keyword
https://read.qxmd.com/read/20406026/characterization-of-three-novel-monoclonal-anti-oka
#21
COMPARATIVE STUDY
M H Tian, G R Halverson
Anti-Ok(a) was first described by Morel and Hamilton in 1979. The Ok(a) antigen has a very high incidence, and only eight probands that are Ok(a-) have been found; all are of Japanese heritage. In this study,we describe the generation and characterization of three novel monoclonal antibodies (Mabs), MIMA-25, MIMA-144, and MIMA-149. The reactivity of these three Mabs was compared with the original human polyclonal anti-Ok(a). Mice were immunized with transfected HEK cells to induce an immune response, and the spleen B lymphocytes were fused with mouse myeloma X63-Ag8...
2009: Immunohematology
https://read.qxmd.com/read/20345514/a-silenced-allele-in-the-colton-blood-group-system
#22
JOURNAL ARTICLE
K Karpasitou, S Frison, E Longhi, F Drago, R Lopa, F Truglio, M Marini, S Bresciani, M Scalamogna, F Poli
BACKGROUND: The antigens of the Colton blood group system, Co(a) and Co(b), are encoded by a single gene that produces the aquaporin-1 (AQP1) protein, a water channel-forming protein, and are characterized by a single nucleotide polymorphism (SNP). A healthy Caucasoid blood donor originally typed as Co(a-b-) with commercial anti-Co(b) typed Co(a-b+) when retested with another anti-Co(b). Retyped with two different molecular biology methods, the sample came out Co(a)/Co(b). With the aim of understanding these discrepancies, serological, cytometric and molecular biology tests were carried out...
August 1, 2010: Vox Sanguinis
https://read.qxmd.com/read/19392786/dna-array-analysis-for-red-blood-cell-antigens-facilitates-the-transfusion-support-with-antigen-matched-blood-in-patients-with-sickle-cell-disease
#23
JOURNAL ARTICLE
K R Ribeiro, M H Guarnieri, D C da Costa, F F Costa, J Pellegrino, L Castilho
BACKGROUND: Blood samples from patients with sickle cell disease (SCD) present to transfusion service with numerous antibodies, making the searching for compatible red blood cells (RBC) a challenge. To overcome this problem we developed an effective strategy to meet needs of supplying RBC-compatible units to SCD patients using DNA arrays. METHODS: We selected DNA samples from 144 SCD patients with multiple (receiving > 5 units) transfusions previously phenotyped for ABO, Rh(D, C, c, E, e), K1, Fy(a) and Jk(a)...
August 2009: Vox Sanguinis
https://read.qxmd.com/read/18186512/dna-based-typing-of-kell-kidd-mns-dombrock-colton-and-yt-blood-group-systems-in-the-french-basques
#24
COMPARATIVE STUDY
Mhammed Touinssi, Jacques Chiaroni, Anna Degioanni, Thomas Granier, Olivier Dutour, Pascal Bailly, Frédéric Bauduer
The Basques demonstrate peculiar characteristics regarding blood group systems. Although ABO, Rhesus, and Duffy have been extensively studied in this population, the distribution of other groups remains largely unknown. Therefore, we evaluated the frequency of less-explored- or still noninvestigated blood groups using DNA-based assays and interpreted these data in the view of population genetics. Polymorphisms of KEL (Kell), SLCA14A1 (Kidd), GYPA/GYPB (MNS), ART4 (Dombrock), AQP1 (Colton), and ACHE (Yt) blood group genes were determined from a sample of more than 100 autochthonous French Basques using allele-specific primer PCR (PCR-ASP) methods...
