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JOURNAL ARTICLE
Leyllane Rafael Moreira, Ana Carla Silva, Cíntia Nascimento da Costa-Oliveira, Claudeir Dias da Silva-Júnior, Kamila Kássia Dos Santos Oliveira, Diego José Lira Torres, Michelle D Barros, Michelle Christiane D S Rabello, Virginia Maria Barros de Lorena
BACKGROUND/INTRODUCTION: Adipose tissue (AT) has been highlighted as a promising reservoir of infection for viruses, bacteria and parasites. Among them is Trypanosoma cruzi , which causes Chagas disease. The recommended treatment for the disease in Brazil is Benznidazole (BZ). However, its efficacy may vary according to the stage of the disease, geographical origin, age, immune background of the host and sensitivity of the strains to the drug. In this context, AT may act as an ally for the parasite survival and persistence in the host and a barrier for BZ action...
2024: Frontiers in Immunology
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JOURNAL ARTICLE
Diego D Santos, Nycole M Belote, Gisela R S Sasso, Rebeca D Correia-Silva, Paulo C Franco, Artur Francisco da Silva Neto, Fernanda T Borges, Lila M Oyama, Cristiane D Gil
This study evaluated the effect of pharmacological inhibition of galectin 3 (Gal-3) with modified citrus pectin (MCP) on the heart and kidney in a model of cisplatin-induced acute toxicity. Male Wistar rats were divided into four groups (n = 6/group): SHAM, which received sterile saline intraperitoneally (i.p.) for three days; CIS, which received cisplatin i.p. (10mg/kg/day) for three days; MCP, which received MCP orally (100mg/kg/day) for seven days, followed by sterile saline i.p. for three days; MCP+CIS, which received MCP orally for seven days followed by cisplatin i...
March 22, 2024: Toxicology
#3
REVIEW
Marta Araujo-Castro, Paola Parra, Patricia Martín Rojas-Marcos, Miguel Paja Fano, Marga González Boillos, Eider Pascual-Corrales, Ana María García Cano, Jorge Gabriel Ruiz-Sanchez, Almudena Vicente Delgado, Emilia Gómez Hoyos, Rui Ferreira, Iñigo García Sanz, Mònica Recasens Sala, Rebeca Barahona San Millan, María José Picón César, Patricia Díaz Guardiola, Carolina M Perdomo, Laura Manjón-Miguélez, Rogelio García Centeno, Ángel Rebollo Román, Paola Gracia Gimeno, Cristina Robles Lázaro, Manuel Morales-Ruiz, María Calatayud, Simone Andree Furio Collao, Diego Meneses, Miguel Sampedro Nuñez, Verónica Escudero Quesada, Elena Mena Ribas, Alicia Sanmartín Sánchez, Cesar Gonzalvo Diaz, Cristina Lamas, María Del Castillo Tous, Joaquín Serrano Gotarredona, Theodora Michalopoulou Alevras, Eva María Moya Mateo, Felicia A Hanzu
PURPOSE: To compare the clinical and hormonal characteristics of patients with familial hyperaldosteronism (FH) and sporadic primary aldosteronism (PA). METHODS: A systematic review of the literature was performed for the identification of FH patients. The SPAIN-ALDO registry cohort of patients with no suspicion of FH was chosen as the comparator group (sporadic group). RESULTS: A total of 360 FH (246 FH type I, 73 type II, 29 type III, and 12 type IV) cases and 830 sporadic PA patients were included...
2024: Frontiers in Endocrinology
#4
JOURNAL ARTICLE
Steven J Drews, Carmen Charlton, Sheila F O'Brien, Samantha Burugu, Gregory A Denomme
BACKGROUND AND OBJECTIVES: In Canada, plasma sent for fractionation is tested for both parvovirus B19 (B19V) and hepatitis A virus (HAV). This study compared positivity rates of B19 and HAV nucleic acid tests (NATs) in Canadian plasma samples for the pre-COVID-19 restriction era (2015 to end of February 2020 [Q1] 2020) and the post-COVID-19 restriction era. MATERIALS AND METHODS: Pooled EDTA plasma specimens were tested within 24 months of blood draw using the Procleix Panther System (Grifols Diagnostic Solutions Inc, San Diego, CA, USA) for B19V and HAV detection...
