keyword
https://read.qxmd.com/read/38520590/left-ventricular-assist-device-temporary-explantation-as-a-strategy-for-infection-control-in-a-pediatric-patient
#1
JOURNAL ARTICLE
Akiko Umetsu, Masaki Taira, Moyu Hasegawa, Takuji Watanabe, Yuji Tominaga, Takayoshi Ueno, Daisuke Yoshioka, Kazuo Shimamura, Shigeru Miyagawa
We report a case of temporary Berlin Heart EXCOR® explantation in a pediatric patient with idiopathic dilated cardiomyopathy who suffered an uncontrollable inflow cannulation site infection while on bridge-to-transplantation. Despite failure to thrive and catheter-related infections, once free of the device, the patient was cured of infection using systemic antibiotics and surgical debridement. The patient underwent EXCOR® reimplantation after four months, and is awaiting heart transplantation in stable condition...
March 23, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38419587/successful-explantation-of-children-from-the-berlin-heart-excor%C3%A2-ventricular-assist-device-a-systematic-review
#2
REVIEW
Matthew F Mikulski, Swati Iyer, Andrew Well, Carlos M Mery, W Richard Owens, Lauren D Glass, Chesney D Castleberry, Charles D Fraser
BACKGROUND: The Berlin Heart EXCOR® (BHE) can bridge children with severe heart failure to transplantation, but some are successfully weaned and spared transplantation. This study seeks to identify characteristics of children amenable to successful explantation with BHE support. METHODS: Preferred Reporting Items for Systematic reviews and Meta-Analyses 2020 guidelines were used. Five databases were screened for original, English articles measuring BHE support in patients <18 years old based on title and abstract...
February 29, 2024: Artificial Organs
https://read.qxmd.com/read/38033221/pediatric-nursing-care-of-the-critically-ill-patient-with-univentricular-physiology-stabilized-with-the-berlin-heart-excor
#3
JOURNAL ARTICLE
Alexandria B Owens
No abstract text is available yet for this article.
December 15, 2023: AACN Advanced Critical Care
https://read.qxmd.com/read/38028456/current-and-future-options-for-adult-biventricular-assistance-a-review-of-literature
#4
REVIEW
Claudia Maria Loardi, Marco Zanobini, Gabriella Ricciardi, Emmanuelle Vermes
In cardiogenic shock various short-term mechanical assistances may be employed, including an Extra Corporeal Membrane Oxygenator and other non-dischargeable devices. Once hemodynamic stabilization is achieved and the patient evolves towards a persisting biventricular dysfunction or an underlying long-standing end-stage disease is present, aside from Orthotopic Heart Transplantation, a limited number of long-term therapeutic options may be offered. So far, only the Syncardia Total Artificial Heart and the Berlin Heart EXCOR (which is not approved for adult use in the United States unlike in Europe) are available for extensive implantation...
2023: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/37591455/widening-care-gap-in-vad-therapy
#5
JOURNAL ARTICLE
Jennifer Conway, Shahnawaz Amdani, David L S Morales, Angela Lorts, David N Rosenthal, Jeffrey P Jacobs, Joseph Rossano, Devin Koehl, James K Kirklin, Scott R Auerbach
BACKGROUND: The removal of the HeartWare ventricular assist device (HVAD) due to pump malfunctions and inferior outcomes compared to HeartMate 3 (HM3) in adults has created a care gap for younger patients. It is unclear if the reported HVAD survival differs by age and if the initial experience with HM3 can bridge the gap. METHODS: Using the Society of Thoracic Surgeons (STS) Intermacs and Pedimacs registries, durable ventricular assist device (VAD) implants between September 2012 and December 2021 were identified...
August 15, 2023: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/37498565/myocardial-recovery-in-children-supported-with-a-durable-ventricular-assist-device-a-systematic-review
#6
JOURNAL ARTICLE
Sofie Rohde, Theo M M H de By, Ad J J C Bogers, Martin Schweiger
OBJECTIVES: A small percentage of paediatric patients supported with a ventricular assist device (VAD) can have their device explanted following myocardial recovery. The goal of this systematic review is to summarize the current literature on the clinical course in these children after weaning. METHODS: A systematic literature search was performed on 27 May 2022 using Embase, Medline ALL, Web of Science Core Collection, Cochrane Central Register of Controlled Trials and Google Scholar to include all literature on paediatric patients supported by a durable VAD during the last decade...
