keyword
MENU ▼
Read by QxMD icon Read
search

Aryl hydrocarbon receptor skin

keyword
https://www.readbyqxmd.com/read/28703805/aryl-hydrocarbon-receptor-activation-restores-filaggrin-expression-via-ovol1-in-atopic-dermatitis
#1
Gaku Tsuji, Akiko Hashimoto-Hachiya, Mari Kiyomatsu-Oda, Masaki Takemura, Fumitaka Ohno, Takamichi Ito, Saori Morino-Koga, Chikage Mitoma, Takeshi Nakahara, Hiroshi Uchi, Masutaka Furue
Filaggrin (FLG) mutation is a well-confirmed genetic aberration in atopic dermatitis (AD). Genome-wide association studies on AD have revealed other susceptibility genes, for example, Ovo-like 1 (OVOL1). Nonetheless, the relation between FLG and OVOL1 is unclear. Because aryl hydrocarbon receptor (AHR; a ligand-activated transcription factor), plays a role in FLG expression in keratinocytes, we hypothesized that AHR regulates FLG expression via OVOL1. To demonstrate this mechanism, we analyzed FLG expression in OVOL1-overexpressing or OVOL1-knockdown normal human epidermal keratinocytes (NHEKs)...
July 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28595996/tapinarof-is-a-natural-ahr-agonist-that-resolves-skin-inflammation-in-mice-and-humans
#2
Susan H Smith, Channa Jayawickreme, David J Rickard, Edwige Nicodeme, Thi Bui, Cathy Simmons, Christine M Coquery, Jessica Neil, William M Pryor, David Mayhew, Deepak K Rajpal, Katrina Creech, Sylvia Furst, James Lee, Dalei Wu, Fraydoon Rastinejad, Timothy M Willson, Fabrice Viviani, David C Morris, John T Moore, Javier Cote-Sierra
Tapinarof (GSK2894512) is a naturally derived topical treatment with demonstrated efficacy for psoriasis and atopic dermatitis (AD) patients, although the biologic target and mechanism of action had been unknown. We demonstrate that the anti-inflammatory properties of tapinarof are mediated through activation of the Aryl hydrocarbon Receptor (AhR). We show that tapinarof binds and activates AhR in multiple cell types, including cells of the target tissue -human skin. In addition, tapinarof moderates proinflammatory cytokine expression in stimulated peripheral blood CD4+ T cells and ex vivo human skin, and impacts barrier gene expression in primary human keratinocytes; both of these processes are likely to be downstream of AhR activation based on current evidence...
June 5, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28573192/modeling-the-effect-of-the-aryl-hydrocarbon-receptor-on-transplant-immunity
#3
Walker Julliard, John H Fechner, Leah Owens, Chelsea A O'Driscoll, Ling Zhou, Jeremy A Sullivan, Lynn Frydrych, Amanda Mueller, Joshua D Mezrich
BACKGROUND: Exposure to pollutants through inhalation is a risk factor for lung diseases including cancer, asthma, and lung transplant rejection, but knowledge of the effects of inhaled pollutants on pathologies outside of the lung is limited. METHODS: Using the minor-mismatched model of male C57BL/6J (B6) to female B6 skin grafts, recipient mice were treated with an inhaled urban dust particle sample every 3 days before and after grafting. Graft survival time was determined, and analysis of the resulting immune response was performed at time before rejection...
May 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28552542/6-formylindolo-3-2-b-carbazole-ficz-accelerates-skin-wound-healing-via-activation-of-erk-but-not-aryl-hydrocarbon-receptor
#4
Saori Morino-Koga, Hiroshi Uchi, Chikage Mitoma, Zhouwei Wu, Mari Kiyomatsu, Yoko Fuyuno, Konosuke Nagae, Mao Yasumatsu, Mary Ann Suico, Hirofumi Kai, Masutaka Furue
Wound healing is an elaborate process composed of overlapping phases, such as proliferation and remodeling, and is delayed in several circumstances, including diabetes. Although several treatment strategies for chronic wounds, such as growth factors, have been applied, further alternatives are required. The skin, especially keratinocytes, is continually exposed to UV rays, which impairs wound healing. The 6-formylindolo[3,2-b]carbazole (FICZ) is a tryptophan photoproduct formed by UV exposure, indicating that FICZ might be one of the effectors of UV radiation...
