keyword
MENU ▼
Read by QxMD icon Read
search

chronic persistent nerve pain

keyword
https://www.readbyqxmd.com/read/29775120/successful-improvement-of-pain-symptomatology-in-a-suspected-case-of-cramp-fasciculation-syndrome-via-interventional-pain-treatment
#1
Anita Gupta, Lucas First, Celeste A Swain
Peripheral nerve hyperexcitability (PNH) syndromes are a rare set of neuromuscular disorders that include cramp-fasciculation syndrome (CFS) and Isaacs syndrome (IS). Successful treatment of these diseases has been achieved with antiepileptic medications; however, chronic pain symptoms can persist. We provide a case report of a 25-year-old female who has suffered from painful severe muscle spasms and fasciculations since childhood. With CFS as our working diagnosis, a treatment regimen using interventional pain techniques, including sympathetic chain blocks, ketamine infusions, and trigger point injections, resulted in a significant decrease in the patient's chronic pain symptoms...
May 18, 2018: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/29763654/obturator-neuromodulation-with-laparoscopic-placement-of-an-obturator-lead-for-the-treatment-of-intractable-opioid-dependent-chronic-pelvic-pain-due-to-obturator-neuralgia
#2
Richard P Marvel
Chronic pelvic pain(CPP) is a common condition in women that can have a devastating effect on quality of life. Some of the most severe forms of CPP are related to peripheral nerve injuries causing persistent neuropathic pain. This is a case of a young woman with severe opioid dependent chronic pelvic and right groin pain due to obturator neuralgia. She had failed a multitude of treatments including multiple medications, manual physical therapy, nerve blocks, surgical neurolysis and spinal cord stimulation without significant benefit...
May 12, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29738328/persistent-postsurgical-pain-pathophysiology-and-preventative-pharmacologic-considerations
#3
Philippe Richebé, Xavier Capdevila, Cyril Rivat
The development of chronic pain is considered a major complication after surgery. Basic science research in animal models helps us understand the transition from acute to chronic pain by identifying the numerous molecular and cellular changes that occur in the peripheral and central nervous systems. It is now well recognized that inflammation and nerve injury lead to long-term synaptic plasticity that amplifies and also maintains pain signaling, a phenomenon referred to as pain sensitization. In the context of surgery in humans, pain sensitization is both responsible for an increase in postoperative pain via the expression of wound hyperalgesia and considered a critical factor for the development of persistent postsurgical pain...
May 7, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29702268/vascular-entrapment-of-both-the-sciatic-and-pudendal-nerve-causing-persistent-sciatica-and-pudendal-neuralgia
#4
Ahmet Kale, Gulfem Basol, Taner Usta, Isa Cam
STUDY OBJECTIVE: To demonstrate the laparoscopic approach to malformed branches of the vessels entrapping the nerves of the sacral plexus. DESIGN: A step-by-step explanation of the surgery using video (instructive video). The Ethics Committee ruled that approval was not required for this video. SETTING: Derince Education and Research Hospital, Turkey PATIENT: : The 26-year-old patient who had failed the medical therapy, complained about numbness and burning pain on the right side of the vagina and pain radiating to the lower limb for approximately 36 months period...
April 24, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29695413/altered-excitability-and-local-connectivity-of-mpfc-pag-neurons-in-a-mouse-model-of-neuropathic-pain
#5
John Cheriyan, Patrick L Sheets
The medial prefrontal cortex (mPFC) plays a major role in both sensory and affective aspects of pain. There is extensive evidence that chronic pain produces functional changes within the mPFC. However, our understanding of local circuit changes to defined subpopulations of mPFC neurons in chronic pain models remains unclear. A major subpopulation of mPFC neurons project to the periaqueductal gray (PAG) which is a key midbrain structure involved in endogenous pain suppression and facilitation. Here, we used laser scanning photostimulation of caged glutamate to map cortical circuits of retrogradely-labeled cortico-PAG (CP) neurons in layer 5 (L5) of mPFC in brain slices prepared from male mice having undergone chronic constriction injury (CCI) of the sciatic nerve...
