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Aryl hydrocarbon receptor skin

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https://www.readbyqxmd.com/read/29115465/trichosanthes%C3%A2-kirilowii-extract-enhances-repair-of-uvb-radiation%C3%A2-induced-dna-damage-by-regulating-bmal1-and-mir%C3%A2-142%C3%A2-3p-in-human-keratinocytes
#1
Ji-Hye Joo, In-Kee Hong, Nam Kyoung Kim, Eunmi Choi
Ultraviolet B (UVB) radiation induces DNA damage, oxidative stress and inflammation, and suppresses the immune system in the skin, which collectively contribute to skin aging and carcinogenesis. The DNA damage response, including DNA repair, can be regulated by the circadian clock and microRNA (miRNA) expression. The aim of the present study was to evaluate the reparative action of Trichosanthes kirilowii extract (TKE) against UVB irradiation‑induced DNA damage in human keratinocytes. TKE demonstrated low cytotoxicity in normal HaCaT keratinocytes at low doses (up to 100 µg/ml)...
October 31, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29102224/an-endogenous-tryptophan-photo-product-ficz-is-potentially-involved-in-photo-aging-by-reducing-tgf-%C3%AE-regulated-collagen-homeostasis
#2
Mika Murai, Gaku Tsuji, Akiko Hashimoto-Hachiya, Yoshihito Kawakami, Masutaka Furue, Chikage Mitoma
BACKGROUND: Persistent ultraviolet (UV) radiation in the form of sunlight causes photo-aging of the skin by reducing the production of type I collagen, the major constituent of the extracellular matrix of the dermis. Transforming growth factor (TGF)-β transforms dermal fibroblasts into α2-smooth muscle actin (ACTA2)-expressing myofibroblasts. Myofibroblasts produce a precursor form of type I collagen, type I procollagen (collagen I), consisting of pro-alpha1 (produced by the COL1A1 gene) and pro-alpha2 chains (produced by the COL1A2 gene)...
October 16, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28973660/high-susceptibility-of-lrig1-sebaceous-stem-cells-to-tcdd-in-mice
#3
F Fontao, L Barnes, G Kaya, J H Saurat, O Sorg
We have previously shown that CYP1A1 was highly induced for a long period of time in a patient who had been poisoned by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a compound known to activate the aryl hydrocarbon receptor (AhR). During that period of time no sebaceous glands could be observed in the skin of this patient. In the present study, starting from observations in the patient exposed to TCDD, we analysed the seboatrophy induced by dioxins in mice. We observed a very different pattern of AhR and CYP1A1 immunostaining in skin biopsies of the patient...
August 30, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28973351/editor-s-highlight-ah-receptor-activation-potentiates-neutrophil-chemoattractant-c-x-c-motif-ligand-5-expression-in-keratinocytes-and-skin
#4
Kayla J Smith, Jacob A Boyer, Gulsum E Muku, Iain A Murray, Krishne Gowda, Dhimant Desai, Shantu G Amin, Adam B Glick, Gary H Perdew
Chemokines are components of the skin microenvironment, which enable immune cell chemotaxis. Traditionally, transcription factors involved in inflammatory signaling (eg, NFκB) are important mediators of chemokine expression. To what extent xenobiotics and their associated receptors control chemokine expression is poorly understood. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor known to mediate physiological responses in the skin through the regulation of genes involved in xenobiotic metabolism, epidermal differentiation, and immunity...
November 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28941474/resolving-inflammation-by-targeting-an-ancient-innate-immune-sensor-with-a-bacterial-metabolite
#5
REVIEW
Andrew Johnston
Bacterial, fungal, and plant metabolites are promising sources of small molecules for drug discovery. Smith et al. show that tapinarof, a bacteria-derived polyphenol, is an aryl hydrocarbon receptor ligand that attenuated inflammatory responses and shows therapeutic potential for inflammatory skin diseases. This work adds to the growing literature stemming from the renewed interest in the discovery and development of novel small molecules with anti-inflammatory activity.
October 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28892018/antioxidant-artemisia-princeps-extract-enhances-the-expression-of-filaggrin-and-loricrin-via-the-ahr-ovol1-pathway
#6
Akiko Hirano, Masashi Goto, Tsukasa Mitsui, Akiko Hashimoto-Hachiya, Gaku Tsuji, Masutaka Furue
The Japanese mugwort, Artemisia princeps (yomogi in Japanese), has anti-inflammatory and antioxidant effects. Skin care products containing Artemisia princeps extract (APE) are known to improve dry skin symptoms in atopic dermatitis. Atopic dry skin is associated with a marked reduction of skin barrier proteins, such as filaggrin (FLG) and loricrin (LOR). Recently, aryl hydrocarbon receptor (AHR), and its downstream transcription factor OVO-like 1 (OVOL1), have been shown to regulate the gene expression of FLG and LOR...