August 1, 2023: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/37120344/mechanical-circulatory-assistance-in-children-clinical-outcome
#7
JOURNAL ARTICLE
Maria Julia De Aro Braz Corbi, Marcelo Biscegli Jatene, Adailson Wagner Da Silva Siqueira, Claudia Regina Pinheiro Castro Grau, Glaucia Maria Penha Tavares, Nana Miura Ikari, Estela Azeka
BACKGROUND: In countries where organ donation is scarce, mortality in the pediatric heart transplant waiting list is high, and ventricular assist devices (VADs) are therapeutic alternatives in these situations. Berlin Heart EXCOR is currently 1 of the few VADs specific for children. METHODS: This retrospective study includes pediatric patients who underwent Berlin Heart EXCOR placement in a Brazilian hospital between 2012 and 2021. Clinical and laboratory data at the time of VAD implantation and the occurrence of complications and outcomes (success as a bridge to transplant or death) were analyzed...
April 28, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37096088/use-of-berlin-excor-cannulas-in-both-venovenous-and-venoarterial-central-extracorporeal-membrane-oxygenation-configurations-overcomes-the-problem-of-cannula-instability-while-bridging-infants-and-young-children-to-lung-transplant
#8
JOURNAL ARTICLE
N Adam Stephens, Corey A Chartan, Maria C Gazzaneo, James A Thomas, Shailendra Das, George B Mallory, Ernestina Melicoff, Adam M Vogel, Amanda Parker, Emily Hermes, Jeffrey S Heinle, E Dean McKenzie, Ryan D Coleman
OBJECTIVES: Infants and young children awaiting lung transplantation present challenges that often preclude successful extracorporeal membrane oxygenation support as a bridge to transplantation. Instability of neck cannulas often results in the need for intubation, mechanical ventilation, and muscle relaxation creating a worse transplant candidate. With the use of Berlin Heart EXCOR cannulas (Berlin Heart, Inc) in both venoarterial and venovenous central cannulation configurations, 5 pediatric patients were successfully bridged to lung transplant...
April 2023: JTCVS techniques
https://read.qxmd.com/read/37042396/investigating-the-hemodynamics-of-berlin-heart-excor-support-in-norwood-patients-across-diverse-clinical-scenarios-with-computational-modeling
#9
JOURNAL ARTICLE
Victoria Yuan, Francesco De Gaetano, Kasra Osouli, Alison L Marsden, Maria Laura Costantino
BACKGROUND: Infants with single-ventricle (SV) physiology undergo the 3-stage Fontan surgery. Norwood patients, who have completed the first stage, face the highest interstage mortality. The Berlin Heart EXCOR (BH), a pediatric pulsatile ventricular assist device, has shown promise in supporting these patients. However, clinical questions regarding device configurations prevent optimal support. METHODS: We developed a combined idealized mechanics-lumped parameter model of a Norwood patient and simulated two additional patient-specific cases: pulmonary hypertension (PH) and post-operative treatment with milrinone...
April 12, 2023: Artificial Organs
https://read.qxmd.com/read/36943709/bivalirudin-compared-to-heparin-as-the-primary-anticoagulant-in-pediatric-berlin-heart-recipients
#10
JOURNAL ARTICLE
Victoria Freniere, David M Salerno, Heather Corbo, Sabrina Law, Jennie McAllister, Cindy Neunert, Justin K Chen
Bivalirudin has been used in increasing frequency as an alternative to unfractionated heparin (UFH) in pediatric recipients of Berlin Heart EXCOR ventricular assist devices (VAD). This single-center, retrospective review characterizes anticoagulant trends and outcomes in pediatric Berlin Heart VAD recipients implanted between September 1, 2013, and August 31, 2021, anticoagulated with either bivalirudin or UFH. Thirty-one patients were included; 65% who received bivalirudin and 35% who received UFH. The median age was 2...
