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https://read.qxmd.com/read/38533374/aryl-hydrocarbon-receptor-role-in-chronic-inflammatory-skin-diseases-a-narrative-review
#1
REVIEW
Michał Dec, Hubert Arasiewicz
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that has gained increasing attention in the field of dermatology due to its multifaceted role in skin health and disease. This review provides a comprehensive overview of the current state of knowledge regarding the AHR and its implications in dermatological conditions. The AHR is well known for its involvement in xenobiotic metabolism, particularly in response to polycyclic aromatic hydrocarbons and dioxins. However, recent research has unveiled its pivotal role in the skin immune response, barrier function, and homeostasis...
February 2024: Postȩpy Dermatologii i Alergologii
https://read.qxmd.com/read/38518996/targeting-aryl-hydrocarbon-receptor-to-prevent-cancer-in-barrier-organs
#2
REVIEW
Francoise Congues, Pengcheng Wang, Joshua Lee, Daphne Lin, Ayaz Shahid, Jianming Xie, Ying Huang
The skin, lung, and gut are important barrier organs that control how the body reacts to environmental stressors such as ultraviolet (UV) radiation, air pollutants, dietary components, and microorganisms. The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that plays an important role in maintaining homeostasis of barrier organs. AhR was initially discovered as a receptor for environmental chemical carcinogens such as polycyclic aromatic hydrocarbons (PAHs). Activation of AhR pathways by PAHs leads to increased DNA damage and mutations which ultimately lead to carcinogenesis...
March 20, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38497283/the-role-of-aryl-hydrocarbon-receptor-in-the-pathogenesis-and-treatment-of-psoriasis
#3
REVIEW
Xiran Lin, Xianmin Meng, Jingrong Lin
The pathogenesis of psoriasis is complex. Aryl hydrocarbon receptor (AhR) is a transcription factor that can be bound and activated by structurally diverse ligands and plays an important role in a range of biological processes and in the pathogenesis of different diseases. Recently, the role of AhR in psoriasis has attracted attention. AhR has toxicological functions and physiological functions. The overexpression and activation of AhR induced by the environmental pollutant and exogenous AhR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can drive the development of psoriasis...
March 18, 2024: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/38496799/topical-management-of-plaque-psoriasis-a-review-and-case-series-discussion-with-focus-on-aryl-hydrocarbon-receptor-modulation
#4
REVIEW
Matthew Bruno, Bruce Strober, James Q Del Rosso
While corticosteroids and a limited number of nonsteroidal agents have formed the basis for United States Food and Drug Administration (FDA)-approved topical treatments of plaque psoriasis, there remains a need for efficacious nonsteroidal topical therapies in patients with psoriasis who cannot tolerate, do not respond well to, or wish to avoid topical corticosteroid therapy. Aryl hydrocarbon receptor (AhR) modulation has been shown to be an effective mechanism of action in the topical treatment of psoriasis...
September 2023: Journal of Clinical and Aesthetic Dermatology
https://read.qxmd.com/read/38458465/effects-and-mechanisms-of-polycyclic-aromatic-hydrocarbons-in-inflammatory-skin-diseases
#5
REVIEW
Hui Jin, Ziyuan Lin, Tianyi Pang, Jingwen Wu, Cheng Zhao, Ying Zhang, Yu Lei, Qilin Li, Xu Yao, Ming Zhao, Qianjin Lu
Polycyclic aromatic hydrocarbons (PAHs) are hydrocarbons characterized by the presence of multiple benzene rings. They are ubiquitously found in the natural environment, especially in environmental pollutants, including atmospheric particulate matter, cigarette smoke, barbecue smoke, among others. PAHs can influence human health through several mechanisms, including the aryl hydrocarbon receptor (AhR) pathway, oxidative stress pathway, and epigenetic pathway. In recent years, the impact of PAHs on inflammatory skin diseases has garnered significant attention, yet many of their underlying mechanisms remain poorly understood...