March 14, 2024: Vox Sanguinis
#5
REVIEW
Gabriel Zúñiga Salazar, Diego Zúñiga, Sneha Balasubramanian, Khawar Tariq Mehmood, Shahad Al-Baldawi
The global increase in dementia cases, driven by improved life expectancy and reduced elderly mortality rates, presents a significant public health challenge. Dementia, characterized by a gradual and irreversible decline in cognitive abilities, affects individuals aged 65 and older, disrupting lives and straining healthcare systems. Hypertension significantly influences dementia development. Research consistently links midlife hypertension to cognitive decline, mild cognitive impairment (MCI), and dementia, but findings in older adults vary...
January 2024: Curēus
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JOURNAL ARTICLE
Maria Garcia-Bonilla, Alexander T Yahanda, Albert M Isaacs, Brandon Baksh, S Hassan A Akbari, Haley Botteron, Diego M Morales, Rowland H Han, James P McAllister Ii, Amit M Mathur, Jennifer M Strahle, Christopher D Smyser, David D Limbrick
BACKGROUND: Interpretation of cerebrospinal fluid (CSF) studies can be challenging in preterm infants. We hypothesized that intraventricular hemorrhage (IVH), post-hemorrhagic hydrocephalus (PHH), and infection (meningitis) promote pro-inflammatory CSF conditions reflected in CSF parameters. METHODS: Biochemical and cytological profiles of lumbar CSF and peripheral blood samples were analyzed for 81 control, 29 IVH grade 1/2 (IVH1/2 ), 13 IVH grade 3/4 (IVH3/4 ), 15 PHH, 20 culture-confirmed bacterial meningitis (BM), and 27 viral meningitis (VM) infants at 36...
February 21, 2024: Fluids and Barriers of the CNS
#7
RANDOMIZED CONTROLLED TRIAL
Aditi Gupta, Hira Chouhdry, Shellie D Ellis, Kate Young, Jonathan Mahnken, Branden Comfort, Denton Shanks, Sheila McGreevy, Courtney Rudy, Tahira Zufer, Sharissa Mabry, Jennifer Woodward, Amber Wilson, Heidi Anderson, Jennifer Loucks, Sravani Chandaka, Noor Abu-El-Rub, Diego R Mazzotti, Xing Song, Nolan Schmitz, Molly Conroy, Mark A Supiano, Lemuel R Waitman, Jeffrey M Burns
Hypertension control remains poor. Multiple barriers at the level of patients, providers, and health systems interfere with implementation of hypertension guidelines and effective lowering of BP. Some strategies such as self-measured blood pressure (SMBP) and remote management by pharmacists are safe and effectively lower BP but have not been effectively implemented. In this study, we combine such evidence-based strategies to build a remote hypertension program and test its effectiveness and implementation in large health systems...
March 2024: Contemporary Clinical Trials
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JOURNAL ARTICLE
Diego T Brunelli, Ivan L P Bonfante, Vinicius O Boldrini, Pedro G Scolfaro, Renata G Duft, Keryma Mateus, Raphael F Fatori, Mara P T Chacon-Mikahil, Alessandro S Farias, Ana M Teixeira, Cláudia R Cavaglieri
Purpose: The aim of this study was to investigate the effects of moderate combined training (CT) on both the gene expression of pro- and anti-inflammatory markers and senescence in the immune system in peripheral blood mononuclear cells (PBMCs) and subcutaneous adipose tissue (SAT) of obese middle-aged individuals with type 2 diabetes (T2D). Methods: Thirty obese individuals (50.2 ± 9.4 years; body mass index: 31.8 ± 2.3 kg/m²) with T2D underwent 16 weeks of a CT group [CT; aerobic (50-60% of VO2max ) plus resistance (50-75% of 1RM) training; 3 times/week, 70 min/session; n = 16)] or a control group (CG, n = 14)...