April 25, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29677029/kindlin-1-regulates-astrocyte-activation-and-pain-sensitivity-in-rats-with-neuropathic-pain
#6
Baisong Zhao, Yongying Pan, Haiping Xu, Xingrong Song
BACKGROUND AND OBJECTIVES: Astrocyte activation has been implicated in the pathogenesis of neuropathic pain, but the involvement of kindlin-1 in astrocyte activation and neuropathic pain has not yet been illustrated. Using a chronic constriction injury (CCI) rat model of neuropathic pain, we investigated the expression levels of kindlin-1 during neuropathic pain and the influences of kindlin-1 on regulating pain sensitivity. METHODS: Neuropathic pain was induced in rats by CCI of the sciatic nerve...
April 19, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29543658/preoperative-pain-sensitization-is-associated-with-postoperative-pillar-pain-after-open-carpal-tunnel-release
#7
Young Hak Roh, Young Do Koh, Jong Oh Kim, Kyu Ho Lee, Hyun Sik Gong, Goo Hyun Baek
BACKGROUND: Postoperative pillar pain (deep-seated wrist pain worsened by leaning on the heel of the hand) sometimes occurs after carpal tunnel release (CTR), leading to weakness in the hand and delayed return to work. Increased pain sensitivity has been found to be associated with worse symptoms and poorer treatment response in a number of chronic musculoskeletal conditions, but few studies have investigated the association of pain sensitization with pillar pain after CTR. QUESTIONS/PURPOSES: (1) Is preoperative pain sensitization in patients with carpal tunnel syndrome (CTS) associated with increased severity of pillar pain after open CTR? (2) What other demographic, electrophysiological, or preoperative clinical characteristics are associated with pillar pain after CTR? METHODS: Over a 35-month period, one surgeon performed 162 open carpal tunnel releases...
April 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29524514/behavioral-effects-of-combined-morphine-and-mk-801-administration-to-the-locus-coeruleus-of-a-rat-neuropathic-pain-model
#8
Meritxell Llorca-Torralba, Juan A Mico, Esther Berrocoso
The persistent activation of N-methyl-d-aspartate acid receptors (NMDARs) seems to be responsible for a series of changes in neurons associated with neuropathic pain, including the failure of opioids that act through mu-opioid receptors (MORs) to provide efficacious pain relief. As the noradrenergic locus coeruleus (LC) forms part of the endogenous analgesic system, we explored how intra-LC administration of morphine, a MORs agonist, alone or in combination with MK-801, a NMDARs antagonist, affects the sensorial and affective dimension of pain in a rat model of neuropathic pain; chronic constriction injury (CCI)...
June 8, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29519721/low-dose-nsaids-reduce-pain-via-macrophage-targeted-nanoemulsion-delivery-to-neuroinflammation-of-the-sciatic-nerve-in-rat
#9
Jelena M Janjic, Kiran Vasudeva, Muzamil Saleem, Andrea Stevens, Lu Liu, Sravan Patel, John A Pollock
Neuroinflammation involving macrophages elevates Prostaglandin E2 , associated with neuropathic pain. Treatment with non-steroidal anti-inflammatory drugs (NSAIDs) inhibits cyclooxygenase, reducing PGE2 . However, NSAIDs cause physiological complications. We developed nanoemulsions incorporating celecoxib and near infrared dye. Intravenous injected nanoemulsion is incorporated into monocytes that accumulate at the injury; revealed in live animals by fluorescence. A single dose (celecoxib 0.24 mg/kg) provides targeted delivery in chronic constriction injury rats, resulting in significant reduction in the visualized inflammation, infiltration of macrophages, COX-2 and PGE2 ...
May 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29510808/from-acute-to-chronic-postsurgical-pain-the-significance-of-the-acute-pain-response
#10
Morten Rune Blichfeldt-Eckhardt
The thesis comprises an overview and four papers, all published or submitted for publication in international peer-reviewed scientific journals.
 
Chronic pain after surgery is a common and debilitating complication after many types of surgery. The cause and pathology behind is still mainly uncovered, though several risk factors have been proposed. One of the strongest risk factors for persistent postsurgical pain is the intensity of the acute pain response though the mechanisms involved remain unsettled...