May 25, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28526404/airborne-polycyclic-aromatic-hydrocarbons-trigger-human-skin-cells-aging-through-aryl-hydrocarbon-receptor
#5
Yuan Qiao, Qiang Li, Hong-Yang Du, Qiao-Wei Wang, Ye Huang, Wei Liu
Accumulating evidence suggests that polycyclic aromatic hydrocarbons (PAH) which adsorbed on the surface of ambient air particulate matters (PM), are the major toxic compound to cause cardiovascular and respiratory diseases, even cancer. However, its detrimental effects on human skin cell remain unclear. Here, we demonstrated that SRM1649b, a reference urban dust material of PAH, triggers human skin cells aging through cell cycle arrest, cell growth inhibition and apoptosis. Principally, SRM1649b facilitated Aryl hydrocarbon receptor (AhR) translocated into nucleus, subsequently activated ERK/MAPK signaling pathway, and upregulated aging-related genes expression...
May 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28390928/itraconazole-cis-diastereoisomers-activate-aryl-hydrocarbon-receptor-ahr-and-pregnane-x-receptor-pxr-and-induce-cyp1a1-in-human-cell-lines-and-human-hepatocytes
#6
Martina Stepankova, Barbora Pastorkova, Petr Bachleda, Zdenek Dvorak
Triazole antimycotic itraconazole contains in its structure three chiral centres; therefore, it forms eight stereoisomers. Commercial preparations of itraconazole are a mixture of four cis-diastereoisomers. There is much evidence that efficacy, adverse effects, and toxicity of chiral drugs may be stereospecific. Therefore, we have prepared 4 pure cis-diastereoisomers of itraconazole and investigated their effects on transcriptional activities of xenoreceptors aryl hydrocarbon receptor AhR and pregnane X receptor PXR...
May 15, 2017: Toxicology
https://www.readbyqxmd.com/read/28376268/ahr-mediates-an-anti-inflammatory-feed-back-mechanism-in-human-langerhans-cells-involving-fc%C3%AE%C2%B5ri-and-ido
#7
Susanne Koch, Tim J Stroisch, Julia Vorac, Nadine Herrmann, Nicole Leib, Sylvia Schnautz, Helene Kirins, Irmgard Förster, Heike Weighardt, Thomas Bieber
BACKGROUND: Aryl hydrocarbon receptor (AhR), an important regulator of immune responses, is activated by UVB irradiation in the skin. Langerhans cells (LC) in the epidermis of atopic dermatitis (AD) patients carry the high affinity receptor for IgE, FcεRI, and are crucially involved in the pathogenesis of AD by inducing inflammatory responses and regulating tolerogenic processes. OBJECTIVES: We investigated AhR and AhR repressor (AhRR) expression and functional consequences of AhR activation in human ex vivo skin cells and in in vitro generated LC...
April 4, 2017: Allergy
https://www.readbyqxmd.com/read/28273792/antioxidants-for-healthy-skin-the-emerging-role-of-aryl-hydrocarbon-receptors-and-nuclear-factor-erythroid-2-related-factor-2
#8
REVIEW
Masutaka Furue, Hiroshi Uchi, Chikage Mitoma, Akiko Hashimoto-Hachiya, Takahito Chiba, Takamichi Ito, Takeshi Nakahara, Gaku Tsuji
Skin is the outermost part of the body and is, thus, inevitably exposed to UV rays and environmental pollutants. Oxidative stress by these hazardous factors accelerates skin aging and induces skin inflammation and carcinogenesis. Aryl hydrocarbon receptors (AHRs) are chemical sensors that are abundantly expressed in epidermal keratinocytes and mediate the production of reactive oxygen species. To neutralize or minimize oxidative stress, the keratinocytes also express nuclear factor-erythroid 2-related factor-2 (NRF2), which is a master switch for antioxidant signaling...
March 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28219704/%C3%AE-lactam-hypersensitivity-involves-expansion-of-circulating-and-skin-resident-th22%C3%A2-cells
#9
Andrew Sullivan, Eryi Wang, John Farrell, Paul Whitaker, Lee Faulkner, Daniel Peckham, B Kevin Park, Dean J Naisbitt
BACKGROUND: β-Lactam hypersensitivity has been classified according to the phenotype and function of drug-specific T cells. However, new T-cell subsets have not been considered. OBJECTIVE: The objective of this study was to use piperacillin as a model of β-lactam hypersensitivity to study the nature of the drug-specific T-cell response induced in the blood and skin of hypersensitive patients and healthy volunteers. METHODS: Drug-specific T cells were cloned from blood and inflamed skin, and cellular phenotype and function were explored...