February 6, 2024: Research Quarterly for Exercise and Sport
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JOURNAL ARTICLE
Cristina de Diego, Ana Belén Lasierra, Lucía López-Vergara, Laura Torralba, Pablo Ruiz de Gopegui, Raquel Lahoz, Claudia Abadía, Javier Godino, Alberto Cebollada, Beatriz Jimeno, Carlota Bello, Antonio Tejada, Salvador Bello
BACKGROUND: Neutrophil extracellular traps (NETs) have repeatedly been related to COVID-19 severity and mortality. However, there is no consensus on their quantification, and there are scarce data on their evolution during the disease. We studied circulating NET markers in patients with COVID-19 throughout their hospitalization. METHODS: We prospectively included 93 patients (201 blood samples), evaluating the disease severity in 3 evolutionary phases (viral, early, and late inflammation)...
January 19, 2024: Respiratory Research
#10
JOURNAL ARTICLE
Lorenzo Mantovani, Elisa Mikus, Elena Tenti, Diego Sangiorgi, Samantha Zannoni, Andrea Cavallucci, Letizia Ferroni, Paolo Cimaglia, Valentina Tolio, Elena Tremoli, Carlo Savini
In elderly patients undergoing cardiac surgery, extracorporeal circulation affects the incidence of post-operative delirium and cognitive impairment with an impact on quality of life and mortality. In this study, a new oxygenator system (RemoweLL 2) was tested against a conventional system to assess its efficacy in reducing the onset of postoperative delirium and cognitive dysfunction and the levels of serum inflammatory markers. A total of 154 patients (>65 y.o.) undergoing cardiopulmonary bypass (CPB) were enrolled and randomly assigned to oxygenator RemoweLL 2 ( n = 81) or to gold standard device Inspire ( n = 73) between September 2019 and March 2022...
December 15, 2023: Bioengineering
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JOURNAL ARTICLE
Emily Leonela Castillo-García, Ana Lizzet Cossio-Ramírez, Óscar Arturo Córdoba-Méndez, Marco A Loza-Mejía, Juan Rodrigo Salazar, Edwin Chávez-Gutiérrez, Guadalupe Bautista-Poblet, Nadia Tzayaka Castillo-Mendieta, Diego A Moreno, Cristina García-Viguera, Rodolfo Pinto-Almazán, Julio César Almanza-Pérez, Juan Manuel Gallardo, Christian Guerra-Araiza
Metabolic syndrome (MetS) is a complex disease that includes metabolic and physiological alterations in various organs such as the heart, pancreas, liver, and brain. Reports indicate that blackberry consumption, such as maqui berry, has a beneficial effect on chronic diseases such as cardiovascular disease, obesity, and diabetes. In the present study, in vivo and in silico studies have been performed to evaluate the molecular mechanisms implied to improve the metabolic parameters of MetS. Fourteen-day administration of maqui berry reduces weight gain, blood fasting glucose, total blood cholesterol, triacylglycerides, insulin resistance, and blood pressure impairment in the diet-induced MetS model in male and female rats...
December 7, 2023: Metabolites
#12
JOURNAL ARTICLE
Andrés Aburto, Diego Zapata, Eduardo Retamales, Jorge Fernández, Gisselle Barra, Francisca Peña, Sofía Cárcamo, Nicolás Saavedra, Cristian Sandoval, Juan Orellana, José Caamaño
INTRODUCTION: The D antigen variants are classified as weak, partial, and extremely weak (DEL) and can be differentiated using molecular tests. In Chile, the laboratories of local blood centers do not identify variants of the D antigen, referring them for study to the Reference Laboratory of the Public Health Institute of Chile. So, our aim was to talk about the results of the molecular analysis of variants of the D antigen in samples that had different results in the serological classification...