May 2008: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://read.qxmd.com/read/16956794/tissue-distribution-of-blood-group-membrane-proteins-beyond-red-cells-evidence-from-cdna-libraries
#25
REVIEW
Markus T Rojewski, Hubert Schrezenmeier, Willy A Flegel
The proteins of blood group systems are expressed on red blood cells (RBC) by definition. We searched nucleotide databases of human expressed sequence tags (EST) to collate the distribution of 22 distinct membrane proteins in cells and tissues other than RBC. The documented blood group genes are: MNS, Rh, Lutheran, Kell, Duffy, Kidd, Diego, Yt, Xg, Scianna, Dombrock, Colton, Landsteiner-Wiener, Kx, Gerbich, Cromer, Knops, Indian, Ok, Raph, John-Milton-Hagen and Gill. The genes were grouped according to their overall and their relative expression in embryo and adults...
August 2006: Transfusion and Apheresis Science
https://read.qxmd.com/read/16800751/in-vivo-performance-evaluation-of-a-transdermal-near-infrared-fluorescence-resonance-energy-transfer-affinity-sensor-for-continuous-glucose-monitoring
#26
JOURNAL ARTICLE
Ralph Ballerstadt, Colton Evans, Ashok Gowda, Roger McNichols
The in vivo performance of a transdermal near-infrared fluorescence resonance energy transfer (FRET) affinity sensor was investigated in hairless rats, in order to validate its feasibility for glucose monitoring in humans. The sensor itself consists of a small hollow fiber implanted in dermal skin tissue, containing glucose-sensitive assay chemistry composed of agarose-immobilized Concanavalin A (ConA) and free dextran. The glucose-dependent fluorescence change is based on FRET between near-infrared-compatible donor and quencher dyes that are chemically linked to dextran and ConA, respectively...
June 2006: Diabetes Technology & Therapeutics
https://read.qxmd.com/read/16563834/red-cell-membrane-co2-permeability-in-normal-human-blood-and-in-blood-deficient-in-various-blood-groups-and-effect-of-dids
#27
COMPARATIVE STUDY
V Endeward, J-P Cartron, P Ripoche, G Gros
The red cell membrane has an exceptionally high permeability for CO2, PCO2 approximately 0.15 cm/s, which is two to three orders of magnitude greater than that of some epithelial membranes and similarly greater than the permeability of the red cell membrane for HCO3-. As shown previously, this high PCO2 can be drastically inhibited by 10 microM 4,4'-diisothiocyanato-2,2'-stilbenedisulfonate (DIDS), indicating that membrane proteins may be involved in this high gas permeability. Here, we have studied the possible contribution of several blood group proteins to CO2 permeation across the red cell membrane by comparing PCO2 of red cells deficient in specific blood group proteins with that of normal red cells...
March 2006: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://read.qxmd.com/read/15945962/auberger-red-cell-antigens-are-not-part-of-the-kell-colton-or-dornbrock-blood-group-systems
#28
JOURNAL ARTICLE
P Tippett, G L Daniels, C Lomas, C A Green
Since 1981, red cell samples from families were tested with anti-Aua and, since 1986, with both anti-Aua and anti-Aub in an attempt to elevate Auberger to a blood group system status. The results show that Auberger is not pan of the Kell (five families), Colton (three Families), or Dombrock (two families) blood group systems. Exclusion from four more systems (Di, Yt, LW, Ch:Rg) is required before system status may be claimed.
1989: Immunohematology
https://read.qxmd.com/read/15783300/abo-rh-mns-duffy-kidd-yt-scianna-and-colton-blood-group-systems-in-indigenous-chinese
#29
JOURNAL ARTICLE
L Yan, F Zhu, Q Fu, J He
The frequencies of selected alleles in the ABO, Rh, MNS, Duffy, Kidd, Yt, Scianna, and Colton blood group systems were determined among four indigenous Chinese ethnic populations: Han, Tajik, She, and Yugu. Genotypes were determined by PCR or PCR with sequence specific primers (PCR-SSP). In the Han population, the frequencies of A1, A2, B, and O1 alleles were 0.189, 0.003, 0.170, and 0.638, respectively, and the O2 allele was not identified. Among D+ Hans, the frequencies of C and c alleles were 0.67 and 0...