March 6, 2024: Science of the Total Environment
https://read.qxmd.com/read/38444426/gene-expression-analysis-of-a-topical-serum-comprised-of-plant-based-adaptogens-developed-to-support-homeostasis-and-skin-quality
#6
JOURNAL ARTICLE
Zoe Diana Draelos, Pearl E Grimes, Jacqueline Watchmaker, Diane B Nelson
OBJECTIVE: A topical serum comprised of plant-based adaptogens was purposefully developed to support the ability of the skin to adapt and achieve balance. The study described herein evaluated changes in the expression of target genes related to skin homeostasis following topical exposure. METHODS: Utilizing an in vitro epidermal skin model, quantitative polymerase chain reaction (qPCR) analysis of gene expression was conducted following 48-hour exposure to 15μL of the study product (MYS serum) to the surface of each tissue (N=4)...
February 2024: Journal of Clinical and Aesthetic Dermatology
https://read.qxmd.com/read/38401701/the-aryl-hydrocarbon-receptor-regulates-epidermal-differentiation-through-transient-activation-of-tfap2a
#7
JOURNAL ARTICLE
Jos P H Smits, Jieqiong Qu, Felicitas Pardow, Noa J M van den Brink, Diana Rodijk-Olthuis, Ivonne M J J van Vlijmen-Willems, Simon J van Heeringen, Patrick L J M Zeeuwen, Joost Schalkwijk, Huiqing Zhou, Ellen H van den Bogaard
The aryl hydrocarbon receptor (AHR) is an evolutionary conserved environmental sensor identified as indispensable regulator of epithelial homeostasis and barrier organ function. Molecular signaling cascade and target genes upon AHR activation and their contribution to cell and tissue function are however not fully understood. Multi-omics analyses using human skin keratinocytes revealed that, upon ligand activation, AHR binds open chromatin to induce expression of transcription factors (TFs), e.g., Transcription Factor AP-2α (TFAP2A), as a swift response to environmental stimuli...
February 22, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38389856/treatment-of-palmoplantar-keratoderma-in-a-patient-with-ichthyosis-with-topical-tapinarof
#8
Sarah N Robinson, Julie S Kranseler, David Rosmarin
No abstract text is available yet for this article.
March 2024: JAAD Case Reports
https://read.qxmd.com/read/38379227/temporal-and-differential-proteomic-profile-of-molecular-mediators-associated-with-chronic-and-acute-wound-healing
#9
JOURNAL ARTICLE
Midhat Batool Zaidi, Faisal Khan, Fatima Jameel, Irfan Khan, Syed Ghulam Musharraf, Asmat Salim
The underlying pathophysiology of nonhealing chronic wounds is poorly understood due to the changes occurring at the gene level and the complexity arising in their proteomic profile. Here, we elucidated the temporal and differential profile of the normal and diabetic wound-healing mediators along with their interactions and associated pathways. Skin tissues corresponding to normal and diabetic wounds were isolated at Days 0, 3, 6, and 9 representing different healing phases. Temporal gene expression was analyzed by quantitative real-time PCR...
March 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38361944/the-role-of-aryl-hydrocarbon-receptor-in-vitiligo-a-review
#10
REVIEW
Yiting Li, Yibin Zeng, Zile Chen, Xi Tan, Xingyu Mei, Zhouwei Wu
Vitiligo is an acquired autoimmune dermatosis characterized by patchy skin depigmentation, causing significant psychological distress to the patients. Genetic susceptibility, environmental triggers, oxidative stress, and autoimmunity contribute to melanocyte destruction in vitiligo. Due to the diversity and complexity of pathogenesis, the combination of inhibiting melanocyte destruction and stimulating melanogenesis gives the best results in treating vitiligo. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that can regulate the expression of various downstream genes and play roles in cell differentiation, immune response, and physiological homeostasis maintenance...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38352592/an-ahr-ovol1-id1-regulatory-axis-in-keratinocytes-promotes-skin-homeostasis-against-atopic-dermatitis
#11
Zeyu Chen, Morgan Dragan, Peng Sun, Daniel Haensel, Remy Vu, Lian Cui, Yuling Shi, Xing Dai
Skin is our outer permeability and immune defense barrier against myriad external assaults. Aryl hydrocarbon receptor (AhR) senses environmental factors and regulates barrier robustness and immune homeostasis. AhR agonist is in clinical trial for atopic dermatitis (AD) treatment, but the underlying mechanism of action remains ill-defined. Here we report OVOL1/Ovol1 as a conserved and direct transcriptional target of AhR in epidermal keratinocytes. We show that OVOL1/Ovol1 impacts AhR regulation of keratinocyte gene expression, and Ovol1 deletion in keratinocytes hampers AhR's barrier promotion function and worsens AD-like inflammation...