2023: Frontiers in Immunology
#13
JOURNAL ARTICLE
Diana Ramírez-Hernández, Pedro López-Sánchez, Diego Lezama-Martínez, Neidy M Kuyoc-Arroyo, Jessica E Rodríguez-Rodríguez, Salvador Fonseca-Coronado, Ignacio Valencia-Hernández, Jazmin Flores-Monroy
Cardiovascular disease incidence increases after menopause due to the loss of estrogen cardioprotective effects. However, there are conflicting data regarding the timing of estrogen therapy (ERT) and its effect on vascular dysfunction associated with impaired glucose metabolism. The aim of this work was to evaluate the effect of early and late ERT on blood glucose/insulin balance and vascular reactivity in aged ovariectomized Wistar rats. Eighteen-month-old female Wistar rats were randomized as follows: (1) sham, (2) 10-week postovariectomy (10 w), (3) 10 w postovariectomy+early estradiol therapy (10 w-early E2), (4) 20-week postovariectomy (20 w), and (5) 20-week postovariectomy+late estradiol therapy (20 w-late E2)...
2023: Journal of the Renin-angiotensin-aldosterone System: JRAAS
#14
JOURNAL ARTICLE
Camous Moslemi, Susanne G Saekmose, Rune Larsen, Jakob T Bay, Thorsten Brodersen, Maria Didriksen, Henrik Hjalgrim, Karina Banasik, Kaspar R Nielsen, Mie T Bruun, Joseph Dowsett, Khoa M Dinh, Susan Mikkelsen, Christina Mikkelsen, Thomas F Hansen, Henrik Ullum, Christian Erikstrup, Søren Brunak, Karen Angeliki Krogfelt, Jill R Storry, Sisse R Ostrowski, Martin L Olsson, Ole B Pedersen
BACKGROUND: Accurate blood type data are essential for blood bank management, but due to costs, few of 43 blood group systems are routinely determined in Danish blood banks. However, a more comprehensive dataset of blood types is useful in scenarios such as rare blood type allocation. We aimed to investigate the viability and accuracy of predicting blood types by leveraging an existing dataset of imputed genotypes for two cohorts of approximately 90,000 each (Danish Blood Donor Study and Copenhagen Biobank) and present a more comprehensive overview of blood types for our Danish donor cohort...
November 3, 2023: Transfusion
#15
JOURNAL ARTICLE
Raquel Carvalho Bouth, Angélica Rita Gobbo, Josafá Gonçalves Barreto, Pablo Diego do Carmo Pinto, Maraya Semblano Bittencourt, Marco Andrey Cipriani Frade, Apolônio Carvalho Nascimento, Sabrina Sampaio Bandeira, Patricia Fagundes da Costa, Guilherme Augusto Barros Conde, Charlotte Avanzi, Ândrea Ribeiro-Dos-Santos, John Stewart Spencer, Moises Batista da Silva, Claudio Guedes Salgado
INTRODUCTION: Leprosy, an infectious disease caused by Mycobacterium leprae , remains a public health concern in endemic countries, particularly in Brazil. In this study, we conducted an active surveillance campaign in the hyperendemic city of Castanhal in the northeastern part of the state of Pará using clinical signs and symptoms combined with serological and molecular tools to diagnose new cases and to identify drug resistance of circulating M. leprae strains and their distribution in the community...
