Anti-Diego

BACKGROUND: The Diegoa antigen commonly occurs in certain Asian and South American Indian populations. In general, hemolysis caused by anti-Diegoa antigen is not severe, and exchange transfusion is rarely needed. Here, we report a neonate with moderate hemolytic disease caused by anti-Diegoa antigen in the Baoji area of China. CASE PRESENTATION: A 39-week gestation male newborn of Han nationality was delivered by second cesarean section because of scarred uterus...

Extramedullary hematopoiesis occurs in the setting of hematologic disorders or malignancies when the activity of the bone marrow is insufficient to generate blood cells. We report a unique case of adrenal extramedullary hematopoiesis diagnosed in a 16 year old female with a history of anti-Diego antibody and congenital dyserythropoietic anemia. She presented with an enlarging adrenal mass and underwent surgical resection. Pathology revealed extramedullary hematopoiesis. On literature review, we identified only two prior existing cases of adrenal extramedullary hematopoiesis in pediatric patients, with no prior case reports of adrenal extramedullary hematopoiesis occurring in patients with anti-Diego antibody or in those with congenital dyserythropoietic anemia...

Anti-Diego b (Di(b) ) antibodies, rare antibodies against red blood cell antigens, can cause severe hemolysis. We report a patient who most likely acquired anti-Di(b) antibodies during pregnancy. The patient was a 39-year-old Japanese woman who delivered by cesarean section at 38 weeks of gestation. She required a second operation to treat re-bleeding of the surgical scar, but it was difficult to schedule this surgery because we could not obtain enough blood for transfusion due to the presence of anti-Di(b) antibodies...

OBJECTIVE: The objective of this study was to determine the percent of the donor population in a South Texas community positive for the red cell antigen Diego(a) (Di(a)) and to determine the percent of anti-Di(a) in previously transfused patients. DESIGN: Donor segments from 270 type A and type O donors were typed with anti-Di(a) and 305 previously transfused patients were screened for anti-Di(a). SETTING: The study was conducted using donor segments from units collected by the South Texas Blood Center and blood samples from patients in three hospitals in Corpus Christi TX...

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All pregnant women with anti-Diegob (anti-Dib) described so far were non-Caucasians. We present the case of a Polish Di(a+b-) woman with anti-Dib, which did not bind complement, was immunoglobulin G3 (IgG3) alone and had very low functional activity. She delivered a Di(a+b+) infant with a positive direct antiglobulin test and the antibody in his serum but very mild haemolytic disease. Both parents of the pregnant woman were Di(a+b+), so were all her three children. The whole family have been living in a small village in southeastern Poland for a long time...

Our aim in this case report was to describe anemia caused by anti-Diego(a) red blood cell (RBC) antibody in a 3-week-old infant derived during pregnancy to low-frequency Diego(a) RBC antigen. Pre- and postnatal maternal serum screening for unexpected RBC antibodies and determination of RBC antibody specificity in the sera of the mother and child and in the elute of the child were performed by use of microcards (Diamed, Basel, Switzerland; BioVue, Ortho Clinical Diagnosis, Raritan, NJ, USA) with commercially prepared test RBCs (Diamed, Ortho Clinical Diagnosis, and Gamma Biologicals, Houston, TX, USA) at 37 degrees C and indirect antiglobulin test (IAT) according to manufacturer instructions...

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A native Cambodian woman delivered a third full-term female baby who had a strongly positive direct antiglobulin test. During the pregnancy and after the delivery, the woman had a negative irregular antibody screening test using standard red blood cell panels, but the indirect antiglobulin test between the mother's serum and the father's red blood cells was strongly positive. The antibody could be eluted from the baby's red blood cells and its was identified as an anti-Dia (Diegoa). The child developed a mild hyperbilirubinemia and recovered without treatment...

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