March 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29463643/hyperactivity-of-anterior-cingulate-cortex-areas-24a-24b-drives-chronic-pain-induced-anxiodepressive-like-consequences
#11
Jim Sellmeijer, Victor Mathis, Sylvain Hugel, Xu-Hui Li, Qian Song, Qi-Yu Chen, Florent Barthas, Pierre-Eric Lutz, Meltem Karatas, Andreas Luthi, Pierre Veinante, Ad Aertsen, Michel Barrot, Min Zhuo, Ipek Yalcin
Pain associates both sensory and emotional aversive components, and often leads to anxiety and depression when it becomes chronic. Here, we characterized, in a mouse model, the long-term development of these sensory and aversive components as well as anxiodepressive-like consequences of neuropathic pain and determined their electrophysiological impact on the anterior cingulate cortex (ACC, cortical areas 24a/24b). We show that these symptoms of neuropathic pain evolve and recover in different time courses following nerve injury in male mice...
March 21, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29447138/inflammation-in-the-pathophysiology-of-neuropathic-pain
#12
Claudia Sommer, Mathias Leinders, Nurcan Üçeyler
Peripheral nerve injuries and diseases often lead to pain persisting beyond the resolution of damage, indicating an active disease-promoting process, which may result in chronic pain. This is regarded as a maladaptive mechanism resulting from neuroinflammation that originally serves to promote regeneration and healing. Knowledge on these physiological and pathophysiological processes has accumulated over the last few decades and has started to yield potential therapeutic targets. Key players are macrophages, T-lymphocytes, cytokines, and chemokines...
March 2018: Pain
https://www.readbyqxmd.com/read/29436370/isoflurane-and-the-analgesic-effect-of-acupuncture-and-electroacupuncture-in-an-animal-model-of-neuropathic-pain
#13
Lauren Naomi Spezia Adachi, Rafael Vercelino, Carla de Oliveira, Vanessa Leal Scarabelot, Andressa de Souza, Liciane Fernandes Medeiros, Stefania Giotti Cioato, Wolnei Caumo, Iraci L S Torres
The present study aimed to determine whether isoflurane interferes with the analgesic effects of acupuncture (Ac) and electroacupuncture (EA), using a neuropathic pain (NP) rat model. In total, 140 male Wistar rats were used; isoflurane-induced nociceptive response was evaluated using the von Frey test, serum calcium-binding protein β (S100β) levels, and nerve growth factor (NGF) levels in the left sciatic nerve. The NP model was induced by chronic constriction injury (CCI) of the sciatic nerve at 14 days after surgery...
February 6, 2018: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29419657/neuroinflammation-of-the-spinal-cord-and-nerve-roots-in-chronic-radicular-pain-patients
#14
Daniel S Albrecht, Shihab U Ahmed, Norman W Kettner, Ronald J H Borra, Julien Cohen-Adad, Hao Deng, Timothy T Houle, Arissa Opalacz, Sarah A Roth, Marcos F Vidal Melo, Lucy Chen, Jianren Mao, Jacob M Hooker, Marco L Loggia, Yi Zhang
Numerous preclinical studies support the role of spinal neuroimmune activation in the pathogenesis of chronic pain, and targeting glia (eg, microglia/astrocyte)- or macrophage-mediated neuroinflammatory responses effectively prevents or reverses the establishment of persistent nocifensive behaviors in laboratory animals. However, thus far, the translation of those findings into novel treatments for clinical use has been hindered by the scarcity of data supporting the role of neuroinflammation in human pain...
May 2018: Pain
https://www.readbyqxmd.com/read/29399464/split-pectoralis-major-transfer-for-chronic-medial-scapular-winging
#15
W Stephen Choate, Adam Kwapisz, John M Tokish
Scapular winging can be a significant source of chronic pain, weakness, and disability of the shoulder. Isolated serratus anterior palsy from long thoracic nerve injury, which is the most common cause of this condition, produces prominent winging and medial malpositioning of the inferior angle of the scapula. In the case of persistent symptoms despite conservative care, treatment options primarily include scapulothoracic fusion and pectoralis major transfer. Outcomes of scapulothoracic fusion are notable for a high complication rate and limited functional improvements...