March 22, 2023: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/36808224/cardiomyocyte-deoxyribonucleic-acid-damage-and-cardiac-recovery-in-pediatric-dilated-cardiomyopathy
#11
JOURNAL ARTICLE
Yuji Tominaga, Masaki Taira, Takuji Watanabe, Yosuke Kugo, Moyu Hasegawa, Jun Narita, Hidekazu Ishida, Ryoto Sakaniwa, Takayoshi Ueno, Shigeru Miyagawa
OBJECTIVES: This study aimed to identify the clinical significance of the deoxyribonucleic acid damage response marker, phosphorylated H2A histone variant X, on the bridge to recovery in low-weight pediatric patients with dilated cardiomyopathy post-Berlin Heart EXCOR implantation. METHODS: Consecutive pediatric patients with dilated cardiomyopathy who underwent EXCOR implantation for dilated cardiomyopathy at our hospital between 2013 and 2021 were reviewed. Patients were classified into two groups according to the degree of deoxyribonucleic acid damage in left ventricular cardiomyocytes-low deoxyribonucleic acid damage group and high deoxyribonucleic acid damage group-using the median value as the threshold...
February 21, 2023: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/36598326/successful-support-of-biventricular-heart-failure-in-an-adult-patient-by-the-berlin-heart-excor-system-as-a-bridge-to-transplant-literature-review
#12
JOURNAL ARTICLE
Michal Hulman, Panagiotis Artemiou, Vladan Hudec, Ingrid Olejarova, Eva Goncalvesova, Ivo Gasparovic
Right heart failure is a huge challenge in left ventricular assist device therapy and its occurrence is associated with increased mortality and morbidity. Other options include the use od temporary right ventricular assist device, use of two continous flow biventricular assist devices, use of total artificial heart and the use of paracorporeal biventricular assist devices.In this report we described the successful use of the paracorporeal pulsatile Berlin Heart EXCOR system as a bridge to transplant in a 62 years old patient with end-stage biventricular heart failure (Tab...
January 4, 2023: Bratislavské Lekárske Listy
https://read.qxmd.com/read/36534818/the-little-ones-are-catching-up-mechanical-circulatory-support-with-a-pulsatile-pneumatic-ventricular-assist-device
#13
JOURNAL ARTICLE
Brigitte Stiller, Rouven Kubicki
No abstract text is available yet for this article.
December 2, 2022: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/36476446/management-of-cannula-wound-problems-with-vacuum-assisted-therapy-for-a-child-who-received-berlin-heart-excor-implantation
#14
JOURNAL ARTICLE
Siwon Oh, Shin Kim, Ji-Hyuk Yang, Young Jin Roh, Ilkun Park
A child being supported with an extracorporeal ventricular assist device, such as the Berlin Heart EXCOR (Berlin Heart GmbH, Berlin, Germany), must have at least 2 large cannulae for a long period. Management of cannula wounds is crucial since a cannula forms a track of prosthetic material passing the mediastinum to the heart. Deep wound complications, if they occur, can be troublesome and difficult to control with conventional methods. We applied vacuum-assisted closure to a patient who had Berlin-Heart EXCOR and a gap at the cannulation site...
December 8, 2022: Journal of chest surgery
https://read.qxmd.com/read/36356800/safety-issues-with-an-inter-hospital-transport-of-a-patient-with-a-berlin-heart-excor-biventircular-assist-device
#15
JOURNAL ARTICLE
Dominikus Schullerer, David Schurter, Anke Meinhold, Sebastian Paal, Susanne Staubli, Isabelle Bichsel, Hitendu Dave, Robert Cesnjevar, Martin Schweiger
BACKGROUND: Interhospital transfers of pediatric patients on the Berlin Heart Excor have been published on an occasional basis. METHODS: Nowadays medicine evolves away from just feasibility towards quality and safety issues. Management tools like risk analysis have found their way into clinical practice. RESULTS: Exemplary, we present a case of a 20 months old boy on a Berlin Heart BiVAD Excor who underwent a 224 km ground transport...