September 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28891677/genetic-variation-in-the-mitf-promoter-affects-skin-colour-and-transcriptional-activity-in-black-boned-chickens
#7
G Wang, J Liao, M Tang, S Yu
1. Microphthalmia-associated transcription factor (MITF) plays a pivotal role in melanocyte development by regulating the transcription of major pigmentation enzymes (e.g. TYR, TYRP1 and DCT). A single-nucleotide polymorphism (SNP), c.-638T>C, was identified in the MITF promoter, and genotyping of a population (n = 426) revealed that SNP c.-638T>C was associated with skin colour in black-boned chickens. 2. Individuals with genotypes CC and TC exhibited greater MTIF expression than those with genotype TT...
October 17, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28887947/therapeutic-pipeline-for-atopic-dermatitis-end-of-the-drought
#8
REVIEW
Amy S Paller, Kenji Kabashima, Thomas Bieber
Until the past year, our therapeutic armamentarium for treating atopic dermatitis (AD) was still primarily topical corticosteroids and, for more severe disease, systemic immunosuppressants. The pipeline of more targeted topical and systemic therapies is expanding based on our growing understanding of the mechanism for AD and is particularly focused on suppressing the skewed immune activation. Most agents are in phase 2 clinical trials. Crisaborole, a topical phosphodiesterase 4 (PDE4) inhibitor, became available in late 2016 in the United States for mild-to-moderate AD, with other PDE4 inhibitors, an agonist of the aryl hydrocarbon receptor, Janus kinase inhibitors, and commensal organisms also in trials for topical application...
September 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28867725/wound-healing-effect-of-slightly-acidic-electrolyzed-water-on-cutaneous-wounds-in-hairless-mice-via-immune-redox-modulation
#9
Hae Sun You, Ailyn Fadriquela, Ma Easter Joy Sajo, Johny Bajgai, Jesmin Ara, Cheol Su Kim, Soo-Ki Kim, Jin Rok Oh, Kwang Yong Shim, Hyun Kyo Lim, Kyu-Jae Lee
Acidic electrolyzed water is an innovative sanitizer having a wide-spectrum of applications in food industry, and healthcare industry but little is known on its effect and mechanism in wound healing. The study was conducted to identify the effect and mechanism of slightly acidic electrolyzed water (SAEW) on cutaneous wounds in hairless mice. SAEW (pH: 5-6.5, oxidation reduction potential: 800 mV, chlorine concentration: 25 ppm) was prepared through electrolysis of water and was applied to the wounds of hairless mice three times a day for seven days...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28761287/adiponectin-upregulates-filaggrin-expression-via-sirt1-mediated-signaling-in-human-normal-keratinocytes
#10
Taewon Jin, Kui Young Park, Seong Jun Seo
BACKGROUND: Filaggrin (FLG) is the major component of the epidermal granular layer and binds to and condenses the keratin cytoskeleton. FLG thus contributes to cell compaction and serves as a natural moisturizing factor by promoting unfolding and degradation into hygroscopic amino acids. Loss or downregulation of FLG has been shown to result in a weak stratum corneum, which causes water loss and increases the possibility of skin barrier-related seizure. Adiponectin (Acrp30) contributes to the functional recovery of somatic cells, including human normal epidermal keratinocytes (NHEKs)...
August 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28703805/aryl-hydrocarbon-receptor-activation-restores-filaggrin-expression-via-ovol1-in-atopic-dermatitis
#11
Gaku Tsuji, Akiko Hashimoto-Hachiya, Mari Kiyomatsu-Oda, Masaki Takemura, Fumitaka Ohno, Takamichi Ito, Saori Morino-Koga, Chikage Mitoma, Takeshi Nakahara, Hiroshi Uchi, Masutaka Furue
Filaggrin (FLG) mutation is a well-confirmed genetic aberration in atopic dermatitis (AD). Genome-wide association studies on AD have revealed other susceptibility genes, for example, Ovo-like 1 (OVOL1). Nonetheless, the relation between FLG and OVOL1 is unclear. Because aryl hydrocarbon receptor (AHR; a ligand-activated transcription factor), plays a role in FLG expression in keratinocytes, we hypothesized that AHR regulates FLG expression via OVOL1. To demonstrate this mechanism, we analyzed FLG expression in OVOL1-overexpressing or OVOL1-knockdown normal human epidermal keratinocytes (NHEKs)...