January 31, 2024: bioRxiv
https://read.qxmd.com/read/38344408/aryl-hydrocarbon-receptor-and-il-13-signaling-crosstalk-in-human-keratinocytes-and-atopic-dermatitis
#12
JOURNAL ARTICLE
Steven P Proper, Alexander T Dwyer, Andrews Appiagyei, Jennifer M Felton, Netali Ben-Baruch Morgenstern, Justin M Marlman, Michael Kotliar, Artem Barski, Ty D Troutman, Marc E Rothenberg, Tesfaye B Mersha, Nurit P Azouz
INTRODUCTION: Atopic dermatitis (AD) is an allergic skin disease mediated by skin barrier impairment and IL-13-driven immune response. Activation of the aryl hydrocarbon receptor (AHR) has shown promise in early clinical trials for AD; however, the mechanism by which AHR partially ameliorates AD is not well known. METHODS: Gene expression data from human biopsies were analyzed, and compared to gene expression from RNA-sequencing in our in-vitro HaCaT cell model system...
2024: Front Allergy
https://read.qxmd.com/read/38306128/targeting-the-aryl-hydrocarbon-receptor-to-address-the-challenges-of-atopic-dermatitis
#13
JOURNAL ARTICLE
Lawrence F Eichenfield, Jonathan I Silverberg, Adelaide A Hebert, Raj Chovatiya, Philip M Brown, Kimberly A McHale, David S Rubenstein, Anna M Tallman
Atopic dermatitis (AD) is a chronic relapsing–remitting disease with a multifactorial etiology involving epidermal barrier and immunologic dysfunction. Topical therapies form the mainstay of AD treatment, but options are limited by adverse effects and restrictions on application site, duration, and extent of use. Tapinarof (VTAMA; Dermavant Sciences, Inc.) is a first-in-class, non-steroidal, topical aryl hydrocarbon receptor (AhR) agonist approved for the treatment of plaque psoriasis. AhR is a ligand-dependent transcription factor with wide-ranging roles, including regulation of homeostasis and immune response in skin cells...
February 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38236441/circadian-clock-gene-expression-and-polymorphism-in-non-segmental-vitiligo
#14
JOURNAL ARTICLE
Azza Gaber Antar Farag, Eman A E Badr, Asmaa Fahmy Ibrahim
BACKGROUND: Vitiligo is an acquired and progressive mucocutaneous disease with the damage of functioning epidermal melanocytes. Metabolic syndrome is associated with inflammatory skin diseases incorporating vitiligo. The circadian dysfunction triggers the pathogenesis of metabolic diseases, so our study aimed to determine the relationship between aryl hydrocarbon receptor nuclear translocator-like gene, a ligand-activated transcription factor and sensor of environmental chemicals, expression and polymorphism with non-segmental vitiligo, as well as its effect on lipid profile...
January 18, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38213229/targeting-the-aryl-hydrocarbon-receptor-as-a-strategy-to-expand-the-therapeutic-armamentarium-in-atopic-dermatitis
#15
EDITORIAL
Lawrence F Eichenfield, Jonathan I Silverberg, Adelaide A Hebert, Mark Boguniewicz
No abstract text is available yet for this article.