February 20, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28067314/the-transcription-factor-epas1-links-dock8-deficiency-to-atopic-skin-inflammation-via-il-31-induction
#10
Kazuhiko Yamamura, Takehito Uruno, Akira Shiraishi, Yoshihiko Tanaka, Miho Ushijima, Takeshi Nakahara, Mayuki Watanabe, Makiko Kido-Nakahara, Ikuya Tsuge, Masutaka Furue, Yoshinori Fukui
Mutations of DOCK8 in humans cause a combined immunodeficiency characterized by atopic dermatitis with high serum IgE levels. However, the molecular link between DOCK8 deficiency and atopic skin inflammation is unknown. Here we show that CD4(+) T cells from DOCK8-deficient mice produce large amounts of IL-31, a major pruritogen associated with atopic dermatitis. IL-31 induction critically depends on the transcription factor EPAS1, and its conditional deletion in CD4(+) T cells abrogates skin disease development in DOCK8-deficient mice...
January 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28057434/atopic-dermatitis-immune-deviation-barrier-dysfunction-ige-autoreactivity-and-new-therapies
#11
REVIEW
Masutaka Furue, Takahito Chiba, Gaku Tsuji, Dugarmaa Ulzii, Makiko Kido-Nakahara, Takeshi Nakahara, Takafumi Kadono
Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder mostly associated with IgE elevation and skin barrier dysfunction due to decreased filaggrin expression. The lesional skin of AD exhibits Th2- and Th22-deviated immune reactions that are progressive during disease chronicity. Th2 and Th22 cytokines further deteriorate the skin barrier by inhibiting filaggrin expression. Some IgEs are reactive to self-antigens. The IgE autoreactivity may precipitate the chronicity of AD...
July 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28057405/genetic-variants-associated-with-skin-aging-in-the-chinese-han-population
#12
Wenshan Gao, Jingze Tan, Anke Hüls, Anan Ding, Yu Liu, Mary S Matsui, Andrea Vierkötter, Jean Krutmann, Tamara Schikowski, Li Jin, Sijia Wang
BACKGROUND: The progression and manifestation of human skin aging has a strong genetic basis; however, most of the supporting evidence has been gathered in Caucasian populations. The genetic contribution to the variation in skin aging in non-Caucasian populations is poorly understood. OBJECTIVE: To investigate the genetic risk factors of relevance for skin aging in East Asians, we conducted the first candidate gene study for signs of skin aging in Han Chinese. METHODS: We collected skin aging and genotype data in 502 female Han Chinese from the Taizhou cohort...
April 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28029781/aryl-hydrocarbon-receptor-activation-contributes-to-benzanthrone-induced-hyperpigmentation-via-modulation-of-melanogenic-signaling-pathways
#13
Sabiya Abbas, Shamshad Alam, Krishna P Singh, Mahadeo Kumar, Shailendra K Gupta, Kausar M Ansari
Benzanthrone (BA), an oxidized polycyclic aromatic hydrocarbon (PAH), has been found to be a potential health threat to occupational workers involved in dye manufacturing factories. It has been observed that occupational workers become exposed to BA either during manufacturing, pulverization, or storage and developed various kinds of skin diseases like contact dermatitis, itching, erythema, roughness, and foremost, hyperpigmentation. It has been shown that some environmental organic pollutants (POPs) like dioxins, furans, and polychlorinated biphenyls (PCBs) may act as ligands for the aryl hydrocarbon receptor (AhR) and regulate hyperpigmentation...
February 20, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27720465/inhibition-of-aryl-hydrocarbon-receptor-signaling-and-induction-of-nrf2-mediated-antioxidant-activity-by-cinnamaldehyde-in-human-keratinocytes
#14
Hiroshi Uchi, Mao Yasumatsu, Saori Morino-Koga, Chikage Mitoma, Masutaka Furue
BACKGROUND: Dioxins and other environmental pollutants are toxic and remain in biological tissues for a long time leading to various levels of oxidative stress. Although the toxicity of these agents has been linked to activation of the aryl hydrocarbon receptor (AHR), no effective treatment has been developed. OBJECTIVE: To explore novel phytochemicals that inhibit AHR activation in keratinocytes. METHODS: Keratinocytes were used in this study because the skin is one of the organs most affected by dioxin and other environmental pollutants...
January 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27670593/the-aryl-hydrocarbon-receptor-is-required-for-the-maintenance-of-liver-resident-natural-killer-cells
#15
Luhua H Zhang, June Ho Shin, Mikel D Haggadone, John B Sunwoo
A tissue-resident population of natural killer cells (NK cells) in the liver has recently been described to have the unique capacity to confer immunological memory in the form of hapten-specific contact hypersensitivity independent of T and B cells. Factors regulating the development and maintenance of these liver-resident NK cells are poorly understood. The aryl hydrocarbon receptor (AhR) is a transcription factor modulated by exogenous and endogenous ligands that is important in the homeostasis of immune cells at barrier sites, such as the skin and gut...