October 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29392206/reduced-intraepidermal-nerve-fiber-density-after-a-sustained-increase-in-insular-glutamate-a-proof-of-concept-study-examining-the-pathogenesis-of-small-fiber-pathology-in-fibromyalgia
#16
Steven E Harte, Daniel J Clauw, John M Hayes, Eva L Feldman, Irene C St Charles, Christopher J Watson
Introduction: Neuroimaging reveals increased glutamate within the insula of patients with fibromyalgia (FM), suggesting a link between FM symptoms and increased central excitatory neurotransmission. Many patients with FM also present with decreased intraepidermal nerve fiber density (IENFD), consistent with small fiber pathology. It remains unknown, however, whether either of these mechanistic findings represent a cause or a consequence of the other. This study tests the hypothesis that an excitatory imbalance within the insula leads to small fiber pathology...
May 2017: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29377353/blockade-of-dopamine-d2-receptors-disrupts-intrahippocampal-connectivity-and-enhances-pain-related-working-memory-deficits-in-neuropathic-pain-rats
#17
H Cardoso-Cruz, M Dourado, C Monteiro, V Galhardo
BACKGROUND: Dopamine (DA) is thought to be important to local hippocampal networks integrity during spatial working memory (sWM) processing. Chronic pain may contribute to deficient dopaminergic signalling, which may in turn affect cognition. However, the neural mechanisms that determine this impairment are poorly understood. Here, we evaluated whether the sWM impairment characteristic of animal models of chronic pain is dependent on DA D2 receptor (D2r) activity. METHODS: To address this issue, we implanted multichannel arrays of electrodes in the dorsal and ventral hippocampal CA1 field (dvCA1) of rats and recorded the neuronal activity during a classical delayed food-reinforced T-maze sWM task...
May 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29372023/therapeutic-lumbar-facet-joint-nerve-blocks-in-the-treatment-of-chronic-low-back-pain-cost-utility-analysis-based-on-a-randomized-controlled-trial
#18
Laxmaiah Manchikanti, Vidyasagar Pampati, Alan D Kaye, Joshua A Hirsch
Background: Related to escalating health care costs and the questionable effectiveness of multiple interventions including lumbar facet joint interventions, cost effectiveness or cost utility analysis has become the cornerstone of evidence-based medicine influencing coverage decisions. Methods: Cost utility of therapeutic lumbar facet joint nerve blocks in managing chronic low back pain was performed utilizing data from a randomized, double-blind, controlled trial with a 2-year follow-up, with direct payment data from 2016...
January 2018: Korean Journal of Pain
https://www.readbyqxmd.com/read/29318865/-advances-in-acupuncture-mechanism-research-on-the-changes-of-synaptic-plasticity-pain-memory-for-chronic-pain
#19
Yi-Ling Yang, Jian-Peng Huang, Li Jiang, Jian-Hua Liu
Previous studies have shown that there are many common structures between the neural network of pain and memory, and the main structure in the pain network is also part of the memory network. Chronic pain is characterized by recurrent attacks and is associated with persistent ectopic impulse, which causes changes in synaptic structure and function based on nerve activity. These changes may induce long-term potentiation of synaptic transmission, and ultimately lead to changes in the central nervous system to produce "pain memory"...
December 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29284194/chronic-calf-pain-caused-by-fibroma-induced-chronic-inflammation-around-the-tibial-and-peroneal-nerves-that-was-misdiagnosed-as-centralized-neuropathic-pain-a-case-report
#20
Jiyoung Park, Seong-Ho Ok, Jeong Yeol Han, Miyeong Park, Eun Hui Seo, Yeon A Kim
INTRODUCTION: The etiology of calf pain varies widely; therefore, it is difficult to diagnose and requires careful history taking and physical examination by primary care unit physicians. Because ultrasonography is easy to perform, cheap, and readily available to physicians during a routine consultation, it is the first choice of modality for the evaluation of calf pain. However, simple inflammation around the nerve should also be considered as a possible etiology. Here we describe a 35-year-old man with chronic pain in the right calf that was actually caused by fibroma-induced chronic inflammation around the tibial and peroneal nerves but misdiagnosed as centralized neuropathic pain...
December 28, 2017: Pain Practice: the Official Journal of World Institute of Pain
keyword
keyword
11777
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"