 beetle species and relatives. Our results show that the major insect opsin class (SW) that typically confers sensitivity to "blue" wavelengths was lost ~300 million years ago, before the origin of modern beetles...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28068426/screening-of-candidate-leaf-morphology-genes-by-integration-of-qtl-mapping-and-rna-sequencing-technologies-in-oilseed-rape-brassica-napus-l
#14
Hongju Jian, Bo Yang, Aoxiang Zhang, Li Zhang, Xinfu Xu, Jiana Li, Liezhao Liu
Leaf size and shape play important roles in agronomic traits, such as yield, quality and stress responses. Wide variations in leaf morphological traits exist in cultivated varieties of many plant species. By now, the genetics of leaf shape and size have not been characterized in Brassica napus. In this study, a population of 172 recombinant inbred lines (RILs) was used for quantitative trait locus (QTL) analysis of leaf morphology traits. Furthermore, fresh young leaves of extreme lines with more leaf lobes (referred to as 'A') and extreme lines with fewer lobes (referred to as 'B') selected from the RIL population and leaves of dissected lines (referred to as 'P') were used for transcriptional analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28057897/review-and-update-of-the-hong-kong-epilepsy-guideline-on-status-epilepticus
#15
REVIEW
E Lw Fung, B Bh Fung
Convulsive status epilepticus is the most extreme form of seizure. It is a medical and neurological emergency that requires prompt and appropriate treatment. Treatment of convulsive status epilepticus is usually divided into stages/steps. The International League Against Epilepsy has released a new definition of status epilepticus that may help to unify the definition in future studies. Over the last few years new information has become available regarding its management. The Rapid Anticonvulsant Medication Prior to Arrival Trial demonstrated non-inferiority of intramuscular midazolam in early status epilepticus compared with intravenous lorazepam...
January 6, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28056054/effect-of-dietary-types-on-feed-intakes-growth-performance-and-economic-benefit-in-tibetan-sheep-and-yaks-on-the-qinghai-tibet-plateau-during-cold-season
#16
Tianwei Xu, Shixiao Xu, Linyong Hu, Na Zhao, Zhe Liu, Li Ma, Hongjin Liu, Xinquan Zhao
Pastoralists on the Tibetan alpine rangeland suffered great economic loss in cold season, due to serious live-weight loss of domestic livestock under traditional grazing management. This study aimed to evaluate the effect of dietary types (crude protein levels) on feed intakes, growth performance and economic returns of local Tibetan sheep and yaks during cold season. Twenty-four yearling Tibetan sheep (25.29±3.95 kg LW) and twenty two-year-old yaks (100.62±4.55 kg LW) with familiar body conditions were randomly assigned to four groups, fed oats hay (OH), oats silage (OS), total mixed ration (TMR) and traditionally grazed on the local cool-season pasture (TG), respectively, over a 135-day experiment...
2017: PloS One
https://www.readbyqxmd.com/read/28046176/effect-of-different-feeding-regimens-on-energy-and-protein-utilization-and-partitioning-for-maintenance-and-growth-in-pre-weaned-lambs-reared-artificially
#17
A S Danso, P C H Morel, P R Kenyon, H T Blair
Estimation of metabolizable energy (ME) requirement for maintenance (ME) and growth (ME) in pre-weaned lambs have been limited to milk-only fed lambs. This study aimed to determine energy and nitrogen metabolisability of milk and pellets when fed together, compare the growth and chemical body composition of lambs fed varying levels of pellets in addition to milk, and to estimate ME, ME, and the CP:ME ratio requirements for growth. The study included 32 twin-born Romney-cross ram lambs. Four lambs were slaughtered at 24 h post-partum to estimate initial body composition and the remaining 28 were assigned to 1 of 4 treatment groups of 7...
December 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/28027981/occurrence-of-halogenated-flame-retardants-in-commercial-seafood-species-available-in-european-markets
#18
Òscar Aznar-Alemany, Laura Trabalón, Silke Jacobs, Vera Liane Barbosa, Margarita Fernández Tejedor, Kit Granby, Christiaan Kwadijk, Sara C Cunha, Federico Ferrari, Griet Vandermeersch, Isabelle Sioen, Wim Verbeke, Lolita Vilavert, José L Domingo, Ethel Eljarrat, Damià Barceló
PBDEs (congeners 28, 47, 99, 100, 153, 154, 183, 209), HBCD (α, β, γ), emerging brominated flame retardants (PBEB, HBB and DBDPE), dechloranes (Dec 602, 603, 604, syn- and anti-DP), TBBPA, 2,4,6-TBP and MeO-PBDEs (8 congeners) were analysed in commercial seafood samples from European countries. Levels were similar to literature and above the environmental quality standards (EQS) limit of the Directive 2013/39/EU for PBDEs. Contaminants were found in 90.5% of the seafood samples at n. d.-356 ng/g lw (n...
December 24, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28013090/walking-duration-and-slope-steepness-determine-the-effect-of-downslope-walking-on-the-soleus-h-reflex-pathway
#19
Elizabeth Arnold, Ben Farmer, Melissa Keightley, Dustin Lee, Taylor Rigel, Maruf Hoque, Manning J Sabatier
The purpose of this study was to determine if the effect of downslope walking (DSW) on spinal excitability depends on walking duration and slope steepness, and if findings from the soleus (Sol) generalize to the tibialis anterior (TA). Sol and TA Hmax and Mmax were measured before and after four DSW doses (time/slope, min/%) on separate days (10/-15, 20/-15, 10/-25, 20/-25, n=14), and one 20-min bout of level walking (LW, n=12), always at 2.5 mph. Heart rate (HR) and ratings of perceived exertion (RPE) were measured during walking...
February 3, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28006931/pharmacokinetics-of-boldine-in-control-and-mrp2-deficient-rats
#20
J Cermanova, A Prasnicka, E Dolezelova, L Rozkydalova, M Hroch, J Chládek, P Tomsik, I Kloeting, S Micuda
The aim of the present study was to describe the currently poorly understood pharmacokinetics (PK) of boldine in control rats (LW, Lewis rats), and Mrp2 transporter-deficient rats (TR(-)). Animals from the LW and TR(-) groups underwent a bolus dose study with 10 mg/kg of boldine applied either orally or intravenously in order to evaluate the major PK parameters. The TR(-) rats demonstrated significantly reduced total clearance with prolonged biological half-life (LW 12+/-4.6 versus TR(-) 20+/-4.4 min), decreased volume of distribution (LW 3...
December 21, 2016: Physiological Research
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