October 17, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27539901/action-spectrum-of-melanoblast-maturation-and-involvement-of-the-aryl-hydrocarbon-receptor
#16
Motoki Nakamura, Emi Nishida, Akimichi Morita
The aryl hydrocarbon receptor (AHR) mediates melanocyte activation and skin tanning. We hypothesized that the AHR also mediates melanoblast-to-melanocyte maturation. In a cloned cell line, NCCmelb4, derived from mouse neural crest cells, we investigated AHR expression in melanoblasts stimulated by UV irradiation and AHR agonists. We irradiated the cells with UV, ranging from 280 to 380 nm in 10-nm increments, using a multiwavelength irradiation spectral apparatus. Tyrosinase expression significantly increased with bimodal peaks at 310 and 360 nm...
August 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27430407/aryl-hydrocarbon-receptor-in-keratinocytes-is-essential-for-murine-skin-barrier-integrity
#17
Katharina Haas, Heike Weighardt, René Deenen, Karl Köhrer, Björn Clausen, Sonja Zahner, Petra Boukamp, Wilhelm Bloch, Jean Krutmann, Charlotte Esser
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in adaptive cell functions, and is highly active in the epidermis. AhR ligands can accelerate keratinocyte differentiation, but the precise role of AhR in the skin barrier is unknown. Our study showed that transepidermal water loss (TEWL), a parameter of skin barrier integrity, is high in AhR-deficient (AhR-KO) mice. Experiments with conditionally AhR-deficient mouse lines identified keratinocytes as the primary cell population responsible for high TEWL...
July 15, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27376471/cd69-controls-the-uptake-of-l-tryptophan-through-lat1-cd98-and-ahr-dependent-secretion-of-il-22-in-psoriasis
#18
Danay Cibrian, María Laura Saiz, Hortensia de la Fuente, Raquel Sánchez-Díaz, Olga Moreno-Gonzalo, Inmaculada Jorge, Alessia Ferrarini, Jesús Vázquez, Carmen Punzón, Manuel Fresno, Miguel Vicente-Manzanares, Esteban Daudén, Pedro M Fernández-Salguero, Pilar Martín, Francisco Sánchez-Madrid
The activation marker CD69 is expressed by skin γδ T cells. Here we found that CD69 controlled the aryl hydrocarbon receptor (AhR)-dependent secretion of interleukin 22 (IL-22) by γδ T cells, which contributed to the development of psoriasis induced by IL-23. CD69 associated with the aromatic-amino-acid-transporter complex LAT1-CD98 and regulated its surface expression and uptake of L-tryptophan (L-Trp) and the intracellular quantity of L-Trp-derived activators of AhR. In vivo administration of L-Trp, an inhibitor of AhR or IL-22 abrogated the differences between CD69-deficient mice and wild-type mice in skin inflammation...
August 2016: Nature Immunology
https://www.readbyqxmd.com/read/27363826/endocrine-disrupting-chemicals-and-skin-manifestations
#19
REVIEW
Qiang Ju, Christos C Zouboulis
Endocrine-disrupting chemicals (EDCs) are exogenous compounds that have the ability to disrupt the production and actions of hormones through direct or indirect interaction with hormone receptors, thus acting as agonists or antagonists. Human health is affected after either individual occupation or dietary and environmental exposure to EDCs. On the other hand, skin is one of the largest organs of the body and its main function is protection from noxious substances. EDCs perturb the endocrine system, and they are also carcinogenic, immunotoxic, and hepatotoxic to human skin...
September 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27313009/urban-particulate-matter-down-regulates-filaggrin-via-cox2-expression-pge2-production-leading-to-skin-barrier-dysfunction
#20
Chiang-Wen Lee, Zih-Chan Lin, Stephen Chu-Sung Hu, Yao-Chang Chiang, Lee-Fen Hsu, Yu-Ching Lin, I-Ta Lee, Ming-Horng Tsai, Jia-You Fang
We explored the regulation of filaggrin, cyclooxygenase 2 (COX2) and prostaglandin E2 (PGE2) expression induced by urban particulate matter (PM) in human keratinocytes. In addition, we investigated the signaling pathways involved in PM-induced effects on COX2/PGE2 and filaggrin. PMs induced increases in COX2 expression and PGE2 production, and decreased filaggrin expression. These effects were attenuated by pretreatment with COX2 inhibitor and PGE2 receptor antagonist, or after transfection with siRNAs of the aryl hydrocarbon receptor (AhR), gp91phox and p47phox...
2016: Scientific Reports
keyword
keyword
117775
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"