2023: Frontiers in Medicine
#16
JOURNAL ARTICLE
Beatriz Gasser, Ricardo Andres Ramirez Uscategui, Luiz Paulo Nogueira Aires, Diego Iwao Yamada, Priscila Del'Aguila-Silva, Bruna Bressianini Lima, Priscila Silva, Igor Cezar Kniphoff da Cruz, Rafael Kretzer Carneiro, Marcus Antônio Rossi Feliciano
BACKGROUND: Sepsis is a condition characterized by organic dysfunction, leading to hemodynamic instability and high morbidity and mortality rates in humans and animals. Early identification of perfusion changes and appropriate management of sepsis are crucial for improving patient prognosis. Currently, the Systemic Inflammatory Response Syndrome (SIRS) and Sequential Organ Failure Assessment (SOFA) scores are widely studied for sepsis identification and evaluation of organ dysfunction...
September 30, 2023: BMC Veterinary Research
#17
JOURNAL ARTICLE
Roland von Känel, Mary Princip, Sarah A Holzgang, Sinthujan Sivakumar, Aju P Pazhenkottil, Diego Gomez Vieito, Claudia Zuccarella-Hackl
BACKGROUND: Occupational burnout has been associated with an increased risk of cardiovascular disease, with sympathetic nervous system (SNS) dysfunction as one explanation. This study examined the effects of burnout on responses of SNS activity measures to acute psychosocial stress in male physicians, a population at risk for burnout. METHODS: Study participants were 60 male physicians, 30 with clinical burnout, assessed with the Maslach Burnout Inventory, and 30 without burnout (controls)...
September 14, 2023: Biological Psychology
#18
JOURNAL ARTICLE
Klaus Rieneck, Grethe Risum Krog, Frederik Banch Clausen, Christoffer Egeberg Hother, Morten Hanefeld Dziegiel
BACKGROUND AND OBJECTIVES: For 5 years, routine genotyping has been performed for selected blood groups of blood donors in the Copenhagen Capital Region, Denmark. The result is summarized in the following. MATERIALS AND METHODS: Genotyping was carried out by an external service provider using the competitive allele specific PCR (KASP) technology. The genotypes were returned to the blood bank and translated into phenotypes by a proprietary IT application. RESULTS: In total, 65 alleles from 16 blood group systems (ABO, MNS, Rh, Lutheran, Kell, Duffy, Kidd, Diego, Yt, Dombrock, Colton, Landsteiner-Wiener, Cromer, Knops, Vel, secretor status) and the HPA1, HPA5 and HPA15 antigens were interrogated...
September 6, 2023: Vox Sanguinis
#19
JOURNAL ARTICLE
Benedict A Capacio, Jayanth S Shankara Narayanan, Diego A Vicente, Yujia Liu, Jason P LaPorte, Bryan F Cox, David B Jaroch, Steven C Katz, Rebekah R White
BACKGROUND: Systemic immunotherapy has had limited clinical benefit in pancreatic ductal adenocarcinoma. This is thought to be due to its desmoplastic immunosuppressive tumor microenvironment in addition to high intratumoral pressures that limit drug delivery. Recent preclinical cancer models and early-phase clinical trials have demonstrated the potential of toll-like receptor 9 agonists, including the synthetic CpG oligonucleotide SD-101, to stimulate a wide range of immune cells and eliminate suppressive myeloid cells...
June 28, 2023: Surgery
#20
COMPARATIVE STUDY
Lemis Yavuz, Sarmad AlHamdani, Samah Alasrawi, Deena Wafadari, Ali Al-Fraihat, Marwa A Bebars, Jaidev Nath, Diego Arango, Marco Pallavidino, Ruchi Jain, Sinan Yavuz, Mohamed AlAwadhi, Abdulla Alkhayat, Ahmad Abou Tayoun, Walid Mohammad Abuhammour
OBJECTIVE: This is a comprehensive characteristic study of Kawasaki disease (KD) and Multi system inflammatory syndrome in children (MIS-C) in the Middle East that creates a formula to differentiate between the two. METHODS: We conducted a descriptive comparative study of KD and MIS-C in the United Arab Emirates. Retrospective MIS-C and KD cohorts were recruited between January 2017 until August 2021.We compared clinical and laboratory characteristics between both groups...
June 29, 2023: Pediatric Rheumatology Online Journal
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