July 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28595996/tapinarof-is-a-natural-ahr-agonist-that%C3%A2-resolves-skin-inflammation-in-mice%C3%A2-and%C3%A2-humans
#12
Susan H Smith, Channa Jayawickreme, David J Rickard, Edwige Nicodeme, Thi Bui, Cathy Simmons, Christine M Coquery, Jessica Neil, William M Pryor, David Mayhew, Deepak K Rajpal, Katrina Creech, Sylvia Furst, James Lee, Dalei Wu, Fraydoon Rastinejad, Timothy M Willson, Fabrice Viviani, David C Morris, John T Moore, Javier Cote-Sierra
Tapinarof (GSK2894512) is a naturally derived topical treatment with demonstrated efficacy for patients with psoriasis and atopic dermatitis, although the biologic target and mechanism of action had been unknown. We demonstrate that the anti-inflammatory properties of tapinarof are mediated through activation of the aryl hydrocarbon receptor (AhR). We show that tapinarof binds and activates AhR in multiple cell types, including cells of the target tissue-human skin. In addition, tapinarof moderates proinflammatory cytokine expression in stimulated peripheral blood CD4+ T cells and ex vivo human skin, and impacts barrier gene expression in primary human keratinocytes; both of these processes are likely to be downstream of AhR activation based on current evidence...
October 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28573192/modeling-the-effect-of-the-aryl-hydrocarbon-receptor-on-transplant-immunity
#13
Walker Julliard, John H Fechner, Leah Owens, Chelsea A O'Driscoll, Ling Zhou, Jeremy A Sullivan, Lynn Frydrych, Amanda Mueller, Joshua D Mezrich
BACKGROUND: Exposure to pollutants through inhalation is a risk factor for lung diseases including cancer, asthma, and lung transplant rejection, but knowledge of the effects of inhaled pollutants on pathologies outside of the lung is limited. METHODS: Using the minor-mismatched model of male C57BL/6J (B6) to female B6 skin grafts, recipient mice were treated with an inhaled urban dust particle sample every 3 days before and after grafting. Graft survival time was determined, and analysis of the resulting immune response was performed at time before rejection...
May 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28552542/6-formylindolo-3-2-b-carbazole-accelerates-skin-wound-healing-via%C3%A2-activation-of-erk-but-not-aryl%C3%A2-hydrocarbon-receptor
#14
Saori Morino-Koga, Hiroshi Uchi, Chikage Mitoma, Zhouwei Wu, Mari Kiyomatsu, Yoko Fuyuno, Konosuke Nagae, Mao Yasumatsu, Mary Ann Suico, Hirofumi Kai, Masutaka Furue
Wound healing is an elaborate process composed of overlapping phases, such as proliferation and remodeling, and is delayed in several circumstances, including diabetes. Although several treatment strategies for chronic wounds, such as growth factors, have been applied, further alternatives are required. The skin, especially keratinocytes, is continually exposed to UV rays, which impairs wound healing. 6-Formylindolo[3,2-b]carbazole (FICZ) is a tryptophan photoproduct formed by UV exposure, indicating that FICZ might be one of the effectors of UV radiation...
October 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28526404/airborne-polycyclic-aromatic-hydrocarbons-trigger-human-skin-cells-aging-through-aryl-hydrocarbon-receptor
#15
Yuan Qiao, Qiang Li, Hong-Yang Du, Qiao-Wei Wang, Ye Huang, Wei Liu
Accumulating evidence suggests that polycyclic aromatic hydrocarbons (PAH) which adsorbed on the surface of ambient air particulate matters (PM), are the major toxic compound to cause cardiovascular and respiratory diseases, even cancer. However, its detrimental effects on human skin cell remain unclear. Here, we demonstrated that SRM1649b, a reference urban dust material of PAH, triggers human skin cells aging through cell cycle arrest, cell growth inhibition and apoptosis. Principally, SRM1649b facilitated Aryl hydrocarbon receptor (AhR) translocated into nucleus, subsequently activated ERK/MAPK signaling pathway, and upregulated aging-related genes expression...