2005: Immunohematology
https://read.qxmd.com/read/15373669/review-other-blood-group-systems-diego-yt-xg-scianna-dombrock-colton-landsteiner-wiener-and-indian
#30
REVIEW
K M Byrne, P C Byrne
No abstract text is available yet for this article.
2004: Immunohematology
https://read.qxmd.com/read/15373591/acute-hemolytic-transfusion-reaction-caused-by-anti-coa
#31
JOURNAL ARTICLE
R B Covin, K S Evans, R Olshock, H W Thompson
Coa is a high-frequency blood group antigen in the Colton blood group system expressed on red blood cells (RBCs) of approximately 99.8 percent of random persons. Anti-Coa has been reported to cause delayed hemolytic transfusion reactions, hemolytic disease of the newborn, and accelerated clearance of RBCs in vivo. Acute hemolytic transfusion reactions (AHTRs) have not previously been reported. A 58-year-old man was hospitalized for vascular surgery. Initial blood bank evaluation revealed anti-Fya. The patient received six units of RBCs during his initial hospitalization and developed anti-E...
2001: Immunohematology
https://read.qxmd.com/read/11606828/an-aqp1-null-allele-in-an-indian-woman-with-co-a-b-phenotype-and-high-titer-anti-co3-associated-with-mild-hdn
#32
JOURNAL ARTICLE
S R Joshi, F F Wagner, K Vasantha, S R Panjwani, W A Flegel
BACKGROUND: The Colton blood group system (CO, ISBT 015) is composed of three antigens, of which Co3 (ISBT 015.003) is carried by almost all persons, except those of the extremely rare Co(a-b-) phenotype. The Colton blood group antigens are expressed by the water channel aquaporin 1 (aqp1; also known as channel-forming integral protein, CHIP-28), which is a highly conserved RBC integral membrane protein. The two most frequent alleles, CO1 and CO2, encode the antigens Co(a) and Co(b), respectively...
October 2001: Transfusion
https://read.qxmd.com/read/10816988/molecular-analysis-of-duffy-yt-and-colton-blood-groups-in-taiwanese-filipinos-and-thais
#33
JOURNAL ARTICLE
C T Peng, C H Tsai, H H Lee, C L Lin, N M Wang, J G Chang
We used a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method for DNA-based typing of Duffy, Yt and Colton blood groups in Taiwanese, Filipinos and Thais. A total of 200 Taiwanese, 115 Filipinos and 105 Thais were studied. In the Duffy blood group in Taiwanese, 180 cases (90%) were homozygote of Fya, 18 cases (9%) were double heterozygote of Fya and Fyb, and 2 cases (1%) were homozygote of Fyb. In Filipinos, 98 cases (85.2%) were homozygote of Fya, 16 cases (14.0%) were double heterozygote of Fya and Fyb and 1 case (0...
February 2000: Kaohsiung Journal of Medical Sciences
https://read.qxmd.com/read/10784073/improved-vascularization-of-planar-membrane-diffusion-devices-following-continuous-infusion-of-vascular-endothelial-growth-factor
#34
JOURNAL ARTICLE
N Trivedi, G M Steil, C K Colton, S Bonner-Weir, G C Weir
Improving blood vessel formation around an immunobarrier device should improve the survival of the encapsulated tissue. In the present study we investigated the formation of new blood vessels around a planar membrane diffusion device (the Baxter Theracyte System) undergoing a continuous infusion of vascular endothelial growth factor through the membranes and into the surrounding tissue. Each device (20 microl) had both an inner immunoisolation membrane and an outer vascularizing membrane. Human recombinant vascular endothelial growth factor-165 was infused at 100 ng/day (low dose: n = 6) and 500 ng/day (high dose: n = 7) for 10 days into devices implanted s...