November 10, 2022: Artificial Organs
https://read.qxmd.com/read/36346169/outcomes-in-small-children-on-berlin-heart-excor-support-age-and-bsa-as-clinical-predictive-factors
#16
JOURNAL ARTICLE
Sofie Rohde, Eugen Sandica, Kevin Veen, Ulrike S Kraemer, Timothy Thiruchelvam, Oliver Miera, Maria L Polo Lopez, Joanna Sliwka, Antonio Amodeo, Ad J J C Bogers, Theo M M H de By
INTRODUCTION: The Berlin Heart EXCOR offers circulatory support across all paediatric ages. Clinically, the necessary care as well as outcomes differ in various age groups. The EUROMACS database was used to study age and size-related outcomes for this specific device. METHODS: All patients <19 years of age from the EUROMACS database supported with a Berlin Heart EXCOR between 2000 and November 2021 were included. Maximally Selected Rank statistics were used to determine BSA cut-off values...
November 8, 2022: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/36294985/wound-infections-in-adult-patients-after-berlin-heart-%C3%A2-excor-biventricular-assist-device-implantation
#17
JOURNAL ARTICLE
Jamila Kremer, Abbas El-Dor, Rasmus Rivinius, Philipp Schlegel, Wiebke Sommer, Gregor Warnecke, Matthias Karck, Arjang Ruhparwar, Anna L Meyer
The Berlin Heart® EXCOR is a paracorporeal, pulsatile ventricular assist device used in patients of all age groups. However, adolescent and adult patients on EXCOR support are scarcely explored. Herein, we present a detailed description of infectious complications in this patient cohort. From 2006 to 2020, 58 patients received a biventricular assist device (BiVAD) at our institution and were included in this study. Postoperative infections were assessed after BiVAD implantation and subsequent heart transplantation (HTx)...
October 6, 2022: Life
https://read.qxmd.com/read/36291431/compound-heterozygous-missense-variants-in-rpl3l-genes-associated-with-severe-forms-of-dilated-cardiomyopathy-a-case-report-and-literature-review
#18
Bibhuti B Das, Viswanath Gajula, Sandeep Arya, Mary B Taylor
Whole exome sequencing has identified an infant girl with fulminant dilated cardiomyopathy (DCM), leading to severe acute heart failure associated with ribosomal protein large 3-like ( RPL3L ) gene pathologic variants. Other genetic tests for mitochondrial disorders by sequence analysis and deletion testing of the mitochondrial genome were negative. Secondary causes for DCM due to metabolic and infectious etiologies were ruled out. She required a Berlin-Excor left ventricular assist device due to worsening of her heart failure as a bridge to orthotopic heart transplantation...
September 29, 2022: Children
https://read.qxmd.com/read/35849328/cerebrovascular-accidents-in-paediatric-patients-supported-by-the-berlin-heart-excor
#19
JOURNAL ARTICLE
Sofie Rohde, Eugen Sandica, Kevin Veen, Oliver Miera, Antonio Amodeo, Carlo Pace Napoleone, Mustafa Özbaran, Joanna Sliwka, Timothy Thiruchelvam, Daniel Zimpfer, Stephan Schubert, Ad J J C Bogers, Theo M M H de By
OBJECTIVES: Ventricular assist device support as a bridge to transplant or recovery is a well-established therapy in children on the cardiac transplant waiting list. The goal of this study was to investigate the incidence of and the associated factors for cerebrovascular accidents in paediatric patients supported by a Berlin Heart EXCOR. METHODS: All patients <19 years of age supported by a Berlin Heart EXCOR between January 2011 and January 2021 from the European Registry for Patients with Mechanical Circulatory Support were included...
August 3, 2022: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/35763237/successful-bridge-to-transplantation-with-long-term-support-using-berlin-heart-excor-in-a-child-with-failing-fontan
#20
JOURNAL ARTICLE
Moyu Hasegawa, Yuji Tominaga, Takuji Watanabe, Takayoshi Ueno, Masaki Taira, Shigeru Miyagawa
A 2-year-old girl underwent the Fontan operation for aortic valve stenosis, mitral valve stenosis, a hypo-plastic left ventricle, and a non-compacted right ventricle. The patient's cardiac function reduced gradually thereafter, mainly due to systemic ventricular dysfunction. A Berlin Heart EXCOR (BHE) ventricular assist device with a 10-mL pump was implanted at 4 years of age. After 465 days, BHE support without major complications, the patient underwent heart transplantation. A safe and long-term BHE support was achieved with proper case selection and repeated examinations...
June 28, 2022: General Thoracic and Cardiovascular Surgery
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