July 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28390928/itraconazole-cis-diastereoisomers-activate-aryl-hydrocarbon-receptor-ahr-and-pregnane-x-receptor-pxr-and-induce-cyp1a1-in-human-cell-lines-and-human-hepatocytes
#16
Martina Stepankova, Barbora Pastorkova, Petr Bachleda, Zdenek Dvorak
Triazole antimycotic itraconazole contains in its structure three chiral centres; therefore, it forms eight stereoisomers. Commercial preparations of itraconazole are a mixture of four cis-diastereoisomers. There is much evidence that efficacy, adverse effects, and toxicity of chiral drugs may be stereospecific. Therefore, we have prepared 4 pure cis-diastereoisomers of itraconazole and investigated their effects on transcriptional activities of xenoreceptors aryl hydrocarbon receptor AhR and pregnane X receptor PXR...
May 15, 2017: Toxicology
https://www.readbyqxmd.com/read/28376268/ahr-mediates-an-anti-inflammatory-feedback-mechanism-in-human-langerhans-cells-involving-fc%C3%AE%C2%B5ri-and-ido
#17
S Koch, T J Stroisch, J Vorac, N Herrmann, N Leib, S Schnautz, H Kirins, I Förster, H Weighardt, T Bieber
BACKGROUND: Aryl hydrocarbon receptor (AhR), an important regulator of immune responses, is activated by UVB irradiation in the skin. Langerhans cells (LC) in the epidermis of patients with atopic dermatitis (AD) carry the high-affinity receptor for IgE, FcεRI, and are crucially involved in the pathogenesis of AD by inducing inflammatory responses and regulating tolerogenic processes. OBJECTIVES: We investigated AhR and AhR repressor (AhRR) expression and functional consequences of AhR activation in human ex vivo skin cells and in in vitro-generated LC...
April 4, 2017: Allergy
https://www.readbyqxmd.com/read/28273792/antioxidants-for-healthy-skin-the-emerging-role-of-aryl-hydrocarbon-receptors-and-nuclear-factor-erythroid-2-related-factor-2
#18
REVIEW
Masutaka Furue, Hiroshi Uchi, Chikage Mitoma, Akiko Hashimoto-Hachiya, Takahito Chiba, Takamichi Ito, Takeshi Nakahara, Gaku Tsuji
Skin is the outermost part of the body and is, thus, inevitably exposed to UV rays and environmental pollutants. Oxidative stress by these hazardous factors accelerates skin aging and induces skin inflammation and carcinogenesis. Aryl hydrocarbon receptors (AHRs) are chemical sensors that are abundantly expressed in epidermal keratinocytes and mediate the production of reactive oxygen species. To neutralize or minimize oxidative stress, the keratinocytes also express nuclear factor-erythroid 2-related factor-2 (NRF2), which is a master switch for antioxidant signaling...
March 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28219704/%C3%AE-lactam-hypersensitivity-involves-expansion-of-circulating-and-skin-resident-th22%C3%A2-cells
#19
Andrew Sullivan, Eryi Wang, John Farrell, Paul Whitaker, Lee Faulkner, Daniel Peckham, B Kevin Park, Dean J Naisbitt
BACKGROUND: β-Lactam hypersensitivity has been classified according to the phenotype and function of drug-specific T cells. However, new T-cell subsets have not been considered. OBJECTIVE: The objective of this study was to use piperacillin as a model of β-lactam hypersensitivity to study the nature of the drug-specific T-cell response induced in the blood and skin of hypersensitive patients and healthy volunteers. METHODS: Drug-specific T cells were cloned from blood and inflamed skin, and cellular phenotype and function were explored...
February 20, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28067314/the-transcription-factor-epas1-links-dock8-deficiency-to-atopic-skin-inflammation-via-il-31-induction
#20
Kazuhiko Yamamura, Takehito Uruno, Akira Shiraishi, Yoshihiko Tanaka, Miho Ushijima, Takeshi Nakahara, Mayuki Watanabe, Makiko Kido-Nakahara, Ikuya Tsuge, Masutaka Furue, Yoshinori Fukui
Mutations of DOCK8 in humans cause a combined immunodeficiency characterized by atopic dermatitis with high serum IgE levels. However, the molecular link between DOCK8 deficiency and atopic skin inflammation is unknown. Here we show that CD4(+) T cells from DOCK8-deficient mice produce large amounts of IL-31, a major pruritogen associated with atopic dermatitis. IL-31 induction critically depends on the transcription factor EPAS1, and its conditional deletion in CD4(+) T cells abrogates skin disease development in DOCK8-deficient mice...
January 9, 2017: Nature Communications
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