January 2000: Cell Transplantation
https://read.qxmd.com/read/10225606/functional-aspects-of-red-cell-antigens
#35
REVIEW
G Daniels
Over 250 blood group determinants are known and most of these are located on integral red cell proteins and glycoproteins. The functions of some of these structures are known: Diego (band 3) is the red cell anion exchanger; Kidd, a urea transporter; Colton (aquaporin 1), a water channel; Cromer (DAF) and Knops (CRI), complement regulators; Diego (band 3) and Gerbich (glycophorin C/D) link the red cell membrane and the membrane skeleton. The Duffy glycoprotein is a chemokine receptor that may act as a scavenger for inflammatory mediators in the peripheral blood, but is also exploited as a receptor by Plasmodium vivax merozoites...
March 1999: Blood Reviews
https://read.qxmd.com/read/9371984/advances-in-the-molecular-biology-of-erythrocyte-antigens
#36
REVIEW
M J Tanner
The past year has seen further advances in our understanding of the molecular biology of the most abundant erythrocyte proteins associated with blood group antigens (band 3, the glycophorins, and the Rh antigen-related proteins). There have also been several important developments in the structural and functional identification of some of the less abundant antigens. These developments include the association of the Colton antigens with the erythrocyte water channel, aquaporin; the cloning of the Duffy antigen and its identification as a chemokine receptor; the cloning of the Kx antigen, which is associated with McLeod syndrome; and the cloning of the LW, CD47, and Xga antigens...
March 1995: Current Opinion in Hematology
https://read.qxmd.com/read/9356672/case-report-anti-coa-in-a-co-a-typed-patient-with-chronic-renal-insufficiency
#37
JOURNAL ARTICLE
A Leo, J P Cartron, M Strittmatter, G Rowe, D Roelcke
The recently identified molecular structure of the Colton blood group system is characterized by an amino acid substitution at position 45 (Colton a: alanine, Colton b: valine) of the archetypical water channel protein Aquaporin-1 (AQP1), which regulates water homeostasis in the erythrocyte membrane and in the proximal tubule of the nephron. We identified a patient with the unique constellation of an antibody with the specificity anti-Coa and the Co (a+) phenotype. The serological antigen typing was confirmed by molecular typing with PCR-RFLP...
1997: Contributions to Infusion Therapy and Transfusion Medicine
https://read.qxmd.com/read/9167305/human-erythrocyte-antigen-expression-its-molecular-bases
#38
REVIEW
N D Avent
This review summarises the considerable body of information now available on the molecular bases of human blood group-antigen expression. The elucidation of this information has only been possible since the identification, purification, and subsequent cDNA cloning of the mRNAs which encode the blood group active proteins. The surface components which are responsible for antigen expression are divided into two types: carbohydrate and protein. All carbohydrate structures are attached covalently to either glycolipids or glycoproteins, and are synthesised in the Golgi apparatus of erythropoietic cells (or in other cell lines in secreted fluids)...
March 1997: British Journal of Biomedical Science
https://read.qxmd.com/read/8925112/-a-molecular-approach-to-the-structure-polymorphism-and-function-of-blood-groups
#39
REVIEW
J P Cartron
Biochemical and molecular genetic studies have contributed to our molecular knowledge of blood group-associated molecules in the past few years. Among the 23 blood group systems presently identified, almost all have a molecular basis and present investigations are oriented towards the analysis of genetic polymorphisms, tissue-specific expression and structure-function relationships. Antigens defined by carbohydrate structures, among which ABO, Hh, Lewis and Secretor are the main representative species, are indirect gene products...
1996: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://read.qxmd.com/read/8542029/urea-transport-and-kidd-blood-groups
#40
REVIEW
J P Cartron, P Ripoche
The gene encoding for the human erythrocyte urea transporter (HUT11 clone) has recently been cloned (Olives et al., J. Biol. Chem., 269, 3/649, 1994). It has been localized at 18q12-q21, like the Kidd blood group gene. In vitro translation experiments indicated that cDNA HUT11 could induce the synthesis of a 36 kDa protein which can be immunoprecipitated by an anti-Jk3 antibody (a human antibody produced by Jk(a-b-) individuals). This antibody also precipitates a 46-60 kDa protein from human red blood cells, except from those with Jk(a-b-) phenotype...
1995: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
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