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38186219/treatment-of-atopic-dermatitis-recently-approved-drugs-and-advanced-clinical-development-programs
#16
REVIEW
Svenja Müller, Laura Maintz, Thomas Bieber
Atopic dermatitis (AD) represents the most common skin disease characterized by heterogeneous endophenotypes and a high disease burden. In Europe, six new systemic therapies for AD have been approved: the biologics dupilumab (anti-interleukin-4 receptor (IL-4R) α in 2017), tralokinumab (anti-IL-13 in 2021), lebrikizumab (anti-IL-13 in 2023), and the oral janus kinase (JAK) inhibitors (JAKi) targeting JAK1/2 (baricitinib in 2020 in the EU) or JAK1 (upadacitinib in 2021 and abrocitinib in 2022). Herein, we give an update on new approvals, long-term safety, and efficacy...
January 8, 2024: Allergy
https://read.qxmd.com/read/38154665/tapinarof-validates-the-aryl-hydrocarbon-receptor-as-a-therapeutic-target-a-clinical-review
#17
REVIEW
Jonathan I Silverberg, Mark Boguniewicz, Francisco J Quintana, Rachael A Clark, Lara Gross, Ikuo Hirano, Anna M Tallman, Philip M Brown, Doral Fredericks, David S Rubenstein, Kimberly A McHale
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that has wide-ranging roles, including regulation of inflammation and homeostasis. AhR is not a cell-surface receptor but exists in a cytoplasmic complex that responds to a wide variety of structurally dissimilar endogenous, microbial, and environmental ligands. The ubiquitous expression of AhR, its ability to be activated by a wide range of ligands, and its capacity to act as a master regulator for gene expression and homeostasis make it a promising new therapeutic target...
December 26, 2023: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38144156/unbalanced-aryl-hydrocarbon-receptor-expression-in-peripheral-and-lesional-t-cell-subsets-of-atopic-dermatitis
#18
JOURNAL ARTICLE
Yu-Qing Hu, Jian-Zhong Zhang
BACKGROUND AND OBJECTIVE: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, which is involved in the pathogenesis of a variety of skin diseases such as atopic dermatitis (AD). In this study, we aimed to study the AhR-expressing cells in T helper 17 (Th17), T helper 22 (Th22), regulatory T cells (Treg) and B cells in peripheral blood and in AD skin lesions. METHODS: Twenty AD patients defined according to the Chinese criteria of atopic dermatitis and eighteen healthy subjects were included in our study...
2023: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38142785/fragrances-as-a-trigger-of-immune-responses-in-different-environments
#19
REVIEW
M Macchione, K Yoshizaki, D P Frias, K Maier, J Smelan, C M Prado, T Mauad
Fragrances can cause allergic skin reactions, expressed as allergic contact dermatitis and reactions in the respiratory tract that range from acute temporary upper airway irritation to obstructive lung disease. These adverse health effects may result from the stimulation of a specific (adaptive) immune response. Th1 cells, which essentially produce interleukin-2 (IL-2) and interferon-γ (IFN-γ), play a key role in allergic contact dermatitis and also on allergic sensitization to common allergens (e...
December 22, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38132754/regulatory-ability-of-lactiplantibacillus-plantarum-on-human-skin-health-by-counteracting-in-vitro-malassezia-furfur-effects
#20
JOURNAL ARTICLE
Alessandra Fusco, Brunella Perfetto, Vittoria Savio, Adriana Chiaromonte, Giovanna Torelli, Giovanna Donnarumma, Adone Baroni
The skin serves as the first barrier against pathogen attacks, thanks to its multifunctional microbial community. Malassezia furfur is a commensal organism of normal cutaneous microflora but is also a cause of skin diseases. It acts on different cell pattern recognition receptors (TLRs, AhR, NLRP3 inflammasome) leading to cellular damage, barrier impairment, and inflammatory cytokines production. Lactobacillus spp. Is an endogenous inhabitant of healthy skin, and studies have proven its beneficial role in wound healing, skin inflammation, and protection against pathogen infections...
November 29, 2023: Journal of Fungi (Basel, Switzerland)
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